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ACIMED

ISSN 1024-9435 versin impresa

ACIMED v.11 n.6 Ciudad de La Habana nov.-dic. 2003

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La Colaboracin Cochrane en Cuba. La produccin de informes sobre ensayos clnicos realizados en Cuba en las bases de datos Medline y en el Web of Science
Lic. Rubn Caedo Andalia,1 Juan A Arajo Ruiz,2 Ricardo Arencibia Jorge3 y Carlos Gutirrez Calzado4 Resumen Con el objetivo de identificar las publicaciones realizadas por autores cubanos para informar sobre los resultados de ensayos clnicos realizados en el pas, tanto en revistas nacionales como extranjeras, as como de ubicar la posicin de Cuba con respecto al resto de los pases iberoamericanos y de la regin, se explor la base de datos PubMed/Medline, disponible en Internet. Adicionalmente, se examinaron las bases de datos del Web of Science. Se hallaron 142 referencias a informes de ensayos clnicos publicados por autores cubanos, con la participacin o sin ella de autores de otros pases, en Medline. De ellas, 116 se encontraron en publicaciones extranjeras y 26 en nacionales. Cuba se ubic en el sexto lugar entre los 20 pases analizados del rea, segn la publicacin de informes sobre ensayos clnicos, donde el primer autor labora en una organizacin perteneciente a dicho pas. Iberoamrica, como regin, gener un nmero de trabajos similar a la que muestra Finlandia; sin embargo, ms de la mitad de esta produccin se concentr slo en dos pases: Brasil y Mxico. Es imprescindible una visin, una conciencia, una infraestructura, una organizacin y una voluntad poltica de los pases de la regin para estimular la actividad clnicoinvestigativa de los pases en Iberoamrica. Descriptores (DeCS): ENSAYOS CLINICOS; INVESTIGACIN; BASES DE DATOS /utilizacin; COOPERACIN INTERNACIONAL; AUTORIA; AMERICA LATINA; CUBA Descriptores (DeCI): PROYECTOS DE INVESTIGACIN; BASES DE DATOS BIBLIOGRAFICAS; BIBLIOGRAFA DE MEDICINA; COOPERACIN INTERNACIONAL; AUTORIA; AMERICA LATINA; CUBA Abstract Pub/Medline database, available in the Internet, was explored aimed at identifying the publication of clinical trial result reports by Cuban authors in national and foreing journals as well as the position of Cuba with regard to the rest of the Iberoamerican countries. The Web of Science was also examined. In Medline, 142 references of clinical trial reports published by Cuban authors were found: 116 in foreing publications and 26 in national journals. Cuba is situated in the 6th place among the 20 countries analyzed according to the production reports where the first author correspond to that country. According the last indicator, Iberoamerica produced a work number similar to those produced by Denmark. Nevertheless, most of the half of this production is located in two countries: Brasil and Mexico. A vision, a conciousness, a frame and also a political willingness of the countries to encourage the clinical research activity of Iberoamerican countries is deeply needed Subject headings (DeCS): CLINICAL TRIALS; RESEARCH; DATABASES,/utilization; INTERNATIONAL COOPERATION; AUTHORSHIP; LATIN AMERICA; CUBA

Subject headings (DeCI): RESEARCH PROJECTS; DATABASES, BIBLIOGRAPHIC; BIBLIOGRAPHY OF MEDICINE; INTERNATIONAL COOPERATION; AUTHORSHIP; LATIN AMERICA; CUBA El ejercicio de una asistencia mdica basada en la evidencia (MBE) ha dejado de ser una simple propuesta terica para convertirse en un fenmeno en expansin que alcanza hoy todos los rincones de la prctica clnica moderna. Los ensayos clnicos, un tipo de estudio planificado con anterioridad, para establecer la seguridad, eficacia y dosificacin de uno o ms drogas profilcticas, teraputicas o diagnsticas, as como de equipos o tcnicas seleccionadas de acuerdo con criterios predeterminados de eligibilidad y evidencias de sus efectos favorables o desfavorables, constituyen la piedra angular de la investigacin clnica actual y el soporte esencial de los metanlisis y las revisiones sistemticas, los estudios integradores y sintetizadores, que conforman, a su vez, las bases donde se sustenta la prctica de la MBE. La realizacin de ensayos clnicos, y la consecuente publicacin de sus resultados, constituye un indicador confiable para medir el nivel alcanzado por la investigacin clnica en un pas. Cuba, un pas con un inters especial en el rea de los ensayos clnicos, derivado de su pujante industria mdico- farmacutica y de la bsqueda constante de una mejor atencin clnica de su poblacin, se enfrenta ahora a la tarea de insertarse en la fuerte corriente de desarrollo que genera la MBE a escala internacional. Y no son pocos los trabajos que se han realizado en un corto periodo de tiempo.1-3 Mtodos Con el objetivo de identificar las publicaciones realizadas con la participacin de autores cubanos para informar sobre los resultados de ensayos clnicos realizados en el pas, tanto en revistas nacionales como extranjeras, se explor la base de datos PubMed/Medline, disponible en Internet. Para ello, se emple la estrategia de bsqueda siguiente: Estrategia de bsqueda 1: (clinical trial) OR (controlled clinical trial) OR (randomized controlled trial) in PT PT es el tipo de publicacin. 2: Nombre del pas [AD] AD es el campo donde se coloca la afiliacin del primer autor del informe. Si el nombre del pas es compuesto, por ejemplo, Costa Rica: 2: Costa AND Rica [AD] Si el nombre del pas, se escribe de formas diferentes, la bsqueda se realiz por cada una de sus equivalencias, por ejemplo: 2: Brasil [AD] 2: Brasil [AD] 3: # 1 AND # 2 Y as sucesivamente, con cada uno de los 20 pases integrantes del territorio iberoamericano. Adicionalmente, y con el objetivo de ampliar la bsqueda de informes de ensayos clnicos publicados por autores cubanos, se realiz una exploracin de las bases de datos del Web of Science. Para este propsito, se utiliz la siguiente estrategia de bsqueda: 1: Cuba Author, Adress 2: Randomized controlled trial All 3: Controlled clinical trial All

4: Clinical trial All 5: #1 AND (#2 OR #3 or #4) Y con el propsito de ubicar la posicin que ocupa Cuba entre los pases iberoamericanos y de la regin con respecto a algunos pases desarrollados seleccionados de acuerdo con su produccin de informes sobre ensayos clnicos, se realiz una bsqueda por pases en la base de datos Medline. La medicin se realiz de acuerdo con el nmero de informes sobre ensayos clnicos cuyo primer autor se afilia a una institucin ubicada en el pas estudiado. Las bsquedas se realizaron entre los das 25 y 27 de agosto del ao 2003. Resultados y discusin Cuba aparece relacionada en 3 064 registros en Medline (27 de agosto del 2003). No obstante, aparece en 2 192 registros en el campo de afiliacin. En Medline, el campo afiliacin (AD) registra, como se conoce, la organizacin donde labora el primer autor del trabajo. El total de ensayos clnicos publicados con la participacin de autores cubanos en revistas extranjeras, identificados en Medline -on line y off line-, asciende a 142. De ellos 26, (18,30) se publicaron en las tres revistas cubanas de medicina procesadas por Medline y 116 (81,69) en revistas extranjeras (tabla 1) (anexos 1 y 2). Tabla 1. Ensayos clnicos publicados en revistas cubanas, registrados en Medline. Revista Rev Cubana Med Trop Rev Cubana Estomatol Rev Cubana Enferm Totales Nmero de trabajos 1 008 314 194 1 516 Nmero de ensayos clnicos 12 8 6 26

Fuente: Medline, 25 de agosto del 2003. El nmero de ensayos identificados en el Web of Science, alcanza la cifra de 56 trabajos (anexo 3). Dicha cifra es el resultado de la eliminacin de los registros duplicados con la base de datos Medline. El primer informe sobre un ensayo clnico realizado en Cuba, publicado en una revista extranjera y registrado en Medline, corresponde al ao 1973. Se trata de un artculo donde se informan los resultados preliminares de un estudio realizado en el pas con el cromiglicato disdico. Los primeros ensayos registrados en una revista cubana procesada por esta base de datos se ubican en el ao 1974 y corresponden a dos estudios publicados en la Revista Cubana de Estomatologa. El primer ensayo clnico aleatorio se public en 1948 en la British Medical Journal. Y es comprensible que Cuba durante las dos dcadas que siguieron a la publicacin del primer ensayo clnico en el mundo no incursionara en la realizacin de esta clase de estudios. En 1959, la Revolucin se encontr con un pas prcticamente sin mdicos y sin una infraestructura de salud que posibilitara la atencin de la poblacin. La primera prioridad fue entonces crear un sistema de salud nacional que permitiera satisfacer las necesidades de salud de una creciente poblacin, realmente una tarea muy difcil y costosa. Sin embargo, no es hasta la dcada de los aos 90, cuando la actividad investigativa en el rea de los ensayos adquiere un lugar prominente dentro de la investigacin en salud en el pas. La creacin del Polo del Oeste y de otros polos de investigacin en el pas, unido a las necesidades de la industria mdicofarmacutica cubana impulsaron significativamente la generalizacin del ensayo clnico como va para obtener pruebas slidas sobre la eficacia de los productos nacionales, un requisito indispensable para su comercializacin y consumo.

El balance de informes publicados en revistas nacionales y extranjeras, procesadas por Medline, as como las debilidades actuales de las revistas cubanas de medicina aconsejan la edicin de estudios clnicos relevantes en revistas visibles internacionalmente, con el objetivo de obtener una mayor difusin de los estudios realizados en el pas. Cuba en Iberoamrica Cuba, segn el indicador utilizado para establecer la posicin que ocupa entre los pases iberoamericanos, donde se mide su liderazgo en la actividad de investigacin en el rea de los ensayos clnicos, se ubic en el sexto lugar detrs de Brasil, Mxico, Argentina, Chile y Venezuela, con 140 registros (tabla 2). Tabla 2. Distribucin de la produccin de ensayos clnicos segn pas en Iberoamrica (1966-2003). Total de ensayos clnicos 1 511 862 621 425 151 140 109 93 71 57 39 38 31 23 11 10 5 4 3 2 4 206 Total de registros 40 106 16 656 17 101 8 112 3 371 2 185 1 642 837 1 920 1 182 330 327 730 560 149 46 30 84 61 250 95 679

Pas (Equivalencias) Brasil (Brasil, Brasil) Mxico Argentina Chile Venezuela Cuba Colombia Per Puerto Rico Uruguay Guatemala Ecuador Costa Rica Panam Bolivia Repblica Dominicana El Salvador Nicaragua Honduras Paraguay Total

Fuente: Medline, 25 de agosto del 2003. Nota: Los trabajos pueden haberse publicado en revistas pertenecientes a los pases de los autores o a otros pases. Es oportuno aclarar que esta cifra no se corresponde con el total de referencias a ensayos clnicos,lo que se anexa a esta exposicin, debido a las diferencias que introduce la revisin manual de los registros. Y en este punto es oportuno indicar que Cuba, segn estos resultados, se halla en una posicin un tanto rezagada con respecto a sus aspiraciones. La accin de factores objetivos y subjetivos, como la carencia de una alta disciplina y profesionalidad editorial entre las revistas cubanas y la carencia de una adecuada cultura de publicacin, ha impedido que muchos estudios clnicos de calidad ingresaran oportunamente a las bases de datos internacionales para obtener la visibilidad necesaria.2

