Nutritional supplement in the form of gel in case if digestive disturbance.

A specialy formulated gel for use during digestive disorders.

Particular nutritional purpose Stabilisation of water and electrolyte balance.

AN INNOVATIVE RANGE OF GELS FOR YOUNG PIGLETS

AN INNOVATIVE CONSISTENCY
Our creamy-gel has a close consistency to what the piglet is familiar with, i.e milk. The aroma (vanilla flavour) and the taste of our gel have been selected for an optimal intake. Here are the nutritional benefits compared to an usual dry feeding : A better digestibility A better intestinal health A beneficial effect on digestive flora with an increase of the microvillis growth

This non-sticky creamy-gel prevents wastage and is really easy to eat for the young piglets. Besides our gel has been formulated with high moisture content and natural intake enhancers to encourage consumption and aid in transition to dry pellets after 10 days while improving intestinal health. 75% of our ingredients are solubilized which means an increased digestibility and an intestine protection.

A PERFECT ACIDIC pH OF OUR GEL

The acidic pH of our gel is also a way to control the harmful bacterias development with the natural acidification action of the stomach. It has also a key role in protein digestibility related to casein emulsification and pepsine optimum pH range of action.

AN INNOVATIVE RAW MATETIALS SELECTION

Each ingredient has been selected to provide : A highly palatable mix of ingredients A high digestibility of nutriments An improved nutrition of the intestine cells A perfect control of the bacterial flora

100% Intestinal cell wall protection 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% Transit regulation CARBOHYDRATES Dextrose Organic acids Energy (fumaric, citric) Prebiotic sugars PROTEIN Enzymatic treated protein Free amino acids Protein Nucleotides Bacteria flora control (MCFA) Bacteria flora control (propionic, sorbic, lactic) Bacteria flora control (yeast cell wall) LIPIDS Medium chain fatty acid MISCELANEOUS Vitamin minerals Immune enhancer Aromatic component

EARLYGUT

- EARLYGUT is high in ash because rich in mineral (balance loss from diarrhea) and clay for a protection effect - Lower in protein - High in sugar to stimulate Na absorption

A SOURCE OF INTESTINAL PROTECTION

A SOURCE OF INTESTINAL PROTECTION

Attapulgite clay
A non-expandable clay with a positive action on the protection of enterocytes, reducing inflammation of the bowels surface and toxin binding. Glycocalyx : a sieve for bacteria and big size molecules
Clays, carbon or YCW can integrate the glycocalyx structure, reinforcing the barrier effect. Glycocalyx is about 200nm length in enterocytes Clays have also antioxydant protective effect

A SOURCE OF INTESTINAL PROTECTION

Tight junctions importance for body integrity

Clays increase the thickness of adherent mucous Clays protect the intestine mucosal from injuries Clays modify the gastrointestinal glycoprotein and enhance its polymerization Clays reinforce the strengthness of the tight junctions, protecting intestine for external invasion

A SOURCE OF INTESTINAL PROTECTION

Clays and intestinal wall strengthness Mucous Role

Calciform cells Mucus production : glucoprotein polymers, lipids, protein linked with covalent bound Physical barrier protecting mucosa against extraneous molecules and physical injury and competing with epithelium surface for micro organism Maintaining pH gradient Chemical barrier

A SOURCE OF INTESTINAL PROTECTION

Clays mode of action in intestine

Smectite, (More et al, 1987); Attapulgite (More et al, 192) increases thickness of adherent mucus Due to interaction with mineral particles and mucus component (Leonard et al, 1994) Modification and of gastrointestinal glycoprotein and enhancement of polymerization (Droy-Lefaix et al, 1986) Reduces mucus degradation (Bouyssou et al, 1990) by improving reohlogical properties such as spinability Better mucous quality (Droy-Lefaix et al, 1985) decreases mucous solubility, increases viscosity and hydrophobicity and adhesion to intestinal cells.

