Immune Restoration

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It is becoming increasingly evident that many if not most chronic co part on an infection and immune response. This includes more than etc., or with the manifestations of CFIDS, Candidiasis, certain forms War Syndrome (GWS), atherosclerosis, and cancer. All of these component of infection and immune response as key contributors Arthritis, fibromyalgia, coronary artery disease, ulcers, psoriasis, inf multiple sclerosis, are just a few of the conditions in which infec appear to be the driving force in the disease. While anti-microbials there is a growing realization that immunology may be the approac answers.

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Restoring balance and function to your immune system, in the face of bacterial, fungal, parasitic, etc) challenge is a fundamental challenge understand the therapeutic approach and goal of optimal immunity, about cytokines, which ultimately control our immune responses. factors to induce or suppress specific cytokine responses is one approa this web page. What are Cytokines?

Jeremy E. Kaslow, MD, FACP, FACAAI Physician and Surgeon Board Certified Internal Medicine NOTICE TO CONSUMERS
Medical Doctors are licensed and regulated by the Medical Board of California

Cytokines are chemical messengers that control immune responses. by white blood cells, T lymphocytes, and epithelial cells. There are cytokines based on the effect they have on lymphocytes: Th1 and T Th1 and Th2 determines the type of immune response and the resu results.

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Th1 (T-cell Helper type 1) promote cell-mediated immunity (CMI) wh 2) induce humoral immunity. Viral infections are largely controlled while humoral immunity involves antibody formation. Robert Da different methods exist by which the body fights infections: humoral the production of antibodies to neutralize foreign invaders outside immunity (Th1) directs Killer T-cells (CD8) to attack microorganism sites of infection inside the cells.

In chronic viral disease, the worst of which is the HIV progression to Th1 (cellular immunity) to the Th2 (humoral immunity). Since antibo defeating viruses as are the cells themselves, viral diseases progress Th1 to Th2.

The term cytokine is derived from the term for cells (cyto as in cytolo or movement (kine from the word kinetic). They include chemica particular action. Some of the cytokines include interleukins and t called alpha, beta and gamma and various subsets. The term interfero interfere with infection.

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Th1 or Th2?

There are multiple factors that affect either Th1 or Th2 cytokines Interleukin-2 (IL-2), Interleukin 12 (IL-12), gamma interferon (IF immunoglobulin that supports mucosal immunity). The Th2 immune interleukins 4, 5, 6 and 10 and alpha interferon.

In many cases, an infection is fought with both arms of the immune s one is needed to control the infection.

A failure of the Th1 arm of the immune system and an overactive Th2 variety of chronic illnesses. These include AIDS, CFIDS, Candidiasis, Chemical Sensitivities (MCS), viral hepatitis, Gulf War Syndrome (G two arms of the immune system could be balanced by stimulating Th many of the symptoms associated with these chronic illnesses would we would have found the answer to immune restoration and balance o With AIDS, it has been reported that as HIV infection progresses from advanced disease, the immune response appears to shift from the mor ineffective Th2 state. The Need for Balance

It is important to realize that a normal functioning immune system need to provide flexibility to respond to different kinds of pathogens (viruse bacteria etc) both inside and outside of the cells. If the Th2 arm is c found in many chronic disease states such as viral infections, candidi Th1 arm is underactive. In end stage illnesses, both arms of immune sy IL-12 & IgA for Mucosal Immunity

The skin and mucus membranes are the bodys primary barrier to keep An open cut and/or a leaky gut is like a fortress with an open door parasites, etc have easy access to get inside. Il-12 stimulates Ki membranes to stop viral invasions before they get enter the body. mucus membranes is also critical to help reduce infectious agents, foo the body. Clearly restoring mucosal immunity is a critical first step to t

The epithelium (mucus membranes) of the intestines are a fine filter out unusable food particles. When pathogens like certain bacteria, c etc., replicate in or on the mucus membranes, they inflame the epithe that allows byproducts of faulty digestion to enter the blood. This tri (Th2) that weakens the cell-mediated immune response systematically a leaky gut (increased intestinal permeability) discussed in more detail

Multiple studies show that high levels of IgA and CD8 Killer T cells i the colon or/and vagina increase the resistance to viral and bacterial CD8 Killer T cells in the mucus membranes and throughout the body, induced with resultant IgA, IL-12, and interferon-gamma (IFN-gam cytokines for restoring mucosal and systemic cellular immunity. FACTORS THAT INCREASE Th2 CYTOKINES

