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Failure of LCP Condylar Plate Fixation in the Distal Part of the Femur.
A Report of Six Cases
Heather A. Vallier, Theresa A. Hennessey, John K. Sontich and Brendan M. Patterson
J Bone Joint Surg Am. 2006;88:846-853. doi:10.2106/JBJS.E.00543
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Publisher Information The Journal of Bone and Joint Surgery
20 Pickering Street, Needham, MA 02492-3157
www.jbjs.org
846
COPYRIGHT © 2006 BY THE JOURNAL OF BONE AND JOINT SURGERY, INCORPORATED
T
he treatment of comminuted, intra-articular distal fem- condylar plate for a distal femoral fracture during a thirty-six-
oral fractures (Orthopaedic Trauma Association [OTA] month period at our hospital, and we identified six implant
classification1 33-C3) is challenging. Many of these inju- failures. Fracture care was provided by fellowship-trained
ries are the result of high-energy trauma, which generates severe traumatologists at a level-I trauma center. Information on
soft-tissue damage and articular and metaphyseal comminu- these patients can be found in Table I and the Appendix. Indi-
tion. Bone loss resulting from open fracture and poor bone cations for the use of this implant included a coronal plane
quality may decrease the stability of fixation. Traditional devices fracture, osteopenia, and/or extensive distal fracture commi-
for internal fixation have included the 95° condylar blade-plate, nution precluding insertion of a conventional 95° condylar
the dynamic condylar screw with a 95° side-plate, and in- blade-plate or a dynamic condylar screw.
tramedullary nails. However, coronal fractures or extensive dis- All forty-six patients underwent assessment and resus-
tal comminution may preclude the use of these devices. In such citation according to Advanced Trauma Life Support (ATLS)
cases, a lateral buttress or neutralization plate may be used. The guidelines17. Open wounds were inspected, and dressings were
condylar buttress plate was the first implant designed to serve applied. Intravenous antibiotics and tetanus prophylaxis were
this function. Unfortunately, when this device is applied in the administered. Closed reductions were performed, and splints
presence of medial comminution or bone loss, failure of fixa- were applied. Open fractures were managed with urgent dé-
tion and varus collapse may eventually result2,3.
Recent advances in technology for the treatment of dis-
TABLE I Information on Patients Treated with the LCP
tal femoral fractures include the Less Invasive Stabilization Condylar Plate at Our Hospital
System (LISS; Synthes, Paoli, Pennsylvania) and the Locking
Compression Plate (LCP) condylar plate (Synthes)4-15. Each of Implant Failure All Cases
these implants offers multiple points of fixed-angle contact Mean age (yr) 62.2 (range, 36-88) 60.0 (range, 21-88)
between the plate and screws in the distal part of the femur, Men 2 19
theoretically reducing the tendency for varus collapse that is
Women 4 27
seen with traditional lateral plates. The LISS differs from the
LCP condylar plate in composition, shape, and placement. Mechanism of injury
Early clinical studies of the LISS have demonstrated a high fre- Automobile acc. 4 26
quency of fracture union with low rates of malalignment7-9,15. Motorcycle acc. 1 11
Few cases of failure of the LISS have been reported11,12,16. To our High-energy fall 1 5
knowledge, there have been no published studies focusing Low-energy fall 0 3
specifically on the LCP condylar plate and no reported cases of Crush 0 1
failure of this implant in the distal part of the femur. The pur- Open fracture 4 25
poses of this report were to describe and critically examine six Closed fracture 2 21
cases of failure of the LCP condylar plate and to discuss the
OTA classification*
limitations of this implant for the treatment of distal femoral
fractures. The patients were informed that data concerning 33-A3 0 5
the cases would be submitted for publication. 33-C1 0 5
33-C2 0 9
Materials and Methods 33-C3 6 27
e retrospectively reviewed the cases of all forty-six pa-
W tients who had been treated primarily with the LCP
*OTA = Orthopaedic Trauma Association.
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Results
deep infection developed postoperatively in one patient.
A She was treated with serial débridement and irrigation,
hardware removal, and intravenous antibiotics. After four-
teen months, she had a nonunion without recurrence of the
infection. Additional surgery was not planned because of
medical comorbidities and functional decline.
