CLASSIFICATION SYSTEMS

EPONYMS
Hunter. Radiologic History Exhibit Musculoskeletal Eponyms: Who Are Those Guys? Radiographics 2000: 20:819-836

Bosworth Frx Fibular frx with posterior dislocation of talus. Named after David Bosworth, an NY orthopedic surgeon who introduced streptomycin for bone and joint TB. Chopart Frx Frx/dislocation involving the midtarsal joints. Francois Chopart, surgeon in Paris, whose amps through midtarsal joint was effective and resisted infection.

Cotton Frx Frx of lateral and medial malleolus and frx of posterior process of tibia. Fredrich Cotton, Boston surgeon, who illustrated his own 1910 book, Dislocations and Fractures. Danis-Weber Classification First described by Robert Danis, Belgian surgeon, in 1949. His pioneering work in internal fixation led colleague Maurice E. Muller to assemble a study group in 1958 for clinical trials of internal fixation Arbeitsgemeinschaft fur Osteosynthesefragen (AO). Later, schaft the system was imodified by Bernhard Georg Weber a prominent orthopedic surgeon in Switzerland. Dupuytren Frx Distal fibular frx above lateral malleolus w/ associated tear of tibiofibular and deltoid ligament. Lateral displacement of talus and possible medial malleolus frx. Guillaume Dupuytren, greatest French surgeon and meanest of men of the 19th century, has his name associated w/ 12 different conditions/operations. Essex Essex-Lopresti Classification Peter Gordon EssexLopresti, surgeon at Britains Birmingham Accident Center during World War II, was an expert in parachuting injuries. Freiberg Infraction Refers to deformity of head of second or third metatarsal from AVN, presumably secondary to trauma. Named after Albert Henry Freiberg, Professor of med Orthopedic Surgery at the University of Cincinnati, OHIO. Gosselin Frx V-shaped frx of distal tibia that extends into shaped the tibial plafond and divides plafond into anterior and posterior fragments. Leon Athanese Gosselin was chief of surgery at the Hopital La Charite in Paris. Jones Frx Base of fifth metatarsal distal to metarsal tuberosity. Described by Sir Robert Jones in 1902 after injurying himself dancing, he was the leading British orthopedic surgeon of the period. Lauge-Hansen Classification Niel Lauge-Hansen, a prominent Danish

physician, performed classic cadaver studies in 1940-50s to cada elucidate mechanisms involved in ankle injuries. Le Fort Fx of the Ankle Vertical frx of the anterior medial portion of the distal fibular with avulsion of the anterior tibiofibular ligament. Leon Clement Le Fort, distinguished French surgeon and sondistinguis in-law to Joseph Francois Malgaigne law (Fx of the pelvis), was best known for discovering direct communication between bronchial and pulmonary blood vessels and uterine prolapse surgery. Lisfranc Frx Refers to frxdislocation or frx-subluxation of TMT f joint. Jacques Lisfranc De Saint Martin, surgeon in Napoleons army, who described a 1-minute amputation 1 method that saved a portion of the foot after distal injury or frostbite. Also described scalene tubercle on the first rib at insertion of the scalenus anterior muscle, Lisfrancs tubercle. nsertion Masionneuve Frx spiral frx of the upper third of fibular w/ tear of distal tibiofibular syndesmosis and interosseous membrane. Also, associated frx of medial malleolus or rupture of the deep deltoid ligament. Jaceuqes Gilles p Maisonneuve was a student of Dupuytren. Osgood-Schlatter Disease Term used to Schlatter describe chronic fatigue injury that affects growth and development of tibial apophysis at site of attachment of patellar tendon to the tibial tuberosity. Robert B. Osgood was a ial Boston orthopedic surgeon during World War I, and Carl Schlatter was a professor of surgery in Zurich Switzerland. Pott Frx Partial dislocation of the ankle w/ frx of the distal fibular shaft and rupture of the medial ligaments. Percival Pott was a ial leading surgeon in London and described TB in the spine (Potts Disease). Salter-Harris Classification Robert Bruce Salter, currently Harris a Canadian surgeon at the University of Toronto. Robert Harris is another Canadian orthopedic surgeon at the University of Toronto. Shepard Frx The lateral tubercle of the posterior process of the talus frx may simulate an os trigonum. Francis J. Shepard was from England, but emigrated to Canada to become a prominent surgeon. Tillaux Frx An avulsion injury of the anterior tibial tubercle at the attachment of the distal anterior tibiofibular ligament. Paul Jules Tillaux, French surgeon and anatomix, never clinically described frx, but did exquisite anatomic studies detailing results of result experimentally produced ankle injuries.

OPEN FRACTURES GUSTILO AND ANDERSON Type I Wound <1cm long, little ST damage, no sign of crush, simple/transverse/oblique fx w/ little comminution Type II Wound >1cm long, minor ST damage, 1cm slight/moderate crush injury, moderate comminution Type III Extensive ST injury, high degree of comminution
IIIa ST coverage of bone is adequate, trauma high high-energy IIIb extensive ST damage requiring free-flap for coverage, assoc w/ flap coverage periosteal stripping and ST contamination IIIc any open fx w/ arterial injury requiring immediate repair
Gustilo & Anderson Prevention of Infection in the Treatment of 1025 Open Fractures of Long Bones. J Bone Joint Surg Am. 1976 Jun;58(4):453-8 Gustilo. Problems in the Management of Type III (severe) Open Frx: A New Classification of Type III Open Frx. J. Trauma. 24:8 1984.

Type IIa closed reducible, disrupted intersesamoidal ligament Type IIb closed reducible, transverse fx of sesamoids Type IIc open reduction, both IIa and IIb.
Jahss MH: Foot Ankle 1980;1:15-21

COMPARTMENTS OF THE FOOT MANOLI AND WEBER Hindfoot (1) CALCANEUS: quadratus plantae, posterior tibial artery, vein, and nerve, lateral plantar artery, vein, nerve, medial plantar artery, vein, nerve, communicates with deep leg Forefoot (5) INTEROSSEUS (X4): interossei; ADDUCTOR: adductor hallucis Full Length (3) MEDIAL: flexor hallucis, abductor ha hallucis; LATERAL: abductor digiti quinti, flexor digiti minimi; SUPERFICIAL: flexor digitorum brevis, lumbricals (4), flexor digitorum longus tendons, medial plantar nerve
Manoli and Weber. Fasciotomy of the foot: an anatomical study with special r reference to release of the calcaneal compartment of the foot. FAI 10(5):267 10(5):267-75, 1990

PRE-DISLOCATION SYNDROME YU Stage I Subtle, mild edema with dorsal and plantar to lesser MTPJ. Alignment of the digit unchanged compared to the contralateral digit. Stage II Mild to Moderate edema. Noticeable deviation of the digit. Loss of toe purchase, noticeable in weight bearing wei Stage III Moderate edema. Pronounced deviation/subluxation
Yu. Predislocation syndrome. Progressive subluxation/dislocation of the lesser metatarsophalangeal joint.JAPMA, April 2002 Apr;92(4):182-99 JAPMA,

5TH METATARSAL BASE FRACTURES STEWART Type I Jones Fracture, transverse fx of diaphyseal / metaphyseal junction. Healing potential is poor. Type II Intraarticular avulsion fx Type III Extraarticular avulsion fx Type IV Intraarticular comminuted fx Type V (peds) Extraarticular fx through epiphysis

CLOSED FRACTURES TSCHERNE Type C0 Little of no soft-tissue injury Type CI Superficial abrasion and mild to moderately severe fracture configuration Type CII Deep contaminatd abrasion with local contusional damage to skin or muscle and moderately severe facture configuration Type CIII Extensive skin contusion or crushing or muscle destruction and severe fracture.
Tscherne H, Gotzen L: Fractures With Soft Tissue Injuries. Berlin, Germany: Springer issue SpringerVerlag, 1984, pp6-7.