En general, se aprecian considerables diferencias en la produccin de informes de ensayos clnicos entre los pases de la regin. As, por ejemplo, Brasil y Mxico produjeron ms trabajos que el resto de los pases. Muy pocos pases, Brasil, Mxico, Argentina, Chile, Venezuela, Cuba y Colombia han generado 100 o ms trabajos, cuyo primer autor pertenece a una institucin del pas. Iberoamrica en el mundo Con el fin de comparar la actividad investigativa en materia de ensayos clnicos de los pases iberoamericanos y de la regin en general, con respecto al mismo indicador, medido en algunos pases desarrollados, se realizaron bsquedas similares a las efectuadas para establecer la participacin de los pases del centro y el sur de Amrica. La exploracin segn regiones de inters contempladas en el MESH, mediante una estrategia que incluy slo el nombre del rea y el tipo de publicacin, permiti establecer la existencia de una cierta inclusin de Amrica del Sur (859), Amrica Latina (267) y Amrica Central (156) en las investigaciones clnicas, en particular como objeto de estudio de ensayos realizados simultneamente en varios pases. Si se suman los totales particulares de ensayos clnicos generados segn pas, puede decirse que cuantitativamente Iberoamrica presenta una produccin similar a la que muestra Finlandia como pas (tabla 3). Tabla 3. Distribucin de la produccin de ensayos clnicos en pases industrializados seleccionados. Pas (Equivalencias) Estados Unidos (USA) Reino Unido (United Kingdom, UK) Italia (Italy) Alemania (Germany) Japn (Japan) Canad (Canada) Francia (France) Holanda (Netherlands) Suecia (Sweden) Australia (Australia) Dinamarca (Denmark) Finlandia (Finland) Espaa (Spain) Suiza (Switzerland) Nmero de ensayos clnicos 70 246 20 189 14 952 14 625 11 991 10 793 10 699 9 730 7 673 5 949 4 754 4 296 3 829 3 648 Nmero de trabajos 1 182 384 416 243 173 189 230 256 421 209 184 056 207 003 116 118 99 978 105 076 47 083 44 835 86 789 59110

Fuente: Medline, 25 de agosto del 2003 Es imprescindible no slo incrementar la actividad clnico-investigativa de la regin como un todo, sino fortalecer la actividad en cada pas en particular. Sin embargo, dicha tarea es sumamente ardua y, sin una conciencia nacional sobre su importancia, una infraestructura, una organizacin y un empeo colectivo, es prcticamente imposible, debido a los recursos y a la coordinacin requerida. Para muchos puede significar partir de cero, y ello exige mucha visin, para lograr ver ms all de los agobiantes problemas que enfrentan a diario las autoridades y los pueblos de Iberoamrica. Antes de concluir el presente trabajo, deseamos tratar un ltimo aspecto: las limitaciones de las bsquedas automatizadas para identificar ensayos clnicos. No son pocas las bases de datos, y no es precisamente el caso de Medline, en que es imposible prcticamente recuperar automticamente estudios con las

caractersticas exigidas para los ensayos clnicos. Sin embargo, an en Medline, una bsqueda de esta clase de estudios requiere de una revisin manual para eliminar algunos registros que realmente no corresponden con el tipo de publicacin buscado. Los resultados de los ensayos clnicos no aparecen slo en forma de artculos originales, sino tambin de cartas, editoriales, revisiones tradicionales y tutoriales, entre otros, entre los que es necesario seleccionar aquellos que verdaderamente contienen resultados originales de ensayos clnicos. En ciertas ocasiones, no se encuentra disponible el resumen del trabajo, imprescindible para determinar si se cumplen con los requisitos exigidos para este tipo de informes. As, por ejemplo, entre los 141 ensayos clnicos publicados por autores cubanos, procesados en PubMed/Medline, slo 66 fueron ensayos controlados aleatorios y una cifra menor, 17, ensayos controlados (27 de agosto del 2003). Y es loable, el esfuerzo realizado por la Biblioteca Nacional de Medicina de los Estados Unidos para facilitar las bsquedas de esta clase en sus bases de datos. Pero, an con los esfuerzos realizados, la presencia de uno o varios revisores manuales, es imprescindible para aportarle una mayor exactitud a los resultados. Ambas vas para la bsqueda, la manual y la automatizada, son complementarias y cada una tiene su propia funcin. A los efectos de este estudio, se analizaron los ensayos clnicos en su totalidad, sin consideracin o distincin a su carcter controlado o aleatorio como exige la Colaboracin Cochrane para su registro en sus bases de datos. Con vistas a la profundizacin de los resultados del presente estudio, es aconsejable la realizacin de un anlisis informtrico sobre el flujo iberoamericano de informes de ensayos clnicos en el futuro. Anexo 1. Ensayos clnicos publicados en revistas cubanas, procesadas por Medline. Revista Cubana de Estomatologa 1- TI - [Clinical validation of the caries preventive effect of mouth rinses with] AU - Rodrguez Mir MJ, Rodrguez Lucas A, Gispert Abru E, Fonte Martnez M. LA - spa PT - Clinical Trial PT - Journal Article TT - Comprobacin clnica del efecto preventivo de caries de los enjuagues bucales con la solucin mineralizante sobre la denticin permanente recin brotada. PL - CUBA SO - Rev Cubana Estomatol 1989 Jul-Sep;26(3):207-18. 2- TI - [Clinical trial of a caries preventive treatment based on the remineralization of the enamel: a preliminary study] AU - Rodrguez Mir MJ, Guerra Deben J, Wasersztejn M, Depres PA. LA - spa PT - Journal Article TT - Ensayo clnico del tratamiento preventivo de caries basado en la remineralizacin del esmalte: estudio preliminar. PL - CUBA SO - Rev Cubana Estomatol 1983 Jan-Apr;20(1):74-85. 3- TI - [Postoperative period in oral surgery and its socioeconomic aspect] AU - Mendez LD, lvarez JC. LA - spa PT - Clinical Trial PT - Journal Article TT - El posoperatorio en ciruga bucal y su aspecto socioeconmico.

PL - CUBA SO - Rev Cubana Estomatol 1974 Sep-Dic;11(3):197-203. 4- TI - [Dental caries preventive program for Cuban school children based on gargles with sodium fluoride solution] AU - Chao RB LA - spa PT - Clinical Trial PT - Journal Article TT - Programa preventivo de la carie dental a escolares de Cuba, basado en enjuagatorios con solucin de fluoruro de sodio. PL - CUBA SO - Rev Cubana Estomatol 1974 Sep-Dic;11(3):221-8. 5- TI - [Ectopic incisors] AU - Otero MB LA - spa PT - Clinical Trial PT - Journal Article TT - Incisivos ectpicos. PL - CUBA SO - Rev Cubana Estomatol 1974 Sep-Dic;11(3):213-20. 6- TI - [Morphological study on streptococcus colonies of dental plaque] AU - Rodrguez Mir M, Villafuerte JR, Puentes Daz JR LA - spa PT - Clinical Trial PT - Journal Article TT - Estudio morfolgico de las colonias de los estreptococos de la placa. PL - CUBA SO - Rev Cubana Estomatol 1974 May-Aug;11(2):109-15. 7- TI - [Determination mesiodistal diameter of permanent teeth in 307 Cuban patients] AU - Cubero W, Wong G, Vzquez L, Valds F, Fuster H, Cano V LA - spa PT - Clinical Trial PT - Journal Article TT - Determinacin del dimetro mesiodistal de dientes permanentes en 307 pacientes cubanos. PL - CUBA SO - Rev Cubana Estomatol 1974 Jan-Apr;11(1):57-63. 8- TI - [Comparison of dental caries incidence in children with or without topical application of sodium fluoride after 42 months] AU - Soto Padrn F AU - Kunzel W LA - spa PT - Clinical Trial PT - Journal Article TT - Comparacin de la frecuencia de carie dental en los nios con la aplicacin local de solucin de fluoruro sdico, o sin ella, al cabo de 42 meses. PL - CUBA SO - Rev Cubana Estomatol 1974 Jan-Apr;11(1):3-8. Revista Cubana de Enfermera 9- TI - [Computerized simulations in nursing education. Faculty of Medical Sciences of Pinar del Ro, 1982-1995]

AD - Facultad de Ciencias Mdicas Pinar del Ro. AU - Pozo Madera E, lvarez Miranda L, Roble Surez A, Ascuy Lezcano M LA - spa PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article TT - Las simulaciones computarizadas en la enseanza de enfermera. Facultad de Ciencias Mdicas De Pinar del Ro. 1992-1995. PL - CUBA SO - Rev Cubana Enferm 1998 May-Aug;14(2):112-6. 10- TI - [Results of preoperative preparation with mannitol in colorectal surgery. January-December 1995] AD - Hospital Provincial Docente Saturnino Lora, Santiago de Cuba. AU - Torres Panuncia B, Rodrguez Fernndez Z, Pina Prieto LR LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - Resultados de la preparacin preoperatoria con manitol en ciruga colorrectal. Enero-Diciembre, 1995. PL - CUBA SO - Rev Cubana Enferm 1998 May-Aug;14(2):107-11. 11- TI - [Adequate programming of weight loss and liquid extraction during dialysis] AU - Garca Lpez M, Martnez Arguello MA LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - Programacin adecuada de la prdida de peso y extraccin de lquidos en dilisis. PL - CUBA SO - Rev Cubana Enferm 1995 Jul-Dic;11(2):125-32. 12- TI - [Education in primary health care. Diagnostic evaluation of teaching using microcomputers] AU - dos Santos BR, Brandt Funcke L, Boettcher Schneider J, Santos de Souza S, Duarte de Oliveira S, Krilow I LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - La educacin de cuidados primarios de salud. Evaluacin diagnstica y de la formacin mediante microcomputadores. PL - CUBA SO - Rev Cubana Enferm 1995 Jul-Dic;11(2):114-24. 13- TI - [Use of Cuban recombinant streptokinase. Nursing care] AU - Arcia Lumpuy S, Lopez Pedrosa GL LA - spa PT - Clinical Trial PT - Journal Article TT - Uso de la estreptoquinasa recombinante Cubana. Atencin de enfermera. PL - CUBA SO - Rev Cubana Enferm 1995 Jul-Dic;11(2):79-86. 14- TI - [Vaginal parasites and acute cervicitis: local treatment with propolis. Preliminary report] AU - Santana Prez E, Lugones Botell M, Prez Stuart O, Castillo Brito B. LA - spa PT - Clinical Trial PT - Journal Article

PT - Randomized Controlled Trial TT - Parasitismo vaginal Y cervicitis aguda: tratamiento local con propoleo. Informe preliminar. PL - CUBA SO - Rev Cubana Enferm 1995 Jan-Jun;11(1):51-6. Revista Cubana de Medicina Tropical 15- TI - [A comparative study between different regimens for administering 2 doses of the Cuban antihepatitis B vaccine] AD - Centro de Ingenieria Genetica y Biotecnologia, Ciudad de La Habana,Cuba. AU - Gonzlez-Griego Mde J, Cinza Z, Ortega A, Gali MM, Santoyo ME, Garca G, Delahanty A. LA - spa PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article TT - Estudio comparativo entre diferentes esquemas de administracin de 2 dosis con la vacuna cubana antihepatitis B. PL - CUBA SO - Rev Cubana Med Trop 1998;50(3):218-20. 16- TI - [The reactogenicity and immunogenicity of the first Cuban vaccine against human leptospirosis] AD - Instituto de Medicina Tropical Pedro Kour, Ciudad de La Habana, Cuba. AU - Martnez Snchez R, Obregn Fuentes AM, Prez Sierra A, Baly Gil A, Daz Gonzlez M, Bar Surez M, Menndez Capote R, Ruiz Prez A, Sierra Gonzlez G, Lpez Chvez AU LA - spa PT - Clinical Trial PT - Clinical Trial, Phase I PT - Journal Article PT - Randomized Controlled Trial TT - Reactogenicidad e inmunogenicidad de la primera vacuna cubana contra la leptospirosis humana. PL - CUBA SO - Rev Cubana Med Trop 1998;50(2):159-66. 17- TI - [Immunogenicity of the Heberbiovac-HB vaccine in the physically and mentally handicapped] AD - Instituto de Medicina Tropical Pedro Kour. AU - Pedroso Flaquet P, Daz Gonzlez M, Rodrguez Lay L, Bravo Gonzlez JR. LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - Inmunogenicidad de la vacuna Heberbiovac-HB en impedidos fsicos y mentales. PL - CUBA SO - Rev Cubana Med Trop 1997;49(1):59-63. 18- TI - [The immunogenicity of the Heberbiovac-HB vaccine in the elderly] AD - Instituto de Medicina Tropical Pedro Kour. AU - Pedroso Flaquet P, Daz Gonzlez M, Rodrguez Lay L, Bravo Gonzlez R. LA - spa PT - Clinical Trial PT - Journal Article TT - Inmunogenicidad de la vacuna Heberbiovac-HB en ancianos. PL - CUBA SO - Rev Cubana Med Trop 1996;48(3):200-3. 19- TI - [The immunogenicity of the Heberbiovac-HB vaccine in children] AD - Instituto de Medicina Tropical Pedro Kour. AU - Daz Gonzlez M, Chiang Maca A, Daz Acosta D, Bravo Gonzlez JR, Rodrguez Lay L, Pedroso Flaquet P, Lpez-Chvez AU.

