International Conference on Radiation Biology (ICRB-2012) & 11th Biennial Meeting of the Indian Society of Radiation Biology:

Cosmic Radiation to Cancer Therapy

November 22-24, 2012

ACTREC, Tata Memorial Centre, Navi Mumbai

Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) TATA MEMORIAL CENTRE Kharghar, Navi Mumbai - 410210, INDIA.
Tel: 022-2740 5035 Fax: 022-27405080 E-mail: mshaikh@actrec.gov.in Web: www.actrec.gov.in

Preconference workshop on Molecular Imaging in Oncology

Wednesday, November 21, 2012, KS Auditorium, ACTREC
9.30-11:00 Lectures: Chairpersons Nuclear Imaging: An Overview Nuclear imaging and tumor characteristics Preclinical radioactive imaging J Creeze & V Rangarajan Venkatesh Rangarajan, TMH, Mumbai Sandip Basu, RMC, Mumbai Abhijit De, ACTREC, Mumbai TEA BREAK Molecular Probes Optical in vivo Imaging Fluorescence microscopic imaging Rao VL Papineni, Carestream Inc. USA Pritha Ray, ACTREC, India D. Bhattacharyya, ACTREC, Mumbai LUNCH PRACTICAL DEMONSTRATION TWO BATCHES IN ROTATION Batch A Microscopic imaging applications
(D. Bhattacharyya/Jayant Goda, ACTREC)

11:30-13:10

SCIENTIFIC SESSION 1: Radiation induced damage repair mechanism Chairperson PK Goyal, Univ. of Rajasthan & Rita Mulherkar, ACTREC, Mumbai Protection by chlorophyllin against radiation induced hematopoietic injury: Cellular and molecular mechanisms. KB Sainis, BARC, Mumbai Induction of non-homologous end-joining repair by hyperthermic inhibition of homologous recombination, Nicolaas Franken, Univ. of Amsterdam, The Netherland Identification of a novel inhibitor of nonhomologous DNA end joining: Implications in DNA Double-strand breakrepair and cancer. Sathees Raghavan, Indian InstItute of Science, Bangalore Prediction of radiotherapy induced normal tissue acute toxicity: Molecular significance of DNA double strandbreaks and its repair. BS Satish Rao, Manipal University, Manipal

11:00-11:15 11:15-13:15

13:15-14:00 14:00-16:30

13:10-14:00 14:00-15:15

LUNCH SCIENTIFIC SESSION 2: Translational radiation biology Chairpersons BB Singh, Mumbai & GK Rath, AIIMS, Delhi Requirement of pre-clinical evidence for radiation oncology clinical trials. Bhadrasain Vikram, NCI, USA Molecular determinants of radiation response in human oral cancers. Tanuja Teni, ACTREC, Mumbai A phase II, RCT (CONCERT-2) of Panitumumab + RT compared with ChemoRT advanced head and neck Squamous Cancer Georges Hatoum, JFK Comprehensive Cancer Institute, Florida USA

Batch A Small animal Imaging applications (Pradip Chaudhari, ACTREC) Batch-2 Batch-1

14:00-15:15 15:15-16:30 16:30-16:45 16:45-17:30

Batch-1 Batch -2

TEA BREAK
PANEL DISCUSSION: Practical Issues in Molecular Imaging for Translational Research

Panelist V. Rangarajan, S Basu, J Creeze, RVL Papineni, P Ray, D Bhattacharyya. Moderator- Abhijit De

15:15-16:45 16:45- 18:25

TEA BREAK and SCIENTIFIC POSTER SESSION I SCIENTIFIC SESSION 3A: Molecular radiation biology of fractionated dose Chairperson Nagraj Huilgol, Nanavati Hospital, Mumbai & Xiadong Wu, USA MicroRNA modulation in single versus fractionated doses: Hunting for novel targets for radiation sensitization. Norman Coleman, NCI, USA Exploiting sensitization windows of opportunity in hypo and hyper fractionated radiation therapy. Mansoor Ahmad, NCI, USA The First Cut is the Deepest.. Colin Seymour, McMaster University, Canada High-dose hypofractionated radiotherapy: radiobiological concepts. Seema Gupta, Biophysics Research Institute, USA.