Type I

Type II

Type III

Type IV

Type V

Stewart I. Jones fracture: fracture of the base of the fifth metatarsal. Clin Orthop 1960; 16:190-198

BONE STRESS INJURY (MRI) KIURU Grade I Endosteal marrow edema Grade II Periosteal bone edema and endosteal edema Grade III Muscle edema, periosteal edema and endosteal marrow edema Grade IV Fracture line Grade V Callus in cortical bone
Kiuru MJ. Bone Stress Injuries. Acta Radiol 2004; 45: 317-326 326

5TH METATARSAL FRACTURES - TORG Stage I Acute fracture on chronic process, evidence of periosteal reaction, plantar-based facture line, absence of plantar medullary sclerosis Stage II Similar to Stage I with additional presences of medullary sclerosis and narrowing; delayed union Stage III Obliteration of medullary canal; non-union non
Torg, JS; Balduini, FC; Zelko, RR; Pavlov, H; Peff, TC; Das, M: Fractures of the base of the fifth metatarsal distal to the tuberosity. J. Bone Joint Surg. 66-A:209, 1984.

FRACTURE STABILITY CHARNLEY Most Stable transverse fx Potentially Stable short obliqe fx, <45 from transverse Least Stable long oblique, >45, comminuted fxs ong
Charnley, The Closed Treatment of Common Ankle Fractures, 4th Ed, Greenwich Medical Media, 2002

NON-UNIONS WEBER & CECH Hypertrophic Type (vascular, reactive) 1. Elephants foot 2. Horses hoof 3. Oligotrophic Atrophic Type (avascular, non-reactive) 1. Torsion wedge 2. Comminuted 3. Defect 4. Atrophic
Weber BG, Cech O. Pseudarthrosis; Grune and Stratton, 1976

NAVICULAR FRACTURES WATSON/JONES CLASSIFICATION Type I Avulsion fx off tuberosity by PT tendon Type II Dorsal lip fx, may resemble os supranaviculare Type IIIa Transverse fx, non-displaced non Type IIIb Transverse fx, displaced Type IV Stress fx
Watson-Jones R: Fractures and Joint Injuries. Vol 2. 4th ed. Baltimore, Md: Williams & Jones Wilkins; 1955

LISFRANCS FRACTURES - QUENU & KUSS CLASSIFICATION Type A Homolateral/partial incongruity of Lisfrancs joint Type B Isolateral/partial incongruity or Lisfrancs joint Type C Divergent fx; dislocation of Lisfrancs joint
Quenu. E, Kuss G. Etude Sur les luxations du metatarse. Reb Chir 39: 281, 1909.

1ST MPJ DISLOCATIONS JAHSS CLASSIFICATION Type I Hallux/sesamoid dislocation, no disruption of sesamoid apparatus, irreducible to closed reduction.

LISFRANCS FRACTURES HARDCASTLE CLASSIFICATION Type A either homolateral (metatarsals displaced laterally) or homomedial (metatarsals displaced medially.) d Type B Partial incongruity; not all metatarsals are displaced in the same direction. Type C Divergent; 1st metatarsal is medially dislocated, 2-5 2 are either partially or completely laterally dislocated.

Critial Angle of Gissane: Measure of calcaneal strut that supports the lateral talar process. Is more specific for intraarticular distortion because it reveals the angular relationship of the calcaneal facets. Normal = 125-140 degrees; Is 125 increased greater than 180 degrees with displacement of the ater posterior facet in joint depression fractures
Knight J, Gross EA, Bradley G, LoVecchio F. The utility of Boehlers angle and the critical angle of Gissane in diagnosing calcaneus fractures in the emergency department. de Acad Emerg Med. 2005;2:114-115.

Hardcastle PH, et al. Injuries to the tarsometatarsal joint. Incidence, Classification and Treatment.. J Bone and Joint Surg 1982; 64B(3):349-56.

LISFRANCS FRACTURES MYERSON MODIFICATION TYPE A Total Incongruity TYPE B1 Partial Incongruity, Medial Dislocation TYPE B1 Partial Incongruity, Lateral Dislocation TYPE C1 Divergent, Partial Displacement TYPE C2 Divergent, Total Displacement
Myerson, M, FAI, 6; 228, 1986

SUBTLE LISFRANCS INJURY NUNLEY & VERTULLO

STAGE 1 - <2mm diastasis, able to WB, local point point-tenderness over Lisfranc ligament & medial TMT joint space, + MRI STAGE 2 similar to Stage 1, >2-5mm diastasis, no collapse 5mm of arch. STAGE 3 >2-5mm diastasis, collapse of arch. 5mm

ROWE CLASSIFICATION Type Ia plantar calcaneal tuberosity fx, secondary to eversion force (medial tuberosity) or inversion (lateral tuberosity.) View w/ axial calcaneal, lateral foot. Type Ib shearing fx of the sustentaculum tali, secondary to inverted landing of heel. View w/ axial calcaneal. Type Ic anterior process fx, may appear similar to os calcaneum secundum. Occurs as a bifurcate ligament avulsion, secondary to adduction and plantarflexion. View w/ pla lateral, lat oblique isherwood. Type IIa beak fracture, meaning a lift-off of the posterior off superior surface of the calcaneus; some cortex still intact. Occurs when heel strikes ground w/ knee extended and foot dorsiflexed. View w/ lateral foot radiograph. Type IIb avulsion fx of the tendo Achilles, same as a IIa but with complete dislocation.

Nunley. Vertullo. Classification, investigation, and management of Midfoot Sprains: Lisfranc Injuries in the Athlete. Am J Sports Med. 2002; 30:871 30:871-878.

CALCANEAL FRACTURES
Signs & Symptoms: Acute pain, edema about heel, pain w/ compression/palpation, pain w/ STJ motion, fx blisters on skin, plantar medial &lateral ecchymosis (mondurs sign) mondurs sign Bohlers Angle: Tuberosity Joint Angle. Measures sagittal plane relationship of talus and calcaneus compare to contralateral side. Normal = 25-40 degrees; angle is reduced 40 when post. facet is depressed into the body of the calcaneus

Type IIIa simple fx, oblique through calcaneal body not involving the STJ. Occurs secondary to a fall, landing on both heels w/ the feet inverted or everted. View w/ lateral foot, axial calcaneal. Type IIIb same as IIIa, but comminuted.

Type IVa&b same as type III, but w/ STJ involvement.

Type Va intraarticular STJ fx w/ comminution and depression of the articular segment. Type Vb intraarticular fx of the calcaneo-cuboid joint. cuboid

Rowe CR, Sakellarides H, Freeman P: Fractures of os calcis - a long-term follow-up long study one hundred forty-six patients. JAMA 1963; 184: 920-923 923

ESSEX-LOPRESTI CLASSIFICATION Tongue Type Axial load planterflexed Joint Type Axial Load Dorsiflexed

Type III (AB, AC, and BC) three part fx w/ central depressed segment. Type IV comminuted fx of posterior facet.

-The current standard for non-articular calcaneal fractures is The non the Rowe system. For intra-articular calcaneal fractures, a intra coronal CT scan is indicated, and the Sanders system is typically used to classify. -The goal of ORIF for intraarticular calcaneal fractures is to he increase the height, decrease the width, return to neutral, and restore anatomy and articular surface.
Essex-Lopresti P: The mechanism, reduction technique, and results in fractures of the os Lopresti calcis, 1951-52. Clin Orthop 1993 May; 3-16

SANDERS CLASSIFICATION (Note: This classification system requires the fracture to be visualized w/ coronal CT scan at widest width of calcaneus) Type I (A, B, and C) one part, nondisplaced articular fx.

