SIGMA-ALDRICH

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Material Safety Data Sheet

Version 5.0 Revision Date 10/31/2012 Print Date 01/29/2013

1. PRODUCT AND COMPANY IDENTIFICATION Product name Product Number Brand Product Use Supplier : : : : :

Cumene hydroperoxide
247502 Aldrich For laboratory research purposes. Sigma-Aldrich Canada Co. 2149 Winston Park Drive OAKVILLE ON L6H 6J8 CANADA +1 9058299500 +1 9058299292 1-800-424-9300 Manufacturer : Sigma-Aldrich Corporation 3050 Spruce St. St. Louis, Missouri 63103 USA

Telephone Fax Emergency Phone # (For both supplier and manufacturer) Preparation Information

: : :

Sigma-Aldrich Corporation Product Safety - Americas Region 1-800-521-8956

2. HAZARDS IDENTIFICATION Emergency Overview Target Organs Liver, Kidney WHMIS Classification B3 C D1A D1B E Combustible Liquid Oxidizing Material Very Toxic Material Causing Immediate and Serious Toxic Effects Toxic Material Causing Immediate and Serious Toxic Effects Corrosive Material Combustible Liquid Oxidizer Highly toxic by inhalation Toxic by ingestion Toxic by skin absorption Corrosive

GHS Classification Flammable liquids (Category 4) Acute toxicity, Inhalation (Category 2) Acute toxicity, Dermal (Category 3) Acute toxicity, Oral (Category 4) Skin corrosion (Category 1B) Serious eye damage (Category 1) Acute aquatic toxicity (Category 2) GHS Label elements, including precautionary statements Pictogram Signal word Hazard statement(s) H227
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Danger Combustible liquid

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H302 H311 H314 H330 H401 Precautionary statement(s) P210 P260 P264 P270 P271 P273 P280 P284 P301 + P312 P301 + P330 + P331 P303 + P361 + P353 P304 + P340 P305 + P351 + P338 P310 P320 P361 P363 P370 + P378 P403 + P233 P403 + P235 P405 P501 HMIS Classification Health hazard: Chronic Health Hazard: Flammability: Physical hazards: Potential Health Effects Inhalation Skin Eyes Ingestion

Harmful if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage. Fatal if inhaled. Toxic to aquatic life. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. Wash skin thoroughly after handling. Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Avoid release to the environment. Wear protective gloves/ protective clothing/ eye protection/ face protection. Wear respiratory protection. IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. IF SWALLOWED: rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/ Take off immediately all contaminated clothing. Rinse skin with water/ shower. IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/ physician. Specific treatment is urgent (see supplemental first aid instructions on this label). Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction. Store in a well-ventilated place. Keep container tightly closed. Store in a well-ventilated place. Keep cool. Store locked up. Dispose of contents/ container to an approved waste disposal plant. 4 * 2 1

Toxic if inhaled. Material is extremely destructive to the tissue of the mucous membranes and upper respiratory tract. Toxic if absorbed through skin. Causes skin burns. Causes eye burns. Toxic if swallowed.

3. COMPOSITION/INFORMATION ON INGREDIENTS Synonyms Formula Molecular Weight CAS-No. Cumene hydroperoxide 80-15-9 4. FIRST AID MEASURES General advice Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
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: : :

,-Dimethylbenzyl hydroperoxide C9H12O2 152.19 g/mol Index-No. 617-002-00-8 Concentration -

EC-No. 201-254-7

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.Continue rinsing eyes during transport to hospital. If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 5. FIREFIGHTING MEASURES Conditions of flammability Flammable in the presence of a source of ignition when the temperature is above the flash point. Keep away from heat/sparks/open flame/hot surface. No smoking. Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Hazardous combustion products Hazardous decomposition products formed under fire conditions. - Carbon oxides Explosion data - sensitivity to mechanical impact no data available Explosion data - sensitivity to static discharge no data available Further information Use water spray to cool unopened containers. 6. ACCIDENTAL RELEASE MEASURES Personal precautions Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal. 7. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge. Conditions for safe storage Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