The three most common factors that drive Th2 cytokine responses are:

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1. Faulty digestion leading to absorption of partially digested and u food particles (increases IgG and IgE antibody responses that are dir food particles). This is the condition called leaky gut due to increas Instead of the intestines serving as a barrier to the outside world, it allo particles to be presented to the body through a non-physiologic entryw home with a security system through a window, the alarm is triggere foreign invader. The result is a recruitment of police and other pro case of the food this represents the immune system. Proper diges supportive bacteria, and a healthy gastrointestinal lining create a strong Likewise, use of digestive enzymes, eating slowly mixing lots of over-eating or processed foods that are difficult to digest, anti-m necessary components to establishing immune balance. To emphasiz digestion is the fact that the largest immune organ in the body is the ga

2. White sugar and glucose and all processed foods containing these bars, cake, pie, sweet rolls etc.) - directly weakens the functioning of cells and other white blood cells and weakens systemic resistanc statement is not just politically correct but has been documented in sev effects last for up to six hours, which means if you consume this at ev immune -suppressed all of the time. It may also explain that in an othe individual, fasting extends lifespan

3. Consuming trans-fatty acids found in almost all heated and pro canola, safflower, corn and sunflower) and food products made wi potato chips, almost any crunchy snack) stimulate IL-6 and depress de (DTH) thus weakening CD8 Killer-T cell activity. The trans-fatty ac normal cis shape and produce cell membranes that are porou infections. In his book Fats that Heal and Fats that Kill, Udo Erasmus atherosclerosis in the arteries of animals, fried and deep fried (vegetab respiration and other cell functions, inhibit immune functions, and lead

Among the most problematic hydrogenated vegetable oils are in marg their high content of trans-fatty acids. Soybean oil, safflower, corn, s other vegetable oils should also be avoided by persons with ch predominant TH2 cytokine profile (too much Il-6, Il-10, TNF and impossible to find vegetable oils that are strictly cold processed. Exce nearly all other vegetables are processed with solvents, hexane or g from the seeds. The oil and hexane/gasoline mixture is then heated to the hexane or heptane (gasoline) (1). At this point, the oils are now to are twisted out of their natural cis shape and become trans-fatty oxygen to oils and the lipid peroxides increase and they become ra taste. The safest and freshest oils to buy are cold pressed (best choice in a can or black bottle to keep out light. It is even better if Vitamin antioxidant to prevent lipid peroxide formation.

It should be clear that consuming canned soda (i.e. Coca-cola) and make you immune compromised. Any situation that allows you to bec more likely to progress into a chronic condition just on the basis of you

Other factors that stimulate a Th2 response include a strain thermophilus, which is widely used in the making of commercia from Michigan State University found that streptococcus thermoph IL-6 production in macrophage lines. They also found that lac

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bifidum also increased IL-6, although less than S. thermoph Jul;61(7):859-64). Most commercial yogurt have to add acidophi thermophilus, which is not shown on the label. Perhaps eating yog after all even though research shows that acidophilus inhibits tu animals (Nutr Cancer 1997;28(2):130-4). If the yogurt contain acidophilus, Th2 cytokine response may dominate over the benefic

Toxins such as asbestos lead, mercury and other heavy metal pollutants imbalance the immune system towards Th-2 dominance

Hormones such as progesterone (pregnancy is a state of elev cytokine predominant profile is needed. A strong Th1 cytokine cause an abortion because the immune system would reject (cortisol), possibly melatonin (conflicting research suggests tha cytokines while very small amounts induce Th1 cytokines), some a gain are hard on the liver and adrenals and suppress Th1 cytokines. Medications such as morphine, tobacco, Thalidomide

Alcohol - Note: Studies on animals show that ethanol (alcohol cytokines and induces Th2. However, beer was not tested.

Infections HIV, candida albicans, HCV, E coli and many other pa

Miscellaneous: Stress (continuous), UVB, sedentary life - lack o up of toxins that weakens CMI, lack of water leads to toxic ove negative attitudes such as suppressed anger/rage, inability to forg grudges, etc. all stresses the adrenal glands and increases cortiso exhaustion... Low body temperature, acid saliva pH, chronic insom tearing increases cortisol levels.