Sanders R, Fortin P, DiPasquale T: Operative treatment in 120 displaced intraarticular calcaneal fractures. Results using a prognostic computed tomography scan classification. neal Clin Orthop 1993 May; 87-95

Type II (A, B, and C) two part fx of posterior facet.

TALAR NECK FRACTURES HAWKINS CLASSIFICATION These fxs are usually seen in MVAs or short-height falls Type I minimal displacement, 7-15% chance of AVN 15% Type II STJ subluxation, 35-50% chance of AVN 50% Type III ankle dislocation, 85% chance of AVN Type IV STJ/ankle/TNJ dislocation, 100% chance of AVN Hawkins Sign subchondral lucency of the body of the talus talu following fx; appears 6-8 weeks post fx; = revascularization 8

Hawkins L: Fractures of the neck of the talus. JBJS 1970;52A:991 1970;52A:991-1002

TALAR DOME LESIONS BERNDT-HARDY CLASSIFICATION Stage I small area of compression in subchondral bone. Stage II partially detached osteochondral fragment. Stage III completely detached fragment, in crater. Stage IV complete fx, out of crater. Poor prognosis.

Sneppen O, Chrstensen SB, Krogsoe O, et al: Fractures of the body of the talus. Acta Orthop Scand 48: 317-324, 1977

LATERAL TALAR PROCESS - HAWKINS CLASSIFICATION Type I Simple fx from AJ articulation to STJ Type II Comminuted fx involving calcaneal & fibular articulations Type III Chip fx of anterior/inferior portion of lat process ip

DIAL a PIMP denotes the location of talar dome lesions dorsiflexion internal rotation = anterior lateral lesion, ateral plantarflexion inversion = medial posterior lesion. osterior
Medial Lesions: (PIMP, 56%) Deep, cup shaped, less likely to displace. 6%) Lateral Lesions: (DIAL, 44% ) Thin, wafer shaped, easily displaced. asily
Berndt, A.L. & Harty, M.: Transchondral fractures of the talus. J Bone Joint Surg [Am] 41: 988-1020, 1959

Hawkins LG: Fractures of the lateral process of the talus. J Bone Joint Surg 1965; 47A: 1170-1175 EPIPHYSEAL FRACTURES SALTER-HARRIS CLASSIFICATION

FRACTURES OF THE TALAR BODY - SNEPPEN Group I Talar Dome Fracture/OCD (use Berndt Berndt-Hardy) Group II Shear Fracture 50% AVN, requires ORIF Coronal Sagittal Horizontal Group III Posterior Tubercle Fracture Shepherds Fx Group IV Lateral Process Fracture (Fjeldborg) Group V Crush injury highly comminuted

Type I shearing force, separation of epiphysis from metaphysis w/o fx, seen at birth and in young children.

Type II fx line extends through physis and exits metaphysis. Shearing or avulsion force, + Thurston Holland sign. Thurston Holland Sign triangle shaped metaphyseal fx. aped Type III fx line extends through physis and exits epiphysis (intraarticular). Due to shearing force. Type IV intraarticular fx through epiphysis, physis, and metaphysis. Prognosis is poor. Type V compression fx, compacted germinal cells of physis die and cause premature closure. Poor prognosis. Type VI (Rang) - contusion of perichondral ring of physis, acts like type V if a bony bridge develops prognosis good. Type VII (Ogden) epiphyseal fx not affecting physis Type VIII (Ogden) partial fx of metaphysis, growth lines Type IX (Ogden) degloving loss of periosteum on diaphysis
RB Salter, WR Harris Injuries involving the eiphyseal plate. JBJS Vol 45. 1963. p 587587 632

II Spiral oblique fx of lateral malleolus (extending ique anterior inferior to posterior superior.) III Rupture of post inferior tibio-fibular ligament tibio IV Deltoid rupture/fx of medial malleolus Pronation External Rotation (PER) I Rupture of deltoid ligament/medial malleolar fx II Rupture of ant inferior tibio-fibular ligament, tibio Intra-osseous ligament, intra-osseous membrane osseous intra III Spiral fx above syndesmosis (high fibular fx) IV Rupture of post inferior tibio-fibular ligament tibio All external rotation injuries may cause DIASTASIS separation of the tibio-fibular syndesmosis. fibular
Lauge-Hansen N. Fractures of the ankle. II Combined experimental-surgical and Hansen experimental experimental-roentgenologic investigations. Arch Surg 1950; 60:957-85 roentgenologic 60:957

LATERAL MALLEOLAR FRACTURE DANIS-WEBER CLASSIFICATION

DIAS-TACHDJIAN CLASSIFICATION Supination-Inversion grade I (A) Supination-Inversion grade II (B) Supination-Plantarflexion (C)

Type A Fracture below the level of the tibial plafond Type B Fracture at the level of the tibial plafond Type C Fracture above the level of the tibial plafond
Danis R. Les fractures malleolaires. In: Danis R (ed): Theorie et practique de l'osteosynthese. Paris, Masson et Cie, 1949, pp133-165 pp133 Weber BG. Die Verletzungen des oberen Sprunggelenkes, ed 2. Bern, Stuttgart, Wien, Verlag Hans Huber, 1972 MEDIAL MALLEOLAR FRACTURE MULLER CLASSIFCATION

Type A Avulsion of tip of medial malleolus Type B Avulsion at the level of the ankle joint Type C Oblique fx Type D Vertical orientation
Muller M, Allgower M, Scheider R, Willenegger H. Manual of Internal Fixation. 3rd Ed. Springer-Verlag, 1991. CHRONIC TIBIOFIBULAR DIASTASIS EDWARDS & DELEE

Supination-Ext Rotation grade I (D) Supination-Ext Rotation grade II (E) Pronation-Eversion-Ext Rotation (F) Juvenile Tillaux Fracture (G) Triplanar Fracture (H)

Type I Straight lateral subluxation of the fibula, w/ medial clear space on x-ray (due to interposition of delroid ligament) ray Type II Lateral fibular subluxation w/ plastic or angular deformity (due to fibular microfracture) bular Type III Posterior rotatory subluxation of distal fibula behind talus w/ PITFL intact Type IV Complete Ankle Diastasis w/ talus dislocated superiorly, wedged between the tibia and fibula.
Edwards S, DeLee C. Ankle diastasis without fracture. Foot Ankle 1984;4:305-12

Dias LS, Tachdjian MO: Physeal injuries of the ankle in children. Clin Orthop Relat Res 1978;136:230233

ANKLE FRACTURES - LAUGE-HANSEN CLASSIFICATION The first word in this classification denotes the position of the foot at time of injury; the second word denotes the motion of the leg. The numerical grades w/in each class occur each in chronological order and relate to the severity of trauma. Supination Adduction I transverse fx of the lateral malleolus II vertical fx of the medial malleolus Pronation Abduction I Rupture of deltoid ligament/medial malleolar fx II Rupture of ant inferior tibio-fibular ligament fibular III Bending fx of fibula 1cm proximal to plafond Pronation Dorsiflexion I Fx of medial malleolus II Large anterior lip fx of tibia III Fracture of superior lateral malleolus IV Fracture of third malleolus (posterior tibia) Supination External Rotation (SER) fibular I Rupture of ant inferior tibio-fibular ligament

