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This page comme from the website Gattefosse. It was printed the le 2011-03-24 : 17:08. The original page is available at this
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PHARMACEUTICALS
Labrasol®
Caprylocaproyl macrogol-8 glycerides EP
Caprylocaproyl polyoxyl-8 glycerides NF
Key Features
Oral
•A non-ionic water dispersible surfactant composed of well-characterised polyethylene glycol (PEG) esters,
a small glyceride fraction and free PEG.
•Able to self-emulsify on contact with aqueous media forming a fine dispersion ie. microemulsion
(SMEDDS).
•Solubilizer and wetting agent: Surfactive power improves the solubility and wettability of active
pharmaceutical ingredients in vitro and in vivo.
•Bioavailability enhancer: Increased bioavailability is reported to be associated with strong inhibition of the
enterocytic efflux transporter (known as P-gP inhibition).
Topical
•An oil-in-water surfactant used to solubilize active pharmaceutical ingredients and promote drug
penetration and permeation.
Safety of use is supported by extensive toxicological evaluations and precedence of use in approved
pharmaceutical products.
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Physical Form
liquid
Hydrophilic-lipophilic Balance
14
Field of use
Administration Route
Oral
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