FACTORS THAT SUPPORT Th1 CYTOKINES

1. Omega 3 fatty acids (DHA/EPA) are found in all cold water f immunity (CMI) and increase Delayed Type Hypersensitivity and Salmon, sardines, mackerel halibut and trout have the highest conce these types of cold water fish have a high fat content. Lesser amounts all varieties of cold water fish. Small amounts of DHA/EPA are fo dark-green leafy vegetables and sea vegetables (blue green algae, ch flaxseed contains a small amount of omega-3 fatty acids, but it must DHA/EPA.

Caution with tuna fish, although high in DHA/EPA, tuna is often also c heavy metal, mercury. For this reason it is suggested that tuna be con than other types of fish. Of course fried fish are not preferable to ra broiled fish. The vegetable oils used in frying fish will promote a T negates the benefits of the good oils. Udo Erasmus also advises cetoleic acid as it is a difficult fatty acid for the body to break down herring, capelin, menhaden and anchovetta.

One aspect of essential fats of relevance is the metabolism of fatty aci or invasion of the body by pathogens. Pro-inflammatory cytokines, IL factor (TNF) are rapidly produced in response to the injury as part o

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response. However, if this pro-inflammatory response fails to shut do (pathology).

Swiss researchers Grimble and Tappia report (Modulation of pro-infla by unsaturated fatty acids. by Grimble RF, Tappia; Z Ernahrungswi excessive production of pro-inflammatory cytokines, or production biological context, are associated with mortality and pathology in a w as malaria, sepsis, rheumatoid arthritis, inflammatory bowel disease, c the nutrients, fats have a large potential for modulating cytokine biolo demonstrated the anti-inflammatory effects of fish oils, which are r fatty acids, in rheumatoid arthritis, inflammatory bowel disease, psoria

French researchers Khalfoun et al found that the addition of n-3 reduced IL-6 production in endothelial cell lines. They report that th oils suppress inflammation. (DHA and EPA acids inhibit in vitro hum of interleukin -6. Adv Exp Med Biol 1997; 400B:589-97)

In addition to the effects of omega-3 oils on the immune system and i in his book, Fats that Heal - Fats that Kill reports that DHA and EP triglycerides by 65% in one study. Erasmus also reports that EPA and sticking, lowers fibrinogen levels in the blood and prevents hardenin strokes and inhibits the growth of cancer and tumors. Mostly good th fatty acid intake. Oleic acids are called monounsaturated and are found in cold pressed oil, green and ripe olives, filberts and hazelnuts, and less so in a Monounsaturated oils are best used raw, but may be used in moderat dressing, use Extra Virgin Olive oil or hazelnut oil.

Coconut oil seems to be neutral - it neither suppresses nor enhances another article by Grimble, he states: Monounsaturated fatty acids suppress TNF and IL-1 production and actions, while n-6 (polyunsatu the opposite effect. (Nutritional modulation of cytokine biology, G Jul-Aug;14(7-8):634-40). For baking purposes, best choices are coco oil. Almond oil is worth a try as well.

Conclusion: Most vegetable oils should be avoided as they suppre (CMI), the exception are those vegetable oils high in monounsaturated olive oil, hazelnut oil, etc. Almond, avocado or peanut oil are also hi and might safely be used in moderation.

2. Vitamin A is a bit more complicated since there are apparently dif depending on the source. In addition, many labels call beta-carotene proper term, pro-vitamin A. Vitamin A has a very different profile carotenes. Sources of vitamin A include cod liver oil, lemon oil. cooked carrots, squash, pumpkin and sweet potatoes (yams).

3. Silica from food sources is abundant in the herb horsetail, millet, o whole grains and in onions and red beets. It is not easily utilized and are available to the body. Horsetail tea, for example, has to be boi active components. Klaus Kaufman in his book Silica - The Amazing G silica gel applied topically cleared a herpes lesion in 5 days. The autho been used to successfully treat tuberculosis, warts, intestinal infections cancer as well as stimulates phagocytes (macrophages and neutrop

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cells). In Positive Health News, Report No 17, scientific research decreases IgG, an immunoglobulin that when in excess diminishes Natu

4. Certain strains of bacteria (L-plantarum and L-Casei) strains o increase Il-12 production along with gamma interferon thus increasing activity against most kinds of intracellular viral infections. Matsuzak Lactobacillus Casei induced the production of several cytokines incl and TNF-alpha, resulting in the inhibition of tumor growth and c cancer. Matsuzaki states that L. Casei has the potential to amelior diseases through modulation of the hosts immune system, spe responses.(Int J Food Microbiol 1998 May 26;41(2):133-40).

