NAME OF DRUG Generic name: Vincristine sulfate Brand Name: Classification: Antineoplastic Agent Dosageand Frequency:

ACTION the inhibition of microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage.

INDICATION Vincristine sulfate injection is indicated in acute leukemia.

CONTRAINDICATION Contraindicated in pregnancy and lactation

ADVERSE EFFECTS Gastrointestinal Constipation, abdominal cramps, weight loss, nausea, vomiting, oral ulceration, diarrhea, paralytic ileus, intestinal necrosis and/or perforation, and anorexia Cardiovascular Hypertension and hypotension Loss of deeptendon reflexes, foot drop, ataxia, and paralysis

NX RESPONSIBILITIES Baseline data is obtained before starting vincristine Before using this medication, ask for medical history

Vincristine sulfate injection has also been Bronchospasm, Jaundice, shown to be useful in Marie tooth syndrome. combination with other oncolytic agents in Hodgkins disease, non Hodgkins malignant lymphomas (lymphocytic, mixed cell, histiocytic, undifferentiated, nodular and diffuse types), rhabdomyosarcoma, neuroblastoma, and Wilms tumor.

Assess patients understanding of the chemotherapeutic agents and administration procedures Emphasize the importance of compliance by the patient with prescribed schedule Avoid contact with the medication by transferring it from the bottle to a medicine cup and into the mouth. Wear gloves when

contact with the medication cannot be avoided and when handling bodily fluids.

NAME OF DRUG

ACTION

INDICATION potent antineoplastic agent which has been shown to be useful in the treatment of carefully selected hospitalized patients with malignant tumors of the testis in whom successful treatment by surgery and/or radiation is impossible. treatment of certain symptomatic patien ts with hypercalcemia andhyp ercalciuria associated with a variety of advanced neoplasms.

CONTRAINDICATION contraindicated in patients with thrombocytopenia, thrombocytopathy, coagu lation disorder or an increased susceptibility to bleeding due to other causes. should not be administered to any patient with impairment of bone marrow function.

ADVERSE EFFECTS gastrointestinal sympto ms: anorexia, nausea, vomiting, diarrhea, and stomatitis. ther less frequently reported side effects include fever, drowsiness, weakness,lethargy, mala ise, headache, depressio n, phlebitis, facial flushing, and skin rash.

NX RESPONSIBILITIES Review- The chemotherapy drugs prescription Before using this medication, ask for medical history Renal function should be monitored before, during and after treatment Assess the clients condition including Most recent report of blood counts including hemoglobin,hemato crit, white blood cells and platelets Assess patients understanding of the chemotherapeutic agents and administration procedures

Inhibits RNA Generic name: plicamycin transcription and Brand Name: Mithracin Inhibits osteoclast response to parathyroid hormone Classification: Cytotoxic Chemotherapy Dosageand Frequency:

NAME OF DRUG Generic name: chlorambucil Brand Name: Leukeran Classification: Dosageand Frequency:

ACTION group of chemicals k nown asalkylating ag ents. It is an antineopl astic andimmunosupp ressant and works by causing crosslinking of DNA, resul ting in altered protein production, decreased cell division, and cell death.

INDICATION Lymphocytic leuke mia Lymphoma/lympho sarcoma Multiple myeloma Polycythemia vera Macroglobulinemia Ovarian adenocarci noma Immunemediated conditions affecting skin, joint s, or kidneys

CONTRAINDICATION Chlorambucil is contraindicated in conditions like Thrombocytopenia, Leukopenia.

ADVERSE EFFECTS Gastrointestinal side effects may occur including anorexia, vomiting and/or diarrhea. Neurotoxic side effects of chlorambucil may include such as myoclonus, tremors, muscular twitching, agitation, and tonicclonic seizures.

NX RESPONSIBILITIES Review- The chemotherapy drugs prescription Before using this medication, ask for medical history Emphasize the importance of compliance by the patient with prescribed schedule instructed the patient to drink plenty of fluids while taking this medication instructed the patient not to increase his dose or take the medication more often without his doctor's approval

NAME OF DRUG Generic name: Vindesine Brand Name: Eldisine Classification: Cytotoxic Chemotherapy Dosageand Frequency:

ACTION binds to particular proteins and causes cell arrest or cell death.

INDICATION For the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis

CONTRAINDICATION pregnancy, lactation. Intrathecal admin, thrombocytopenia, leucopenia (neutrophil <1500/mm3.

ADVERSE EFFECTS pain or tenderness at injection site Hair loss Diarrhea occurs infrequently. mouth sores and ulcers Nausea and vomiting rarely occurs.

NX RESPONSIBILITIES Review- The chemotherapy drugs prescription Before using this medication, ask for medical history

Emphasize the importance of compliance by the patient with prescribed schedule Emphasize the importance of compliance by the patient with prescribed schedule Avoid contact with the medication by transferring it from the bottle to a medicine cup and into the mouth. Wear gloves when contact with the medication cannot be avoided and when handling

bodily fluids.

NAME OF DRUG Generic name: mechlorethamine Brand Name: MUSTARGEN Classification: Cytotoxic Chemotherapy Dosageand Frequency:

ACTION an antineoplastic nitrogen mustard also known as HN2 hydrochloride, is a nitrogen analog of sulfur mustard

INDICATION indicated for the palliative treatment of Hodgkin's disease (Stages III and IV), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, and bronchogenic carcinoma.

CONTRAINDICATION contraindicated in the presence of known infectious diseases and in patients who have had previous anaphylactic reactions to mustagen

ADVERSE EFFECTS Nausea and vomiting. . Hair loss Mouth sores Darkening of veins used for infusion Redness, dryness, irritation with topical use

NX RESPONSIBILITIES Before using this medication, ask for medical history instructed the patient to drink plenty of fluids while taking this medication Emphasize the importance of compliance by the patient with prescribed schedule Avoid contact with the medication by transferring it from the bottle to a medicine cup and into the mouth. Wear gloves when contact with the medication cannot be avoided and when handling bodily fluids.