LA - spa PT - Clinical Trial PT - Journal Article TT - Inmunogenicidad de la vacuna Heberbiovac-HB en nios. PL - CUBA SO - Rev Cubana Med Trop 1996;48(3):195-8. 20- TI - [The reactogenicity of Heberbiovac-HB vaccine at different doses] AD - Instituto de Medicina Tropical Pedro Kour. AU - Daz Gonzlez M, Navia Molina O, Bravo Gonzlez JR, Pedroso Flaquet P, Urbino Lpez A LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - Reactogenicidad de la vacuna Heberbiovac-HB a diferentes dosis. PL - CUBA SO - Rev Cubana Med Trop 1995;47(1):65-70. 21- TI - [Evaluation of the counterimmunoelectrophoresis technique for the serologic diagnosis of leptospirosis] AD - Instituto de Medicina Tropical Pedro Kour. AU - Obregn Fuentes AM, Lpez Acosta C, Prez Herrera C. LA - spa PT - Clinical Trial PT - Journal Article TT - Evaluacin de la tcnica de contrainmunoelectroforesis para el diagnstico serolgico de la leptospirosis. PL - CUBA SO - Rev Cubana Med Trop 1993;45(1):67-71. 22- TI - [Standardization of an inhibition ELISA technique for the serologic diagnosis of coxsackie virus group B infections] AD - Instituto de Medicina Tropical Pedro Kour. AU - Balmaseda Hechavarra A, Mas Lago P, Vzquez Ramudo S, Comellas Fernndez MM. LA - spa PT - Clinical Trial PT - Journal Article TT - Normalizacin de un ELISA de inhibicin para el diagnstico serolgico de las infecciones por virus coxsackie del grupo B. PL - CUBA SO - Rev Cubana Med Trop 1993;45(1):63-6. 23- TI - [Field trial of the Cuban recombinant vaccine against hepatitis B (Heberbiovac HB). Study in newborn infants born to AgsHB+ mothers] AD - Instituto de Medicina Tropical Pedro Kour. AU - Galbn Garca E, Bravo Gonzlez JR, Castaneda Guillot C, Toledo Curbelo G, Gonzlez Griego A, Delgado Gonzlez MG. LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - Ensayo de campo de la vacuna recombinante cubana contra la hepatitis B Heberbiovac HB). Estudio en recin nacidos, hijos de madres AgsHB+. PL - CUBA SO - Rev Cubana Med Trop 1992;44(2):149-57. 24- TI - [Evaluation of the anti-influenza vaccine in students from basic high school] AU - Prez Rodrguez AE, Gonzlez Ochoa E, de Armas Prez L, Goyenechea Hernndez A.

LA - spa PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article TT - Evaluacin de la vacuna antigripal en escolares de secundaria bsica. PL - CUBA SO - Rev Cubana Med Trop 1989 Sep-Dic;41(3):419-34. 25- TI - [Acute intestinal amebiasis treated with aminosidine] AU - Fernndez Hernndez H, Porro Abdo Y, Ciolli Martnez M. LA - spa PT - Clinical Trial PT - Journal Article TT - Amebiasis intestinal aguda tratada con aminosidina. PL - CUBA SO - Rev Cubana Med Trop 1977 Sep-Dic;29(3):153-61. 26- TI - [1st clinical therapeutic trial of mebendazole in some cases of helmenthiasis in Cuba] AU - Otero Domnguez R, Glvez Oviedo M, Estvez Cazallas B. LA - spa PT - Clinical Trial PT - Journal Article TT - Primer ensayo clnico-teraputico en Cuba con mebendazole en algunas helmintiasis. PL - CUBA SO - Rev Cubana Med Trop 1977 Jan-Apr;29(1):13-6. Total: 26 registros Anexo 2. Relacin de ensayos clnicos publicados con la participacin de autores cubanos en revistas extranjeras. 1973 1- TI - [Disodium cromoglycate: preliminary report of its clinical trial in Cuba] AU - Gmez Echevarra AH, Santn Gmez JM, Fernndez LA, Prez Rodrguez R, Banderas NP, Garca AB, Cabrera Jimnez M, Rodrguez AA, Hernndez Valds A, Mico GS, Machado RG. LA - spa PT - Journal Article TT - Cromoglicato disdico: comunicacin preliminar de su ensayo clnico en Cuba. PL - MXICO SO - Alergia 1973 Aug;21(1):21-30. 1981 2- TI - Phase I clinical trial of two contraceptive preparations. Norethisterone enanthate (NEN) and norethisterone acetate (NET). AU - Andino N LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - UNITED STATES SO - Contraception 1981 Feb;23(2):141-55.

1982 3- TI - Minilaparotomy or laparoscopy for sterilization: a multicenter, multinational randomized study. World Health Organization, Task Force on Female Sterilization, Special Programme of Research, Development and Research Training in Human Reproduction. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - UNITED STATES SO - Am J Obstet Gynecol 1982 Jul 15;143(6):645-52. 1985 4- TI - Oral poliovirus vaccine: history of its development and use and current challenge to eliminate poliomyelitis from the world. AU - Sabin AB. LA - eng PT - Clinical Trial PT - Journal Article PL - UNITED STATES SO - J Infect Dis 1985 Mar;151(3):420-36. 1988 5- TI - [Clinical trial with a preparation based on propolis "propolisina" in human giardiasis] AD - Centro de Histoterapia Placentaria, La Habana, Cuba. AU - Miyares C, Hollands I, Castaneda C, Gonzlez T, Fragoso T, Curras R, Soria C. LA - spa PT - Clinical Trial PT - Journal Article TT - Ensayo teraputico con un preparado a base de propoleo "propolisina" en la giardiasis del humano. PL - ARGENTINA SO - Acta Gastroenterol Latinoam 1988;18(3):195-201. 1989 6- TI - The WHO multicentre trial of the vasopressor effects of combined oral contraceptives: 2. Lack of effect of estrogen. Task Force on Oral Contraceptives. WHO Special Programme of Research, Development and Research Training in Human Reproduction. LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - UNITED STATES SO - Contraception 1989 Aug;40(2):147-56. 1991 7- TI - Vaccine against group B Neisseria meningitidis: protection trial and mass vaccination results in Cuba. AD - Finlay Institute, Center for Research and Production of Vaccines and Sera, Havana, Cuba. AU - Sierra GV, Campa HC, Varcacel NM, Garca IL, Izquierdo PL, Sotolongo PF, Casanueva GV, Rico CO, Rodrguez CR, Terry MH.

LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - NORWAY SO - NIPH Ann 1991 Dec;14(2):195-207; discussion 208-10. 8- TI - [The inoculation properties of live recombinant influenza vaccine types A and B used separately and jointly in children 3 to 14] AU - Rudenko LG, Ramirez A, Barro M, Gushchina MI, Armanda RE, Ermachenko TA, Romanova IuR, Grigor'eva EP, Aleksandrova GI, Lonskaia NI. LA - rus PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - Privivochnye svoistva zhivoi grippoznoi rekombinantnoi vaktsiny tipov A i B pri razdel'nom i sovmestnom primenenii detiam 3--14 let. PL - USSR SO - Vopr Virusol 1991 Nov-Dec;36(6):472-4. 9- TI - [A comparative study of celiprolol and nicardipine in stable angina of effort] AD - Hospital Clnico- Quirrgico Hermanos Ameijeiras, Instituto de Cardiologa y Ciruga Cardiovascular,Cuba AU - Prohias Martnez JA, Chaple M, Rivero-Varona MM, Hernndez-Acosta K, Toruncha-Chukram A, Garca-Barreto D. LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - Efecto comparativo de celiprolol y nicardipina en angina de esfuerzo estable PL - MXICO SO - Arch Inst Cardiol Mex 1991 Jul-Aug;61(4):345-9. 10 TI - [Atopic dermatitis. Treatment with transfer factor. A controlled clinical trial] AD - Servicio de alergologa del Hospital Clnico Quirrgico Hermanos Ameijeiras, La Habana, Cuba. AU - Valds Snchez AF, Fernndez Ortega C, Gmez Echeverra AH, Gillama Niebla E, Lastra Alfonso G, Lpez Saura P. LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - Dermatitis atpica. Tratamiento con factor de trasferencia. Ensayo clnico controlado PL - MXICO SO - Rev Alerg 1991 Nov-Dic;38(6):158-62. 11- TI - [The effect of vitamin C on the lipolytic activity in type-II diabetics with angiopathy] AD - Instituto de Angiologa y Ciruga Vascular, Ciudad de La Habana, Cuba. AU - Triana Mantilla ME, Simn Carballo R, Fernndez Montequn JI, Lima Santana B, Cardona lvarez

ME, Morejn Reinoso O. LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - "Efecto de la vitamina C sobre la actividad lipoltica en pacientes diabticos tipo II con angiopata". PL - SPAIN TA - Angiologa SO - Angiologa 1991 Mar-Apr;43(2):77-81. 12- TI - [The antioxidative activity of drugs in the liver microsomal system of rats] AU - Novikov KN, Herrera M, Pascual C, Gonzlez R. LA - rus PT - Clinical Trial PT - Journal Article PT - Multicenter Study TT - Antiokislitel'naia aktivnost' nekotorykh lekarstv v mikrosomal'noi sisteme pecheni krys. PL - USSR SO - Nauchnye Doki Vyss Shkoly Biol Nauki 1991;(12):19-27. 1992 13- TI - All-trans retinoic acid in acute promyelocytic leukemia: preliminary results in Cuba. AB - Seven patients with acute promyelocytic leukemia (APL) were treated with all-trans retinoic acid (ATRA). Five (71.4%) achieved complete remission (CR). Most side effects were transient and well tolerated. Hyperleukocytosis was the major adverse effect. These observations confirm the efficacy of ATRA for inducing CR in APL. AD - Instituto de Hematologia e Inmunologia, Ciudad de La Habana, Cuba. AU - Hernndez P, Carnot J, Dortics E, Espinosa E, Gonzlez A, Rodrguez I. LA - eng PT - Clinical Trial PT - Journal Article PL - GERMANY SO - Ann Hematol 1992 Sep;65(3):121-3. 14- TI - Recombinant streptokinase for the treatment of thrombotic disorders. AD - Centro de Ingeniera Gentica y Biotecnologa, Havana, Cuba. AU - Hernndez L, Rodrguez P, Serrano R, Munoz E, Estrada MP, Dela Fuente J, Herrera L. LA - eng PT - Clinical Trial PT - Journal Article PL - UNITED STATES SO - Ann N Y Acad Sci 1992 Dec 4;667:424-7. 15- TI - Inhibition of human monocyte function by prophylactic doses of chloroquine. AD - Departamento de Parasitologa, Instituto de Medicina Tropical Pedro Kour (IPK), Havana, Cuba. AU - Osorio LM, Fonte L, Finlay CM. LA - eng PT - Clinical Trial PT - Journal Article

