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  • Carbamazepine

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    Jessica Harrell
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    Carbamazepine and oxcarbazepine are anti-epileptic drugs that work by prolonging the inactivation of sodium channels. They have high lipid solubility and their metabolites are as active as the parent molecules, with carbamazepine having a half-life of 10-20 hours that can be reduced to 9 hours by other anti-epileptic drugs due to metabolism through the P450 system. These drugs are used to initiate therapy for simple and complex partial seizures and tonic-clonic seizures, starting at 200 mg twice daily and titrating up to 600-1200 mg daily to achieve therapeutic concentrations between 6-12 micrograms per mL. Common side effects include drowsiness, diplo

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    Carbamazepine and oxcarbazepine are anti-epileptic drugs that work by prolonging the inactivation of sodium channels. They have high lipid solubility and their metabolites are as active as the parent molecules, with carbamazepine having a half-life of 10-20 hours that can be reduced to 9 hours by other anti-epileptic drugs due to metabolism through the P450 system. These drugs are used to initiate therapy for simple and complex partial seizures and tonic-clonic seizures, starting at 200 mg twice daily and titrating up to 600-1200 mg daily to achieve therapeutic concentrations between 6-12 micrograms per mL. Common side effects include drowsiness, diplo

    Drepturi de autor:

    Attribution Non-Commercial (BY-NC)
    Descărcați ca DOCX, PDF, TXT sau citiți online pe Scribd
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    2K vizualizări1 pagină

    Carbamazepine

    Încărcat de

    Jessica Harrell
    Carbamazepine and oxcarbazepine are anti-epileptic drugs that work by prolonging the inactivation of sodium channels. They have high lipid solubility and their metabolites are as active as the parent molecules, with carbamazepine having a half-life of 10-20 hours that can be reduced to 9 hours by other anti-epileptic drugs due to metabolism through the P450 system. These drugs are used to initiate therapy for simple and complex partial seizures and tonic-clonic seizures, starting at 200 mg twice daily and titrating up to 600-1200 mg daily to achieve therapeutic concentrations between 6-12 micrograms per mL. Common side effects include drowsiness, diplo

    Drepturi de autor:

    Attribution Non-Commercial (BY-NC)
    Descărcați ca DOCX, PDF, TXT sau citiți online pe Scribd
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    din 1

    CARBAMAZEPINE (Tegretol) OXCARBAZEPINE (Trileptal)

    Class MOA Anti-epileptic Prolonged inactivation of Na+ channels No effect on glutamate or GABA neurotransmission Very high lipid solubility Oxidized to 10,11-epoxide which is as active as parent molecule t1/2 = 10-20h (high variability between patients) Phenobarbital or phenytoin reduces t1/2 to 9h Lots of DDIs due to metabolism through P450 system

    Pharmacokinetics

    Pharmacodynamics Clinical Use Initiation of therapy of simple and complex partial seizures Initiation of therapy of tonic-clonic seizures Therapeutic concentrations: 6-12 g/mL CNS side-effects prominent above 9 g/mL Add phenytoin if treatment unsatisfactory after a month or more Start 200 mg BID and titrate to 600-1200 mg/d Toxicity Drowsiness Diplopia Ataxia Aplastic anemia (1 in 200,000) Agranulocytosis Transient leucopenia Transient changes in hepatic enzymes Teratogen Primary generalized epilepsy (may induce status epilepticus)

    Side Effects

    Contraindications

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