BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE

Cheryl L. Thompson
eRA COMMONS USER NAME (credential, e.g., agency login)

Assistant Professor

CHERYLTHOMPSON
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable)

Case Western Reserve University, Cleveland, OH Case Western Reserve University, Cleveland, OH Case Western Reserve University, Cleveland, OH Case Western Reserve University, Cleveland, OH A. Personal Statement

BSE MS PhD Fellow

05/00 08/03 05/07 07/09

Computer Engineering Computer Science Genetic and Molecular Epidemiology Computational Genomic Epidemiology of Cancer

I am a new investigator in the area of genetic and molecular epidemiology of cancer. I am interested in identification of genetic and molecular factors influencing risk of cancer as well as factors associated with prognosis and treatment outcomes. I am also currently working on projects to identify molecular factors that may be used to detect and diagnose cancer. My current research focuses on breast and non-small cell lung cancer although I continue to be involved in research on multiple colon cancer projects. I have experience in both genetic linkage studies with family data as well as case-control population data. B. Positions and Honors Academic Positions 2007-2008 Senior Research Associate, Department of Family Medicine Research Division, Case Western Reserve University, Cleveland, OH 2009 Senior Instructor, Department of Family Medicine Research Division, Department of Epidemiology and Biostatistics, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 2010Assistant Professor, Department of Family Medicine Research Division, Department of Epidemiology and Biostatistics, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH Honors and Awards 2005 National Eye Institute ARVO 2005 Travel Grant 2010 National Cancer Institute Transdisciplinary Research in Energetics and Cancer Trainee Award for Excellence 2010 National Institutes of Health Loan Repayment Program Awardee Other Experience and Professional Memberships 2004-07 Member, Association for Research in Vision and Ophthalmology 2004Member, International Genetic Epidemiology Society 2005Member, American Society of Human Genetics 2006-2010 Ad Hoc Professional Development Committee Member, American Society of Human Genetics 2006-08 Member, American Association for the Advancement of Science 2009Member, American Society of Preventive Oncology
PHS 398/2590 (Rev. 06/09) Page Biographical Sketch Format Page

2010-11 2011-12 20112010-

Chair, Career Development Session, Professional Development Committee Program Committee Junior Members Representative Editorial Board, Frontiers in Applied Genetic Epidemiology NIH/National Cancer Institute -- Small Grants in Cancer Epidemiology Review Panel Member