Day 1 - Thursday, November 22, 2012

09:30-9:55 INAUGURATION About ICRB 2012 About ISRB Inaugural Address
Rajiv Sarin, General Secretary, ICRB-2012 & Director, ACTREC

P.K. Goyal, President, ISRB R.K. Sinha, Chairman, Atomic Energy Commission

INAUGURAL SESSION : Radiation and the Public Chairpersons: Maj. Gen. JK Bansal, Member NDMA & Anil DCruz, Director, TMH 9:55-10:45 10:45-11:10 11:10-11:30 KEY NOTE ADDRESS - Norman Coleman, NCI, USA Radiological and nuclear emegencies: Preparedness and countermeasures Fukushima Nuclear Accident Radiobiological Aspects. Yoshihisa Matsumoto, Tokyo Institute of Technology, Japan TEA BREAK

16:45- 18:25

SCIENTIFIC SESSION 3B: Radiation effect on non-human biota Chairperson KP Mishra, NGBU, Allahabad & Carmel Mothersill, McMaster University, Canada. Deinococcus Radiodurans: Worlds most radioresistant bacterium offers novel opportunities for basic research and applications. SK Apte, BARC, Mumbai Radiation response mechanisms of highly radioresistant insect cells: Learning Natures Lessons for Radioprotection. S Chandna, INMAS, Delhi An insight into gamma radiation tolerance of an ancient extremophilic insect Chironomus ramosus. B Nath,Univ. of Pune, Pune Performance of gamma irradiated wheat under terminal heat stress. B Singh, IARI, Delhi

Development of organoselnium compounds as new class of radioprotectors, Indira Priyadarsini, BARC, Mumbai Apigenin, a dietary flavone, modulates gamma radiation-induced cellular and molecular changes in human peripheral blood lymphocytes and Swiss albino mice. R Prasad, Annamalai Univ., Tamilnadu Protective efficacy of Emblica officinalis Linn against radiation and lead induced changes in the jejunum of Swiss albino mice. RK Purohit, Govt. Dungar College, Bikaner 12.20-13:10 13:10- 13:40 LUNCH PLENARY LECTURE: Peter Vaupel, Univ. of Mainz, Germany Title : Chronic versus acute hypoxia in tumors: Experimental evidence and potential clinical relevance Chairperson - Nagraj Huilgol, Nanavati Hospital, Mumbai & Xiadong Wu, USA SCIENTIFIC SESSION 6A: Radiation physics and mathematical modelling Chairperson DD Deshpande, TMH, Mumbai & HD Sarma, BARC, Mumbai The Physics and Radiobiology of Space-Time Fractionated Radiation Therapy. Xiaodong Wu, Biophysics Res. Inst., USA Mathematical modelling of the biological effect of hyperthermia and radiation. Johannes Crezee, University of Amsterdam, The Netherland Recent Advances in Physical, Clinical and Biological Dosimetry in Radiation Therapy. SD Sarma, BARC, Mumbai 13:40- 15:20 SCIENTIFIC SESSION 6B: Proferred papers Chairperson Tejpal Gupta, ACTREC & Rita Mukhopadhyaya, BARC, Mumbai 4 amino-5-methyl-4H-1,2,4-triazole-3-thiol accelerates the Red Blood Cell turn over by protecting the Erythropoietic Progenitor Cells against Electron Beam Radiation. Suchetha Kumari N, Nitte University Clinical scale preparation and bio-evaluation of 131I Rituximab for nonHodgkin's lymphoma. Mythili Kameswaran, BARC, Mumbai Mechanism of DNA double-strand break repair: Biochemical characterization of classical NHEJ and microhomology mediated alternative DNA end joining. Sheetal Sharma, IISc , Bangalore

16:30-21:00

CULTURAL PROGRAM & DINNER 13:40- 15:20

Day 2 - Friday, November 23, 2012

9:00- 9:30 PLENARY LECTURE: Christian Streffer, Univ. Clinics, Essen, Germany Title : Changing the paradigm in radiation Biology? Chairperson S.K. Shrivastava, TMH, Mumbai and JP Sharma, Bhopal SCIENTIFIC SESSION 4: Nanomedicine Chairperson J Bellare, IIT, Mumbai & Abhijit De, ACTREC, Mumbai Laminin Receptor Specific Therapeutic Gold Nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer. Kattesh Katti, University of Missouri, USA Nanotechnology Platforms in Cancer: Current Status & Future Directions. Rinti Banerjee, Indian Institute of Technology, Mumbai

9:30-10:20

10:20- 10:40
10:40- 12:20

TEA BREAK
SCIENTIFIC SESSION 5A: Molecular imaging Chairperson Andreas Kjaer, Univ. of Copenhagen, Denmark & Rao VL Papineni, USA Molecular imaging with PET for tailored cancer therapy. Andreas Kjaer, Univ of Copenhagen, Denmark PET/PEM Imaging of Breast Cancer: Bench to Bedside. Mathew Thakur, Thomas Jefferson Univ., USA Radiopharmaceuticals as molecular medicines for cancer management. MRA Pillai, BARC, Mumbai Molecular imaging of tumor angiogenesis: Peptides, proteins & nanoparticles. Weibo Cai, Wisconsin, USA

