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  • 01 Virus Hepatitis 2 2

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    Refangga Lova Efendi
    19 vizualizări18 pagini
    Symptoms (if present) are the same, regardless of cause (e.g., A, B, C, other viruses, toxins) hepatitis virus is the most common cause of Cirrhosis in the u.s.

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    Symptoms (if present) are the same, regardless of cause (e.g., A, B, C, other viruses, toxins) hepatitis virus is the most common cause of Cirrhosis in the u.s.

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    19 vizualizări18 pagini

    01 Virus Hepatitis 2 2

    Încărcat de

    Refangga Lova Efendi
    Symptoms (if present) are the same, regardless of cause (e.g., A, B, C, other viruses, toxins) hepatitis virus is the most common cause of Cirrhosis in the u.s.

    Drepturi de autor:

    Attribution Non-Commercial (BY-NC)
    Descărcați ca PDF, TXT sau citiți online pe Scribd
    Indicator pentru conținut neadecvat
    din 18

    Purnomo H, Mikrobiologi FK UNDIP

    Mahasiswa memahami tentang hepatitis dalam hal:


    Diferensial diagnosis

    Etiologi, patogenesis, diagnosis hepatitis virus A


    Etiologi, patogenesis, diagnosis hepatitis virus B

    Etiologi, patogenesis, diagnosis hepatitis virus C


    Etiologi, patogenesis, diagnosis hepatitis virus D

    Etiologi, patogenesis, diagnosis hepatitis virus E

    Inflammation of Liver:
    Viral, immune, Drugs, Toxins & other.

    Viral Hepatitis:
    Specific Heptitis A, B, C, D, E, & other

    Systemic - CMV, EBV, other.

    virus yang menyebabkan infeksi sistemik dengan target utama pada sel-sel hepar (hepatosit). tidak termasuk: virus-virus yang menyerang sel hati sebagai serangan sampingan, mis. Mononucleosis, Cytomegalo, Herpes simplex, Rubella

    5 kelompok, + kelompok baru (GB virus) 1. HAV : Hepatitis A Virus. 2. HBV : Hepatitis B Virus. 3. HDV : Hepatitis Delta Virus. 4. HCV (PT-NANB) : Par. trans. n-A, n-B 5. HEV (ET-NANB) : Ent. trans n-A, n-B The GB hepatitis viruses:
    GBV-A GBV-B GBV-C

    VIRAL HEPATITIS
    HISTORICAL PERSPECTIVE
    Enterically E Transmitted (1983)

    Infectious
    Viral hepatitis Serum

    A
    NANB (1975)

    C
    Parenterally Transmitted (1989) other

    B D

    Viral Hepatitis Overview


    Types of Viral Hepatitis

    A
    Source of virus Route of transmission Chronic infection Prevention
    feces

    E
    feces

    blood/ blood/ blood/ blood-derived blood-derived blood-derived body fluids body fluids body fluids percutaneous percutaneous percutaneous permucosal permucosal permucosal yes yes yes

    fecal-oral

    fecal-oral

    no

    no

    preexposure immunization

    pre/postexposure immunization

    blood donor pre/postscreening; exposure risk behavior immunization; modification risk behavior modification

    ensure safe drinking water

    Estimates of Acute and Chronic Disease Burden for Viral Hepatitis, United States
    HAV
    Estimated infections (x 1000)/year* Fulminant deaths/year
    Chronic infections Chronic liver disease deaths/year 93 100 0

    HBV
    78 150 1-1.25 million 5,000

    HCV
    25 ? 2.7 million 8-10,000

    HDV
    6-13 35 70,000 1,000

    * Range based on estimated annual incidence, 2001.

    Carrier state / Asymptomatic phase Acute hepatitis Chronic Hepatitis

    Chronic Persistent Hepatitis Chronic Active Hepatitis

    Fulminant hepatitis Cirrhosis

    Incubation phase. 2. Symptomatic pre-icteric phase. 3. Symptomatic icteric phase. 4. Convalescence.


    1.

    Symptoms (if present) are the same, regardless of cause (e.g., A, B, C, other viruses, toxins) Nausea, vomiting Abdominal pain Loss of appetite Fever Diarrhea Light (clay) colored stools Dark urine Jaundice (yellowing of eyes, skin)

    1.

    2. 3. 4. 5. 6. 7. 8.

    Ballooning deg Cholestasis Apoptosis Periportal Necrosis Macrophages Inflammation Portal inflammation Fatty change(C)

    Ground glass (B) Apoptosis Periportal Necrosis Macrophages Portal Lymphoid infiltrate Bridging fibrosis Fatty change(C)

    Hepatic failure with in 2-3 weeks. Reactivation of chronic or acute hepatitis Massive necrosis, shrinkage, wrinkled Collapsed reticulin network Only portal tracts visible Little or massive inflammation time More than a week regenerative activity Complete recovery or - cirrhosis.

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