Monoclonal Antibodies Eclizumab- anti c5 complement, used in PNH Rituximab- anti-CD20 in waldenstorms macroglobulinemia, refractory ITP,Bcell NHL ,Refractory

SLE Natalizumab- directed against the 4 subunit of 41 integrin, a cellular adhesion molecule expressed on the surface of lymphocytes. It prevents lymphocytes from binding to endothelial cells, thereby preventing lymphocytes from penetrating the BBB and entering the CNS, used in Multiple sclerosis Bevacizumab- humanized vascular endothelial growth factor (VEGF) monoclonal antibody, has activity in recurrent glioblastoma, colo rectal carcino ma OKT3- monoclonal antibodies to T cells Belimumab-target BLyS - SLE Epratuzumab- target CD22- SLE Ocrelizumab,Ofatumumab-target CD 20- SLE Tocilizumab-target IL-6R-SLE gemtuzumab ozogamicin, a monoclonal CD33 antibody linked to the cytotoxic agent calicheamicin, have shown favorable response in high-risk Acute pro myelocytic leukemia doc for psvt is adenosine doc for svt is verapimil doc for neonatal siezures is phenobarbitone doc in pregnancy is obviously mgso4 regimen,or lytic cocktyl regimen Doc for cholera adult: tetracycline children: doxycycline pregnant: furazolidone ACETAMINOPHEN POISING - ACETYLCYSTEINE, Acute bronchial asthma -salbutamol, acute gout- nsaids ( except aspirin), acute hyperkalemia- calcium gluconate, acute severe digitalis toxicity - digibind, acute severe migraine - sumatriptan, adhd - methylphenidate, all flukes (except fasciola & echinococcus)- praziquentel, Alzheimer's disease - donepezil, Anaerobes- metronidazole, Anaphylactic shock -adrenaline, Antithyroid in pregnancy- propylthouracil, Anticoagulant for HIT - lepirudin, Atonic seizures- valproate , Atropine poisoning- physostigmine, Atypical pneumonia - tetracycline/ erythromycin, Benzodiazepine poisoning - flumazenil Beta blocker poisoning - glucagon, Bipolar disorder'- lithium,

Brucella-doxycycline + rifampicin, Carbamate poisoning- atropine HHM(humaral hypercalcemia of malignancy)-Bisphosphonates preferably 2nd/3rd gen. calcitonin may be used osteoporosis-zolendronic acid once a year Herpes simplex encephalitis- acyclovir Neonatal herpes simplex- acyclovir Herpes simplex keratitis- trifluridine/vidarabine Herpes simplex pro labialis- pencyclovir slow acetylators of INH will develop peripheral neuritis and fast acetylators wi ll develop hepatotoxicity DOC Wegners granulomatosis- cyclophosphamide Multiple myeloma-melphalan Hodgkins ds - mechlorethamine Hairy cell leukemia- cladiribine CLL-fludaribine pancreatic cancer - gemcitabine CML & GIST - imatinib Brain tumors- nitrosoureas lowering lipid in CRF : Gemfibrozil or hmg co a red inhibitors (never use in com bination- inc chances of myositis, rhabdomyolysis) doc for fetal adrenal suppression--dexamethasone Rx of choice in hyperhomocystinuria in crf : Folate supplementation 1-5mg/day Non calcium containg phosphate lowering agent in crf - Sevelamer (calcium contai ning agents cause adynamic bone disease) doc for digoxin inducd vt ..iv lidocaine doc fr bradyarrythmias atropine doc for psvt acute-adenosine chronic-ccb acute in asthmatics-verapamil IVIg doc 4 kawasaki GBS ITP acute myasthenic crisis agammaglobulenimia. NIPRODILOL- newer beta blocker wth NO donar action doc for septic shock is noradrenaline 01. 02. 03. 04. 05. 06. 07. 08. Enterococcus: Ampicillin + Gentamicin Staphylococcus aureus (methicillin-susceptible): Nafcillin Staphylococcus aureus (methicillin-resistant): Vancomycin Streptococcus pneumonia (penicillin-susceptible): Penicillin G, Amoxicillin Streptococcus pneumonia (penicillin-resistant): Vancomycin + Ceftriaxone Neisseria gonorheae: Ceftriaxone (IV), Cefixime (oral) Treponema pallidum: Penicillin G M. meningitidis: Penicillin G

09. Moraxella catarrhalis: Cefuroxime, Fluoroquinolones 10. Clostridium difficile: Metronidazole 11. Bacteroides fragilis: Metronidazole 12. Mycoplasma pneumoniae: Macrolide 13. Chlamydia trachomatis: Azithromycin or other Macrolides 14. Klebsiella pneumoniae: 3rd generation cephalosporin 15. Enterobacter: Carbapanem, Cefipime 16. Escherichia coli: 3rd generation cephalosporin 17. Campylobacter jejuni: Macrolide 18. Gardnerella vaginalis: Metronidazole 19. Proteus mirabilis: Ampicillin 20. Proteus indole positive: 3rd generation cephalosporin 21. Salmonella typhi: Ceftriaxone 22. Shigella: Fluoroquinolone 23. Serratia: Carbapanem yersinia & francisella--streptomycin Drug of choice in toxoplasmosis in pregnancy is spiramycin DOC for Nocardia & Pneumocystis pneumonia--Co-trimoxazole. DOC for Brucella: Doxycyclin + Gentamicin DOC to treat Listeria Monocytogenes sepsis and meningitis--ampicillin DOC for psedomembranous colitis : metronidazole(1st line),vancomycin(2nd line) Doc heat stroke or hiccups is CHLORPROMAZINE Doc for sleep walking- CARBAMAZEPINE DOC for chronic pain- Tricyclic anti depressants doc torsades de pointes - magnesium sulphate doc pulmonary hypertension - nitric oxide inhalation doc muscle relaxant in liver and kidney disease - atracurium anesthesia of choice in porphyria - propofol DOC - tocolytic of choice in cardiac cases ATOSIBAN- oxytocin antagonist Drug of choice for malaria in pregnancy - chloroquine DOC for chloroquine resistant malaria in pregnancy - quinine + clindamycin DOC for severe/complicate malaria in pregnancy - IV quinidine DOC for malaria prophylaxis for pregnant women travelling to an endemic area - m efloquine Antimalarial contraindicated in pregnancy - primaquine