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Hemoragiile digestive superioare Clasificarea hemoragiilor digestive Hemoragii digestive superioare (HDS) Sangerare de la nivelul esofagului pana la nivelul

ul unghiului Treitz(jonctiunea duodeno jejunala)*ligament Treitz-intre ultima parte a duodenului si ultima parte a stomacului. Hemoragii digestive medii (HDM) Unghiul Treitz Valva ileocecala Hemoragii digestive inferioare (HDI) Valva ileocecala Anus Hemoragii digestive oculte(prezenta sangelui in scaun,dar fara a fi vazut cu ochiul liber) Reactia Adler (1.5 2.5 ml sange in scaun)-reactia de culoare dintre Hb si apa oxigenata,pusa cu un reactive apoiculoare Hemocult (> 5 ml sange in scaun) Hemoquant-cantitativ observa transformarea hemului nonfluorescent in porfirina fluorescenta. Importanta HDS Generalitati Frecventa - 1/ 2000 locuitori (UK) Mortalitate 10 % (recent 4 %) De 2 ori mai frecvente la varste > 60 ani 50 % prin ULCER 1/ 3 AINS(antiinflamatoare nesteroidiene) 4 % prin VARICE 1 / 3 DECES De ce se produc sangerarile digestive? 1)Leziune mucozala inflamatorie injurie 2)Leziune vasculara De 1 si 2 -Responsabil - tubul digestiv. 3)Deficit al hemostazei Factori de coagulare Trombocitele Vasele sangvine 4)Deficit al procesului de reparare al injuriei

De 3 si 4 -Responsabil ficatul. Abordarea unei HDS Diagnosticul pozitiv Evaluarea gravitatii Stabilirea efectelor hemodinamice Diagnosticul etiologic Tratamentul hemostatic Etiologia HDS Leziuni ale tubului digestiv Patologie esofagiana o Hemoragie esofagiana explozie sau eroziune (85%) sunt hemoragii medii sau severe o Esofagita de reflux sunt hemoragii usoare o Hernie gastrica transhiatala o Ulcere esofagiene o Cancere esofagiene o Tumori benigne esofagiene Patologie gastrica o Ulcer gastric Mica curbura, unghi gastric, sub cardial Prepiloric, fata anterioara 30% sunt severe o Gastrita eroziva Stress chirurgical, arsuri intinse Medicamente (AINS) HDS moderate o Cancer gastric operat HDS moderate o Polipi/polipoze HDS usoare o Cauze rare Angiodisplazia gastrica (malformatii vasculare) Sd. Mallory-Weiss (alcool + varsaturi) o Stomac operat Sutura / ulcer / cancer gastric Patologie duodenala o Ulcere duodenale mai ales de fata posterioara sangerari moderate sau severe (70%) o Duodenita acuta + gastrita acuta hemoragica o Tumori duodenale rar o Cauze rare

Varice duodenale Pancreas ectopic Leziuni la nivelul glandelor anexe Patologie hepatica o Hipertensiune portala o Hemobilia singe la nivelul cailor biliare manifestat prin triada COLICA + MELENA + ICTER Origine ficat / vezicula biliara / cai biliare / pancreas Patologie pancreatica o Cauze benigne PAC, PCR? o Cancere pancreatice invazive o HTP segmentara Cauze extradigestive Sindroame hemoragipare prin: Coagulopatii Purpure Hemofilie CLINICA Hemoragia Exteriorizare Hematemeza Melena Hematochezie Oculte Consecinta Hematologica Hemodinamica Cauza Paraclinic EDS

Forrest I = Activa a. jet pulsatil / nepulsatil b. panza II = Stigmate a . Cheag

b . Vas III = potentiale HDS AOB Hb, Ht, L Uree FOBT Rx Arterio Hematii marcate * BOALA DE BAZA Ciroa Hemopatii Coagulopatii Gravitate (Smith & Weil) Usoare = 25% 1250 ml AV = 100b/min TA = 90 mmHg IS <1? PVC =N D (diureza)= N Medii = 35 % 1750 ml AV = 120 TA= 90 IS <1,5 PVC scade D scade Severe = 50 % 2500 ml AV > 120 TA < 60 IS > 1,5 PVC F. scazuta ANURIE =soc ! TIMP !!!

