Code No: RR212303 Set No.

1
II B.Tech I Semester Supplimentary Examinations, November 2007
BIOORGANIC CHEMISTRY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
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1. (a) What is an antibiotic? [8]

(b) Explain in detail about antimetabolite with different examples. [4+4]

2. Explain the following with suitable examples: [4x4=16]

(a) Bio-chemical transformations

(b) Assymetric synthesis of amino acids
(c) Chemical mutations
(d) Drug design.

3. (a) Define mutation. [5]

(b) What is chemical mutation. [5]
(c) Explain transition state analogue of chemical mutation. [6]

4. (a) How does binding energy contribute to reaction specificity and catalysis? [4+4]
(b) Methods to test the purity of the enzyme. [8]

5. Describe different proteins that are in association with metals. [16]

6. Explain in detail how copper ion forms complexes with different ligands. [12+4]

7. Expalin the capping in cyclodextrin molecules. [16]

8. (a) Explain how stearic acid is converted to oleic acid. [8]

(b) Explain the strategies of Breslow’s. [8]

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Code No: RR212303 Set No. 2
II B.Tech I Semester Supplimentary Examinations, November 2007
BIOORGANIC CHEMISTRY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. (a) What do you mean by organic chemistry? [8]

(b) Explain with different examples how organic chemistry plays important role
in bio-organic chemistry. [4+4]

2. Write short notes [4x4=16]

(a) Clasien condensation

(b) Benzoin condensation
(c) Cannizaro reaction
(d) Bayer-viller reaction.

3. (a) Explain molecular modeling study performed on leu-enkephalin with suitable

examples. [4+4]
(b) Describe about molecular modeling in the field of peptidomimetic. [4+4]

4. Describe various industrial applications of immobilized enzymes. [16]

5. Describe different proteins that are in association with metals. [16]

6. (a) What is a metal ion ? [8]

(b) Explain different biomodels of copper ions. [8]

7. Expalin the capping in cyclodextrin molecules. [16]

8. Explain in detail how isoeuphenol is synthesized. [16]

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Code No: RR212303 Set No. 3
II B.Tech I Semester Supplimentary Examinations, November 2007
BIOORGANIC CHEMISTRY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. What do you mean by molecular adaptation? Explain with three examples. [8+8]

2. (a) What are amino acids? Give their names. [6]

(b) Explain the chemistry of amino acids. [5]
(c) How the amino acids involve in living cell activities. [5]

3. Explain molecular recognition with different examples. [12+4]

4. Describe various industrial applications of immobilized enzymes. [16]

5. How does the structure of hemoglobin play its role in binding oxygen for its Trans-
port. [16]

6. Explain about Lindsys moores model. [16]

7. Discuss in detail what are the new development in crown ether Chemistry. [16]

8. Discuss in detail about β-acetoxy-ketones. [16]

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Code No: RR212303 Set No. 4
II B.Tech I Semester Supplimentary Examinations, November 2007
BIOORGANIC CHEMISTRY
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆

1. (a) What is an catalyst? [8]

(b) Explain with different examples how the catalyst increases the rate of the
reactions. [8]

2. Explain in detail about nonribosomal peptide bond formation. [12+4]

3. (a) Describe how the nonenzymatic reanugument of chorismate to prephenate

prefers a transition state of chainlike geometry . [8]
(b) How do you associate the prodigeous capacity of molecular recognition of
antibodies with potential enzymatic activity. [4+4]

4. (a) What is an enzyme? [8]

(b) Explain mechanism of chymotrypsin. [8]

5. Describe the following mechanisms in hydrolytic enzymes. [8+8]

(a) Peptide hydrolysis.

(b) Catalytic triads.

6. Discuss in detail the role of copper ion in biological system. [16]

7. (a) What are Amphiphilic molecules. [8]

(b) Explain in detail about the spherical model of an ionic micelle. [8]

8. How cyclization of squalene is initiated? [16]

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