Research Proposal For Ph.D.

Chemistry Programme
Submitted to

Saurashtra University,Rajkot
Name: - Satyajeet S.Biniwale (Ph.D. Eligibility Test Seat No.319, Merit No.28)

Title: -

Design and Development of Pharmaceutically Important Heterocyclic Compounds.

Heterocyclic compounds having 2/3 and 4 hetero atoms at symmetric or asymmetric positions have already been studied because of their interesting medicinal properties. It is also well established that various derivatives of Pyrazols, Pyridines, Pyrimidines & their fused analogues exihibit broad spectrum of pharmacological properties. In view of these facts. We proposed to synthesize some novel biologically important hetero cyclic compounds as described under.

OBJECTIVES:

To

synthesize

pharmacologically

active

compounds

possessing

heterocyclic moieties like Pyrazolinones, Pyrazolo-pyrimidines and Pyrazols their analogues. To characterize these products for structure elucidation by several analytical techniques like IR, NMR and Mass spectral studies etc. To screen these products for biological activities.

REVIEW OF LITERATURE:

Literature survey for this Ph.D. program will be carried out from various Organic Chemistry Journals, Heterocyclic Chemistry Journals, Medicinal Chemistry Journals, Chemical Abstracts, Reference Books and also by using of E-Source etc.

METHODOLOGY: Below proposed molecules will be synthesized by using different reactions and reagents.

CHARACTERIZATION: Synthesized Compounds will be characterized after purification by the following techniques:

H1-NMR,C13 -NMR

FT-IR Mass Spectrometry

C, H,[O], N analysis (Elemental Analysis)

BIOLOGICAL ACTIVITY SCREENING (PROPOSED): Synthesized compounds will be screened for the following biological activities:

Anti Bacterial Anti Fungal

-: PROPOSED RESEARCH WORK :-

N HO

CHR1R2 N

R N O

NR2

NR2

N R

NR2 N CN RN R N N R2N N R
R2N

R2N N

N N

NR2

Here R=Alkyl (Me/Et/ etc...) / Aryl (Substituted Halo, -NO2 Phenyl etc...) / Heteroalkyl (Urea/Thiourea/Substituted Amine Derivatives etc...) / Heteroaryl (Py. Pym. etc...)

References: -

(1) Mohammed,Y.S.;Regaila.H.A.A ;Gohar A.K.M.N. ;Abdel Latif.F.F. ;Ahmed,E.Kh-Egypt. J-Pharm. Sci.1988,29,419;Chem Abstr.1989, 110,231314.

(2)

Mohareb R.M. ;Sherif, S.M.Sulphur Lett.1992,15,91 ;Chem.

Abstr.1993, 118, 80892K.

(3) GTYL BUDAGYAN, A.L. ; AKO

HAYASTANI KIMIAN HANDES

PYAN M.E.

;VARTAYAN R.S. ;SHEIRANYAN, M.A.,

2002,55,58; CHEM. ABSTR. 2003,139,307714

Signature of the Candidate

Signature of the Supervisor

( Satyajeet S. Biniwale )

( Dr. M. S. Vadodaria )