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DEZVOLTAREA SISTEMULUI NERVOS

Stadiile Carnegie pentru dezvoltarea embrionar uman

Dup st. C. 23: fetus

Fecundaia

Fecundaia

Mayer W, Smith A, Fundele R, Haaf T. (2000) Spatial separation of parental genomes in preimplantation mouse embryos. J Cell Biol. 2000 Feb 21;148(4):629-34.

Formarea morulei

Fecundaia, formarea blastocistului i nidarea

Formarea blastocistului i nidarea

Formarea blastocistului i nidarea

Formarea blastocistului i nidarea

13-15 zile

Formarea blastocistului i nidarea

St. C. 7 (15-17 zile)

Discul embrionar i anul primitiv

Neurulaia

REPERELE MORFOLOGICE ALE STADIILOR EMBRIONARE (toate duratele sunt exprimate n zile gestaionale trecute de la fecundaie) nidarea: 7-12 zile apariia anului primitiv: 13-15 zile gastrulaia i apariia notocordului: 15-17 zile apariia curburii cefalice, a primordiului cardiac i anului neural: 19-21 zile (1-3 somite) ncheierea neurulaiei: 22-23 zile (12 somite) nchiderea neuroporului rostral: 23-23 zile (13-20 somite) nchiderea neuroporului caudal: 26-30 zile (21-29 somite) apar mugurii picioarelor: 28-32 zile (30 somite) ncepe osificarea: 44-48 zile se disting capul rotund, corpul i membrele

Published by AAAS

J. C. Venter et al., Science 291, 1304 -1351 (2001)

Factori de transcripie

Molecule de semnalizare

Sindrom Waardenburg

Aniridia

Fig. 1 Schematic diagram of embryonic brain organization showing the principal expression domains of Hoxb-1, Dlx-1, Dlx-2, Emx-1, and Emx-2 in the hindbrain, ventral thalamus and basal ganglia, and cerebral cortex, respectively. The expression domains respect boundaries that delineate the transverse and longitudinal subdivisions of the central nervous system. CB = cerebellum; DT = dorsal thalamus; is = isthmus; LGE = lateral ganglionic eminence; LV = lateral ventricle; MGE = medial ganglionic eminence; ME = mesencephalon; p16 = prosomeric subdivisions; PT = pretectum; r17 = rhombomeric subdivisions; sc = spinal cord; VT = ventral thalamus.

Chick, 60-70hour , whole mount, chicken (H 2195)

Golgi-stained sections of human cerebral cortex taken from equivalent areas of the anterior portion of the middle frontal gyrus at different ages. Note that there is a tremendous increase in the complexity of dendritic aborizations with increasing age. There are 30 billion neurons and 62,000 miles of axons and dendrites in the human cerebral cortex. Each one of these neurons will make up to 10,000 connections with other neurons. This maturational process is going on at the same time children are usually exposed to the highest levels of lead paint dust by virtue of their normal hand-tomouth behavior. Ref: Conel, JL. The postnatal development of the human cerebral cortex. Cambridge, Mass: Harvard University Press, 1959.

Nature Neuroscience 4, 1177 - 1182 (2001) Published online: ; | doi:10.1038/nn749


Telencephalic cells take a tangent: non-radial migration in the mammalian forebrain
Joshua G. Corbin, Susana Nery & Gord Fishell

Figure 2. Major routes of tangential migration. Numbered arrows are superimposed on Fig. 1 to broadly depict the major routes of cell migration in the developing telencephalon. The question mark on arrow (2) indicates that this route is less well characterized than the others. Key to migratory routes: (1) MGE to the dorsal telencephalon (2) CGE to dorsal telencephalon (3) Cortical-striatal boundary to the ventrolateral telencephalon (lateral cortical stream) (4) LGE to the olfactory bulb (rostral migratory stream).

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