DEPARTMENT OF BIOMEDICAL ENGINEERING QUESTION BANK COURSE: M.

E Biomedical Engineering SEMESTER: III

BIO-MATERIALS
UNIT-1 PART-A 1. What is meant by biomaterials? 2. How are biomaterials classified? 3. What is Carbon ceramic material? 4. Draw the different types of solid crystalline structures. 5. What are composites? 6. Write short note on polyurethane. 7. Give a couple of biomedical applications of composites. 8. What are biopolymers? 9. Write short notes on silicone implants. 10. What are biodegradable polymers, give examples? 11. Write short note on Teflon. 12. Bioceramics are classified into how many types explain with examples? 13. Give a few properties of bioceramics. 14. How does polymer degradation affect the human body? 15. Write short note on temporary implants. 16. Mention some advantages of ceramics. 17. Give the salient features of hydroxyapatite. 18. Write about the types of failures that occur in orthopedic implants. 19. What is creep? 20. Write short note on polymers. Give examples? 21. What are the types of stainless steel used in implants? 22. Mention some advantages of metals. 23. Write short notes on strength of biological tissues. 24. Give names of some polymeric materials. 25. Categorize the shape of the heterogeneities in the composite material. PART-B 1. Describe the properties of two widely used metals in the manufacture of Orthopedic implant devices. 2. What are the various types of bonding in solid materials? Explain briefly. 3. Give the effects of polymer degradation and Write about the need and applications of restorable polymers. 4. Give an account of the salient features of polymers used in biomedical applications in details.

5. Describe the terms in the field of polymers i) Polyurethane ii) Polymer sterilization iii) Hydrogels iv) Silicone rubber. 6. Bioceramics are used as implant materials what are the various types, illustrate with properties and examples. 7. Give a few details of the various surface modification techniques employed to increase the performance of implantation materials. 8. Explain in detail about Carbon ceramic material. 9. Describe the analysis of ceramic surfaces. 10. Write in detail about biodegradable synthetic polymers. UNIT-2 PART-A 1. How does the probability of failure vary with implantation period? 2. What are osteoblasts and osteoclasts? 3. Give the composition of human bone OR major and minor constituents of human Bone. 4. What is the role of microorganisms in polymer applications? 5. Bioceramics are classified into how many types? 6. Write about the tissue response to various types of implant materials and how the performance of implants is affected. 7. What is the general response to ceramic and wear particles? 8. Write about the types of failures that occur in orthopedic implants. 9. How does polymer degradation affect the human body? 10.Differentiate between normal and abnormal cells. 11.Write about the histology of normal tissues. 12.Write about the pathology of normal tissues. 13.Describe the biological environment. 14.What is wound healing process? 15.Draw the figure of soft tissue wound healing sequence. 16.Write short notes on cellular response to repair. 17.Draw the sequence of events following bone fracture. 18.How the degree of tissue response varies? 19.Write short notes no systemic effects of implants. 20.What is blood compatibility? 21.What are the failure characteristics of living tissue? 22.Draw the figure of interdependent engineering factors affecting the success of joint replacement. 23.What is necrosis? 24.Give a brief summary of tissue response to implants. 25.What are the organizations involved in framing the protocols, give examples.

PART-B 1. 2. 3. 4. 5. What are the various types of tissue responses to implants? Explain briefly. Discuss a few methods to test the biological performance of implant materials. Schematically illustrate the various types of interfaces that exist with bone implants. Describe briefly the surface properties affecting biomaterials. Schematically represent and illustrate the interactions that occur at the HAP-bone interface on implantation of hydroxyapatite coated implants. 6. Describe the various invitro and invivo test methods adopted to test and evaluate biomaterials? What are the organizations involved in framing the protocols, give examples. 7. When a surgical implantation is performed? What are the various ways in which the tissues respond to implants? Explain briefly. 8. Describe in detail about wound healing process. 9. Briefly explain about blood compatibility. 10. Explain in detail about body response to implants. UNIT-3 PART-A 1. Draw the structure of acrylic polymers. 2. Name any four orthodontic materials and their uses. 3. Name at least four different types of polymers used for biomedical applications. 4. How are polymers synthesized? 5. State the advantage and disadvantage of polymers used in bone cement. 6. What is mean by matched filter? 7. Classify the types of wavelets. 8. What is Calcium Orthophosphates? 9. Mention the application of Calcium Phosphate Cement in orthopedics. 10. Write short note on HAcollagen? 11. Give the application of calcium phosphate ceramics in tissue engineering. 12. Define osteoblast. 13. What is the role of hard tissue in dental application? 14. Define Scaffold. 15. Write about inert ceramics. 16. How bones are classified? 17. Draw the graph of cellular events in bone healing. 18. What are the metals used for dental application? 19. What is THR? 20. What is orthopedic implant? 21. Define osteoclast. 22. Draw the schematic representation of poorly crystalline carbon. 23. Give some uses of alumina in orthopedic implant. 24. Mention some advantages of bioglass implants. 25. What are the properties of fibers used for composite materials?