MIDTARSAL FRACTURES MAIN & JOWETT 1) Medial Force (30%) precursor to STJ dislocation Type A - flake fx of dorsal talus or navicular and lateral calcaneus or cuboid Type B - medial displacement of FF w/ TN and CC joints Type C - FF rotates medially around interosseous talocalcaneal lig w/ TN disassociation and CCJ intact 2) Longitudinal Force (40%) worst prognosis of non-crush non Type A - maximally PF ankle giving a characteristic pattern of through and through navicular compression fracture navicu A1 - force through 1st ray: crushes medial 3rd w/ tuberosity displaced medially A2 - force thru 2nd ray: crushes middle 3rd w/ middle 3rd & tuberosity displaced medially A3 - force thru 3rd ray: crushes lateral 3rd w/ medial 2/3 & tuberosity displaced medially Type B - submaximally PF ankle resulting in dorsal displacement of superior navicular, crush of inferior on x-ray n 3) Lateral Force (17%) Type A - FF forced into valgus w/ fx of navicular tuberosity ced or dorsal talus and compression fx of CCJ (Nutcracker fx) Type B - TNJ displaces laterally w/ comminution of CCJ 4) Plantar Force (7%) Type A -avulsion fx of dorsal navicular or talus & ant process avulsion Type B - impaction fracture of inferior CCJ

5) Crush Injury (6%)

Main and Jowett. Injuries of the Midtarsal Joint. J Bone Joint Surg Br 57-B (1): 89.

PILON FRACTURES RUEDI & ALLGOWER CLASSIFICATION Type 1- Mild to moderate displacement & no comminution, w/o major disruption of ankle joint Type 2- Moderate displacement & no comminution w/ significant dislocation of ankle joint Type 3- Explosion fx, severe comminution & displacement ,

sagittal plane is 105 degrees. The CFL is stressed in i dorsiflexion and also with frontal plane inversion of STJ. Two tests can be used test mechanical instability of the ankle: The anterior drawer test and talar tilt. tilt ANTERIOR DRAWER TEST Castaing: 5-8 mm of anterior displacement = ATF rupture 8 10-15 mm = ATF, CF > 15 mm = ATF, CF, PTF

Ruedi T, Allgower M. Fractures of the lower end of the tibia into the ankle joint. Injury, 1969; 1: 92-99.

AO CLASSIFICATION (MUELLER) Type A - extra articular Type B - partially articular Type C - completely articular
All three can involve: a. no comminution or impaction in articular or metaphyseal surface b. impaction involving supra-articular metaphysic c. comminution & impaction of articular surface with metaphyseal impaction

TALAR TILT TEST Bonnin: 00 to 150 = ATFL rupture. 150 to 300 = ATFL and CFL rupture. More than 300 = ATFL, CFL, and PTFL. Karlsson: 50 to 100 > contralateral ankle or more than 150 unilaterally is abnormal. ANKLE SPRAIN DIAS CLASSIFICATION Grade I partial rupture of CFL Grade II complete rupture of ATFL Grade III complete rupture of ATFL, CFL, and/or PTFL Grade IV complete rupture of all 3 lateral ligaments + partial rupture of deltoid ligament
Dias LS. The lateral ankle sprain: an experimental study. J Trauma 1979;19(4):266-9 : 1979;19(4):266

ANKLE SPRAIN ODONOGHUE CLASSIFICATION 1st Degree ligament stretch w/ minimal disruption 2nd Degree partial ligament disruption w/ joint instability 3rd Degree complete ligament disruption
O'Donoghue DH: Treatment of Injuries to Athletes. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1970

ANKLE SPRAIN LEACH CLASSIFICATION 1st Degree partial or complete tear of ATFL 2nd Degree partial or complete tear of ATFL & CFL 3rd Degree partial or complete tear or ATFL, CFL, & PTFL
Leach RE, Naiki O, Paul GR, Stockel J. Secondary reconstruction of the lateral ligaments of the ankle. Clin Orthop 1982; 226:169-73 226:169

STJ DISLOCATION Subtalar joint dislocations are commonly classified according to the position of the foot in relation to the talus Type I Medial dislocation of STJ or Acquired clubfoot Type II Lateral dislocation of STJ or Acquired flatfoot Type III Anterior/posterior dislocation of STJ
Buckingham WW Jr. Subtalar dislocation of the foot. J Trauma 1973;13:753-765 STRAUS DC: Subtalar dislocation of the foot. J Bone Joint Surg 30: 427, 1935.

Muller ME, Nazarian S, KochP, et al.; Springer-Verlag, Berlin. Classification AO des Verlag, fractures. 1990

LATERAL ANKLE SPRAINS The ATFL injured more frequently followed by the anterolateral ankle capsule, CFL, and then PTFL. The ATFL is oriented so that it is under most tension during plantarflexion. The angle between ATFL and CFL in the

PTTD JOHNSON AND STROM Stage I Medial pain, tenosynovitis, mild weakness on heelheel raise test Stage II Medial/lateral pain, tendon elongation, flexible pes planus, weakness on heel raise, + too many toes sign Stage III Medial/lateral pain, tendon degeneration, fixed pes planus, no inversion on heel raise, + too many toes sign, STJ arthritis

Stage IV Medial/lateral pain, tendon degeneration, fixed pes planus, no inversion on heel raise, + too many toes sign, STJ arthritis, Valgus talus, Ankle arthritis

Rosenberg ZS, et al: Rupture of posterior tibial tendon: CT and MR imaging with : surgical correlation. Radiology 1988;169:229-235 1988;169:229

Johnson KA, Strom DE. Tibialis posterior tendon dysfunction. Clinical Orthopedics. 1989;239:196-206 Myerson, MS. Adult acquired flatfoot deformity: Treatment o dysfunction of the posterior tibial tendon. Instr. Course Lecture, AAOS. 1997; 46: 393 393-405.

PTTD MUELLER CLASSIFICATION Based on Etiology Type I Direct injury Type II Rupture secondary to systemic disease Type III Idiopathic Type IV Rupture secondary to mechanical dysfunction

ACHILLES RUPTURE KUWADA CLASSIFICATION The achilles is an conjoined tendon that internally rotates to insertion. It has a watershed area at 2-6cm proximal to ar insertion. The vascular supply is received at the myotendinous junction, osseous insertion, and paratenon anteriorly. Use the anteriorly Daughter-Thompson Test (passive Daughter plantarflexion) to diagnosis rupture. Patients will recall a Pop sensation sens and feel stuck. There will be pain and edema at the area, with a palpable gap. Patients may present with an antalgic gait. Type I Partial rupture of tendon Type II Complete rupture of tendon, <3cm gap Type III Complete rupture, 3-6cm gap Type IV Complete rupture, >6cm gap
Kuwada GT. Diagnosis and treatment of Achilles tendon rupture. Clin Podiatr Med Surg 1995;12: 633-52 rupture

Mueller TJ: Acquired flatfoot secondary to tibialis posterior dysfunction: Biomechanical aspects. J. Foot Surg. 30:2, 1991

PTTD CONTI CLASSIFICATION (MRI) Stage I One or two fine, longitudinal tears Stage II Intramural degeneration, variable diameter, wide longitudinal tears Stage III Scarring in tendon, complete tear
Conti S et al. Clinical significance of MRI in pre-operative planning for reconstruction of posterior tibial tendon ruptures. Foot and Ankle 1992; 13:208

RADIOPAQUE LESIONS OF THE TENDO ACHILLES__________ Type I: Localized to the Achilles I tendon insertion and the posterosuperior aspect of the calcaneus Type II: Localized to the distal 1 to 3 cm of the Achilles : tendon Type IIIA: Intratendinous, involving a large portion of the : tendon Type IIIB: Intratendinous, involving ALL of the tendon from : the myotendinous junction to the insertion. ion
Morris KL, Giacopelli JA, Granoff D. Classifications of adiopaque lesions of the tendo Achilles. J Foot Surg 1990;29:533-542. 542.