C. Selected Peer-reviewed Publications in Chronological Order 1. Thompson CL, Baechle D, Lu Q, Mathew G, Song Y, Iyengar SK, Gray-McGuire C, Goddard KAB. Effect of Genotyping Error in Model-Free Linkage Analysis using Microsatellite or SNP Marker Maps. BMC Genet. 2005;6 Suppl 1:S153. 2. Thompson CL, Rybicki BA, Iannuzzi MC, Elston RC, Iyengar SK, Gray-McGuire C and the SAGA Research Group. Reduction of Sample Heterogeneity Using Population Substructure: An Example from a Population of African-American Sarcoidosis Families. Am J Hum Genet. 2006; 79(4):606-13. 3. Thompson CL, Jun G, Klein BEK, Klein R, Capriotti J, Lee KE, Iyengar SK. Genetics of Pigment Changes and Geographic Atrophy. Invest Ophthalmol Vis Sci. 2007; 48(7):3005-13. 4. Thompson CL, Klein BEK, Klein R, Xu Z, Capriotti J, Joshi T, Leontiev D, Lee KE, Elston RC, Iyengar SK. Complement Factor H and Hemicentin-1 in Age-Related Macular Degeneration and Renal Phenotypes. Hum Mol Genet. 2007;16(17):2135-48. 5. Thompson CL, Khiani V, Chak A, Berger NA, Li L. Carbohydrate consumption and esophageal cancer: an ecological assessment. Am J Gastro. 2008;103:555-61. 6. Li L, Plummer SJ, Thompson CL, Merkulova A, Acheson LS, Tucker TC, Casey G. A Common 8q24 Variant and Risk of Colon Cancer: A Population-Based Case-Control Study. Cancer Epidemiol Biomarkers Prev. 2008;27:339-42. 7. Li L, Plummer SJ, Thompson CL, Tucker TC, Casey G. Association between Phosphatidylinositol 3Kinase p85 Regulatory Subunit Met326Ile Polymorphism and Colon Cancer Risk. Clin Cancer Res. 2008;14:633-7. 8. Nock N, Thompson CL, Tucker TC, Berger NA, Li L. Associations between obesity and changes in body mass index over time and colon cancer risk. Obesity 2008;16:1099-1104. 9. Ochs-Balcom HM, Cicek MS, Thompson CL, Tucker TC, Elston RC, Plummer S, Casey G, Li L. Association of Vitamin D Receptor Gene Variants, Adiposity and Colon Cancer. Carcinogenesis 2008;29:1788-93. PMCID: PMC2722851. 10. Stein CM, Zalwango S, Malone LL, Won S, Mayanja-Kizza H, Mugerwa RD, Leontiev DV, Thompson CL, Cartier KC, Elston RC, Iyengar SK, Boom WH, Whalen CC. Genome Scan of M. tuberculosis Infection and Disease in Ugandans. PLoS One 2008;3:e4094. PMCID: PMC2605555. 11. Thompson CL, Plummer SJ, Acheson LS, Tucker TC, Casey G, Li L. Association of common genetic variants in SMAD7 and risk of colon cancer. Carcinogenesis 2009; 30(6):982-6. PMCID: PMC2691142. 12. Thompson CL, Plummer SJ, Merkulova A, Cheng I, Tucker TC, Casey G, Li L. No Association between COX-2 and UGT1A6 Genetic Polymorphisms and Colon Cancer Risk. World J Gastroenterol 2009; 15(18):2240-2244. PMCID: PMC2682239. 13. Phillips LS, Thompson CL, Plummer SJ, Tucker TC, Casey G, Li L. No association between four PTEN SNPs and colon cancer. World J Gastroenterol. 2009; 15(30):3771-3775. PMCID: PMC2726455. 14. Nock N, Wang X, Thompson CL, Song Y, Baechle D, Raska P, Stein CM, Gray-McGuire C. Defining genetic determinants of the metabolic syndrome in the Framingham Heart Study using association and structural equation modeling methods. BMC Proc 2009; 3(suppl 7): S50. PMCID: PMC2795950. 15. Thompson CL, Plummer SJ, Tucker TC, Casey G, Li L. No Association of Obesity and Type 2 Diabetes Mellitus-related Genetic Variants with Colon Cancer. Gastroenterology Research. 2009; 2(6): 311-316. PMCID: In Process. 16. Thompson CL, Plummer SJ, Tucker TC, Casey G, Li L. Interleukin-22 Genetic Polymorphisms and Risk of Colon Cancer. Can Causes Control. 2010; 21(8):1165-70. PMCID: In Process. 17. Ochs-Balcom HM, Thompson CL, Plummer S, Luo G, Tucker TC, Casey G, Li L. A RecQ protein-like 5 haplotype is associated with colon cancer in a case control study. Gastroenterology Research. 2010; 3(3): 101-105. PMCID: In Process.