A SOURCE OF INTESTINAL PROTECTION

Betaine
A molecule that helps the intestines fight hydric instability, such as water loss during diarrhea. Betaine is an osmolyte, which is a molecula able to accumulate in great quantities in the cells without affecting the cells function. During hydric stress, loss of salts, osmolytes play a major role; Osmolytes can maintain cell volume and fluid balance.

A SOURCE OF INTESTINAL PROTECTION

Betaine function in enterocytes : Osmoprotection

Betain is a dipolar zwiterrion

Osmoprotective properties Maintain cell volume constant, keeps water into cell, can replace missing minerals Maintain enzymes activities, more anabolism, better nutriment absorption

A SOURCE OF INTESTINAL PROTECTION

Betaine function in enterocytes : Osmoprotection Betain reduces energy expenditure for ion pumping
Moeckel et al. 2002

Spared energy Promote cell proliferation and digestive tract development Increase villi height

A SOURCE OF INTESTINAL PROTECTION

Betaine function in enterocytes : membran activity Betaine uptake is Na+ dependent co transport
Kettunen et al. 2001

Consequence supplemental betaine improves Na+ absorption

A SOURCE OF INTESTINAL PROTECTION

Betaine function in the gut Betaine can modify the fermentation profil in broiler chicks : more lactic acid and volatil fatty acids
Kettunen et al. 1999

Consequence Improving the positive lactic flora Control the pathogenous flora

A SOURCE OF INTESTINAL PROTECTION

Sodium glutamate
The preferred source of energy for the enterocytes it promotes the quick reconstitution of the intestinal flora following stress. Glutamate is an important precursor of bioactive molecules such as glutamine, proline, argininine, histidine and ornithine and serves as a key constitutive amino acid of glutathione the major cellular anti-oxidant in the intestinal cells.

A SOURCE OF INTESTINAL PROTECTION

Glutamate effects on piglet

Improved effective gastric secretions Improved digestion (Pepsinogen pepsin) Improved regulated digestive Improved appetite (Umami sensors)

Trophic effect on intestinal villi = elongation of the intestinal villi Enhanced nutrients absorbtion Improved effectivity of M-cells and goblet cells Stimulated cell proliferation Reduction/ inhibition of apoptosis Highly positive mitosis to apoptosis ratio Rapid restoration of crypts injured by enterotoxic E-coli

A SOURCE OF TRANSIT REGULATION

A SOURCE OF TRANSIT REGULATION

Natural fiber
Purified cellulose that contributes to regulating the digestive transit, particularly in the event of digestive problems. Because it is not absorbed through the bowels, it helps preserve polymeric structures in fecal matter, inducing drier feces. Natural Fiber consists of finest, fibrillated fibres which for a stable and solid network. The typical capillary effects of these fibres bind free water in its fibre capillaries and thus makes it unavailable for microorganism the water activity consequently reduces.

A SOURCE OF TRANSIT REGULATION

Consequence

Control of fluid in case of diarrhea risk Restore quickly a ferm structure of the feces

A SOURCE OF TRANSIT REGULATION

Inulin
A FOS source, this prebiotic contributes to the development of a balanced digestive flora by stimulating bifidobacteria and inhibiting pathogens.

A SOURCE OF TRANSIT REGULATION

Inuline effects on digestive flora

Regulate intestinal transit and fecal mass Acidify fecal content and increase fatty acid volatil production in colon

Strong health effect on digestive system health and development Optimal balance of digestive flora Reduction of bacterial toxin risk

Reduces the amoniac level of amoniac in the intestine

Improves mineral assimilation (especially in the second part of the digestive tract) Stimulates the sanitary status of the piglet Improves immunity resistance

A SOURCE OF TRANSIT REGULATION

Sanguinarine
It is a natural anti-inflammatory from the alkaloid family, it has a beneficial action against pathogen bacteria.

Tannin extracted from chesnut tree

A hydrolysable polyphenol that activates the intestinal mucus layer, beneficial for intestinal cell protection and offering additional positive action by reducing the bodys oxidation.