PTTD ROSENBERG CLASSIFICATION (MRI) Stage I Hypertrophic tears in tendon (appears bulbous) Stage II Atrophic tears Stage III Complete tear

PERONEAL TENDON DISLOCATION - ECKERT & DAVIS Grade I retinaculum ruptured from cartilaginous lip to posterior lateral malleolus Grade II distal 1-2cm fibrous lip of malleolus is elevated w/ 2cm retinaculum Grade III a thin fragment of bone w/ cartilage is avulsed from deep surface of peroneal retinaculum & deep fascia Grade IV (Oden) a mid-substance tear

Ib secondary arthritis, tx w/ triple arthrodesis

Type II intra-articular coalition articular

IIa no secondary arthritis, tx w/ triple or isolated arthrodesis IIb secondary arthritis, tx w/ triple arthrodesis
Downey, MS: Tarsal coalitions: a surgical classification. J Am Podiatr Med Assoc classi 81:187-197, 1991

TARSAL COALITIONS PERLMAN AND WERTHEIMER CLASSIFICATION Type I Congenital coalition Type II Acquired coalition
Perlman MD, Wertheimer SJ: Tarsal coalitions. J Foot Surg 1986; 25(1): 58-67 coalitions

TARSAL COALITIONS TACHDJIAN CLASSIFICATION TIONS I. Isloated Anomaly

Ia TC, CN, CC, or NC Ib multiple combinations of Ia Ic massive tarsal coalition

II. Part of Complex Malformation

IIa assoc w/ other synostoses (carpal coalition, synphalangism) IIb manifestation of a syndrome (Aperts, Nievergelt-Perlman) Nievergelt
Eckert WR, Davis EA Jr: Acute rupture of the peroneal retinaculum. J Bone Joint Surg Am 1976 Jul; 58(5): 670-2

III. Associated w/ Major Limb Abnormalities POLYDACTYLY VENN & WATSON A. Wide Metatarsal Head B. T-shaped Metatarsal Head shaped C. Y-shaped Metatarsal Head shaped D. Digital Duplication E. Complete Duplication
Venn-Watson EA: Problems in polydactyly of the foot. Watson Orthop Clin North Am 1976 Oct; 7(4): 909-27 909

OSTEOMYELITIS BUCKHOLZ Type I wound induced osteomyelitis

Ia open fx w/ complete discontinuity Ic post-op infection Ib penetrating wound

Type II mechanogenic infection

IIa implants, internal fixation IIb contact instability/bone on bone apposition

Type III physeal osteomyelitis Type IV ischemic limb disease Type V combination osteo of types I-IV Type VI osteitis from septic arthritis Type VII chronic osteomyelitis
Buckholz, JM 1987. The surgical management of osteomyelitis: with special reference to : a surgical classification. J. Foot Surg. 26:S17-S24

OSTEOMYELITIS CIERNY-MADER CLASSIFICATION Type I medullary osteo Type II superficial osteo Type III localized osteo Type IV diffuse osteo Type A good immune system and vascularity Type B local or systemic immune compromise Type C tx will be more harmful to patient than disease
Cierny G, Mader JT: Adult chronic osteomyelitis. Orthopaedics 1984; 7 .

POLYDACTYLY TETAMY & MCKUSICK CLASSIFICATION Post-axial polydactyly only axial Type A Complete digit that articulates w/ 5th MT head or duplicate 5th MT Type B Accessory digit w/o osseous attachment
Tetamy Sa, McKusick VA: Synopsis of hand malformations with particular emphasis on genetic factors. Birth Defects 5(3):125, 1969

POLYDACTYLY BLAUTH & OLASON CLASSIFICATION Type A Arrangement based on duplication distal to prox o
A1 distal phalanx A3 proximal phalanx A2 middle phalanx A4 metatarsal A5 tarsal bone

Type B Transverse numbering of digits medial to lateral

Blauth W., Olason AT Classification of polydactyly of the. hands and feet. Arch. Orthop. Trauma. Surg., 1988, 107,. 334-344

OSTEOMYELITIS WALDVOGEL CLASSIFICATION Type I Hematogenous osteo Type II Osteo secondary to contiguous source Type III Osteo assoc w/ vascular insufficiency Type IV Chronic osteo
Waldvogel FA et al: Osteomyelitis: a review of clinical features, therapeutic : considerations and unusual aspects. N Engl J Med 1970 Jan 22; 282(4): 198-206 198

SYNDACTYLY DAVIS & GERMAN Type I incomplete webbing between digits Type II complete webbing to ends of digits Type III simple syndactyly, no phalangeal involvement Type IV complicated, phalangeal bones appear abnormal
Davis JS, German WJ (1930) Syndactylism. Arch Surg 21 : 32-. 75. 5 32

OSTEOMYELITIS PATZAKIS CLASSIFICATION Zone I Distal metatarsal neck (most common) Zone II MT neck to MTJ (least common) Zone III calcaneus or talus
Patzakis PJ, Calhoun JH, Cierny G, Holtom P, Mader JT, Nelson CL Symposium: , Current Concepts in the Management of Osteomyelitis. Contemporary Orthopaedics, Orthopaedics 28(2): 157-185 passim, 1994

TARSAL COALITIONS DOWNEY A. Juvenile (Osseous Immaturity) Type I extra-articular coalition

Ia no secondary arthritis, tx w/ badgley procedure Ib secondary arthritis, tx w/ resection, triple arthrodesis

CHARCOT FOOT EICHENHOLTZ, SHIBATA, YU Stage 0 swelling, warmth, w/ joint instability Stage I destructive phase w/ joint laxity, subluxation, and sublux osteochondral fragmentation Stage II coalescence; absorption of debris and fusion of larger fragments to adjacent bone Stage III remodeling; revascularization and remodeling of bone and fragments
Eichenholz SN. Charcot Joints. Springfield: Charles C. Thomas, 1966 C Yu, Evaluation and Treatment of Stage 0 Charcots Neuroarthropathy of the Foot and Ankle. JAPMA 92(4): 210-220, 2002 Shibata, Results of arthrodesis of the ankle in leprotic neuropathy pts. JBJS 1990

Type II intra-articular coalition

IIa no secondary arthritis, tx w/ resection or triple arthrodesis dary IIb secondary arthritis, tx w/ triple arthrodesis

B. Adult (Osseous Maturity) Type I extra-articular coalition

Ia no secondary arthritis, tx w/ resection or triple arthrodesis

CHARCOT FOOT DEFORMITY ONVLEE Pattern A Plano-valgus-abductus foot Pattern B Rocker bottom foot Pattern C Ankle deformity in varus direction Pattern D Extremely flat foot.

Onvlee GJ. The Charcot Foot. A critical review and an observational study of a group of 60 patients. Thesis. The netherlands: University of Leiden, 1998.

CHARCOT ANATOMIC CLASSIFICATION Zone 1 Distal and proximal interphalangeal joints, metatarsophalangeal joints Zone 2 Tarsometatarsal joints (Lisfrancs) Zone 3 Naviculo-cunieform joints, talo-navicular joint, calcaneocuboid joint Zone 4 Ankle joint, subtalar joint Zone 5 Calcaneus
Sanders LJ, Frykberg RG. The Charcot Foot. In: Frykberg RG, ed. The high risk foot in diabetes mellitus. First edition. New york: Churchill Livingstone, 1991: 325-335.

