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Black berry administration minimizes the toxic effects of sodium fluoride via free radicalscavenging and potent anti-oxidant activities. - GreenMedInfo Summary

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Abstract Title: Evaluation of free radical-scavenging and anti-oxidant properties of black berry against fluoride toxicity in rats. Abstract Source: Food Chem Toxicol. 2010 Aug-Sep;48(8-9):1999-2004. Epub 2010 May 22. PMID: 20472017

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Abstract Author(s): H A Hassan, A F Abdel-Aziz Article Affiliation: Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura,

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Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura,

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Egypt. drhanaahassan@yahoo.com Abstract: Oxidative damage to cellular components such as lipids and cell membranes by free radicals and other reactive oxygen species is believed to be associated with the development of degenerative

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diseases. Fluoride intoxication is associated with oxidative stress and altered anti-oxidant defense mechanism. So the present study was extended to investigate black berry anti-oxidant capacity towards superoxide anion radicals, hydroxyl radicals and nitrite in different organs of fluorideintoxicated rats. The data indicated that sodium fluoride (10.3mg/kg bw) administration induced oxidative stress as evidenced by elevated levels of lipid peroxidation and nitric oxide in red blood cells, kidney, testis and brain tissues. Moreover, significantly decreased glutathione level, total anti-oxidant capacity and superoxide dismutase activity were observed in the examined tissues. On the other hand, the induced oxidative stress and the alterations in anti-oxidant system were normalized by the oral administration of black berry juice (1.6g/kg bw). Therefore it can be concluded that black berry administration could minimize the toxic effects of fluoride indicating its free radical-scavenging and potent anti-oxidant activities. Pubmed Data : Food Chem Toxicol. 2010 Aug-Sep;48(8-9):1999-2004. Epub 2010 May 22. PMID: 20472017 Article Published Date : Aug 01, 2010

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Study Type : Animal Study Additional Links Substances : Blackberry : CK(17) : AC(13) Diseases : Fluoride Toxicity : CK(142) : AC(40) Pharmacological Actions : Antioxidants : CK(3508) : AC(1292)

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