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A. ANTIHISTAMINES
1. Oral – first line drugs for allergic rhinitis
- can relieve sneezing, rhinorrhea, and nasal itching
- do not reduce nasal congestion
- no value against the common cold
- most effective if taken prophylactically, even when symptoms are
absent
- sedation is the most common adverse effect
- anticholinergic effects (dry mouth, constipation, urinary
hesitancy) may occur
B. INTRANASAL GLUCOCORTICOIDS
- Flonase, Beconase, Nasonex, Nasolide
- most effective drugs for treating seasonal and perennial rhinitis
- over 90% of patients respond
- because of their anti-inflammatory actions, can prevent or suppress all of
the major symptoms of
allergic rhinitis (congestion, rhinorrhea, sneezing, nasal itching, and
erythema)
- now considered a first-line therapy drug
- administered using a metered spray device
- for seasonal allergic rhinitis - - maximal effects may require a week
or more to develop
- for perennial rhinitis - - maximal responses may take 2 – 3 weeks to
develop
- if nasal passages are blocked, they should be cleared with a
topical decongestant
prior to glucocorticoid administration
Adverse Effects: generally mild, include drying of the nasal mucosa
and burning or itching sensation
- caused by the vehicle employed for administration and
not by the steroids
themselves
- aqueous vehicles are much less irritating than
non-aqueous
D. SYMPATHOMIMETICS (DECONGESTANTS)
- phenylephrine
- reduces nasal congestion by stimulating alpha1-adrenergic receptors on
nasal blood vessels, causing
vasoconstriction, in turn causing shrinkage of swollen membranes
followed by nasal drainage
- topical administration vasoconstriction is both rapid and intense
- oral administration responses are delayed, moderate and
prolonged
- only relieves stuffiness in allergic rhinitis patients
- do not reduce rhinorrhea, sneezing or itching
Adverse Effects:
rebound congestion – develops when topical agents are used more
than a few days
- with prolonged use, the effects of each application wears off
and congestion becomes
progressively more severe
- to overcome this condition, the patient must use
progressively larger and
more frequent doses
- to break this cycle of escalating congestion and
increased drug use, abrupt
decongestant withdrawal will work but is
extremely uncomfortable
- less drastic approach is to discontinue drug use in one
nostril at a time
- can be minimized by limiting use of topical agents to 3 – 5
days
A. ANTITUSSIVES
- drugs that suppress cough
B. NONOPIOID ANTITUSSIVES
1. Dextromethorphan – most effective nonopioid cough medicine
- acts in the CNS
- although a derivative of the opioids, it does not produce euphoria
or physical dependence and
lacks any potential for abuse
- does not depress respiration
2. Others –
Diphenhydramine – mechanism of antitussive action is unclear
- has sedative and anticholinergic properties
- cough suppression is achieved only at doses that
produces prominent
sedation
What are the most frequently used drugs for cough suppression?