PART-B 1. Describe the Characteristics of a Biomaterial as a Tissue Engineering Substrate 2. Explain in detail about cartilage regeneration by biomaterials in orthopedic? 3. Explain with example a) natural polymer b) synthetic polymer 4. Describe with example hard tissue in dental applications. 5. Explain about polymers, metals and ceramics used for hard tissue replacement 6. Describe about physiochemical properties of polymeric materials. 7. Write about the various types of soft and hard tissue orthopaedic fixation devices? 8. Write about the different types of orthodontic materials metal, polymers and Ceramics. Explain briefly. 9. Explain in detail about polymers and its types. 10. Explain the following. i) Alumina ii) Carbons UNIT-4 PART-A 1. 2. 3. 4. 5. 6. 7. 8. Define biocompatibility. Define Biomaterials and relate it with biocompatibility. Define Hemocompatibility. What is a tissue? List the basics criteria for tissue replacement. Schematically depict a tissue-biomaterial interaction. What are the basic qualifications of implant materials? Name the internal organizations agencies that lay down protocols for testing of implants. 9. Write a short note on elastic tissues with examples. 10. Depict the typical tissue response to implants. 11. What is wound healing? 12. How does the body respond to release of wear particles? 13. Write about invivo testing of implants. 14. List a few common type of failures of metallic implants. 15. How are sutures classified? Give examples. 16. What is surgical tape? 17. What are the factors involved in the development of percutaneous devices? 18. Write short notes on artificial skin. 19. What is eye implant? 20. Mention some materials used in fluid transfer implants. 21. What are the uses of collagen? 22. Write a note on bulk implants. 23. What types of polymers are used in soft tissue applications? 24. Categorize implants in soft tissue. 25. Write a short note on hydrogels.

PART-B 1. Illustrate the types of materials used in percutaneous and skin implants. 2. What are the various types of tissue responses to implants and what are the various factors affection the performance of implants? Explain briefly. 3. Define biocompatibility and write in detail about the impact of biomaterials on the society. 4. Discuss a few properties that effect the performance of biomaterials. 5. Discuss a few methods to test the biological performance of implant materials. 6. Explain in detail the various reasons for failure of implantation materials. 7. What are soft tissue implants? Categorize them and explain the properties of any three. 8. Describe the nature and types of corrosion that are responsible for the degradation of implant materials invivo. 9. Explain in detail about sutures materials. 10. Explain in detail about maxillofacial implants with diagram. UNIT-5 PART-A 1. List the draw backs of heart lung machines. 2. State the principle of right ventricular bypass pumps. 3. What are oxygenators? 4. List the limitations of artificial organs. 5. Write about: autograph, allograft. 6. Write about heart lung assist devices with examples. 7. Differentiate between mechanical valves and tissue valves. 8. Write down a few drawbacks of materials used in heart valves. 9. State the principle of artificial heart 10. Write short note on xenograft and rejected. 11. Highlight a few basic engineering concerns related to design of heart valves. 12. Write about cardiac pacemakers. 13. What is effective orifice area? 14. What is meant by effective orifice area? 15. When does a patient require an artificial heart? 16. What are the pathological aspects of patient? who needs cardiac assist devices? 17. Differentiate internal and external pacemaker. 18. What is heart lung machine? 19. Write down the types of oxygenators. 20. Illustrate mechanical and chemical characteristics of natural versus artificial lung. 21. What are SA and AV node? 22. What are the uses of heart lung machine during surgery? 23. What is meant by pressure gradient? 24. What are the characteristics an ideal heart valve? 25. What are oxygenators?

PART-B 1. Compare the salient features and drawbacks of mechanical versus tissue heart Valves. 2. What are oxygenators? Explain in detail the principle and functioning of any three types of oxygenators. 3. Highlight the important concepts to be considered in the design of artificial organs. 4. What are the characteristics an ideal heart valve should possess? Explain the terms pressure gradient, effective orifice area and regurgitation. 5. Write about the different types of mechanical heart valves which are used to restore the normal cardiac functions? Explain briefly. 6. Explain the various engineering concerns to be followed in the design of prosthetic heart valves. 7. Discuss the history of development of artificial heart. 8. Describe in detail about Heart lung machine. 9. Explain the blood compatibility of synthetic vascular implant materials. 10. Describe in detail about cardiac pacemakers.