Three closed fractures were treated with morsellized al-
lograft bone during the index procedure. Six patients with an
open fracture underwent autogenous iliac crest bone-grafting
between six and ten weeks after fixation. After a minimum of
twelve months of follow-up, thirty-nine patients had fracture
union. The fixation failed in six patients. The initial fracture
alignment, assessed on plain anteroposterior and lateral radio-
graphs, was acceptable in all six patients.
Case Reports
ASE 1. A fifty-four-year-old man was struck by a bus
C while riding a motorcycle. His injuries included an APC
(anteroposterior compression) type-III18 pelvic ring disrup-
Fig. 1-A
Figs. 1-A through 1-D Case 2. Fig. 1-A Anteroposterior radio-
graph made after the initial fixation and placement of provi-
tion, a type-IIIA19,20 open right distal femoral fracture (OTA
sional antibiotic-impregnated polymethylmethacrylate beads.
33-C3), and a right ulnar fracture. The patient was hypoten-
sive on arrival at the hospital and was immediately taken to
the operating room, where he underwent internal fixation of of one of the locking screws at the screw-plate interface and
the pelvis, exploratory laparotomy, and débridement and irri- impending fatigue failure of the plate. The nonunion healed
gation and spanning external fixation of the open femoral after four months. At twenty-one months, the patient had no
fracture. Approximately thirty-six hours later, he underwent knee pain and could flex the knee from 0° to 115°.
definitive fixation of the right distal femoral fracture with an
LCP condylar plate. The wounds healed uneventfully, and CASE 2. A thirty-six-year-old, otherwise healthy man was in-
knee motion returned to nearly normal by six months, at volved in a high-speed motor-vehicle accident. On the right
which time he reported mild pain in the stance phase of gait. side, he sustained a fracture of the femoral shaft, a type-
At nine months, he presented with increased pain and defor- IIIA19,20 open fracture of the patella, a type-IIIA open fracture
mity. Radiographs demonstrated a femoral nonunion, varus of the tibial plateau, a fracture-dislocation of the calcaneus,
collapse, and implant failure. He was treated with a 95° condy- and fractures of the radial and ulnar shafts with compartmen-
lar blade-plate and application of iliac crest bone graft and al- tal syndrome. On the left, there was a type-IIIA open Monteg-
lograft. Inspection of the removed hardware showed a fracture gia fracture-dislocation and a type-IIIA open distal femoral
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fracture with extensive comminution and articular fractures crest and morsellized allograft croutons were applied at the
in both the sagittal and the coronal plane (OTA 33-C3). site of the distal femoral fracture. Cultures of intraoperative
On the day of injury, the patient underwent débride- specimens were negative, and all of the hardware appeared to
ment and irrigation of all of the open fractures and definitive be stable. Four months after the injury, the patient had 115° of
fixation of the upper extremities as well as the right femur, pa- flexion of the left knee and he was taking no pain medications.
tella, and tibia. He also underwent provisional spanning exter- At that time, he began progressive weight-bearing. He re-
nal fixation of the left femoral fracture. After forty-eight turned to working on his farm.
hours, he was returned to the operating room for repeat Fourteen months after the injury, the patient noted the
débridement and irrigation as well as open reduction and in- sudden onset of severe pain and deformity in the left thigh
ternal fixation of the distal part of the left femur with an LCP while he was walking in his barn. Radiographs demonstrated a
condylar plate. Antibiotic polymethylmethacrylate beads were nonunion with failure of the plate in the distal femoral meta-
placed into a massive metaphyseal defect (Fig. 1-A). Range-of- physis (Figs. 1-B and 1-C). He underwent a revision open re-
motion exercise of the left knee was initiated three days after duction and internal fixation with a 95° condylar blade-plate,
the surgery. Seven weeks after the surgery, autogenous iliac and augmentation with iliac crest and allogenic bone graft.
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did not require medication. Radiographs showed two screws pain and swelling in the knee. Radiographs showed two screws
that were broken at the distal screw-plate interface and 5° of that were broken at the distal screw-plate interface and four
varus collapse. Abundant medial metaphyseal callus was distal screws backing out of the distal part of the femur with
present at that time. The patient subsequently had a decrease 10° of varus collapse (Fig. 2-C). Revision open reduction and
in the pain over the following ten months with additional internal fixation was performed. The malunion was corrected,
healing of the fracture and no further malalignment. At the and the bone was stabilized with use of a 95° condylar blade-
time of final follow-up, she was using a cane for walking out- plate, iliac crest bone graft, and morsellized allograft bone
side of her home and knee flexion was from 0° to 100°. (Fig. 2-D). Twenty months later, the fracture was healed, func-
tion had improved, and knee flexion was from 0° to 110°.