Type III severe DJD, loss of articular cartilage Type IV epiphyseal dysplasia, multiple head involvement
Freiberg AH: Infraction of the second metatarsal bone, a typical injury. Surg Gyn Ob 1914; 19: 191-163

AVN OF THE 2ND METATARSAL KATCHERIAN Level A fissures noted in distal metaphysis or epiphysis Level B increased fissuring w/ bone resorbtion Level C increased fissuring w/ central collapse of MT head Level D collapse & fx w/ fragments on either side of joint Level E complete collapse of MT head
Katcherian DA: Treatment of Freiberg's Disease. Orthop Clin North Am 25: 69, 1994

HALLUX LIMITUS/RIGIDUS DRAGO, ORLOFF, AND JACOBS Grade I Functional limitus

Hallux equinus/flexus, plantar subluxation of proximal phalanx, MPE, no DJD, hyperextension of HIPJ, pronatory architecture, joint ROM normal NWB, but is limited on WB.

Grade II Adaptation; proliferative/destructive joint change

Flattening of 1st MT head, pain on end ROM, passive ROM limited, osteochondral defect/cartilage fibrillation & erosion, small dorsal exostosis, subchondral eburnation, periarticular lipping or phalanx base and 1st MT head

COMPLEX REGIONAL PAIN SYNDROME IASP (1993) CRPS type I (RSD) regional pain, sensory changes, abnormalities of temperature, abnormal sudomotor activeity, edema, and abnormal skin color CRPS type II (causalgia) All former symptoms in addition to a peripheral nerve lesion.
Reinders. Complex regional pain syndrome type I: use of the international association for the study of pain diagnostic criteria defined in 1994. Clin J. Pain 18: 207-215, 2002.

Grade III- Joint deterioration/arthritis, established arthrosis

Severe flattening of 1st MT head, osteophytosis dorsally, non-uniform narrowing of joint space, degeneration of articular cartilage, erosions, creptius, subchondral cysts, pain on ROM, assoc inflammatory arthritis

Grade IV Ankylosis/Hallux Rigidus

Obliteration of joint space w/ loss of majority of articular surface, exuberant osteophytosis w/ joint mice, less than 10 ROM, deformity, malalignment
Drago JJ, Oloff L, Jacobs AM: A comprehensive review of hallux limitus. J Foot Surg 23: 213, 1984

NERVE INJURY SEDDEN Neuropraxia interruption of nerve impulse due to extrinsic pressure, resulting in pinpoint segmental demyelination Axonotmesis severance of individual nerve fibers, resulting in partial severance of nerve Neurotmesis complete severance of nerve, resulting in wallerian degeneration
Seddon HJ: Three types of nerve injuries. Brain 1943; 66: 237

HALLUX LIMITUS/RIGIDUS REGNAULD CLASSIFICATION 1st Degree Limitation of 1st MPJ ROM to 40, pain at end ROM, narrowing of joint space, flattening of MT head, periarticular spurring, no sesamoidal dz 2nd Degree Arthrosis, enlargement of joint, loss of ROM, painful ROM, crepitus, narrowing of joint space, flattening of MT head, periarticular spurring, sesamoid hypertrophy 3rd Degree Ankylosis, crepitus, little or no ROM, pain, loss of joint space, marked hypertrophy of joint, joint mice, marked involvement of sesamoids
Regnauld B. Hallux rigidus. In The Foot, pp 345-359, edited by B Regnauld, SpringerVerlag, Berlin, 1986

NERVE INJURY SUNDERLAND CLASSIFICATION 1st Degree disruption of nerve impulses w/o wallerian degeneration 2nd Degree disruption of axon, w/ wallerian degeneration distal to the point of injury 3rd Degree fibrosis of nerve, regrowth w/ fusiform swelling 4th Degree incomplete severance of nerve 5th Degree - complete severance of nerve
Sunderland S: A classification of peripheral nerve injuries producing loss of function. Brain 74:491-516, 1951

HALLUX LIMITUS/RIGIDUS MODIFIED REGNAULD/ORLOFF CLASSIFICATION Stage I Functional hallux limitus

No DJD, no pain on end ROM, limited ROM on WB but normal NWB

FOOT ULCERATION WAGNER Grade 0 Skin is intact, no open lesions. Grade 1 Skin only lesion, large or small, dirty or clean Grade 2 Deeper lesion involving tendon, muscle, or bone Grade 3 Grade 2 w/ infection (abscess, osteomyelitis) Grade 4 Partial gangrene in the forefoot Grade 5 Entire foot is gangrenous, no procedures possible
Wagner FW Jr. The diabetic foot. Orthopedics 1987;10:163-72

Stage II Joint adaptation

Pain on end ROM, flattening of 1st MT head, small dorsal osteophyte

Stage III Joint deterioration

Crepitus on ROM, non-uniform joint space narrowing, subchondral sclerosis and cyst formation, osteophytosis, severe flatting of 1st MT head

Stage IV Ankylosis
Obliteration of joint space, osteophyte fragmentation, minimal to no ROM
Vanore JV et al. Clinical Practice Guideline First Metatarsophalangeal Joint Disorders Panel. Diagnosis and treatment of first metatarsophalangeal joint disorders. Section 2: hallux rigidus. J Foot Ankle Surg 42:124-136, 2003

HALLUX VALGUS DEFORMITIES Mild Hallux Valgus <20, Intermetatarsal angle <11, MPJ may be
congruent, up to 50% subluxation of fibular sesamoid Moderate Hallux Valgus btw 20-40, Intermetatarsal angle btw 11-16, MPJ may be subluxed, fibular sesamoid displaced 75% Severe Hallux Valgus >40, Intermetatarsal angle >16, MPJ significant subluxation, fibular sesamoid displaced 100%
Couglin MJ and Mann RA. Chapter 6: Hallux Valgus. Surgery of the Foot & Ankle, 8th edition. Mosby Elsevier, Philadelphia: 2007.

UTSA CLASSIFICATION Grade 0 pre or post ulcerative lesion, epithelialized Grade 1 superficial wound, w/ out tendon, capsule or bone Grade 2 wound penetrating to capsule, tendon, or bone Grade 3 wound penetrating to bone or joint Type A Clean, vascular wound Type B Infected, vascular wound Type C Clean, ischemic wound Type D Infected, ischemic wound
Lavery LA, Armstrong DG, Harkless LB. Classification of diabetic foot wounds. J Foot Ankle Surg. 1996 Nov-Dec;35(6):528-31

AVN OF THE 2ND METATARSAL FREIBERG Type I no DJD, articular cartilage intact Type II periarticular spurs, articular cartilage intact

BURN CLASSIFICATION 1st Degree superficial, involving outer layer of skin, erythema, no blisters 2nd Degree superficial or deep, may or may not have blisters assoc w/ erythema, anesthetic 3rd Degree full-thickness destruction of skin, can extend to bone and is anesthetic. Includes electric burns, radiation burns, and frostbite. Can lead to physeal growth arrest.

Minor <10% TBSA in adults; <5% TBSA in children or 5% elderly; <2% full-thickness burn outpatient management Moderate 10%-20% TBSA in adults; 5%-10% TBSA in 10% children or elderly; 2%-5% full-thickness burn; high thickness high-voltage injury; suspected inhalation injury; circumferential burn; concomitant medical problem predisposing to infection (eg, itant diabetes, sickle cell disease) Hospital Admission Major N20% TBSA in adults; N10% TBSA in children and elderly; N5% full-thickness burn; high-voltage burn; any voltage significant burn to face, eyes, ears, genitalia, or joints; significant associated injuries (eg, fracture, other major trauma) Refereral to Burn Center
J Burn Care Rehabil 1990;11:98-104 and from Guidelines for the Operations of Burn 104 Units. Resources for Optimal Care of the Injured Patient: 1999, Committee on Trauma, American College of Surgeons.

and joint capsule) Metastasis: M0: No identifiable skip lesions or distant metastases. M1: Any skip lesions, regional lymph nodes, or distant metastases.