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8. EXPOSURE CONTROLS/PERSONAL PROTECTION Contains no substances with occupational exposure limit values. Personal protective equipment Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Hand protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. Eye protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin and body protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Hygiene measures Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Specific engineering controls Use mechanical exhaust or laboratory fumehood to avoid exposure. 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Form Colour Safety data pH Melting point/freezing point Boiling point Flash point Ignition temperature Autoignition temperature Lower explosion limit Upper explosion limit Vapour pressure Density Water solubility Partition coefficient: n-octanol/water Relative vapour density
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liquid no data available

no data available no data available 100 - 101 C (212 - 214 F) at 11 hPa (8 mmHg) - lit. 79 C (174 F) - closed cup no data available no data available no data available no data available 0.5 hPa (0.4 mmHg) at 55 C (131 F) < 0.04 hPa (< 0.03 mmHg) at 20 C (68 F) 1.03 g/mL at 25 C (77 F) soluble no data available 5.25 - (Air = 1.0)
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Odour Odour Threshold Evaporation rate

no data available no data available no data available

10. STABILITY AND REACTIVITY Chemical stability Stable under recommended storage conditions. Possibility of hazardous reactions no data available Conditions to avoid Heat, flames and sparks. Extremes of temperature and direct sunlight. Materials to avoid Powdered metals, Organic materials Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - no data available 11. TOXICOLOGICAL INFORMATION Acute toxicity Oral LD50 LD50 Oral - rat - 382 mg/kg Remarks: Kidney, Ureter, Bladder:Hematuria. Inhalation LC50 LC50 Inhalation - rat - 4 h - 220 ppm Remarks: Lungs, Thorax, or Respiration:Dyspnea. Dermal LD50 LD50 Dermal - rat - 500 mg/kg Remarks: Behavioral:Convulsions or effect on seizure threshold. Kidney, Ureter, Bladder:Hematuria. Other information on acute toxicity no data available Skin corrosion/irritation Skin - rabbit - Mild skin irritation Serious eye damage/eye irritation Respiratory or skin sensitization no data available Germ cell mutagenicity Genotoxicity in vivo - mouse - Intraperitoneal Dominant lethal test Carcinogenicity Carcinogenicity - mouse - Subcutaneous Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Tumorigenic:Tumors at site or application. Carcinogenicity - mouse - Unreported Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Blood:Lymphomas including Hodgkin's disease. Skin and Appendages: Other: Tumors. IARC: ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH.
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Reproductive toxicity
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no data available Teratogenicity no data available Specific target organ toxicity - single exposure (Globally Harmonized System) no data available Specific target organ toxicity - repeated exposure (Globally Harmonized System) no data available Aspiration hazard no data available Potential health effects Inhalation Ingestion Skin Eyes Toxic if inhaled. Material is extremely destructive to the tissue of the mucous membranes and upper respiratory tract. Toxic if swallowed. Toxic if absorbed through skin. Causes skin burns. Causes eye burns.

Signs and Symptoms of Exposure Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, Nausea Synergistic effects no data available Additional Information RTECS: MX2450000 12. ECOLOGICAL INFORMATION Toxicity Toxicity to fish Toxicity to daphnia and other aquatic invertebrates LC50 - Oncorhynchus mykiss (rainbow trout) - 3.9 mg/l - 96 h LC50 - Daphnia magna (Water flea) - 16 mg/l - 24 h

Persistence and degradability Biodegradability Biotic/Aerobic Bioaccumulative potential no data available Mobility in soil no data available PBT and vPvB assessment no data available Other adverse effects An environmental hazard cannot be excluded in the event of unprofessional handling or disposal. Toxic to aquatic life. no data available 13. DISPOSAL CONSIDERATIONS Product This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.
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Contaminated packaging Dispose of as unused product. 14. TRANSPORT INFORMATION DOT (US) UN number: 3109 Class: 5.2 Packing group: II Proper shipping name: Organic peroxide type F, liquid (Cumyl hydroperoxide) (Cumene hydroperoxide) Reportable Quantity (RQ): 10 lbs Marine pollutant: No Poison Inhalation Hazard: No IMDG UN number: 3109 Class: 5.2 (8) EMS-No: F-J, S-R Proper shipping name: ORGANIC PEROXIDE TYPE F, LIQUID (CUMYL HYDROPEROXIDE) (Cumene hydroperoxide) Marine pollutant: No IATA UN number: 3109 Class: 5.2 (HEAT, 8) Proper shipping name: Organic peroxide type F, liquid (Cumyl hydroperoxide) (Cumene hydroperoxide) 15. REGULATORY INFORMATION WHMIS Classification B3 C D1A D1B E Combustible Liquid Oxidizing Material Very Toxic Material Causing Immediate and Serious Toxic Effects Toxic Material Causing Immediate and Serious Toxic Effects Corrosive Material Combustible Liquid Oxidizer Highly toxic by inhalation Toxic by ingestion Toxic by skin absorption Corrosive

This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all the information required by the Controlled Products Regulations. 16. OTHER INFORMATION Further information Copyright 2012 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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