CASE 6. A fifty-five-year-old woman with long-standing type-I
diabetes mellitus and tobacco use fell down stairs, sustaining a Discussion
comminuted distal femoral fracture (OTA 33-C3). On the day igh-energy distal femoral fractures are frequently associ-
of the injury, she underwent open reduction and internal fixa-
tion with an LCP condylar plate. No wound complications
H ated with articular and metaphyseal comminution. Coro-
nal plane fractures and extensive distal comminution generally
were noted. She was instructed to remain non-weight-bearing preclude the use of traditional fixed-angle devices or retrograde
for twelve weeks. nails. Fixation of these fractures with a lateral plate alone has
At twelve weeks, radiographs demonstrated stable align- historically been associated with nonunion and/or malunion
ment of the fracture and the implant with the exception of with varus collapse. Prior to the advent of locked plates, this
loosening of one distal screw (Figs. 2-A and 2-B). Some early problem may have been addressed with dual medial and lateral
fracture-healing was evident, so progressive weight-bearing fixation, causing additional surgical insult to the local fracture
was started. The patient returned seven months postopera- biology21,22. Reports have also described adjunctive medial exter-
tively, at which time she was experiencing mild activity-related nal fixation, or medial endosteal substitution with the use of in-
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Fig. 2-C
Anteroposterior radiograph showing varus collapse and bro-
ken screws at the screw-plate interface.
The slow appearance of callus on early postoperative radio- In all three cases of plate fatigue (Cases 1 and 2 and the
graphs may have been an indication for bone-grafting after patient treated at another hospital), the fracture occurred
three to six months, and this intervention may have prevented through the most proximal of the locking holes in the condylar
the failure of the implant at nine months. Because function portion of the plate. None of our patients had a screw inserted
was not limited by pain, a less aggressive approach was taken there. We speculate that increasing the cross-sectional thickness
initially. (He was observed—i.e., no surgery was anticipated.) of the plate and/or eliminating the screw hole at that level
The second patient had implant failure at fourteen months. would improve the fatigue strength of the plate and reduce the
He had previously undergone bone-grafting of a massive frequency of implant failure. Alternatively, routine placement of
metaphyseal defect and was functioning at a high level. We a screw through that hole could be considered to reduce the me-
have encountered another patient with this type of failure. She chanical stress in the fixation construct at that level25.
was initially treated, at an outside hospital, with the same de- We believe that locking plates represent a valuable ad-
vice. The plate was placed posteriorly on the lateral femoral vancement in fracture treatment. However, the limitations of
condyle with 2 cm of shortening and malalignment in external this new technology and the indications for its use have not
rotation, which may have increased the potential for plate been completely elucidated. Despite the introduction of new
breakage. That patient also had a history of diabetes and was implants, principles of fracture management remain un-
of advanced age, which may have decreased the ability of the changed. Severe medial comminution necessitates the use of
fracture to heal. indirect methods of reduction, preservation of biology, and
The remaining patients (Cases 3 through 6) all had failure protected weight-bearing. Additionally, we propose that the
at the screw-plate interface with 5° to 10° of medial collapse. All LCP condylar plate be used only when conventional fixed-angle
of these patients had metabolic factors that contribute to a di- implants cannot be placed. A recent study demonstrated that
minished healing response, including advanced age, osteoporo- the 95° condylar blade-plate has greater stiffness than the LISS
sis, obesity, diabetes mellitus, or tobacco use. Furthermore, two under both axial and torsional loading26. Although no biome-
(Cases 4 and 5) had an open fracture, which may have been as- chanical studies of the LCP condylar plate have been pub-
sociated with greater disruption of the local blood supply at the lished to our knowledge, each of the failed implants that
time of injury. Allograft bone was placed at the time of the ini- required a reoperation in our series was successfully revised to
tial surgery in one patient (Case 3); however, none of the others a blade-plate. Furthermore, we propose that traditional fixed-
underwent primary bone-grafting. It is possible that more judi- angle devices may be more cost-effective for most distal femo-
cious use of bone graft or bone-graft substitutes would have en- ral fractures. In our hospital, the cost of an eight-hole, 95°
hanced the healing response and decreased the propensity for condylar blade-plate construct is $370 compared with $743
mechanical failure and varus collapse. Fortunately, only one for a dynamic condylar screw with a 95° side-plate and $2089
of these four patients required revision fixation. The other for an LCP condylar plate of similar size.
