Chem ch 30 quizbank 1) Of the following analytic methods, which is most commonly used as the method for identification of drugs

of abuse? a) Gas chromatography or mass spectrophotometry* b) Immunoassay c) Scanning differential coloimetry d) Nephelometry e) Ion-specific electrode 2) A patient with suspected organophosphate poisoning presents with a low SChE level. However, the confirmatory test, erythrocyte acetyl cholinesterase, presents with a normal result. Excluding analytic error, which of the following may explain these conflicting results? a) All of these are correct b) The patient was exposed to low level organophosphate c) The patient has late-stage hepatic cirrhosis d) The patient has a variant of SChE that displays low activity e) The patient has a late-stage hepatic cirrhosis, or the patient has a variant of SchE that diplays low activity* 3) A child presents with mircrocytic, hypochromic anemia. The physcician suspects iron-deficiency anemia. Further laboratory testing reveals a normal total serum iron and iron-binding capacity; however, the zinc protophphyrin level was very high. A urinary screen for porphyrins was positive. Erythrocytic basophilic stippliling was noted on the peripheral smear. Which of the following laboratory tests would be best applied? a) Whole blood lead* b) Urinary thiocyanate c) Carboyhemoglobin d) Urinary anabolic sterooids e) Uriniary benzoylecgonine 4) Compound A is reported to have an oral LD50 of 5mg/kg of body weight. Compound B is reported to have an LD 50 mg/kg of body weight. Of the following statements regarding the relative toxicity of these two compound, which is true? a) Ingestion of the low amounts of compound A would be predicted to cause more deaths than an equal dose of compound B.* b) Neither compound A nor compound B is toxic at any level of oral exposure c) Compound A is more rapidly absorbed from the gastrointestinal tract than compound B d) Ingestion of compound B would be expected to produce no toxic effects at a dose of greater than 100mg/kg of body weight e) Compound B would be predicted to be more toxic than compound A if the exposure route were transformed 5) Which of the following statements concerning cyanide toxicity is TRUE? a) All are true b) Inhalation of smoke from burning plastic is a common cause of cyanide exposure, and cyanide expresses its toxicity by inhibition of oxidative phosphorylation* c) Cyanide expresses its toxicity by inhibitionof oxidative phosphorylation

Chem ch 30 quizbank d) Inhalation of smoke from burining plstic is a common cause of cyanide exposure e) Cyanide is a relatively nontoxic compound that requires chronic exposure to produce toxic effects which of the following statements best describes the TD50 of a compound? a) The dosage of a substance that would produce therapeutic benefit in 50% of the population b) The percentage of individuals who would experience a toxic response at 50% of the lethal dose c) The dosage of a substance that s lethal to 50% of the population d) The dosage of a substance that would be expected to cause an toxic effect in 50% of the population* e) The percentage of the population who would experience a toxic reponse after an oral doeage of 50mg. What is the primary product of metabolism by the alcohol-aldehyde dehydrogenase system? a) Oxalic acid b) Acetaldehyde c) Formic acid* d) Acetone e) Formaldehyde Which of the following laboratory results would be consistent with acute high-level oral exposure to an inorganic form of mercury Hg2 ? a) All of these* b) None of these c) Positive occulut blood in stool d) Proteinuria e) High concentrations of mercury in a whole blood and urine A weakly acidic toxicin (PK=4.0) that is ingested will a) Passively absorbed in the colon PH =7.5 b) Not be absorbed because it is ionized c) Not be absorbed unless a specific transported is present d) Be passively absorbed in the stomach ph=3.0* e) Be absorbed only if a weak base is ingested at the same time A patient enters the emergency department in a coma. The physician suspects a drug overdose. Immunoassay screening tests for opiated barbiturates, benzodiazepines, THC, amphetamines, and PCP were all negative. No ethanol was detected in serum. Can the physician rule out drug overdose as the cause of the coma with these results? a) No* b) Yes c) Maybe?

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