18. Nock NL, Patrick-Melin A, Cook M, Thompson C, Kirwan JP, Li L. Higher Bone Mineral Density is Associated with a Decreased Risk of Colorectal Adenomas. Int J Cancer. 2011; 129(4):956-64. PMCID: PMC3125467. 19. Thompson CL, Larkin EL, Patel S, Berger NA, Redline S, Li L. Short duration of sleep increases risk of colorectal adenoma. Cancer 2011;117(4):841-7. PMCID: PMC3021092. 20. Nock NL, Plummer SJ, Thompson CL, Casey G, Li L. FTO Polymorphisms are Associated with Adult Body Mass Index (BMI) and Colorectal Adenomas in African-Americans. Carcinogenesis 2011; 32(5):74856. PMCID: PMC3086700. 21. Ortiz AP, Thompson CL, Chak A, Berger N, Li L. Insulin Resistance, Central Obesity and Colorectal Adenomas. Cancer 2011 (in press). PMCID: In Process. 22. Thompson CL, Berger NA, Chak A, Li L. Racial Differences in Measures of Obesity and Risk of Colon Adenoma. Obesity (in revision). PMCID: In Process. D. Research Support Ongoing Research Support 1K07CA136758-01A1 (Thompson, Cheryl L., PI) 08/01/09-07/31/14 National Cancer Institute Genetic Variants in the PI3K Pathway in Mammographic Density and Breast Cancer This is a mentored career development with a focus on investigation of genetic variation in the PI3K to progesterone receptor pathway on mammographic density and risk of breast cancer. Role: Principal Investigator 1RO1 CA136726-01 (Li, Li, PI) 09/01/09-08/30/14 National Cancer Institute Obesity-Related Insulin Resistance Signaling Pathway Factors and Colon Cancer The major goal of this project: To investigate the relationship between colon cancer with obesity and genes in the critical insulin-related signaling pathways Role: Co-investigator P30 CA043703 12/01/10-11/30/11 National Cancer Institute A Biorepository for Research in Lung Cancer Risk, Detection and Prognosis This pilot project aims to build a biorepository of newly diagnosed non-small cell lung cancer (NSCLC) patients and patients with benign solitary pulmonary nodules. The data collection includes surveying of each patient on demographic and cancer risk factors, abstraction of medical records and collection of blood for buffy coat, serum and plasma banking. These samples and data are collected in order do future projects investigating the ability of microRNAs to discriminate between patients with benign and malignant lesions on imaging as well as other future projects to aid in our understanding of NSCLC. Role: Principal Investigator of Pilot Grant R03 CA143917 (Li, Li., PI) 1/1/11-12/31/12 National Cancer Institute Integrating Longitudinal Changes in Mammographic Density into Breast Cancer Risk Prediction This study investigates the effectiveness of adding longitudinal changes in mammographic density to improve the value of the Gail model on predicting breast cancer risk. Role: Co- Investigator Completed Research Support Genetics of Aberrant Breast Development 6/01/10-5/31/11 This is a pilot grant funded through Cases CTSC. The goal of this project is to complete linkage analysis on a large family with inherited amastia. We will conduct whole genome SNP arrays on a number of family

members and perform the statistical analyses to locate the genomic region linked to this condition in this family. Role: Principal Investigator of Pilot Grant R25 CA094186-06 (Robert Elston, PI) 08/01/07-07/31/09 National Cancer Institute Training in Computational Genomic Epidemiology of Cancer (CoGEC) This program provides postdoctoral training in the transdisciplinary area of training at the intersection of cancer research, epidemiology, biostatistics, genetics, and computer science. Role: Fellow 1 U54 CA-116867-01 (Nathan Berger, PI) 06/1/06-07/31/07 National Cancer Institute CASE Center for Transdisciplinary Research on Energetics and Cancer Project II: Insulin Resistance Syndrome Pathway Factors and Colon Polyps (PI: Li Li) Role: Project Manager of Project II This project comprehensively examines the relation of colon polyps and insulin resistance syndrome, associated gene polymorphisms, haplotypes, diet, and biomarkers in an incident case-control study. 1 U54 CA-116867-01 (Nathan Berger, PI) 10/1/07-9/30/08 National Cancer Institute CASE Center for Transdisciplinary Research on Energetics and Cancer Pilot Project: Retinol Binding Protein-4 (RBP4): A novel biomarker for colon neoplasia Role: Principal Investigator of pilot project This pilot project investigates serum levels of retinol binding protein 4 (RBP4) and genetic polymorphisms in the RBP4 pathway with respect to both colon polyps and colon cancer. 1 U54 CA-116867-01 (Nathan Berger, PI) 9/01/08-8/31/09 National Cancer Institute CASE Center for Transdisciplinary Research on Energetics and Cancer Pilot Project: Effect of obesity and insulin resistance on the activation of IRS1, AKT and mTOR and the development of colon adenomas Role: Principal Investigator of pilot project This pilot project investigates the activation of the IRS1, AKT and mTOR genes in colon adenoma and normal colon tissue in obese, diabetic and non-diabetic lean individuals. 1 U54 CA-116867-01 (Nathan Berger, PI) 08/01/09-7/31/10 National Cancer Institute CASE Center for Transdisciplinary Research on Energetics and Cancer Pilot Project: Variation in Breast Tissue Gene Expression by Mammographic Density This pilot project investigates the activation of the AKT and Vitamin D genes in normal breast tissue surrounding the tumor from recently diagnosed breast cancer cases. Role: Principal Investigator of pilot project IRG-91-022-15 9/01/09-8/31/10 American Cancer Society Variation in Breast Tissue Gene Expression by Mammographic Density This pilot project investigates the activation of the IRS1, AKT and mTOR genes in normal breast tissue surrounding the tumor from recently diagnosed breast cancer cases. Role: Principal Investigator Institutional Review Grant