fractures united, and to date the patients have not had pain In conclusion, the LCP condylar plate represents an evo-
or functional impairment that was sufficient to warrant addi- lutionary approach to the surgical management of distal fem-
tional surgery. oral fractures, but it does not completely solve the age-old
To our knowledge, this is the first report of failures of problems of nonunion and malunion. We encountered six
the LCP condylar plate. Previously described failures of LCP cases of implant failure. Accurate reduction and fixation, judi-
plates in other anatomical locations were speculated to be cious use of bone-grafting, and protected weight-bearing, per-
secondary to technical errors, including inappropriate plate haps combined with modifications in implant design, may
length or size, an insufficient number of screws, or the use of decrease the prevalence of these problems in the future.
unicortical (instead of bicortical) screws23. It is possible that
additional fixation in our patients would have decreased the Appendix
risk of implant failure. Simonian et al. described angled screw A table showing clinical details of the six cases is avail-
placement through the plate from the lateral metaphysis into able with the electronic versions of this article, on our
the medial femoral condyle as an adjunct in the stabilization web site at jbjs.org (go to the article citation and click on
of distal femoral fractures24. In their model, the addition of a “Supplementary Material”) and on our quarterly CD-ROM
single screw in this location more than doubled the stiffness of (call our subscription department, at 781-449-9780, to order
the construct under an axial load, reducing the tendency for the CD-ROM).
varus collapse. Three of our patients had screw placement in
this location as part of the initial fixation, but failure still oc-
curred. Modification of the design of the LCP condylar plate
to permit locked screws to be directed obliquely, from proxi- Heather A. Vallier, MD
mal and lateral to distal and medial, could be advantageous. Theresa A. Hennessey, MD
John K. Sontich, MD
Furthermore, the LCP condylar plate could be modified to Brendan M. Patterson, MD
eliminate the cannulation of the locked screws. This could re- Department of Orthopaedic Surgery, MetroHealth Medical Center, 2500
duce the frequency of screw breakage at the screw-plate inter- MetroHealth Drive, Cleveland, OH 44109. E-mail address for H.A. Val-
face, as solid screws may be less likely to fail over time. lier: hvallier@metrohealth.org
853
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The authors did not receive grants or outside funding in support of foundation, educational institution, or other charitable or nonprofit
their research for or preparation of this manuscript. They did not re- organization with which the authors are affiliated or associated.
ceive payments or other benefits or a commitment or agreement to pro-
vide such benefits from a commercial entity. No commercial entity paid
or directed, or agreed to pay or direct, any benefits to any research fund, doi:10.2106/JBJS.E.00543
References
1. Fracture and dislocation compendium. Orthopaedic Trauma Association Commit- ing of the LCP—how can stability in locked internal fixators be controlled? Injury.
tee for Coding and Classification. J Orthop Trauma. 1996;10 Suppl 1:v-ix, 1-154. 2003;34 Suppl 2:SB11-9.
2. Bolhofner BR, Carmen B, Clifford P. The results of open reduction and internal 15. Weight M, Collinge C. Early results of the less invasive stabilization system
fixation of distal femur fractures using a biologic (indirect) reduction technique. for mechanically unstable fractures of the distal femur (AP/OTA types A2, A3, C2,
J Orthop Trauma. 1996;10:372-7. and C3). J Orthop Trauma. 2004;18:503-8.
3. Mast J, Jakob R, Ganz R. Planning and reduction technique in fracture surgery. 16. Button G, Wolinsky P, Hak D. Failure of less invasive stabilization system plates
New York: Springer; 1989. in the distal femur: a report of four cases. J Orthop Trauma. 2004;18:565-70.
4. Egol KA, Kubiak EN, Fulkerson E, Kummer FJ, Koval KJ. Biomechanics of locked 17. Advanced Trauma Life Support provider manual. 7th ed. Chicago: American
plates and screws. J Orthop Trauma. 2004;18:488-93. College of Surgeons; 2005.
