1. On the picture wrists of the patient L. 37 years old, female. Her diagnosis is systemic scleroderma.

.What medicines are DMARD for this disease? A. ntifibrotic medicine* B. Immunostimulators C. Intravenous immunoglobuline D. NSAID E. None of above

2. On the picture patient L., 45 years old. She is ill for the 10 years. Her diagnosis is systemic scleroderma. She can not use D-penicilamine because of allergy. What are the other medicine which can be used as DMARD in case of systemic sclerosis? A. NSAID B. Prednisone C. Vascular medicine

D. Cytostatics E. None of above

3. On the picture - Livedo reticularis. Patient is female, 35 years old, with SLE and antiphospholipid syndrome. What medicine are the basic in treatment of this disease? A. Immunosuppresive medicine* B. mmunostimulators C. mmunoglobulines D. NSAID E. None of above. 4. On the picture - Livedo reticularis. Patient is female, 35 years old, with SLE and antiphospholipid syndrome. What group of medicine are DMARDs for this disease? A. Prednisone B. Cytostatics * C. NSAID D. Vascular medicine E. None of above.

5. On the picture X-ray of the female, 25 years old with rheumatoid arthritis. What medicine is the standart in treatment of this disease? A. D-penicilamine B. thotrexate* C. Aspirin D. Sulindac E. Prednisone 6. On the picture X-ray of the female, 25 years old with rheumatoid arthritis. For the long period of time (1year 7 months) uses mthotrexate, but did not get clear effect of it. What medicine the doctor should recommend the patient? A. Immunostimulators B. mmunoglobulines . noclonal ntibodies* D. Vascular medicine E. Add more pain-killers

7. On the picture wrist of the patient G., 40 . Shi is ill for the last 10 years. The patient uses mthotrexate 15 mg once a week? How to reduce side effects of methotrexate? A. To prescribe NSAID B. To prescribe prednisone . To prescribe polyvitamins D. To prescribe folate* E. None of above.

8. On the picture patient ., 42 years old, with idiopathic dermatopolymyositis. What medicines have to be prescribed? A. ntibiotic B. Skin cream C. Cytostatic+glucocorticosteroid* D. NSAID+pain-killers E. Sulfonamides 9. On the picture patient ., 42 years old, with idiopathic dermatopolymyositis. What indications for the prescription of intravenous immunoglobuline in such a patient? A. Juvenile DM, resistant DM to cytostatic and glucocorticosteroid B. Severe joint syndrome C. Severe weakness in muscles D. Combination of skin syndrome and severe weakness in muscles E. High activity of the inflammation

10. What is the influence of this medicine? A. Suppression of IL-1, TNF-, IL-6* B. Stimulation of endogenic interferon C. Immunostimulator with prevalence influence on cell chain of immunity D. Elimination of immune complexes E. None of above. 11. What group of medicine Zinaxin belongs to? A. Medicine for the treatment of the lung inflammatory diseases B. Immunostimulators C. Antiallergic medicines D. Medicine for the treatment of musculoskeletal disorders* E. None of above.

12. On the picture rash of the patient with psoriatic arthritis. Prescribe the treatment: A. Cytostatic + NSAID + skin cream * B. Immunostimulator with prevalence influence on cell chain of immunity C. Stimulators of endogenic interferon + NSAID D. Stimulators of endogenic interferon + glucocorticosteroid E. Stimulators of endogenic interferon + NSAID + skin cream

13. What medicini is DMARD for the disease, wich is presented on X-ray? A. Sulfasalazin* B. Diklofenak C. Diclofenac-Natrium D. Prednisone E. ydocalm 14. X-ray of the patient with ankylosing spondylitis is presented on the picture. Patient uses sulfasalazin for the long period of time What side effect can happen to the patient? A. xanthema, itching* B. Areas of skin necrosis C. Secondary vasculitis

D. Hyperpigmentation E. Hypopigmentation

15. What biological medicine is recommended for the patient with ankylosing spondylitis, whose X-ray is presented on picture? A. Immunoglobulinum anticytomegalovirusum humanum B. Bioven mono C. Tumor necrosis factor inhibitor* D. Immunoglobulinum humanum antichlamidicum E. Mycoplasma-imun

16. Patient L., 35 years old, with ankylosing spondylitis uses sulfasalazin, but the doctor noticed progretion of the disease. What another DMARD can be recomended? A. Prednisone B. drol C. thotrexate D. Diklofenak E. None of above