PT - Randomized Controlled Trial PL - UNITED STATES SO - Am J Trop Med Hyg 1992 Feb;46(2):165-8. 16- TI - An update of the results of intensive therapy in children with acute lymphoblastic leukemia. AU - Pavlovsky S, Sackmann Muriel F, Santarelli MT, Svarch E, Jimnez E, Kohan R, Rosso A. LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PL - ENGLAND SO - Leukemia 1992;6 Suppl 2:167-70. 1993 17- TI - Comparative study on the efficacy and acceptability of two contraceptive pills administered by the vaginal route: an international multicenter clinical trial. AD - Maternidade Climerio de Oliveira, Federal University of Baha, Salvador,Brasil AU - Coutinho EM, de Souza JC, da Silva AR, de Acosta OM, lvarez F, Brache V, Garza Flores J, Vsquez-Estrada L, Santo R, Bassol S, et al. LA - eng PT - Clinical Trial PT - Journal Article PL - UNITED STATES SO - Clin Pharmacol Ther 1993 Jan;53(1):65-75. 18- TI - [Treatment of extrinsic bronchial asthma with transfer factor] AD - Servicio de Alergologa, Hospital Clnico Quirrgico Hermanos Ameijeiras, La Habana, Cuba. AU - Valds Snchez AF, Martn Rodrguez OL, Lastra Alfonso G. LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - Tratamiento del asma bronquial extrnseca con factor de trasferencia. PL - MXICO SO - Rev Alerg Mex 1993 Sep-Oct;40(5):124-31. 19- TI - Treatment of schizophrenic disorder, paranoid type, with intramuscular recombinant alpha-2b interferon. AD - Hosp. Provincial Dr. Gustavo Alderegua, Cienfuegos, Cuba. AU - Cabrera Gmez JA, Cordero Gutirrez JR, Fernndez Lpez O, Reyes Gutirrez B, Romero Garca K, Simn Consuegra J, Feas Cruz R, Gonzlez Quevedo A, Alfaro Capdegille I, Del Pino Falcn M, et al. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - NETHERLANDS SO - Biotherapy 1993;7(1):27-37. 20- TI - [Arteriosclerosis obliterans and ozone therapy. Its administration by different routes] AD - Instituto de Angiologa y Ciruga Vascular, La Habana, Cuba. AU - Romero Valds A, Blanco Gonzlez R, Menndez Cepero S, Gmez Moraleda M, Ley Pozo J.

LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - Ateroesclerosis obliterante y ozonoterapia. Administracion por diferentes vias. PL - SPAIN SO - Angiologa 1993 Sep-Oct;45(5):177-9. 21- TI - [Ozone therapy in the advanced stages of arteriosclerosis obliterans] AD - Instituto Nacional de Angiologa y Ciruga Vascular, La Habana, Cuba. AU - Romero Valds A, Menndez Cepero S, Gmez Moraleda M, Ley Pozo J. LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - La ozonoterapia en los estadios avanzados de la aterosclerosis obliterante. PL - SPAIN SO - Angiologa 1993 Jul-Aug;45(4):146-8. 22- TI - Effect of transfer factor on myelosuppression and related morbidity induced by chemotherapy in acute leukaemias. AD - Hospital Universitario Dr. Carlos J. Finlay, Marianao, Cuba. AU - Fernndez O, Daz N, Morales E, Toledo J, Hernndez E, Rojas S, Madriz X, Lpez Saura P. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - ENGLAND SO - Br J Haematol 1993 Jul;84(3):423-7. 23- TI - [The immunogenic properties and prophylactic efficacy of a live polyvalent influenza vaccine in children 5 to 14 years old] AU - Grigor'eva EP, Rekstin AR, Rudenko LG, Ramirez A, Barro M, Lisovskaia KV, Klimov AI, Aleksandrova GI. LA - rus PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article TT - Izuchenie immunogennykh svoistv i profilakticheskoi effektivnosti zhivoi grippoznoi polivalentnoi vaktsiny u detei 5--14 let. PL - RUSSIA SO - Vopr Virusol 1994 Jan-Feb;39(1):26-9. 24- TI - Measurements of postmenopausal bone loss with a new contact ultrasound system. AD - Department of Nuclear Medicine, Guy's Hospital, London, UK. AU - Herd RJ, Blake GM, Ramalingam T, Miller CG, Ryan PJ, Fogelman I. LA - eng PT - Clinical Trial PT - Journal Article PL - UNITED STATES SO - Calcif Tissue Int 1993 Sep;53(3):153-7. 1994

25- TI - The Latin American Multicenter Trial on psychosocial support during pregnancy: methodology and baseline comparability. Latin American Network for Perinatal and Reproductive Research (LANPER). AD - Centro de Pesquisas Epidemiologicas, Universidade Federal de Pelotas, Brasil. AU - Victora CG, Langer A, Barros F, Belizan J, Farnot U, Villar J. LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - UNITED STATES SO - Control Clin Trials 1994 Oct;15(5):379-94. 26- TI - [Treatment of promyelocytic leukemia with retinoic acid: results in Cuba] AD - Instituto de Hematologa e Inmunologa, La Habana, Cuba. AU - Hernndez P, Carnot J, Dortics E, Espinosa E, Gonzlez A, Hernndez G, Nordet I, Prez A, Valds C, Vergara B. LA - spa PT - Clinical Trial PT - Journal Article TT - Tratamiento de la leucemia promielocitica con cido retinoico: resultados en Cuba. PL - SPAIN SO - Sangre (Barc) 1994 Oct;39(5):357-63. 27- TI - [The immunogenic properties and prophylactic efficacy of a live polyvalent influenza vaccine in children 5 to 14 years old] AU - Grigor'eva EP, Rekstin AR, Rudenko LG, Ramirez A, Barro M, Lisovskaia KV, Klimov AI, Aleksandrova GI. LA - rus PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article TT - Izuchenie immunogennykh svoistv i profilakticheskoi effektivnosti zhivoi grippoznoi polivalentnoi vaktsiny u detei 5--14 let. PL - RUSSIA SO - Vopr Virusol 1994 Jan-Feb;39(1):26-9. 28- TI - [Long term study of the treatment with recombinant alfa 2b interferon in chronic active hepatitis due to B virus in children and adolescents] AD - Instituto Nacional de Gastroenterologa, Seccin de Gastroenterologa Peditrica .La Habana, Cuba. AU - Castaneda Guillot C, Escobar Capote MD, Garca Bacallao E, Borbolla Bousquets E. LA - spa PT - Clinical Trial PT - Journal Article TT - Estudio a largo plazo del tratamiento con interfern recombinante alfa 2b en la hepatitis crnica activa por virus b en nios y adolescentes. PL - VENEZUELA SO - G E N 1994 Oct-Dic;48(4):219-25. 29- TI - Use of recombinant interferon-alpha in human immunodeficiency virus (HIV)-infected individuals. AD - Santiago de las Vegas Sanatorium, Havana, Cuba. AU - Rivero J, Limonta M, Aguilera A, Fraga M, Lpez Saura P. LA - eng

PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - NETHERLANDS SO - Biotherapy 1994;8(1):23-31. 30- TI - Neurotransplantation in Parkinson's disease: from open microsurgery to bilateral stereotactic approach: first clinical trial using microelectrode recording technique. AD - Centro Internacional de Restauracin Neurolgica, C. Habana, Cuba. AU - Molina H, Quiones-Molina R, Muoz J, lvarez L, Alaminos A, Ortega I, Ohye C, Macas R, Piedra J, Gonzlez C, et al. LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - SWITZERLAND SO - Stereotact Funct Neurosurg 1994;62(1-4):204-8. 31- TI - Effects of successive dose increases of policosanol on the lipid profile of patients with type II hypercholesterolaemia and tolerability to treatment. AD - Plaza Polyclinical Centre, Havana, Cuba. AU - Pons P, Rodrguez M, Robaina C, Illnait J, Mas R, Fernndez L, Fernndez JC. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - SWITZERLAND SO - Int J Clin Pharmacol Res 1994;14(1):27-33. 32- TI - Immune response of Brazilian children to a Neisseria meningitidis serogroup B outer membrane protein vaccine: comparison with efficacy. AD - Bacteriology Division, Adolfo Lutz Institute, Sao Paulo, Brazil. AU - Milagres LG, Ramos SR, Sacchi CT, Melles CE, Vieira VS, Sato H, Brito GS, Moraes JC, Frasch CE. LA - eng PT - Clinical Trial PT - Journal Article PL - UNITED STATES SO - Infect Immun 1994 Oct;62(10):4419-24. 1995 33- TI - [Influence of colloidal bismuth subcitrate, metronidazole, and amoxycillin on Helicobacter pylori and gastroduodenal ulcer healing] AD - Instituto Nacional de Gastroenterologa, La Habana, Cuba. AU - Quintero M, Moderos I, Buesa F, Gonzlez Cansino R, Haedo W. LA - spa PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article TT - Influencia del subcitrato de bismuto coloidal, metronidazol y amoxicilina sobre el Helicobacter pylori y sobre la cicatrizacin de la lcera gastro-duodenal. PL - VENEZUELA

SO - G E N 1995 Apr-Jun;49(2):116-22. 34- TI - Immune response in Cuban epidemic neuropathy. AD - Hospital Peditrico. San Miguel, Ciudad de La Habana, Cuba. AU - Dorta-Contreras AJ. LA - eng PT - Clinical Trial PT - Journal Article PL - UNITED STATES SO - Mol Chem Neuropathol 1995 Feb-Apr;24(2-3):263-6. 35- TI - Fate in humans of dietary intake of cyanogenic glycosides from roots of sweet cassava consumed in Cuba. AD - Institute of Toxicology, Finlay Hospital, Havana, Cuba. AU - Hernndez T, Lundquist P, Oliveira L, Prez Cristia R, Rodrguez E, Rosling H. LA - eng PT - Clinical Trial PT - Journal Article PL - UNITED STATES SO - Nat Toxins 1995;3(2):114-7. 36- TI - A two-year study on the efficacy and tolerability of policosanol in patients with type II hyperlipoproteinaemia. AD - "Salvador Allende" Hospital, Havana, Cuba. AU - Canetti M, Moreira M, Mas R, Illnait J, Fernndez L, Fernndez J, Daz E, Castano G. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - SWITZERLAND SO - Int J Clin Pharmacol Res 1995;15(4):159-65. 37- TI - [Sympathomimetics and theophylline: combined use?] AD - Medicina Interna y Cuidados Intensivos, Hospital Clnico-Quirrgico Docente, Calixto Garca, La Habana, Cuba. AU - lvarez Sintes R, lvarez Castro MR. LA - spa PT - Clinical Trial PT - Clinical Trial, Phase II PT - Journal Article PT - Randomized Controlled Trial TT - Simpaticomimeticos y teofilinas: uso combinado? PL - SPAIN SO - An Med Interna 1995 Sep;12(9):438-41. 38- TI - Treatment of hypercholesterolemia in NIDDM with policosanol. AD - Julio Trigo Hospital, Havana, Cuba. AU - Torres O, Agramonte AJ, Illnait J, Mas Ferreiro R, Fernndez L, Fernndez JC. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - UNITED STATES

