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Lowers arteriolar resistance and increases venous capacitance

Profound hypotension following first dose


Causes mild dry cough
ACE Inhibitor Contraindicated in bilateral renal artery stenosis (reduced renal
artery blood flow) - perform peripheral vascular exam
Check renal function after very change of dose

Directly causes vasodilation and reduce secretion of aldosterone


Preventable cause of Drugs
ARB / AT-II Used in patients who cannot tolerate ACE-I
premature morbidity and
mortality Major risk factor for CV disease
Causes arteriolar dilatation and reduces force of cardiac contraction
Often asymptomatic Calcium Channel Blocker SE: headaches, ankle swelling, sweating

Inhibits Na / Cl cotransporter
S/E: low K
<130 / <85 mmHg Thiazide Diuretic
Normal Affect serum cholesterol and glucose levels

Persistantly high BP > 160 / 100 mmHg


Persistantly BP > 140 / 100 mmHg + raised CV risk
High risk: FH, obesity, high LDL, impaired Diet and exercise
fasting glucose, south Asian, smoker Hypertension
Treat Decrease alcohol consumption
ACE Inhibitor < 55 yrs
Lifestyle Interventions Decrease caffine consumption
Thiazide diuretic or Drug therapy Decrease salt intake
calcium channel blocker > 55yrs / Black
Stop smoking

Urine dipstick Renal / renovascular disease


Serum creatine / electrolytes Investigations Endocrine disease
Secondary
Fasting glucose / cholesterol Pregnancy
Drugs

Hypertension.mmap - 07/09/2010 -

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