MALIGNANT MELANOMA CLARK Level 1 epidermis to dermal/epidermal junction Level 2 papillary dermis Level 3 to reticular dermis Level 4 reticular dermis Level 5 subcutaneous fat
Clark, W.H., Jr.: A classifiation of malignant melanoma in man correlated with , histogenesis and biologic behavior. In Montagna W, Hu F (eds): Advances in Biology and Skin, Vol 8, The Pigmentary System, Pergamon Press, New York, 1966: 612-647 , 612

Enneking WF: Musculoskeletal Tumor Surgery. New York, Churchll Livingstong, 1983 PLANTAR FIBROMATOSIS SAMMARCO

MALIGNANT MELANOMA BRESLOWS CLASSIFICATION (SURVIVIAL RATES) Level 1 - <0.75mm 83-100% 100% Level 2 0.76-1.5mm 37-90% Level 3 1.51-2.25mm 37-83% Level 4 2.26-3.0mm 44-72% Level 5 - >3mm 9-55%
Breslow, A.: Thickness, cross-sectional areas and depth of invasion in the prognosis of sectional cutaneous melanoma. Ann Surg 1970;172:902-908

Grade 1 Focal disease isolated to a small area on the medial and/or central aspect of the fascia. No adherence to the skin. No deep extension to the flexor sheath. Grade 2 Multifocal disease, with or without proximal or distal extension. No adherence to the skin. No deep extension to the flexor sheath. Grade 3 Multifocal disease, with or without proximal or distal extension. Either adherence to the skin or deep extension to the flexor sheath. Grade 4 Multifocal disease, with or without proximal or distal extension. Adherence to the skin and deep extension to the flexor sheath.
Sammarco, G. James M.D. Mangone, Peter G. M.D. Classification and Treatment of Plantar Fibromatosis. FAI 21(7), 563-9: 2000 563 NAIL INJURIES ROSENTHAL

Zone 1 to distal phalanx

Tx: w/o bony exposure, let granulate if <1cm, graft if >1cm injury If bony exposure, treat as zone 2 injury

Zone 2 distal to lunula BENIGN AND MALIGNANT TUMORS - ENNEKING BENIGN TUMORS (applies to both bone and soft tissue) Stage 1: Lesions are static or tend to heal spontaneously Stage 2: Lesions have a more aggressive radiographic appearance, are less mature histologically, and show evidence of continued growth Stage 3: Lesions are locally aggressive and histologically immature and show progressive growth that is not limited by natural barriers. MALIGNANT LESIONS Stage determined by three different sub-categories categories Grade: Histology with aid of radiographic findings and clinical correlation G1: Low grade, uniform cell type without atypia, few mitoses, G2: High grade, atypical nuclei, mitoses pronounced Site: T1: Intracompartmental (Confined within limits of periosteum), T2: Extracompartmental (Breach in an adjacent joint cartilage, bone cortex (or periosteum) fascia lata, quadriceps,
Stasoy/Kutler pedicle flaps after wound is clean

Zone 3 proximal to lunula

Amputation of distal phalanx (including DIPJ) on

Rosenthal EA. Treatment of fingertip and nail bed injuries, Orthop Clin North Am 14:675-697, 1983

CLINICAL ANTIBIOSIS
Infection: Pathologic presence of bacteria in a wound or tissue site, numbering 106. It is clinically signified by inflammation, erythema, pain, warmth, and loss of function. History: May present with nausea, vomiting, shaking, chills. Get history of prior tx, PMH, allergies, social Hx, travel Hx, and any pets the patient may have. (Cats = pasturella) D/Dx: Gout, DVT (r/o venous Doppler/venogram), chronic venous insufficiency (bilateral pitting edema, hemosiderin deposition), acute charcot, acute trauma, normal wound healing, post-surgical healing. Labs: WBC>10, left shift, elevated ESR, CRP. Hospital Admission: Indicated for osteomyelitis, large draining wound, sustained fever (over 101F), diabetes, immunocompromised state, gas present in tissues, failure of PO antibiosis, sepsis indicated on blood labs.

PENICILLINS Original Penicillins Not used often in foot infections for gonococcus, anaerobes PEN G: IV or IM 5-6 million U q4h PEN VK: PO 250-500mg QID, causes hypokalemia Aminopenicillins Good broad spectrum, but useless against staph. AMPICILLIN: IM, IV, PO 250-500mg QID or 2g q4h AMOXICILLIN: PO only 250-500mg QID Semisynthetic PCNnase resistant, good vs. staph, used in specific situations NAFCILLIN: IM or IV 1-2g q4-6h, metabolized in liver DICLOXACILLIN: PO 250-500mg QID Uriedopenicillins (Expanded Spectrum) Active against pseudomonas, resistance is common CARBENICILLIN: No use in lower extremity TICARCILLIN: IV 3-4g q4h, high in sodium PIPERICILLIN: No use in lower extremity Beta-Lactamase Inhibitors First choice antibiotics w/ cephalosporins Staph, Strep, Anaerobes, Gram - coverage TIMENTIN (TICARCILLIN + 100MG CLAVULANATE) IV 3.1g q6-8h Empiric for DM foot infections, bites AUGMENTIN (AMOXICILLIN + 125MG CLAVULANATE) PO 250/500/875 BID Good for outpatient DM, bites UNASYN (1 PART AMPICILLIN + PART SULBACTAM) IV 3g loading dose, 1.5g following doses Better at gram + but worse for gram than timentin ZOSYN (PIPERICILLIN + TAZOBACTAM) IV 4.5g q8h Better against enterococci CEPHALOSPORINS First Generation Cephalosporins Good for gram +, most common pre-op prophylaxis CEFAZOLIN (ANCEF): IV or IM, 1g q8h CEFALEXIN (KEFLEX): PO, 250-500mg BID/QID CEFADROXIL (DURICEF): PO, 500mg q12h Second-Generation Cephalosporins Used mainly for ear infections, pneumonia not podiatry IV: CEFOXITIN (MEROXIN), CEFUROXIME (ZINACEF), CEFOTETAN (CEFOTAN)