SO - Diabetes Care 1995 Mar;18(3):393-7. 39- TI - [Premedication for the prevention of adverse reactions to ionic iodized contrast media. Comparative study] AD - Servicio de alergologa Hospital CQ Hermanos Ameijeiras, Centro Habana, Cuba. AU - White Mediaceja VL, Alfonso Fernndez LA, Ginard Cabanas A, Gmez Echevarra AH. LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - Premedicacin preventiva de reacciones adversas a contrastes yodados inicos. Estudio comparativo. PL - MXICO SO - Rev Alerg Mex 1995 May-Jun;42(3):45-8. 40- TI - Evolutive levels of NGF in neurodegenerative disorders. AD - Centro Internacional de Restauracin Neurolgica, C. Habana, Cuba. AU - Lorigados L, Molina H, Serrano T, Pavn N, Robinson MA, lvarez L, Soderstrom S, Ebendal T. LA - eng PT - Clinical Trial PT - Journal Article PL - UNITED STATES SO - Mol Chem Neuropathol 1995 Feb-Apr;24(2-3):231-4. 41- TI - [Humoral immune response to the capsular polysaccharide of Neisseria meningitidis serogroup C in an antimeningococcal BC vaccination trial in Antioquia, Colombia] AD - Instituto Finlay, La Habana, Cuba. AU - Echeverry Uribe ML, Malberty Aguero JA, Galeano Marn LA, Sotolongo Padrn FT, Galguera Domnguez MA, Montoya Barrientos CM, Martnez Ruiz O, Nerey MC, Camarasa MA, Bacallao Gallestey J, et al. LA - spa PT - Clinical Trial PT - Journal Article TT - Respuesta inmune humoral al polisacarido capsular de Neisseria meningitidis serogrupo C en un ensayo de vacunacin antimeningoccica BC en Antioquia, Colombia. PL - UNITED STATES SO - Bol Oficina Sanit Panam 1995 Apr;118(4):295-301. 42- TI - [Humoral immune response to the proteins of an antimeningococcal BC vaccine in a trial carried out in Antioquia, Colombia] AD - Instituto Finlay, La Habana, Cuba. AU - Echeverry Uribe ML, Malberty Aguero JA, Galeano Marn LA, Sotolongo Padrn FT, Galguera Domnguez MA, Montoya Barrientos CM, Blanco Gonzlez R, Martnez Ruiz O, Martnez Fernndez OM, Aguirre Munoz CA, et al. LA - spa PT - Clinical Trial PT - Journal Article TT - Respuesta inmune humoral a las protenas de una vacuna antimeningoccica BC en un ensayo realizado en Antioquia, Colombia. PL - UNITED STATES SO - Bol Oficina Sanit Panam 1995 Apr;118(4):285-94. 1996

43- TI - Prescription of antibiotics for mild acute respiratory infections in children. AD - Pedro Kour Institute, Havana, Cuba. AU - Gonzlez Ochoa E, Armas Prez L, Bravo Gonzlez JR, Cabrales Escobar J, Rosales Corrales R, Abru Surez G. LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - UNITED STATES SO - Bull Pan Am Health Organ 1996 Jun;30(2):106-17. 44- TI - UltramicroELISA for measuring tetanus antitoxin in human sera. AD - Carlos J. Finlay Biologicals Production Company, Havana, Cuba. AU - Fajardo EM, Fernndez JL, Solis RL, Portuondo B, Heredia L, Norona M, Urquiza H, Amat M. LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - UNITED STATES SO - Bull Pan Am Health Organ 1996 Mar;30(1):9-17. 45- TI - Evaluation of enzyme-linked immunosorbent assay for the serodiagnosis of tuberculosis in patients with AIDS in Cuba. AD - Laboratorio Nacional de Referencia de Microbacteria y Tuberculosis, Instituto de Medicina Tropical Pedro Kour, (IPK), Cuba. AU - Montoro E, Daz R, Echemenda M, Valdivia JA. LA - eng PT - Clinical Trial PT - Journal Article PL - BRAZIL SO - Mem Inst Oswaldo Cruz 1996 Mar-Apr;91(2):191. 46- TI - Clinical and epidemiological evaluation of a live, cold-adapted influenza vaccine for 3-14-yearolds. AD - Department of Virology, Institute of Experimental Medicine, St. Petersburg, Russian Federation. AU - Rudenko LG, Lonskaya NI, Klimov AI, Vasilieva RI, Ramrez A. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - SWITZERLAND SO - Bull World Health Organ 1996;74(1):77-84. 47- TI - Aprotinin effects related to oxidative stress in cardiosurgery with mechanical cardiorespiratory support (CMCS). AD - Biomedical Research Center Victoria de Giron, Havana, Cuba. AU - Broche VF, Surez AR, Olembe E, Fernndez GE, Cspedes EM, Garca JC, Reynoso E, Nunez P, Prieto E. LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - UNITED STATES

SO - Ann N Y Acad Sci 1996 Sep 30;793:521-4. 48- TI - Effect of policosanol successive dose increases on platelet aggregation in healthy volunteers. AD - Departamento de Farmacologa, Centro Nacional de Investigaciones Cientficas, Habana, Cuba. AU - Arruzazabala ML, Valds S, Mas R, Fernndez L, Carbajal D. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - ENGLAND SO - Pharmacol Res 1996 Nov-Dic;34(5-6):181-5. 49- TI - Effect of policosanol on platelet aggregation in healthy volunteers. AD - Center of Natural Products, National Center for Scientific Research, Cubanacan, Havana, Cuba. AU - Valds S, Arruzazabala ML, Fernndez L, Mas R, Carbajal D, Alemn C, Molina V. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - SWITZERLAND SO - Int J Clin Pharmacol Res 1996;16(2-3):67-72. 50- TI - Nerve growth factor levels in normal human sera. AD - Department of Neuroimmunology, International Center for Neurological Restoration (CIREN), Havana, Cuba. AU - Serrano T, Lorigados LC, Armenteros S. LA - eng PT - Clinical Trial PT - Journal Article PL - ENGLAND SO - Neuroreport 1996 Dec 20;8(1):179-81. 51- TI - Modulation of human papillomavirus type 16 mRNA in cervical invasive carcinoma patients by interferon-alpha therapy. AD - Departamento de Biologa Celular, Centro de Investigaciones Biolgicas, Ciudad Habana, Cuba. AU - Garca-Milin R, Ros MA, Amigo M, Daz D, Guilar O, Silveira M, Arana MJ, Perea SE. LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - UNITED STATES SO - J Interferon Cytokine Res 1996 Sep;16(9):739-43. 52- TI - Oral human recombinant epidermal growth factor in the treatment of patients with duodenal ulcer. AD - National Institute of Gastroenterology, Havana City, Cuba. AU - Haedo W, Gonzlez T, Mas JA, Franco S, Gra B, Soto G, Alonso A, Lpez-Saura P. LA - eng LA - spa PT - Clinical Trial PT - Controlled Clinical Trial

PT - Journal Article PT - Randomized Controlled Trial PL - SPAIN SO - Rev Esp Enferm Dig 1996 Jun;88(6):409-18. 53- TI - Effect of policosanol on hyperlipidemia and coronary heart disease in middle-aged patients. A 14month pilot study. AD - Cardiovascular Laboratory, Havana University, Cuba. AU - Batista J, Stusser R, Sez F, Prez B. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - GERMANY SO - Int J Clin Pharmacol Ther 1996 Mar;34(3):134-7. 1997 54- TI - Misoprostol 3, 4, or 5 days after methotrexate for early abortion. A randomized trial. AD - Hospital Docente Gineco-Obsttrico Eusebio Hernndez (Maternidad Obrera), Ciudad de La Habana, Cuba. AU - Carbonell I Esteve JL, Velazco A, Varela L, Cabezas E, Fernndez C, Snchez C. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - UNITED STATES SO - Contraception 1997 Sep;56(3):169-74. 55- TI - Safety, efficacy, and acceptability of medical abortion in China, Cuba, and India: a comparative trial of mifepristone-misoprostol versus surgical abortion. AD - Population Council, New York, NY 10017, USA. AU - Winikoff B, Sivin I, Coyaji KJ, Cabezas E, Xiao B, Gu S, Du MK, Krishna UR, Eschen A, Ellertson C. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - UNITED STATES SO - Am J Obstet Gynecol 1997 Feb;176(2):431-7. 56- TI - The use of misoprostol for abortion at < or = 9 weeks' gestation. AD - Hospital Docente Gineco-Obsttrico Eusebio Hernndez (Maternidad Obrena), Ciudad de La Habana, Cuba. AU - Carbonell JL, Varela L, Velazco A, Fernndez C, Snchez C. LA - eng PT - Clinical Trial PT - Journal Article PL - ENGLAND SO - Eur J Contracept Reprod Health Care 1997 Sep;2(3):181-5. 57- TI - [Treatment of acute attack of migraine with sumatriptan] AD - Servicio de Neurologia, Hospital C.Q. Hermanos Ameijeiras, Ciudad de La

Habana, Cuba. AU - Gonzlez-Espinosa LE, Gmez-Viera N, Olivera-Leal I, Reyes-Lorente R. LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial TT - Tratamiento del ataque agudo de la cefalea migranosa con sumatriptan. PL - SPAIN SO - Rev Neurol 1997 Nov;25(147):1672-5. 58- TI - Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. AD - Department of Pharmacology, Centre of Natural Products, CNIC, Habana, Cuba. AU - Arruzazabala ML, Valds S, Mas R, Carbajal D, Fernndez L. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - ENGLAND SO - Pharmacol Res 1997 Oct;36(4):293-7. 59- TI - Long-term treatment with recombinant interferon alpha-2b prolongs survival of asymptomatic HIV-infected individuals. AD - Sanatorio Santiago de las Vegas, La Habana, Cuba. AU - Rivero J, Fraga M, Cancio I, Cuervo J, Lpez-Saura P. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - NETHERLANDS SO - Biotherapy 1997;10(2):107-13. 60- TI - Electrophysiological targeting in stereotaxic surgery for Parkinson's disease. AD - Centro Internacional de Restauracin Neurolgica, La Habana, Cuba. AU - Macias R, Teijeiro J, Torres A, lvarez L. LA - eng PT - Clinical Trial PT - Journal Article PL - UNITED STATES SO - Adv Neurol 1997;74:175-82. 61- TI - [Effect of microcrystalline cellulose on alkaline gastritis due to bile reflux] AD - Instituto de Gastroenterologa, Habana, Cuba. AU - Paniagua M, Pinol F, Cendan A. LA - spa PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article TT - Accin de la celulosa microcristalina en la gastritis alcalina por reflujo biliar. PL - ARGENTINA SO - Acta Gastroenterol Latinoam 1997;27(2):75-9.