5. Frigg R, Appenzeller A, Christensen R, Frenk A, Gilbert S, Schavan R. The 18. Burgess AR, Eastridge BJ, Young JW, Ellison TS, Ellison PS Jr, Poka A, Bathon
development of the distal femur Less Invasive Stabilization System (LISS). In- GH, Brumback RJ. Pelvic ring disruptions: effective classification system and
jury. 2001;32 Suppl 3:SC24-31. treatment protocols. J Trauma. 1990;30:848-56.
6. Frigg R. Development of the locking compression plate. Injury. 2003;34 Suppl 19. Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thou-
2:SB6-10. sand and twenty-five open fractures of long bones: retrospective and prospective
analyses. J Bone Joint Surg Am. 1976;58:453-8.
7. Kregor PJ, Stannard J, Zlowodzki M, Cole PA, Alonso J. Distal femoral fracture
fixation utilizing the Less Invasive Stabilization System (L.I.S.S.): the technique 20. Gustilo RB, Mendoza RM, Williams DN. Problems in the management of
and early results. Injury. 2001;32 Suppl 3:SC32-47. type III (severe) open fractures: a new classification of type III open fractures.
J Trauma. 1984;24:742-6.
8. Kregor PJ, Hughes JL, Cole PA. Fixation of distal femur fractures above total
knee arthroplasty using the Less Invasive Stabilization System (L.I.S.S.). Injury. 21. Jazrawi LM, Kummer FJ, Simon JA, Bai B, Hunt SA, Egol KA, Koval KJ. New
2001;32 Suppl 3:SC64-75. technique for treatment of unstable distal femur fractures by locked double-
plating: case report and biomechanical evaluation. J Trauma. 2000;48:87-92.
9. Kregor PJ, Stannard JA, Zlowodzki M, Cole PA. Treatment of distal femur frac-
tures using the less invasive stabilization system: surgical experience and early 22. Sanders R, Swiontkowski M, Rosen H, Helfet D. Double-plating of commi-
clinical results in 103 fractures. J Orthop Trauma. 2004;18:509-20. nuted, unstable fractures of the distal part of the femur. J Bone Joint Surg Am.
1991;73:341-6.
10. Marti A, Fankhauser C, Frenk A, Cordey J, Gasser B. Biomechanical evalua-
tion of the Less Invasive Stabilization System for the internal fixation of distal 23. Sommer C, Babst R, Muller M, Hanson B. Locking compression plate loosen-
femur fractures. J Orthop Trauma. 2001;15:482-7. ing and plate breakage: a report of four cases. J Orthop Trauma. 2004;18:571-7.
11. Schandelmaier P, Partenheimer A, Koenemann B, Grun OA, Krettek C. Distal 24. Simonian PT, Thompson GJ, Emley W, Harrington RM, Benirschke SK, Swiont-
femoral fractures and LISS stabilization. Injury. 2001;32 Suppl 3:SC55-63. kowski MF. Angulated screw placement in the lateral condylar buttress plate for
supracondylar femoral fractures. Injury. 1998;29:101-4.
12. Schutz M, Muller M, Krettek C, Hontzsch D, Regazzoni P, Ganz R, Haas N.
Minimally invasive fracture stabilization with the LISS: a prospective multicenter 25. Hipp JA, Hayes WC. Biomechanics of fractures. In: Browner BD, Jupiter JB,
study. Results of a clinical study with special emphasis on difficult cases. Injury. Levine AM, Trafton PG, editors. Skeletal trauma: basic science, management,
2001;32 Suppl 3:SC48-54. and reconstruction. Philadelphia: Saunders; 2003. p 90-119.
13. Sommer C, Gautier E, Muller M, Helfet DL, Wagner M. First clinical results of 26. Zlowodzki M, Williamson S, Cole PA, Zardiackas LD, Kregor PJ. Biomechani-
the Locking Compression Plate (LCP). Injury. 2003;34 Suppl 2:B43-54. cal evaluation of the less invasive stabilization system, angled blade plate, and
retrograde intramedullary nail for the internal fixation of distal femur fractures.
14. Stoffel K, Dieter U, Stachowiak G, Gachter A, Kuster MS. Biomechanical test-
J Orthop Trauma. 2004;18:494-502.