Drug Study

Name of Drugs Classification Anti-emetic and anti-vertigo Mode of Action dopaminereceptor blocking agent. It action on the dopaminereceptors in the chemo-emetic trigger zone produces an anti-emetic effect Indication GERD, esophagi-tis, feeling of abdominal di stension, upper abdominal pain; bloating , flatulence; he artburn w/ or w/o regurgitation s of gastric contents in the mouth. Relieves accumulation of gas in the GIT, sensation of pressure and fullness in the epigastrium. Also used in preparation for x-ray examina-tion Contraindication GI hemorrhage, mechanical obstruction or perforation; in patients w/ prolactinreleasing pituitary tumor (prolactinoma). Known intolerance to the drug. Side Effects Increased prolactin levels. GI disorders. Transient intestinal cramps. Galactorrhe a Gynecomas tiaAmenorr hea Nursing Interventions -Should be taken on an empty stomach. (Take 15-30 min before meals.) -Assess for extrapyramidal effects such as jerking and tongue protrusion. - Check for hypotension

Motilium
10 mg/tab TID

Disflatyl
10 mg/tab TID

GIT Regulators, Antiflatulents & AntiInflammatories By its defoami ng action, drug disperses or prevents formation of mucussurrounded gas pockets in the GI tract.

Hypersensitivity

Laxatives

allergic to simethicone or reaction; skin any component irritation, of the redness, difficulty in formulation. breathing, Intestinal swelling,che obstruction, st pain, chest Obstructive congestion, diseases of the swelling of digestive system the face, lips tongue or throat. N&V,

Advise patient that changing positions often and walking will help pass flatus

-assess condition

Lactulose (movelax)
30cc defer for BM 3x/day ODHS Proton pump inhibitor

(stomach, intestine, Causes an gallbladder, influx of fluid kidney) and in the before intestinal tract gastroscopy. by increasing Constipation, the osmotic salmonellosis pressure , treatment of within the hepatic intestinal encephalopat lumen. hy

headache, abdl cramps Patients who require a low lactulose diet. Galactosemia deficiency. Intestinal obstruction. Abdominal discomfort associated with flatulence and intestinal cramps, N&V, diarrhea on prolonged use.

before and reassess regularly thereafter to monitor drugs effectiveness. -monitor patients for any adverse GI reactions, nausea and vomiting, diarrhea

Nexium
40 mg IV BID suppresses gastric acid secretion by specific inhibition of H+/K+ATPase in the gastric parietal cell. It blocks the final step in acid production, thus reducing gastric acidity. contraindicated in patients with known hypersensitivity to esomeprazole or other substituted benzimidazoles such as omeprazole or lansoprazole (i.e., known proton pump inhibitors (PPIs) hypersensitivity)

Monitor for any adverse reaction

Antacids, Antireflux Agents &

used to treat stomach and throat (esophagus) problems caused by too much stomach acid (e.g., acid reflux or GERD, erosive esop hagitis, Zollinger-

diarrhea, N&V, headaches, rash and dizziness. Nervousnes s, abnormal heartbeat, muscle pain, weakness, leg cramps, and water

Rebamipi de
100 mg/tab TID

Antiulcerants

Ellison syndrome).

retention occur infrequently .

Monitor for any adverse reaction

Antibacterial

Ciproflox acin
200 mg IV OD

used to treat infections of interferes with the skin, DNA lungs, replication in airways, susceptible bones, gramand joints negative caused by bacteria susceptible preventing bacteria.Cipr cell ofloxacin is GIT Regulators, reproduction. also Antiflatulents frequently

mucosal protective agent and is postulated to increase gastric blood flow, prostaglandin biosynthesis and decrease free oxygen radicals.

Peptic ulcer, Gastritis

Lactation Rash, pruritus, constipation , diarrhea, nausea. -Instruct patient not to take ciprofloxacin with dairy products such as milk or yogurt, or with calciumfortified juice. He may eat or drink dairy products or calcium-fortified juice with a regular meal, but do not Headache, dizziness,in use them alone when taking somnia ciprofloxacin. They fatigue, depression, could make the medication less blurred effective. vision, Arrhythmias - Ensure that , patient is well hypotension hydrated. ,

Contraindi cated with allergy to ciprofloxacin, nor floxacin, pregnancy, lactation.

& AntiInflammatories

Gascon
40 mg/tab TID

used to treat urinary infections caused by bacteria such as E. coli.

Anticonvulsant

breaks up small gas bubbles by lowering their surface tension and combining them into a free gas

Dilantin
100mg/ta b BID

Acts in the motor cortex

Improvement of abdominal symptoms due to gas in the gastrointestin al tract. Elimination of foamy mucus in the stomach prior to gastric endoscopy. Elimination of gas in the intestine prior to abdominal xray examination.

angina, N& V dry mouth, diarrhea, ab dl pain, Elevated BUN, AST, ALT, serum creat inine and alkaline pho sphatase; decreased WBC, neutr ophil count, Hct, Fever, rash

Should be taken on an empty stomach. (Take after or between meals.)