PO: CEFACLOR (CECLOR) 250-500mg TID, CEFUROXIME (CEFTIN), CEFPROZIL (CEFZIL) Third-Generation Cephalosporins More gram -, less gram +, fortaz also anti pseudomonal IV: CEFTRIAXONE (ROCEPHIN) 1-2g QD (long half-life) Rocephin principal antibiotic in Lyme disease treatment CEFTAZIDIME (FORTAZ): some antipseudomonal coverage PO: CEFDINIR (OMNICEF) 300mg BID, better staph coverage CEFPODOXIME (VANTIN), CEFIXIME (SUPRAX) Fourth-Generation Cephalosporins Good gram + and gram -, antipseudomonal CEFEPIME (MAXIPIME) IV, 1-2g q12h CARBAPENEMS PRIMAXIN (IMIPENEM + CILASTATIN): PO 500mg q6h Gram +, gram -, anaerobes cilastatin added to protect kidneys. Expensive, save for life-threatening infections MEROPENEM (MERREM) some antipseudomonal coverage ERTAPENEM (INVANZ): IV, IM, 1g q24h Good against enterobacteria, but not pseudomonas AZTREONAM (AZACTAM): IV, 1-2g q8h Only good against gram anaerobes; use in combination AMINOGLYCOSIDES Staph, strep, gram -, but not anaerobes ADRs: reversible nephrotoxicity, irreversible ototoxicity, Neuromuscular blockade if infused too quickly GENTAMYCIN, TOBRAMYCIN, AMIKACIN Loading doses: Gentamycin/Tobramycin 2mg/kg Amikacin 7.5mg/kg Maintenance doses: Gent/Tobra 6mg/kg/day Amikacin 15mg/kg/day Peak level: Gent/Tobra 6-10g/ml, Amikacin 20-30g/ml Trough level: Gent/Tobra 2g/ml, Amikacin 10g/ml (Peak = immediately after dosing, Trough = 20-30 minutes before dosing) FLOUROQUINOLONES CIPROFLOXACIN (CIPRO): PO 500/750mg, IV 400mg BID Good gram coverage, antipseudomonal Not for peds, Sx prophylaxis, or weak/tenotomized tendons LEVOFLOXACIN (LEVAQUIN): PO or IV 500/750mg BID Good for staph and strep, not as strong antipseudomonal MOXIFLOXACIN (AVELOX): PO or IV 400mg QD Good staph, strep, and antipseudomonal GATIFLOXACIN (TEQUIN): Not for foot infections, lengthens QT TROVAFLOXACIN (TROVAN): Taken off market for hepatic failure SULFONAMIDES BACTRIM/SEPTRA (TRIMETHOPRIM + SULFAMETHOXAZOLE): PO only - QD dosing, double-strength (DS) 160mg TMX, 800mg sulfamethoxazole Broadest possible spectrum, not antipseudomonal Allergies common MACROLIDES ERYTHROMYCIN: PO 250-500mg QD, IV 1g QD Good against staph, gram + and gram anaerobes AZITHROMYCIN (ZITHROMAX): PO 500mg QD day 1, 250mg QD days 2-4. Postbiotic effect for 10 days following dosing. Gram +, some Gram organisms, usually for pts who are allergic to other antibiotics, or peds (Paronychia) CLARITHROMYCIN (BIAXIN): Not often used for foot infections

TETRACYCLINES

TETRACYCLINE, DOXYCYLINE, MINOCYCLINE Limited use in podiatry mainly used for acne, Lyme disease

CHLORAMPHENICOL Mainly a historical footnote; not really used anymore ANTI-ANAEROBIC MISCELLANY METRONIDAZOLE (FLAGYL): PO or IV, 500mg TID Mainly gram but some gram +, amebiasis, colorectal Sx Used also to treat pseudomembranous colitis (see below) CLINDAMYCIN (CLEOCIN): PO 150-300mg BID, IV or IM 600-900mg q8h. Good bone penetrance, good for anaerobes Can cause pseudomembranous colitis ANTI-GRAM + MISCELLANY VANCOMYCIN (VANCOCIN): PO 125mg QD (only for c. difficile), IV 1g q12h infuse slowly Good for all gram + except VRSA and VRE. ADRs: nephrotoxicity, ototoxicity, red man syndrome (rash) Can be used for prophylaxis if PCN, clindamycin allergic Peak 20-500g/ml, Trough - 10g/ml, like aminoglycosides SYNERCID (QUINUPRISTIN + DALFOPRISTIN): IV 7.5mg/kg q12h Used for VRE LINEZOLID (ZYVOX): PO, IV 600mg BID Used for MRSA, all gram +. Can cause thrombocytopenia RIFAMPIN: PO 300mg BID Good for resistant staph and strep Causes rash, orange discoloration of all body fluids. ADVERSE REACTIONS -Pseudomembranous Colitis Clindamycin, cephalosporins, uriedopenicillins: Tx w/ metronidazole, oral vancomycin -Tendon rupture, cartilage degeneration Ciprofloxacin -Ototoxicity (irreversible), nephrotoxicity (reversible), neuromuscular blockade Gentamycin, Tobramycin, Amikacin -Ototoxicity, nephrotoxicity, red man synd. Vancomycin -Hypokalemia Pen G, Pen VK: Tx w/ K-exelate -Thrombocytopenia, bone marrow suppression Linezolid -Rash, orange discoloration of body fluid Rifampin -QT interval lengthening Tequin ANTI-PSEUDOMONAL DRUGS Penicillins: Ticarcillin (weak), Timentin (weak) Cephalosporins: Fortaz (weak), Maxipime (strong) Carbapenems: Meropenem (weak) Quinolones: Cipro (strong), Levaquin (weak), Avelox (strong) Aminoglycosides: Tobramycin (strong) EMPIRIC TREATMENT OPTIONS Soft tissue infections: Unasyn, Zosyn, Timentin, Maxipime, Invanz, Avelox, Cipro, Levaquin, Bactrim. SURGICAL PROPHYLAXIS Indications: Prolonged surgery, immunocompromise, trauma, implant surgery. Most Common: Ancef, Rocephin, Vancomycin, Clindamycin Never Used: Quinolones, particularly cipro. Administration: IV, h prior to surgery (usually done in OR) LOWER EXTREMITY MICOBIOLOGY REVIEW
GRAM + COCCI Staph Aureus Coagulase +

Incidence: Normal flora, common infection, high resistance ABx: 1st Cephalosporins, PCNase resistant PCN, Cleocin, Bactrim, Erythromycin, Vanco (resistant), Cipro (resistant) Staph Epidermidis/Saprophyticus Coagulase Incidence: Normal flora Epi seen in implant sx, sap in UTI ABx: Same as S. Aureus Strep Pyogenes Group A, Strep Agalactiae Group B Incidence: Pyo usually superficial, Agalactiae seen in DM ABx: PCNs, 1st gen Cephalosporins, Cleocin, Vanco Strep Faecalis/Faecium Group D/Enterococci Incidence: GI flora, highly resistant, ST infection component ABx: Gentamycin + PCN/Ampicillin/Amoxicillin or Vanco Peptostreptococcus/Peptococcus Anaerobic Incidence: DM foot infections ABx: PCN, 1st gen Cephalosporins, Cleocin, Erythromycin GRAM + BACILLI Clostridium Tetani Anaerobic, Spore-forming Incidence: Ubiquitous in environment, puncture wounds ABx: PCNs (mainly useless b/c of neurotoxin production) Clostridium Perfringens Anaerobic Incidence: Fast growing, gas gangrene (necrotizing fasciitis) ABx: Sx debridement indicated PCN, Cleocin, Imipenem Corynebacterium diptheroid Incidence: Nosocomial, Immunocompromised infections ABx: Cleocin, Erythromycin, Vanco GRAM COCCI Neisseria Gonorrhoeae Incidence: Major cause of septic arthritis is LE, resistant ABx: Rocephin, Cipro (resistant) GRAM RODS (ENTERIC) Bacteroides Incidence: Most common in DM infection, resistant ABx: Flagyl, primaxin, cleocin, 3rd or 4th gen cephalosporins Enterobacter/Citrobacter/Morganella/Serratia Incidence: Nosocomial infections, elderly ABx: 3rd gen cephalosporins, cipro, bactrim, aminoglycosides Escherichia Coli Incidence: Common in LE infections ABx: Any cephalosporin, ampicillin, cipro, bactrim Proteus/Providencia Incidence: Normal flora, common in interdigital infections ABx: Cephalosporins, Ampicillin, Cipro, Bactrim OTHER GRAM RODS Aeromonas Hydrophilia Incidence: Injuries sustained under water (fresh water) ABx: Cipro, Bactrim, Primaxin, Aminoglycosides Haemophilus Influenzae Incidence: Most common in children, nosocomial infections ABx: 3rd/4th gen cephalosporins, bactrim, ampicillin Pseudomonas Aeruginosa Incidence: Ubiquitous, common in osteomyelitis ABx: See left