Atitudinea terapeutica in HDS Conditii necesare Personal medical calificat / interdisciplinaritate: gastroenterolog, endoscopist, anestezist, chirurg, asitent medical Camera de garda dotare ATI adecvata Posibilitate de a institui transfuzii sangvine Laborator aceesibil 24 ore din 24 Posibilitatea de a efectua EDS 24 h din 24 Existenta unor protocoale de inteventie si monitorizare a bolnavilor Accesul la serviciul de chirurgie Protocol HDS Diagnostic pozitiv hematemeza + melena TR + sonda Da Nu acasa Evaluarea gravitatii Usoara / Medie + pacient < 60 ani, Hb>10, TA (N) Sectie boli interne sau gastroenterologie, EDS 5 zile Grava + pacient > 60 ani, Hb < 10, hipovolemie, boli asociate ATI, PEV?, chirurgie Se determina: Hb, uree, grup sg., coagulograma, teste hepatice Rechilibrare hidroelectrolitica Detectarea sursei de sangerare Selectarea tipului de tratament: Medical Endoscopic Interventional (TIPS)- Transjugular Intrahepatic Portosystemic Shunt
(TIPS)? *

Chirugical *TIPS

Interventional radiologists perform this procedure to treat a condition called portal hypertension. Portal hypertension occurs most frequently in patients with liver disease such as cirrhosis or hepatitis. Scarring in the liver creates a restriction to the flow of blood through the liver. The main vein to the liver is the portal vein. The pressure in the portal vein becomes very high, causing adjacent veins in the abdomen to become dilated (varices) and can potentially rupture and cause life-threatening internal bleeding. By lowering the pressure in the portal vein, the risk of hemorrhage is greatly reduced. The TIPS procedure has also been effective in the treatment of ascites secondary to liver disease. In addition, TIPS has been successfully applied in less common situations including treatment of Budd-Chiari syndrome, decompression of lower GI and stomal varices, and treatment of malignant compression of hepatic or portal veins. This procedure is a good alternative to the surgical treatment of this condition with a shorter recovery time. The initial TIPS procedure is performed under general anesthesia. The interventional radiologist threads a thin catheter (tube) through a small incision in the neck and guides it to the blood vessels in the liver. Under x-ray guidance a connection between the inflow vein of the liver (portal vein) and the outflow vein of the liver (hepatic vein) is made to divert the flow of blood and decompress the portal vein. The connection is held open by an expandable metal tube that remains inside the liver. You may be admitted to the hospital before or directly after the procedure and can potentially be discharged the following day. Within the first year routine follow-up at 3 month intervals is necessary to assure that the shunts remain open and adequately functioning. Revisions of the shunt are performed in a similar manner to the original TIPS procedure but are typically performed as an outpatient. Pre-procedure Information Your doctor will schedule you for a pre-procedure evaluation by the Vascular & Interventional Radiology (VIR) service. Report to Diagnostic Imaging-D (3rd floor, Green Zone) for your scheduled appointment. The procedure will be performed on a subsequent day. They will discuss the planned procedure with you and answer any questions you may have about the procedure, its risks and benefits. Please inform us if you are diabetic, pregnant, or allergic to contrast media ("dye"). We will also need to know if you have a history of heart disease or have respiratory problems. If additional laboratory or imaging studies are needed prior to your scheduled procedure they will be arranged during this visit. Bring any outside films (x-rays) with you, if you have not already given them to your physician. Pre-procedural patient work-up and preparation includes visualization of hepatic arterial and venous structures as well as assessing patency of the portal venous system. This is most commonly performed with Doppler ultrasound but can also be assessed with magnetic resonance venography. It is critical to aggressively correct a patients coagulopathy with vitamin K, fresh frozen plasma, and if necessary, platelets given the high risk of intraperitoneal bleeding. In addition, patients receive broad spectrum antibiotic coverage. Please call (713) 794-1180 (during working hours) if you are unable to keep your appointment. Important Instructions You must be accompanied by a responsible adult following your procedure Do not eat or drink for a minimum of 6 hours prior to your procedure You may take your daily medications with sips of water

Discharge Instructions Rest at home and avoid strenuous activities for for a minimum of 24 hours. You should also contact your doctor if you have a fever of 101 degrees Fahrenheit (38.3 degrees Celsius) or higher, or if you

have redness, swelling, bleeding or drainage from the site where the catheter was inserted. Please call Diagnostic Imaging-D at (713) 794-1180 (during working hours) or the M.D. Anderson Emergency Center at (713) 792-3722 (24 hours a day).