A SOURCE OF ENERGY
CARBOHYDRATES

A SOURCE OF ENERGY / CARBOHYDRATES

Dextrose
The simplest and most important sugar, its digestion requires no enzymes. It helps balance the fundamental hormonal regulation process by regulating insulin levels. The most simple sugar, 100% digestible without any enzyme.

A SOURCE OF ENERGY / CARBOHYDRATES

Citric acid, fumaric acid

Two powerful acidulants that stimulate salivation and reduce pH, in order to reach a pH value allowing good preservation and optimum digestion in the animals' bowels.

Potassium sorbate
An interesting source of energy with antibacterial and antifungal activity, potassium sorbate also contributes, combined with trisodium citrate, to regulating the acid-base balance.

Propionic acid
A very specific monocarboxylic acid, a source of energy for animals and a strong antibacterial and antifungal component.

A SOURCE OF PROTEIN
1- VEGETAL PROTEIN

A SOURCE OF PROTEIN / VEGETAL PROTEIN

Soya protein concentrate

A protein derived from soybeans, very rich in essential amino acids and enzymatically processed; the product, featuring smallsized proteins, is free of allergenic effects and any standard soybean antinutritional factors, therefore offering optimum digestibility.

A SOURCE OF PROTEIN / VEGETAL PROTEIN

Soybean protein : responsible of allergy

Glycinine : Globuline wich represents 40% of total protein. Molar weight 320 350 KDa Composed of 12 sub units (6 acid sub units (A, 40 KDa) et 6 basic sub units (B, 20 KDa).

High size protein of soybean meal, Glycinine and beta conglycinine are responsible of allergy. Enzymatic treatment reduce considerably the protein size and modify its structure in order to suppress the allergenic effect.

A SOURCE OF PROTEIN / VEGETAL PROTEIN

Reduction of antinutrional factors of soybean by fermentation Anti-trypsique factor

0.3 2.5% of protein 8 20 KDa (2 main proteins) Link irreveribly with trypsine reducing its activity, and so reduce protein digestibility Reinforce the allergenic power of the storage protein

Lectines

5 200 ppm 60 120 KDa Fixation on intestinal membranes Reduction amino acid, Vitamin B12, polysaccharides absorption Can reach blood stream when intestine is damaged Association with enterocytes membranes, function alteration Growth reduction, anemia, colites, etc..

A SOURCE OF PROTEIN / VEGETAL PROTEIN

Urease

Less damaging at a nutritional point of vue because easily destroyed with heat Degrade urea in amonia, which is more toxic and create damage in intestinal membrane

Enzymatic treatment reduce considerably the protein structure in order to suppress the antinutritionnal function.

A SOURCE OF PROTEIN
2- AMINO ACIDS

A SOURCE OF PROTEIN / AMINO ACIDS

Lysine, Methionine, L Thronine, Tryptophane

The main essential amino acids are : Lysine for growth and enzymatic activities; methionine for liver metabolism and muscle deposition; threonine for the immune system's development and tryptophane (a precursor of serotonin) for feed intake stimulation Synthetic amino acids 100% digestible to balance and supplement piglet according to its requirement

A SOURCE OF LIPIDS

A SOURCE OF LIPIDS / MCFA

Medium-chain fatty acids

Two times smaller than most standard fatty acids (18-carbon), caprylic (8-carbon) and capric (10-carbon) acids are highly digestible lipids that quickly provide high amounts of energy to piglets. These MCFA have also an anti-bacterial activity by weakening the harmful bacterias membrane. Fat is essential because the most concentrated source of energy Digestibility requires emulsification and then lipase action

A SOURCE OF LIPIDS / MCFA

MCFA = C8 and C10 fatty acid Caprylic and Capric fatty acid The lower the chain, the easier to emulsify. C8 water solubility is 75mg/100ml, vs 0.04mg for palmitic acid, a common milk fatty acid The lower the chain, the more affinity with the lipase The lipase hydrolyze preferentially the shorter chain fatty acid MCFA are a very important source of energy for the young piglet because easily digested.