Dynamics of G1-phase specific loss of H3-Serine 10 phosphorylation in response to IR induced DNA damage in human cells .
Ajit K Sharma, ACTREC, Mumbai Gamma radiation and static magnetic field affecting seed quality under accelerated ageing of soybean. Mahesh Kumar, NIASM, Maharashtra Identification and evaluation of radiation countermeasures from protozoa fractions using High Throughput Screening (HTS) Technology. Damodar Gupta, INMAS, Delhi 15:25- 16:35 TEA BREAK and SCIENTIFIC POSTER SESSION II

10:40- 12:20

SCIENTIFIC SESSION 5B: Radiation protectors Chairperson GB Maru, ACTREC & Madhubala, INMAS Mitigating deleterious effects of radiation by phytoceuticals and nutraceuticals, CKK Nair, PIMS, Kerala

16:50 18:00 18:45 18:45 19:30

19:30 21:30

Leave for General Body Meeting & Banquet in Lonavala (1 hour drive) ISRB General Body Meeting COMPANY SCIENTIFIC PRESENTATIONS (Interterra & Inkarp /Xstrahl) BANQUET DINNER

12:10-13.30 13:30- 14:00 14:00-15:40

M.R. RAJU AWARD & Best Thesis / Idea / Poster Award Presentation Packed Lunch SCIENTIFIC SESSION 9: Bystander Effects Chairperson RC Chaubey, BARC, Mumbai and Pranela Rameshwar, UMD New Jersey, USA Transmission of signals between irradiated and non-irradiated organisms: mechanisms and significance CarmelMothersill, McMaster Univ. Canada Focused vertical microbeam system for proton irradiation of living cells for radiobiological research at NIRS Teruaki Konishi, NIRS, Japan Studies on bleomycin induced bystander response and their significance in cancer chemotherapy P.Venkatachalam, SRM Univ. Chennai Role of soluble factors from tumor cells on survival & radiosensitivity of bystander cells BN Pandey, BARC, Mumbai

Day 3 - Saturday, November 24, 2012

9:00- 9:30 PLENARY LECTURE: Taisei Nomura, Osaka University, Japan Chairperson: Subha Chiplunkar, ACTREC, Mumbai "Direct effect of radiation on human tissues maintained in super SCID mice SCIENTIFIC SESSION 7: Developing radiation modifiers for the clinic Chairperson Mansoor Ahmed, NCI, USA & ...... Novel signal transduction targets for radiation sensitization. Stephen Yoo, NCI, USA Poisoning the sweetness of tumors with 2DG: Excitement & challenges, BS Dwarkanath, INMAS, Delhi Radiation modifiers (2DG & Ocimum): Taking pre-clinical evidence to clinical trials. Rajiv Sarin, ACTREC, Mumbai 10:45- 11:00 TEA BREAK

9:30- 10:45

15:40-16:55

11:00- 12:15

SCIENTIFIC SESSION 8A: Radiation biology of Space & Cell Phone radiation Chairperson Yoshihisa Matsumoto, Tokyo Institute of Technology & Jayant Goda, ACTREC, Mumbai
Model calculations of GCR environment in space: Radiation biological assessment. Premkumar Saganti. Prairie View A&M University, USA Space radiation and what we learn from small model organisms. Sharmila Bhattacharya, NASA, USA Radiobiological basis for hazards from cell phones and cell towers. SC Jain, CFEES, Delhi

SCIENTIFIC SESSION 10: Radiation induced molecular changes and cell signalling Chairperson D Bhattacharjee, Mumbai & Neelam Shirsat, ACTREC, Mumbai. Chromatin modifications & DNA damage response to ionizing radiation. Tej Pandita, Univ. of SW Texas, USA How do you increase radio-sensitivity in radio-resistant tumor cells? Sorab N. Dalal, ACTREC, Mumbai. Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy. Pranela Rameshwar, UMD New Jersey, USA AWARD CEREMONY AND VALEDICTORY FUNCTION

16.55-17.10

11:00- 12:10

SCIENTIFIC SESSION 8B: Radiological & Nuclear Disasters Chairperson - N Roy, BARC, Mumbai & Bhawana Sirohi, TMH, Mumbai Medical countermeasures for nuclear & radiological emergencies: INMAS perspective. A Bhatnagar, INMAS, Delhi Radiation Biodosimetry: Preparedness for management of nuclear exposure scenario, NK Chaudhury, INMAS Development of field-compatible, self-usable radio-decontamination formulations for medical management of nuclear and radiological emergencies. RK Sharma, INMAS, Delhi

Role of radioprotectors in medical management of radiation injuries.

Manju Gupta, INMAS, Delhi

Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) TATA MEMORIAL CENTRE Kharghar, Navi Mumbai - 410210, INDIA.
Tel: 022-2740 5035 Fax: 022-27405080 E-mail: mshaikh@actrec.gov.in Web: www.actrec.gov.in