History of hypersensitivit y to phenytoin or other hydantoins.

-Give oral drug with food to enhance absorption and to reduce GI upset. - Discontinue drug if rash, depression of blood count, enlarged lymph nodes, hypersensitivity reaction, signs of

Proton pump inhibitor

Omepraz ole
40 mg/tab Before Breakfast OD

Antibiotic, Fluoroquinolon e

of the brain to reduce the spread of electrical discharges from the rapidly firing epileptic foci in this area. This is accomplished by stabilizing hyperexcitabl e cells possibly affecting sodium efflux. Also, phenytoin decreases activity of centers in the brain stem responsible for the tonic phase of grand mal seizures. Has few sedative effects suppresses

used for preventing or treating gene ralized tonicclonic (grand mal) seizures, complex partial seizures (psychomotor seizures), and seizures occurring during or after neurosurgery . Long-term use for gastroesopha geal reflux disease, duodenal ulcers; lactation.

liver damage occurs GI disturbance s; ataxia, slurred speech; diplopia, nystagmus & mental confusion w/ headache, dizziness, gingival hyperplasia, hirsutism,hy perglycemia , osteomalaci a.

-Administer before meals. -Administer antacid s with, if needed. -Have regular medical follow-up visits. -Report severe headache, worsening of symptoms, fever, chills

Duodenal and gastric ulcer. Gastro

Headache,

Levofloxa cin
500mg/ta b OD

gastric acid secretion by specific inhibition of H+/K+ATPase in the gastric parietal cell. It blocks the final step in acid production, thus reducing gastric acidity.

esophageal reflux disease inclu ding severe erosive esophagitis (4 to 8 wk treatment). Long-term treatment of pathologic hypersecreto ry conditions.

Contraindicated with allergy to fluoroquinolones, pregnancy, lactation.

dizziness, fatigue. Diarrhea, abdominalp ainnausea, mild transient increases in liver function tests. Hematuria, proteinuria. Rash.

Antiemetic, GI stimulant

used to treat infections of the sinuses, Bactericidal: skin, lungs, interferes with ears, airways, DNA by bones, and inhibiting DNA joints caused synase by replication in susceptible susceptible bacteria. gramused to negative and treat urinary Hypersensitivity; gram-positive infections, Possible GI bacteria, effective in

Headache, dizziness, insomnia, fatigue, somnolence , blurred vision N&V, dry mouth, diarrhea,

-Administer oral drug 1 hr before or 2 hr after meals with a glass of water; separate oral drug from other cation administration, including antacids, by at least 2 hr. -Ensure that patient is well hydrated during course of therapy. -Discontinue drug at any sign of hypersensitivity (rash, photophobia) or at complaint of tendon pain, inflammation, or rupture.

Metoclop ra-mide
amp IV RTC X4 doses q8

preventing cell reproduction.

treating infectious diarrhea. used to treat various obstetric infections, including mastitis (infection of the breast).

GIT Regulators, Antiflatulents & AntiInflammatories

Gasmotin
1tab TID

Prevention of chemotherap y-induced Blocks dopami emesis. Treatment of ne receptors postsurgical in chemorecepto and diabetic r trigger zone gastric stasis. Facilitation of of the CNS. small bowel Stimulates intubation motility of in radiograph the upper GI ic tract and procedures. accelerates Management gastric of esophagea emptying. l reflux. Treatment and preventi

obstruction or hemorrhage; History of seizure disord ers; Pheochromocyto ma; Parkinsons disea se. Use Cautiously in: History of depression; Diabetes (may alter response to insulin); Renal impairment

abdominal pain, constipation , flatulence, Fever, rash, photosensiti vity, muscle and joint tenderness.

-Monitor BP carefully during IV administration. -Monitor diabetic patients, arrange for alterations in insulin dose or timing if diabetic control is compromised by alterations in timingof food restlessness absorption. , drowsiness, fatigue, insomnia, dizziness, anxiety, transient hypertension, nausea and diarrhea

Patients w/ GI hemorrhage, mechanical obstruction or perforation.

P==May be taken with or without

on of postope rative nausea and vomiting when nasogastric suctioning is undesirable. Gastrointesti nal symptoms associated with functional dy spepsia(chronic gastritis) (heartburn, nausea/vomit ing)

food. (Take before or after meals.)

Mosapride citrate is a selective 5HT4 receptor agonist. It is considered that this drug stimulates 5HT4 receptors in thegastrointes tinal nerve plexus, which increases the release of acetylcholine, resulting in enhancement of gastrointestin al motility and gastric

Diarrhea, dry mouth, malaise, eosinophilia , increased triglycerides , AST (GOT), ALT (GPT), ALP, bilirubin; leukopenia, abdominal pain, nausea, vomiting, taste abnormality , palpitation, dizziness, lightheaded ness, headache.

emptying.