The Journal of the American Medical Assn (JAMA 1996;275( therapeutic uses of intestinal flora reviewed all the published material They reported that controlled studies have established that L. Casei, and Saccharomyces boulardii have been successfully used to treat in antibiotics. They said the time has come to explore the therapeutic app

5. Ginseng (Red Korean or concentrated Siberian Ginseng extract) - i and NK function. Researchers in Korea have found that an acid derived from Panax ginseng promotes TH1 cytokines. Kim KH et al cytotoxic to a wide range of tumor cells after 5 days of culture w histocompatibility restricted manner and the activity of ginsan was 1 lentinian.... ginsan induced LAK cells were CD8+- cells...ginsan induc for IL-2, IFN-gamma, IL-1 alpha, and GM-CSF....ginsan generates LA T cells...This property may contribute to its effectiveness in th immunotherapy of cancer. (Kim KH et al; Planta Med 1998;64(2):110

Cho YK, Lee, Oh and Kim report on a study comparing 5.4 grams of on 16 HIV+ patients versus 10 patients who took no anti-HIV medicat group using this form of ginseng, the average CD4 count increased fr In the control group, the average baseline CD4 count of 352 decr concluded that KRG has definite long-term immune modulating eff HIV-infected patients. (Long term immunological effect of ginseng Cho YK et al; Abstr Gen Meet Am Soc Microbiol 1997;97:247 (abstra

In another study from Seoul, Korea, Yun and Choi reported that ginsen developing cancer than non-users. The data they published indicat effective in preventing cancer that the Korean white ginseng (Preventi against various human cancers; Yun TK et al; Cancer Epi 1995;4(4):401-8).

PCM-4 has been reported reduced tumor necrosis factor (TNF). Stu TNF levels are associated with wasting syndrome and increased HIV concentrated extract of Siberian Ginseng. There is basis to believe sim at a lower cost with the Siberian Ginseng.

6. Soil Based Organisms (SBOs) (bacillus subtilis and lichenformi inactivates lipid envelope viruses (HIV, CMV, herpes etc), kills myco and candida albicans. By reducing candida albicans, SBOs reduce T reported that Bacillus subtilis helped symptoms associated with C allergies, Streptococcal and Staphylococcal infections. There are pu helped shift the cytokine profile from Th2 to Th1.

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Bacillus subtilis and lichenformis produced a detergent-like substa dissolves the lipid envelope around certain microbes thereby re inactivated. German researcher Vollenbroich D reported The antiv cyclic lipopeptide antibiotic and biosurfactant produced by Bacillus su broad spectrum of viruses especially herpes and ret 1997;25(3):289-97)

Mycoplasma and bacterial membranes also disintegrated by exposure Microbiol 1997;63(1):44-9). A lipopeptide similar to surfactin lichenformis that may be even more potent at dissolving lipid enve from subtilis (Appl Environ Microbiol 1994;60(1):31-8). Potent anti inactivated most types of fungus are produced by bacillus subtilis (F Bacteriol 1994;76(4):395-4-5).

Products that contain both the bacillus subtilis and lichenformis ha symptoms. Scientific research demonstrates that surfactin produced b envelope viruses (HIV, HHV-6 strains A and B, EBV, CMV, herpes.

7. Sunlight has been blamed for skin cancer in many published s increases white blood cell counts, improves delayed type hyperse calcium absorption and stimulates deeper restful states of sleep. Sunlig light, UVA primarily with some UVB and a small amount of UVC reported (Journal Cell Physiol 1998;177(3):492-8) that UVA promo Considering that IL-12 promotes activation of Th1 cells and p cells...our results suggest that UVA modulates skin immune function di

Skov L et al report that exposure of the skin to ultraviole immunosuppression relevant to the induction of skin cancer. light on the skin and found their cytokine effects were o 1998;138(2):216-20). They found UVB increased Il-10 (Th-2) signif this with UVA. With UVA, they found a decrease in TNF-alpha wh increase in TNF-alpha with UVB. Other researchers have found an persons with psoriasis who undergo extensive UVB light treatments. wholesome diet rich in antioxidants and use vitamins that promote prop