62- TI - Cardiovascular autonomic dysfunction in sickle cell anemia: a possible risk factor for sudden death? AD - Instituto Nacional de Endocrinologa, Ciudad de La Habana, Cuba. AU - Romero Mestre JC, Hernndez A, Agramonte O, Hernndez P. LA - eng PT - Clinical Trial PT - Journal Article PL - ENGLAND SO - Clin Auton Res 1997 Jun;7(3):121-5. 63- TI - Use of interferon-alpha in laryngeal papillomatosis: eight years of the Cuban national programme. AD - Otorhinolaryngology Services of Hospitals throughout Cuba, Ministry of Public Health, Havana, Cuba. AU - Deunas L, Alcantud V, lvarez F, Arteaga J, Bentez A, Bopuza M, Carniege L, Cartaya B, Comas C, Cotayo R, Escobar H, Fernndez H, Fernndez M, Fernndez R, Garca M, Iznaga N, la O F, Marquez J, Nordet D, Prez J, Quintero J, Redonavich A, Robeleco M, Rodrguez H, Strander H, et al. LA - eng PT - Journal Article PL - ENGLAND SO - J Laryngol Otol 1997 Feb;111(2):134-40. 64- TI - The effect of ankle oedema on bone ultrasound assessment at the heel. AD - Academic Department of Geriatric Medicine, University of Wales College of Medicine, Cardiff, UK. AU - Johansen A, Stone MD LA - eng PT - Clinical Trial PT - Journal Article PL - ENGLAND SO - Osteoporos Int 1997;7(1):44-7 65- TI - An epidemic of optic neuropathy in Tanzania: characterization of the visual disorder and associated peripheral neuropathy. AD - National Hospital for Neurology and Neurosurgery, London, UK. AU - Plant GT, Mtanda AT, Arden GB, Johnson GJ. LA - eng PT - Clinical Trial PT - Journal Article PL - NETHERLANDS SO - J Neurol Sci 1997 Feb 12;145(2):127-40. 66- TI - Cross-cultural neuropsychological assessment: a comparison of randomly selected, demographically matched cohorts of English- and Spanish-speaking older adults. AD - Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, USA. AU - Jacobs DM, Sano M, Albert S, Schofield P, Dooneief G, Stern Y. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - NETHERLANDS SO - J Clin Exp Neuropsychol 1997 Jun;19(3):331-9. 1998

67- TI - Medical versus surgical abortion. AD - Department of Obstetrics and Gynecology, Eusebio Hernndez Hospital, J Grupo Nacional de Ginecobstetricia, Havana, Cuba. AU - Cabezas E. LA - eng PT - Clinical Trial PT - Journal Article PL - IRELAND SO - Int J Gynaecol Obstet 1998 Dec;63 Suppl 1:S141-6. 68- TI - Oral methotrexate and vaginal misoprostol for early abortion. AD - Hospital Docente Gineco-Obsttrico Eusebio Hernndez (Maternidad Obrera), Ciudad de La Habana, Cuba. AU - Carbonell JL, Varela L, Velazco A, Cabezas E, Fernndez C, Snchez C. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - UNITED STATES SO - Contraception 1998 Feb;57(2):83-8. 69- TI - Effect of policosanol on platelet aggregation in type II hypercholesterolemic patients. AD - Center of Natural Products, National Center for Scientific Research, Havana, Cuba. AU - Arruzazabala ML, Mas R, Molina V, Carbajal D, Mendoza S, Fernndez L, Valds S. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - SWITZERLAND SO - Int J Tissue React 1998;20(4):119-24. 70- TI - [The evaluation of patients with ischemic cerebral lesions by CT, SPECT and qEEG in acute, subacute and chronic phases] AD - Centro Internacional de Restauracin Neurolgica, CIREN, La Habana, Cuba. jsanchez@neuro.sld.cu AU - Snchez-Chvez JJ, Barroso E, Cubero L, Gonzlez-Gonzlez J, Farach M. LA - spa PT - Clinical Trial PT - Journal Article TT - Evalucin mediante TC, SPECT y qEEG de pacientes con lesiones isqumicas cerebrales durante las fases aguda, subaguda y crnica. PL - SPAIN SO - Rev Neurol 1998 Aug;27(156):213-23. 71- TI - [Exfoliative cytology for diagnosis of Helicobacter pylori] AD - Instituto de Gastroenterologa, Habana, Cuba. AU - Paniagua M, Valds L, Borbolla E, Hernndez M. LA - spa PT - Clinical Trial PT - Journal Article TT - Citologa exfoliativa en el diagnstico de Helicobacter pylori. PL - ARGENTINA SO - Acta Gastroenterol Latinoam 1998;28(2):203-8.

72- TI - A novel cancer vaccine composed of human-recombinant epidermal growth factor linked to a carrier protein: report of a pilot clinical trial. AD - Center of Molecular Immunology, Havana, Cuba. AU - Gonzlez G, Crombet T, Catala M, Mirabal V, Hernndez JC, Gonzlez Y, Marinello P, Guilln G, Lage A. LA - eng PT - Clinical Trial PT - Journal Article PL - NETHERLANDS SO - Ann Oncol 1998 Apr;9(4):431-5. 73- TI - Use of recombinant interferon gamma in pediatric patients with advanced juvenile chronic arthritis. AD - Pedro Borrs Pediatric Hospital, Havana, Cuba. AU - Coto C, Varela G, Hernndez V, del Rosario M, Lpez-Saura P. LA - eng PT - Clinical Trial PT - Journal Article PL - NETHERLANDS SO - Biotherapy 1998;11(1):15-20. 74- TI - Usefulness of inhaled furosemide in a bronchial asthma attack. AD - Pneumonology Service (Library), Hermanos Ameijeiras Hospital, Havana, Cuba. AU - Rodrguez Vzquez JC, Pino Alfonso PP, Gassiot Nuno C, Paez Prats I. LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - SPAIN SO - J Investig Allergol Clin Immunol 1998 Sep-Oct;8(5):290-3. 75- TI - [Clinical evaluation of the use of propoleum in Peyronie's disease] AD - Servicio de Urologa, Radiologa, Hospital de Andrade, Centro Habana, Cuba. AU - Lemourt Oliva M, Filgueiras Lpez E, Rodrguez Barroso A, Gonzlez Oramas E, Bordonado R. LA - spa PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article TT - Evaluacin clnica del uso del propoleo en la enfermedad de Peyronie. PL - SPAIN SO - Arch Esp Urol 1998 Mar;51(2):171-6. 76- TI - [Indicators of oxidative stress and the effect of antioxidant treatment in patients with primary Parkinson disease] AD - Departamento de Neurobioqumica, CIBIOMED, Ciudad de La Habana, Cuba. cineuro@neuro.sld.cu AU - Gonzlez-Fraguela ME, Cspedes EM, Arencibia R, Broche F, Gmez AA, Castellano O, Garca JC. LA - spa PT - Clinical Trial PT - Journal Article TT - Indicadores de estrs oxidativo y efecto del tratamiento antioxidante en

pacientes con enfermedad de Parkinson primaria. PL - SPAIN SO - Rev Neurol 1998 Jan;26(149):28-33. 77- TI - Single dose study of the bioequivalence of two sustained-release theophylline formulations. AD - Department of Chemistry, National Center for Scientific Research, Havana, Cuba. AU - Contreras J, Prez N, Gonzlez R, Ontivero E, Lpez M. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - GERMANY SO - Arzneimittelforschung 1998 Mar;48(3):259-62. 78- TI - Switching attention without shifting the spotlight object-based attentional modulation of brain potentials. AD - Centro de Neurociencias de Cuba, La Habana, Cuba. AU - Valds-Sosa M, Bobes MA, Rodrguez V, Pinilla T. LA - eng PT - Clinical Trial PT - Journal Article PL - UNITED STATES SO - J Cogn Neurosci 1998 Jan;10(1):137-51. 79- TI - [The use of mebendazole associated with inoxuprin in the treatment of Schistosomiasis haematobium] AD - Departamento de Parasitologa, Instituto Pedro Kour, Habana, Cuba. AU - Dona Lpez MC, Ramrez Fernndez E, Vzquez Gonzlez MT, Prez Caloto M. LA - spa PT - Clinical Trial PT - Journal Article TT - Uso de inoxuprin asociado a Mebendazol en el tratamiento de Schistosoma haematobium. PL - SPAIN SO - An Med Interna 1998 Jan;15(1):18-20. 80- TI - Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers. AD - Center of Natural Products, CNIC, Cubanacan Habana, Cuba. AU - Carbajal D, Arruzazabala ML, Valds S, Mas R. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - SCOTLAND SO - Prostaglandins Leukot Essent Fatty Acids 1998 Jan;58(1):61-4. 81- TI - Blood loss with mifepristone--misoprostol abortion: measures from a trial in China, Cuba and India. AD - Population Studies Center, University of Pennsylvania, Philadelphia, USA. AU - Harper C, Winikoff B, Ellertson C, Coyaji K. LA - eng PT - Clinical Trial

PT - Journal Article PT - Multicenter Study PL - IRELAND SO - Int J Gynaecol Obstet 1998 Oct;63(1):39-49. 82- TI - [Hyperbaric oxygenation and neurological recovery in children with organic brain damage] AD - Hospital Peditrico Provincial Docente Mrtires de Tunas, Las Tunas, Cuba. AU - Crdoba-Cabeza T, Prez-Fonseca R, Morales-Vargas D, Lpez A. LA - spa PT - Clinical Trial PT - Journal Article TT - Oxigenacin hiperbrica y restauracin neurolgica en nios con dao cerebral orgnico. PL - SPAIN SO - Rev Neurol 1998 Oct;27(158):571-4. 1999 83- TI - The multi-epitope polypeptide approach in HIV-1 vaccine development. AD - Departamento SIDA, Centro de Ingeniera Gentica y Biotecnologa, La Habana, Playa, Cuba. AU - Cano CA. LA - eng PT - Clinical Trial PT - Clinical Trial, Phase I PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - NETHERLANDS SO - Genet Anal 1999 Nov;15(3-5):149-53. 84- TI - [Alpha interferon in the treatment of multiple sclerosis. Update and experience in Cuba] AD - Seccin de Esclerosis Mltiple, Hospital Gustavo Alderegua, Cienfuegos, Cuba. AU - Cabrera-Gmez JA, Lpez-Saura P. LA - spa PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Review PT - Review of Reported Cases TT - Interfern alfa en el tratamiento de la esclerosis mltiple. Actualizacin y experiencia en Cuba. PL - SPAIN SO - Rev Neurol 1999 May 1-15;28(9):849-58. 85- TI - Immunogenicity of 2 serogroup B outer-membrane protein meningococcal vaccines: a randomized controlled trial in Chile. AD - Centers for Disease Control and Prevention, Meningitis and Special Pathogens Branch, Atlanta, GA 30333, USA. AU - Tappero JW, Lagos R, Ballesteros AM, Plikaytis B, Williams D, Dykes J, Gheesling LL, Carlone GM, Hoiby EA, Holst J, Nokleby H, Rosenqvist E, Sierra G, Campa C, Sotolongo F, Vega J, Garca J, Herrera P, Poolman JT, Perkins BA. LA - eng PT - Clinical Trial PT - Journal Article

PT - Randomized Controlled Trial PL - UNITED STATES SO - JAMA 1999 Apr 28;281(16):1520-7. 86- TI - Comparative study of the efficacy and tolerability of policosanol and lovastatin in patients with hypercholesterolemia and noninsulin dependent diabetes mellitus. AD - Enrique Cabrera Hospital, Havana, Cuba. AU - Crespo N, Illnait J, Mas R, Fernndez L, Fernndez J, Castano G. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - SWITZERLAND SO - Int J Clin Pharmacol Res 1999;19(4):117-27. 87- TI - Effects of policosanol and pravastatin on lipid profile, platelet aggregation and endothelemia in older hypercholesterolemic patients. AD - Medical Surgical Research Center, Havana, Cuba. AU - Castano G, Mas R, Arruzazabala ML, Noa M, Illnait J, Fernandez JC, Molina V, Menendez A. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - SWITZERLAND SO - Int J Clin Pharmacol Res 1999;19(4):105-16. 88- TI - A comparative study of policosanol Versus acipimox in patients with type II hypercholesterolemia. AD - Department of Cardiology, Mexico General Hospital, Mexico City. AU - Alcocer L, Fernndez L, Campos E, Mas R. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - SWITZERLAND SO - Int J Tissue React 1999;21(3):85-92. 89- TI - Effects of policosanol in patients with type II hypercholesterolemia and additional coronary risk factors. AD - Center of Natural Products, National Center for Scientific Research, Havana City, Cuba. AU - Mas R, Castano G, Illnait J, Fernndez L, Fernndez J, Alemn C, Pontigas V, Lescay M. LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - UNITED STATES SO - Clin Pharmacol Ther 1999 Apr;65(4):439-47. 90- TI - A double-blind, placebo-controlled study of the effects of policosanol in patients with intermittent claudication. AD - Medical Surgical Research Center, Havana City, Cuba. AU - Castano G, Mas R, Roca J, Fernndez L, Illnait J, Fernndez JC, Selman E.

LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - UNITED STATES SO - Angiology 1999 Feb;50(2):123-30. 91- TI - Three treatment schemes with colloidal bismuth subcitrate (Q-ULCER) in peptic ulcer with Helicobacter pylori. AD - Centro de Investigaciones Mdico-Quirrgicas, Habana, Cuba. AU - Surez MS, Gonzlez Cansino J, Velasco Ilizalde C, Sabatier CA, Castillo Hernndez J. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - MEXICO SO - Arch Med Res 1999 Jan-Feb;30(1):55-9. 92- TI - Preliminary assessment of the safety and immunogenicity of a new CTXPhi-negative, hemagglutinin/protease-defective El Tor strain as a cholera vaccine candidate. AD - Grupo de Gentica, Centro Nacional de Investigaciones Cientficas, " Habana, Cuba. AU - Bentez JA, Garca L, Silva A, Garca H, Fando R, Cedre B, Prez A, Campos J, Rodrguez BL, Prez JL, Valmaseda T, Prez O, Prez A, Ramrez M, Ledn T, Jidy MD, Lastre M, Bravo L, Sierra G. LA - eng PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PL - UNITED STATES SO - Infect Immun 1999 Feb;67(2):539-45. 93- TI - The epidemiological impact of antimeningococcal B vaccination in Cuba. AD - Instituto de Medicina Tropical 'Pedro Kour', La Habana, Cuba. AU - Rodrguez AP, Dickinson F, Baly A, Martnez R. LA - eng PT - Journal Article PL - BRAZIL SO - Mem Inst Oswaldo Cruz 1999 Jul-Aug;94(4):433-40. 94- TI - The efficacy and tolerability of triclabendazole in Cuban patients with latent and chronic Fasciola hepatica infection. AD - Instituto de Medicina Tropical Pedro Kour, Habana, Cuba. AU - Millan JC, Mull R, Freise S, Richter J. CN - Triclabendazole Study Group. LA - eng PT - Clinical Trial PT - Journal Article PL - United States SO - Am J Trop Med Hyg 2000 Nov-Dic;63(5-6):264-9. 95- TI - A randomized trial of the effect of moistening misoprostol before vaginal administration when used with methotrexate for abortion. AD - Department of Obstetrics, Gynecology and Reproductive Sciences, University

of Pittsburgh School of Medicine, Magee-Womens Hospital, Pennsylvania 15213-3180, USA. AU - Creinin MD, Carbonell JL, Schwartz JL, Varela L, Tanda R. LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - UNITED STATES SO - Contraception 1999 Jan;59(1):11-6. 2000 96- TI - TERIMA-2: national extension of thrombolytic treatment with recombinant streptokinase in acute myocardial infarct in Cuba. CN - TERIMA Group of Investigators. LA - eng PT - Clinical Trial PT - Clinical Trial, Phase IV PT - Journal Article PT - Multicenter Study PL - Germany SO - Thromb Haemost 2000 Dec;84(6):949-54. 97- TI - [Diagnostic clinical trial with allergen extract from Blomia tropicalis in allergic adults and healthy volunteers] AD - Departamento de Alergenos, Centro Nacional de Biopreparados La Habana. olimpio@finlay.cmw.sld.cu AU - Rodrguez Santos O, Bentez Trujillo M, Labrada A, Jove Morales V. LA - spa PT - Clinical Trial PT - Journal Article TT - Ensayo clnico diagnstico con extracto alergnico de Blomia tropicalis en adultos alrgicos y voluntarios sanos. PL - MXICO SO - Rev Alerg Mex 2000 Mar-Apr;47(2):58-60. 98- TI - [Actual status of multiple sclerosis in Cuba. National cooperative group for the clinical trial "Recombinant interferon alpha-2b in multiple sclerosis".] AD - Seccin de Esclerosis Mltiple, Hospital Universitario Dr. Gustavo Alderegua Lima, Cienfuegos, Cuba. AU - Cabrera-Gmez JA, Santana-Capote E, Echazabal-Santana N, Daz de la Fe A, Casanova M, Gmez L, Bez-Martn MM, Gonzlez-Quevedo A, Fernndez R, Vals O, Pena A, Rodrguez A, Cabrera-Nuez JA, Moscoso ME, Ruiz M. LA - spa PT - Journal Article TT - Estado actual de la esclerosis mltiple en Cuba. Grupo Cooperativo Nacional para el Ensayo Clnico 'Interfern alfa-2b recombinante en la esclerosis mltiple'. PL - SPAIN SO - Rev Neurol 2000 Sep 1-15;31(5):482-93. 99- TI - [Evaluation of the effectiveness of a new vaccine against human leptospirosis in groups at risk] AD - Instituto de Medicina Tropical Pedro Kour, Ciudad de La Habana, Cuba. AU - Martnez Snchez R, Prez Sierra A, Bar Surez M, lvarez AM, Menndez Hernndez J, Daz

Gonzlez M, Cruz de la Paz R, de los Reyes G, Montoya Batista B, Sierra Gonzlez G, Armesto del Ro M, Saltaren Cobas A, Sabournin Ramos O. LA - spa PT - Evaluation Studies PT - Journal Article TT - Evaluacin de la efectividad de una nueva vacuna contra la leptospirosis humana en grupos en riesgo. PL - United States SO - Rev Panam Salud Pblica 2000 Dic;8(6):385-92. 100- TI - Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro. AD - Center of Natural Products, National Center for Scientific Research, Havana, Cuba. AU - Menndez R, Mas R, Amor AM, Gonzlez RM, Fernndez JC, Rodeiro I, Zayas M La - eng PT - Clinical Trial PT - Controlled Clinical Trial PL - ENGLAND SO - Br J Clin Pharmacol. 2000 Sep;50(3):255-62. 101- TI - Effects of policosanol on postmenopausal women with type II hypercholesterolemia. AD - Medical Surgical Research Center (CIMEQ), Siboney, Cuba. AU - Castano G, Mas R, Fernndez L, Fernndez JC, Illnait J, Lpez LE, lvarez E. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - ENGLAND SO - Gynecol Endocrinol 2000 Jun;14(3):187-95. 102- TI - The efficacy and tolerability of triclabendazole in Cuban patients with latent and chronic Fasciola hepatica infection. AD - Instituto de Medicina Tropical Pedro Kour, Habana, Cuba. AU - Millan JC AU - Mull R AU - Freise S AU - Richter J CN - Triclabendazole Study Group. LA - eng PT - Clinical Trial PT - Journal Article PL - United States SO - Am J Trop Med Hyg 2000 Nov-Dec;63(5-6):264-9. 2001 103- TI - [Pilot study with the monoclonal antibody IOR-C5 as a potential agent of radioimmunoscintigraphy in colorectal cancer] AD - Departamento de Medicina Nuclear, Instituto Nacional de Oncologa y Radiobiologa, (INOR), C. Habana 10400, Cuba. AU - Oliva JP, Pimentel G, Borron M, Peralta R, Ortiz R, Oliver B, Daz N, Snchez I, Vzquez AM, Baum RP. LA - spa PT - Clinical Trial PT - Journal Article TT - Ensayo piloto con el anticuerpo monoclonal ior-C5 como agente potencial de

la inmunocentelleografa del cncer colorrectal. PL - Spain SO - Rev Esp Med Nucl 2001 Jun;20(4):282-8. 104- TI - Immunogenicity of a serogroup B meningococcal vaccine against multiple Neisseria meningitidis strains in infants. AD - Departments of Paediatrics and Infectious Diseases and Microbiology, Imperial College School of Medicine, St. Mary's Campus, London, UK. AU - Morley SL, Cole MJ, Ison CA, Camaraza MA, Sotolongo F, Anwar N, Cuevas I, Carbonero M, Campa HC, Sierra G, Levin M. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States SO - Pediatr Infect Dis J 2001 Nov;20(11):1054-61. 105- TI - Homeopathy in Cuban epidemic neuropathy: an open clinical trial. AD - Instituto Finlay, Avenida 27, La Lisa, Ciudad Habana, Cuba. AU - Cairo J, Elliot BE, Barnouin J, Fleites P, Araoz A, Morales M, Verdura T, Snchez M, Serrano C, lvarez JL, Veillard JJ. LA - eng PT - Clinical Trial PT - Journal Article PL - England SO - Br Homeopath J 2001 Jul;90(3):154-7. 106- TI - [Clinical diagnostic assay of allergic patients with pollen extract from Parthenium hysterophorous L] AD - Servicio de alergia, Hospital Wilian Soler, Ciudad Habana, Cuba. AU - Rodrguez Santos O, Rodrguez Gavald R, Silva Prez R. LA - spa PT - Clinical Trial PT - Journal Article TT - Ensayo clnico diagnstico en pacientes alrgicos con extracto de polen de Parthenium hysterophorus L. PL - Mxico SO - Rev Alerg Mex 2001 Mar-Apr;48(2):45-7. 107- TI - WHO antenatal care randomised trial for the evaluation of a new model of routine antenatal care. AD - UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development, and Research Training in Human Reproduction, Department of Reproductive Health and Research, World Health Organisation, Geneva, Switzerland. AU - Villar J, Ba'aqeel H, Piaggio G, Lumbiganon P, Miguel Belizan J, Farnot U, Al-Mazrou Y, Carroli G, Pinol A, Donner A, Langer A, Nigenda G, Mugford M, Fox-Rushby J, Hutton G, Bergsjo P, Bakketeig L, Berendes H, Garca J. CN - WHO Antenatal Care Trial Research Group. LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - England SO - Lancet 2001 May 19;357(9268):1551-64.

