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IV B.Tech I Semester Regular Examinations, November 2007
MOLECULAR BIOLOGY OF CANCER
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆
2. Name one proto oncogene that functions in signal transduction pathway controlling
cellular proliferation and its oncogenic protein leading to malignant transformation.
[16]
7. What are Microarray assays? How useful are they in tumor diagnosis? Comment.
[16]
8. What is the main purpose of palliation (surgery) and in what type of cancer is it
recommended? [16]
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Code No: RR412305 Set No. 2
IV B.Tech I Semester Regular Examinations, November 2007
MOLECULAR BIOLOGY OF CANCER
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆
1. Enumerate in detail the pathway by which Ras protein checks cell cycle progression
in response to environmental factors. [16]
3. Describe the function of the normal Rb gene in controlling cell cycle progression.
[16]
4. Which chemical carcinogens are involved in the induction of skin cancers? Name
the source of these carcinogens. [16]
5. Discuss on the every day exposure of human population to radiations from nat-
ural and artificial sources and proportions contributed by each. Correlate these
exposures with cancers in the present era. [16]
7. What is the main difference between normal radiographic imaging and Magnetic
Resonance Imaging? Which is superior in diagnosis and why? [16]
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Code No: RR412305 Set No. 3
IV B.Tech I Semester Regular Examinations, November 2007
MOLECULAR BIOLOGY OF CANCER
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆
(a) TGF-
(b) Family of E2 F
(c) MPF
(d) Cyclins. [8+8]
3. Describe Rb gene locus and the possible mutations that repress the activity of Rb
protein which induces cancer. [16]
4. Which chemical carcinogens are involved in the induction of skin cancers? Name
the source of these carcinogens. [16]
5. What are the 3 types of UV light? Describe in detail the specific mutagenic actions
produced by each and mention their carcinogenic potentials. [16]
7. What is Aspiration biopsy? Describe the technique, its usefulness and the risk
involved. [16]
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Code No: RR412305 Set No. 4
IV B.Tech I Semester Regular Examinations, November 2007
MOLECULAR BIOLOGY OF CANCER
(Bio-Technology)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆
1. Enumerate in detail the pathway by which Ras protein checks cell cycle progression
in response to environmental factors. [16]
3. What type of mutation causes proto oncogenes to convert them to oncogenes? Give
one specific example. [16]
4. Discuss the different sources of carcinogens that enter our environment and the
proportion contributed by each of these sources towards the development of human
cancers. [16]
6. Environmental factors including diet play a very important role in developing can-
cer. Distinguish the dietary factors associated with carcinogenesis showing the
association of food with a specific cancer. [16]
7. What is the main difference between normal radiographic imaging and Magnetic
Resonance Imaging? Which is superior in diagnosis and why? [16]
⋆⋆⋆⋆⋆
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