8. In studies on mice, electro-acupuncture increased Natural Killer c not increase the quantity of NK cells. Electroacupuncture caused the increasing beta-endorphin production and also increased IFN-gamma i Neuroimmunol 1998;90(2):176). In a controlled study on 25 cance acupuncture given for 30 minutes daily for 10 days increased IL-2 l Pressure points used were ST36, LI11 and RN6. In the placebo group levels remained below normal and unchanged. Wu concluded: a enhance the cellular immune function of patients with malignant tumo effect in anti-cancer treatment. (Chung Kuo Chung Hsi I Chieh Ho Ts

9. Digestive enzymes - improves digestion and assimilation of pro reduces circulating immune complexes that cause antibody and autoan

10. Broken cell wall Chlorella increases IL-12, GM-CSF and a Hasegawa (Immunopharmacology 1997;35(3):273-82) reported that mice with murine acquired immunodeficiency syndrome (MAIDS cell-mediated immunity, increased the levels of IL-1 alpha, Il-12, GM genes in the peritoneal adherent cells. They conclude that chlorella m

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TH1 responses against Listeria via activation of macrophages to produ defense against Listeria infection in both normal and MAIDS mice. T much Chlorella was given to the mice to enhance their cellular imm other sea vegetables may have similar benefits.

11. L-thyroxine (T4) is a thyroid hormone that is a potent inducer of 1997 Oct;273(4 Pt 1):C125-32 and J Immunol 1998 Jul 15;161(2):843-

12. Garlic - raw or aged extract - promotes NK function and IL-2. Raw AIDS. 1992 Jul 19-24;8(3):39(abstract no PuA 6173), many kind including forms of tuberculosis (J Antimicrob Chemother. 1993 Oct; (Hunan I Ko Ta Hsueh Pao 1997;22(3):246-8) reports that garl experiments on Wistar rats. He states that this effect may be due to NK cells, the function of T-lymphocytes and the level of IL-2. daily restored Natural Killer cell function in a small group of HIV+ garlic is far more powerful than aged garlic extract in directly killing infections. If fact, there is no evidence that garlic capsules will directly aged garlic has immunologic value in activating NK function.

Raw garlic can be irritating to sensitive mucus membranes. Eating raw of a meal may help. Fresh parsley helps deodorize the garlic.

13. Glutathione has a very important role as an anti-oxidant, neutralize many toxins form inside the cells. Research indicates that a lack of int antigen presenting cells to shift from a Th1 to a Th2 cytokine profile in Peterson et al reports By using three different methods to deple transgenic and conventional mice and studying in vivo and/or in vitro antigens, we show that glutathione levels in antigen-presenting cells Th2 response patterns predominate. (Proc Natl Acad Sci USA 1998;9

Glutathione promotes antigen presentation and stimulates CD8 cytoto Lipoic acid, selenium, N-Acetylcysteine, cysteine, cold processed w milk and L-glutamine are used to increased glutathione levels. B12, Vitamin B6 and B2 (Riboflavin) are also necessary. methionine to cysteine, the rate limiting amino acid in glutathione syn regenerate reduced glutathione. Vitamin B12 should be taken subling with intrinsic factor, which is necessary for absorption of vitamin B12 that replaces glutathione helps Th1 responses. We use our own excellent clinical response. To my knowledge it is the only oral form the clinical response as with intravenous GSH.

14. DHEA or AED (androstenediol) increases IL-2, IFN-gamma an DHEA or AED promotes Th1 and decreases Th2 cytokines. Hernandez-Pando R et al in mice exposed to B. Tuberculosis (TB (Dehydroepiandrosterone) or AED (androstendiol) had antiglucocorti Th1 cytokines. They reported that immunity to TB requires a Th1 cyto suggest that adrenal exhaustion may promote a cytokine shift from Th AED was particularly protective, causing a fall in bacterial count (Immunology 1998 Oct;95(2):234-41). Inserra (Proc Soc Exp Biol Me at the University of Arizona found DHEA significantly increased IFN-gamma) and decreased Th2 cytokines (IL-6 and Il-10) in aged mic 16. UVA light promotes IL-12.

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17. Vitamin E increases IL-2, NK function and IFN-gamma. Reduces

18. Transfer factor (antigen specific) - protein immuno-modulators from immunologically stimulated animals that promotes DTH and sp antigens (viruses etc.).