A SOURCE OF LIPIDS / MCFA

MCFA have an antibacterial role MCFA incorporate in the membrane of bacteria inducing a weakness in the membrane MCFA contributes to avoid the development of pathogen bacteria.

A SOURCE OF MINERALS

A SOURCE OF MINERALS

Diarrhea induce loss of water and also mineral

Na from gut lumen K from cell content Mg from cell content

Na absorption is linked with glucose absorption

Correlation with Na and glucose on proportion

A SOURCE OF MINERALS

Potassium chloride
Provides potassium, an essential mineral in intestinal cells, and helps maintain the products mineral balance.

Magnesium oxide
A source of magnesium, an important mineral in cells, necessary to compensate the losses that occur during diarrhea.

MISCELANEOUS
A SOURCE OF VITAMINS

MISCELANEOUS / A SOURCE OF VITAMINS

Vitamins A,D3,E,B group,C

Hydro-and liposoluble vitamins are essential for the piglets' metabolism (Vit. A, D3, E, B1, B2, B5, B6, B12, A. folique, Vit. K3, PP, Biotine) Vitamin supplementation
Vitamins are essential for the optimum function of the metabolism EARLY WEAK is supplementated in all vitamins : Liposoluble A, D3, E, K3 Hydrosoluble B group Vitamins stimulates protein and energy metabolism

MISCELANEOUS
A SOURCE OF IMMUNE ENHANCER

MISCELANEOUS / A SOURCE OF IMMUNE ENHANCER

Calcium butyrate
Calcium butyrate affects the bowels' maturation, helps regulate the immune system and controls pathogen flora by regulating the production of digestive hormones (gastrin, ghrelin, etc.) and the maturation of the digestive nervous system. It is also a milk component recognized by piglets, which stimulates their feed consumption

MISCELANEOUS / A SOURCE OF IMMUNE ENHANCER

= Nutritional additive for enterocytes Reinforcement of intestinal cell wall Development of intestinal villi Increase of digestive enzymatic production = Nutritional additive for intestinal flora balance Stimulates development of positive bifidobacteria flora Inhibit pathogen flora development Repress pathogenic activity of pathogen bacteria

MISCELANEOUS / A SOURCE OF IMMUNE ENHANCER

Algae extract ( DHA )

The most important omega-3 fatty acid that regulates the balance between ecosanoid hormones, prostaglandins, thromboxanes and leukotrienes Omega 3 is essential for young animal development DHA is the most important omega 3 fatty acid and the very young animals have poor ability to transform shorter chain omega 3 into DHA Extra supplementation of DHA improves heath, immunity development, reduce inflammation, .

MISCELANEOUS
A SOURCE OF MOS AND BETA GLUCANS

MISCELANEOUS / A SOURCE OF MOS AND BETA GLUCANS

Premium yeast cell wall

Rich in MOS (manno-oligosaccharides) and eta Glucans. At low levels, this components are known to have an immune booster effect especially through the mannane mode of action. eta Glucans are also very important components responsible of the aggregation of pathogen bacteria on the beta glucan cell membranes.

MISCELANEOUS / A SOURCE OF MOS AND BETA GLUCANS

Pathogen bacteria used to agglomerate on mannose of the yeast cell wall, reducing by this way their pathogenicity

Macrophages activity is boosted by the contact with yeast beta glucan, resulting in a better immune answer

MISCELANEOUS
A SOURCE OF ORGANIC ACIDS

MISCELANEOUS / A SOURCE OF ORGANIC ACIDS

Organic acid supplementation

Mix of acid and salt of organic acid to provide an optimum pH (<4), ideal for stimulation of lactic acid flora development, feed digestibility Dicarboxylic acid like fumaric acid as a regulator of acidity and 100% digestible energy source Monocarboxylic acid such as propionic as pathogen bacteria control and regulator of acidity

THANK YOU
Please do not hesitate to contact us should you need any further information; our EarlyPIG team will be happy to assist you. info@earlypig.com