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Ashour Abdelsalam
Medical Research Institute Date: 03/03/2009
Tumor Cell Biology Dept.
1. Heat shock proteins that play an important roles in normal intracellular proteins
are called housekeeping proteins
2. The ubiquitin-proteosome pathway is responsible for the degradation of many
cytosolic and nuclear proteins
3. Mallory body, an eosinophilic intracytoplasmic inclusion in hepatocytes ,
indicates alcoholic liver.
4. Excessive intracellular deposits of glycogen are associated with abnormalities in
the metabolism of glucose or glycogen
5. Pigments are colored substances that are exogenous or endogenous materials
6. Lipofuscin represents complexes of lipid and proteins
7. Lipofuscin is derived from the radical catabolized peroxidation of polyunsaturated
lipids of subcellular proteins
8. Lipofuscin is a marker of past free radical injury
9. Dystrofic calcification is the deposition of calcium in dead tissues while
metastatic calcification is deposition of calcium in normal tissues
10. Calcium accumulates by its affinity for membrane phospholipids while
phosphorous accumulates as a result of the action of membrane-bound
phosphatases
11. Mitochondria have the ability to regulate intracellular calcium
12. Early ultrastructure markers of irreversible injury is the accumulation of calcium-
rich deposits in mitochondrial matrix
13. Activation of endogenous phospholipids in ischemic liver tissues is associated
with decrease in membrane phospholysis
14. Activation of proteases by increased intracellular calcium may result in damage to
cytoskeleton
15. Collagen bundles serve to repair injury forming what is known as scar tissues
16. In injury with pathogens or their toxins, plasma cells produce specific proteins
called antigens
17. In injury with local damage, basophils release their granules in the site of injury
and histamine causes vasodilatation but heparin prevents clotting of blood in
intact vessels