19. Colostrum contains IgA, which promotes mucosal immunity and im to which the animal was exposed.

20. Naltrexone - promotes NK function and resistance to candida a cytokines. 21. IP6 - found in brown rice and corn - promotes NK function.

23. Lentinian and certain other mushrooms - promote Th1 cytokines an 24. Thymic factors increase IL-2 and T cell counts. 25. DNCB - promotes DTH and CD8 CTL activity 26. Licorice root and Dong Quai - reduces antibody production.

27. Beta 1, 3 glucan - found in the common yeast and in oats and stimulates macrophage and neutrophil function. Note: may also spi cross-regulatory role. When given beta-glucan, IL-4 and IL-5 levels i decrease significantly, while IL-12 levels were found to have significan

28. Noni -Tahitian - 2 tablespoons twice daily - promotes NK func cancer.

29. Neem is a botanical that has been used in animal experiments to te has been attributed by several researchers to a strong Th1 cytok IFN-gamma and TNF (Talwar et al; Am J Reprod Immunol 1997;3 CD8 cells have been reported. Talwar reports that Neem has in spectrum of micro-organisms, including candida albicans, C tropicalis resistant Staphylococcus aureus and urinary tract Escherichia coli, Her (Talwar et al, Immunol Cell Biol 1997;75(2):190-2)

30. Gingko Biloba - reduces cortisol production that suppresses Th1 cy

31. Exercise - aerobic - light and fun. Walking, gardening, dan endorphin levels - improves NK function - removes toxins from body. Pulsed Protocols

Some substances induce both Th1 and Th2 cytokines including echinac glucan. These substances are best used in a pulsed protocol, 1 to continuously. Excessive intake of zinc is immunosuppressive immunosuppressive. A safe dose range for adults is 25 to 50 mg daily.

Vitamin C activates Natural Killer cell function if used in a high dose ( per week only. When used every daily, the body creates an enzyme t rendering it ineffective.

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To kill stubborn candidiasis and fungal infections other than prescripti Oregamax (Northern Spice and Herb Co). Several persons with CFID this is the most effective product they have found for Candida Alb taken as much as 3 capsules three times a day. It is important to supp the yeast in its single cell state where it is noninvasive. Japanese re oregano also kills the HIV virus. The wild crafted oregano is the m market. One lady told me she used oil of oregano (Northern Spice excellent results. However, unless you turn on those Th1 cytokines, th the first sweet roll you eat. Other factors that Stress the Immune Response in Digestion

CD4 and many other types of white blood cells are in the intestines to safety of the byproducts of digestion. Proteins and other nutrients tha are attacked by the immune system when they get past the mucu importance of eating foods in a way to assist in their complete digestio mixing lot of saliva with each mouthful. The use of cultured, fermente in natural digestive enzymes or the taking of supplemental enzymes process. When you combine poor digestion with leaky gut syndrome c overgrowth, you have a combination that causes serious stress on weakens the capacity of the immune system to deal effectively elsewhere in the body.

This stress is further exacerbated when the mucus membranes are we mucosal immunity (i.e.. lack of IgA and CD8 cytotoxic lymphocytes in These factors that can stress the immune response occur not only HHV-6A, CFIDS, Candidiasis, Hepatitis, GWS, cancer and in persons chemical sensitivities. Other Infections of the Intestinal Tract

The large intestines (colon) is a nest for the growth and replicatio contribute to immune dysfunction and many symptoms. Pub demonstrates that the gut can be heavily infected with HIV, parasite tuberculosis, hepatitis viruses, cytomegalovirus and mycobacterium av to name a few.

In CFIDS, restoring mucosal integrity and immunity should substant digestive disorders and improve the immune response against HHV-6 aberrations elsewhere.

Healthy mucus membranes are a first line of defense against path papilloma, herpes, hepatitis etc.) and foreign proteins. Incompletely toxins from putrefying bacteria and parasites results from 1. Faulty digestion 2. Leaky gut syndrome 3. Yeast, parasites and putrefying bacterial overgrowth 4.

The integrity of the mucus membranes themselves. The mucu colon and vagina are a common route for the transmission of

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papilloma virus, herpes and hepatitis. Belyakov et al at the reports We conclude that protection against GI mucosal c (Th-1) mediated but also requires local mucosal CTL at the s found surprising persistence not only of memory CTL in the mu immunity against mucosal viral challenge. The article also rep the CTL mucosal response (J. Clin Invest 1998;102(12):2072-8

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