Tratament medical in HDS I. Combaterea efectelor hemodinamice II. Substante vasoactive III. Tratament hemostatic temporar - EDS T IV. Tratament hemostatic definitiv Combaterea efectelor hemodinamice IMEDIAT CACI IMPREVIZIBIL NU SANGEE CACI MICROCIRCULATIE MOMENT REVERSIBIL Scade volemiascade debit incetinire circulatie Scade volemia Scade vascozitatea creste hematocrit capilar = ORT MOMENT IREVERSIBIL Dezoxigenare eritrocit rigidizare ORD RigidizareAgregare plachetara CID Modalitate Inlocuire volemica = solutii cristaloide Sange si O2 hiperbara Volum PVC TA AV Substante vasoactive Doar in soc Doar la pacientul cu inlocuire volemica Doar scurt timp Dopamina, Dobutamina Tratament hemostatic temporar = endoscopic

Variceala Ligatura Scleroterapie clips-uri Nonvariceala Injectare Electrocauterizare Laser Argon plasma HDS non - variceala Tratamentul HDS nonvariceala Gastrite, duodenite, sindroame hemoragipare tratament medical Sindromul Mallory Weiss injectare de alcool Ulcer gastric, cancer gastric trat. chirurgical Ulcer duodenal < 40 ani la prima sangerare trat. medical a doua sangerare trat. chirurgical > 40 ani, recidiva la 48 ore trat. chirurgical HDS variceala Tratament HDS variceala Varice Tratament HDS Tratament HTP Tratament EPH? Tipul de interventie in HDS variceale Profilaxia primei sangerari EDS Trat HTP Antisecretor Profilaxia resangerarii Tratamnetul HTP Antisecretor Tratamentul HDS variceale acute Medical (octreotid/vapreotid, antisecretor manevre locale (sonda) endoscopic radiologie interventionala (TIPPS)-trans illuminated powered phlebectomy surgery) chirurgical

*Procedure At A Glance TIPPS Procedure is intended to reduce varicose and spider veins, and resurface the skin on the legs by improving blood vessels. This procedure is likely to be expensive and possibly painful, and also requires a significant amount of time for an individual to heal. Well take a closer look. TIPPS Procedure is a surgery that requires an incision, during which doctors distribute saline solution and insert a suction device to remove problematic veins. During TIPPS Procedure, doctors remove abnormal veins, allowing those that are functioning more blood flow. However, with some of the amazing products available on the market today, we feel TIPPS Procedure seems unnecessary for most. With top quality products that include ingredients like Diosmin 95, many people are finding that they may achieve amazing skin care without having to schedule appointments or undergo surgical procedures. When searching for a skin care formula, we strongly believe people should always look for Diosmin 95. Diosmin 95 is an ingredient that was recently made available over the counter, and has shown amazing results for addressing varicosity. This ingredient has been clinically proven to repair blood vessels and rebuild damaged skin areas. When searching for a skin care product, we think it is crucial for individuals to look for this ingredient.
Positives Procedure In Focus

Minimally invasive surgery Said to reduce varicosity Claimed to remove broken veins

Doesnt use Diosmin 95 Rather high cost Requires time to heal No refund policy or customer service Cost 10,000 - 35,000 $ / EPISOD HDS VARICEALA Sharara A, Rockey D - New Engl J Med, 2001; 345; 669 - 81 Concluzii

1. HDS reprezinta inca o cauza importanta de morbiditate si mortalitate la populatia adulta. 2. Modalitatile terapeutice sunt diferite in HDS variceale si non-variceale. 3. Terapia endoscopica a produs modificari majore in mortalitatea prin HDS indiferent de cauza; tratamentul antisecretor reprezinta una din cele mai importante solutii adjuvante ale terapiei endoscopice. Hemoragie obscura-apare in scaun dar nu se cunoaste cauza ?