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Predisposing Factor Hereditary Age Sex

Precipitating Factor Poor dental hygiene Low intake of fluids Too much intake of sweet foods

Invasion of group A B- hemolytic streptococcus

Pharyngeal infection

Abnormal humoral and cell mediated immune response to group A streptococcal cell membrane antigens called M Proteins.

Acute rheumatic fever

Diffuse, proliferate and exudative inflammatory lesions develop

Joints

Heart

Skin

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