108- TI - Minimally invasive selective osteotomy of the knee: A new surgical technique. AD - Orthopaedic Division, Hospital Hermanos Ameijeiras, Habana, Cuba. AU - Leon HO, Blanco CE, Guthrie TB. LA - eng PT - Clinical Trial PT - Journal Article PL - United States SO - Arthroscopy 2001 May;17(5):510-6. 109- TI - Effects of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: a 6-month double-blind study. AD - Medical Surgical Research Center, National Center for Scientific Research, Havana City, Cuba. AU - Castano G, Mas R, Fernndez L, Illnait J, Gmez R, lvarez E. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - Switzerland SO - Int J Clin Pharmacol Res 2001;21(1):43-57. 110- TI - Effects of policosanol in older patients with type II hypercholesterolemia and high coronary risk. AD - Medical Surgical Research Center, National Center for Scientific Research, Havana City, Cuba. AU - Castano G, Mas R, Fernndez JC, Illnait J, Fernndez L, lvarez E. LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - United States SO - J Gerontol A Biol Sci Med Sci 2001 Mar;56(3):M186-92. 111- TI - A long-term study of policosanol in the treatment of intermittent claudication. AD - Medical Surgical Research Center, Havana City Cuba. AU - Castano G, Mas Ferreiro R, Fernndez L, Gmez R, Illnait J, Fernndez C. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States SO - Angiology 2001 Feb;52(2):115-25. 112- TI - Efficacy and tolerability of policosanol in hypercholesterolemic postmenopausal women. AD - Eva Peron Hospital, Rosario, Argentina. AU - Mirkin A, Mas R, Martinto M, Boccanera R, Robertis A, Poudes R, Fuster A, Lastreto E, Yanez M, Irico G, McCook B, Farre A. LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - Switzerland

SO - Int J Clin Pharmacol Res 2001;21(1):31-41. 113- TI - Effects of D-002 on Lipid Peroxidation in Older Subjects. AD - Center of Natural Products, National Center for Scientific Research, Havana, Cuba. AU - Menndez R, Mas R, Illnait J, Prez J, Amor AM, Fernndez JC, Gonzlez RM. LA - ENG PT - JOURNAL ARTICLE SO - J Med Food 2001 Summer;4(2):71-77. 114- TI - Obtaining family consent for participation in Alzheimer's research in a Cuban-American population: strategies to overcome the barriers. AD - University of Miami School of Nursing, Coral Gables, Florida, USA. AU - Williams CL, Tappen R, Buscemi C, Rivera R, Lezcano J. LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States SO - Am J Alzheimers Dis Other Demen 2001 May-Jun;16(3):183-7. 2002 115- TI - Cuban experience in the treatment of acute promyelocytic leukemia with ALL transretinoic acid followed by intensive chemotherapy. AU - Hernndez P, Martnez G, Losada R, Machn S, Cayado N, Gramatges A. LA - eng PT - Clinical Trial PT - Letter PL - Italy SO - Hematolgica 2002 Mar;87(3):ELT14. 116- TI - [Clinico-diagnostic trial in adults allergic to pollen extracts from Cynodon dactylon (L). Pers.] AD - Hospital Willian Soler, Ciudad de La Habana, Cuba. AU - Rodrguez Santos O, Rodrguez Gavald R LA - spa PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article TT - Ensayo clnico-diagnstico en adultos alrgicos con extracto de polen de Cynodon dactylon (L) Pers. PL - Mxico SO - Rev Alerg Mex 2002 Nov-Dic;49(6):168-70. Anexo 3. Relacin de registros identificados en el Web of Science 1- UI - FG662 AU - Pascual C, Gonzlez R, Romay C TI - Drugs Effects on Superoxide Generation and Chemiluminescence Response of Human-Leukocytes. LA - English SH - Article RF - 15 AD - CTR NACL INVEST CIENT, APARTADO 6990, HAVANA, CUBA SO - AGENT ACTION 1991;32(3-4):277-282 2- UI - JU459

AU - Pons P, Mas R, Illnait J, Fernndez L, Rodrguez M, Robaina C, Fernndez JC TI - Efficacy and Safety of Policosanol in Patients with Primary Hypercholesterolemia. LA - English SH - Article RF - 12 AD - NATL CTR SCI RES, POB 6990, HAVANA, CUBA GEN HOSP CALIXTO GARCA, HAVANA, CUBA PLAZA POLICLIN CTR, HAVANA, CUBA AD - GEN HOSP CALIXTO GARCA, HAVANA, CUBA PLAZA POLICLIN CTR, HAVANA, CUBA AD - PLAZA POLICLIN CTR, HAVANA, CUBA SO - CURR THER RES 1992;52(4):507-513 3- UI - JA196 AU - Daz JW, Gonzlez MA, Avedo F, Mallea L, Rodrguez N TI - Use of an ATP-Supplemented Medium for the Conservation of Human Semen and the Effect of Caffeine on the Motility of Preserved Sperm - Results in Artificial-Insemination. LA - English SH - Article RF - 14 AD - HOSP GINECO OBSTET RAMN GONZLEZ CORO, CALLE 21 854 ENTRE 4 & 6 VEDADO, CP 10400, HAVANA 4, CUBA SO - ANDROLOGIA 1992;24(3):131-133 4- AU: Coutinho-EM Desouza-JC Dasilva-AR Deacosta-OM lvarez-F Brache-V Flores-JG Vsquez Estrada-L Santo-R Bassol-S Alvarado-G Gu-ZP Ladipo-OA Adekunle-AO Otolorin-EO Mati-JKG Maggwa-ABN Shaaban-MM Sayed-EH Abdelaleem-H Sikazwe-NC Segal-SJ TI: Comparative-Study on the Efficacy and Acceptability of 2 Contraceptive Pills Administered by the Vaginal Route - An International Multicenter Clinical-Trial LA: English SH: Article AD: FED-UNIV-BAHIA, MATERNIDADE CLIMERIO OLIVEIRA, RUA LIMOEIRO 1, BR-40055 SALVADOR, BA, BRAZIL SO: CLINICAL PHARMACOLOGY & THERAPEUTICS 1993, Vol 53, Iss 1, pp 65-75 5- AU: Segura-J Pascual-JA Ventura-R Ustaran-JI Cuevas-A Gonzlez-R TI: International-Cooperation in Analytical-Chemistry - Experience of Antidoping Control at the 11th PanAmerican Games LA: English SH: Article AD: AUTONOMOUS-UNIV-BARCELONA, INST MUNICIPAL INVEST MED, DEPT PHARMACOL & TOXICOL, DOCTOR AIGUADER 80, E-08003 BARCELONA, SPAIN LAB-ABC-QUIM-INVEST-&-ANAL, MEXICO-CITY 06760, MEXICO CTR-NACL-INVEST-CIENT, HAVANA, CUBA SO: CLINICAL CHEMISTRY 1993, Vol 39, Iss 5, pp 836-845 6- AU: Pons-P Rodrguez-M Mas-R Illnait-J Fernndez-L Robaina-C Fernndez-JC TI: One-Year Efficacy and Safety of Policosanol Inpatients with Type-II Hypercholesterolemia 9, pp 1084-1092 LA: English SH: Article RF: 26 AD: NATL-CTR-SCI-RES, CTR NAT PROD, HAVANA 6880, CUBA PLAZA-POLICLIN-CTR, HAVANA, CUBA CALIXTO-GARCIA-HOSP, HAVANA, CUBA SO: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL 1994, Vol 55, Iss 7- UI - QH574

AU - Aneiros E, Mas R, Caldern B, Illnait J, Fernndez L, Castano G, Fernndez JC TI - Effect of Policosanol in Lowering Cholesterol Levels in Patients with Type-II Hypercholesterolemia. LA - English SH - Article RF - 28 AD - NATL CTR SCI RES, CTR NAT PROD, HAVANA, CUBA TOMAS ROMAY POLICLIN CTR, HAVANA, CUBA MED SURG RES CTR, HAVANA, CUBA AD - TOMAS ROMAY POLICLIN CTR, HAVANA, CUBA MED SURG RES CTR, HAVANA, CUBA AD - MED SURG RES CTR, HAVANA, CUBA SO - CURR THER RES 1995;56(2):176-182 8- UI - RR796 AU - Castano G, Canetti M, Moreira M, Tula L, Mas R, Illnait J, Fernndez L, Fernndez JC, Daz E TI - Efficacy and Tolerability of Policosanol in Elderly Patients with Type-II Hypercholesterolemia - A 12Month Study. LA - English SH - Article RF - 28 AD - NATL CTR SCI RES, CTR NAT PROD, HAVANA 6880, CUBA SALVADOR ALLENDE HOSP, HAVANA, CUBA CTR MED SURG RES, HAVANA, CUBA LUIS DIAZ SOTO HOSP, HAVANA, CUBA AD - SALVADOR ALLENDE HOSP, HAVANA, CUBA CTR MED SURG RES, HAVANA, CUBA LUIS DIAZ SOTO HOSP, HAVANA, CUBA AD - CTR MED SURG RES, HAVANA, CUBA LUIS DIAZ SOTO HOSP, HAVANA, CUBA AD - LUIS DIAZ SOTO HOSP, HAVANA, CUBA SO - CURR THER RES 1995;56(8):819-828 9- UI - QN641 AU - Castano G, Mas R, Nodarse M, Illnait J, Fernndez L, Fernndez JC TI - One-Year Study of the Efficacy and Safety of Policosanol (5 Mg Twice-Daily) in the Treatment of Type-II Hypercholesterolemia. LA - English SH - Article RF - 35 AD - NATL CTR SCI RES, CTR NAT PROD, HAVANA 6880, CUBA NATL CTR SCI RES, MED SURG RES CTR, HAVANA 6880, CUBA AD - NATL CTR SCI RES, MED SURG RES CTR, HAVANA 6880, CUBA SO - CURR THER RES 1995;56(3):296-304 10- UI - QK346 AU - Norman J, Thong KJ, Alzugaray MG, Ho PC, Pretnardarovec A, Res P, Kovacs L, Nemeth G, Chen JK, Zhu YH, Swahn ML, Song LJ, Wang YJ, Vanlook PFA, Belsey EM, Bernerslee N, Laperriere N, Vonhertzen H, Machn D, Ali M TI - Menstrual Regulation by Mifepristone Plus Prostaglandin - Results from a Multicenter Trial. LA - English SH - Article RF - 24 AD - UNIV EDINBURGH, DEPT OBSTET & GYNAECOL, EDINBURGH EH3 9EW, MIDLOTHIAN, SCOTLAND AD - NATL INST ENDOCRINOL, HAVANA 4, CUBA UNIV HONG KONG, QUEEN MARY HOSP, DEPT OBSTET & GYNAECOL, HONG KONG, HONG KONG UNIV LJUBLJANA, DEPT OBSTET & GYNAECOL, LJUBLJANA 61000, SLOVENIA ALBERT SZENT GYORGYI MED UNIV, SZEGED, HUNGARY SHANGHAI INST PLANNED PARENTHOOD RES, SHANGHAI 200032, PEOPLES R CHINA KAROLINSKA HOSP, DEPT OBSTET & GYNECOL, S 10401 STOCKHOLM, SWEDEN TIANJIN MUNICIPAL RES INST FAMILY

PLANNING, TIANJIN 300191, PEOPLES R CHINA TONGJI MED UNIV, WUHAN 430030, PEOPLES R CHINA WHO, SPECIAL PROGRAMME RES DEV & RES TRAINING HUMAN RE, CH 1211 GENEVA 27, SWITZERLAND AD - UNIV HONG KONG, QUEEN MARY HOSP, DEPT OBSTET & GYNAECOL, HONG KONG, HONG KONG AD - UNIV LJUBLJANA, DEPT OBSTET & GYNAECOL, LJUBLJANA 61000, SLOVENIA AD - ALBERT SZENT GYORGYI MED UNIV, SZEGED, HUNGARY SHANGHAI INST PLANNED PARENTHOOD RES, SHANGHAI 200032, PEOPLES R CHINA KAROLINSKA HOSP, DEPT OBSTET & GYNECOL, S 10401 STOCKHOLM, SWEDEN TIANJIN MUNICIPAL RES INST FAMILY PLANNING, TIANJIN 300191, PEOPLES R CHINA TONGJI MED UNIV, WUHAN 430030, PEOPLES R CHINA WHO, SPECIAL PROGRAMME RES DEV & RES TRAINING HUMAN RE, CH 1211 GENEVA 27, SWITZERLAND AD - SHANGHAI INST PLANNED PARENTHOOD RES, SHANGHAI 200032, PEOPLES R CHINA AD - KAROLINSKA HOSP, DEPT OBSTET & GYNECOL, S 10401 STOCKHOLM, SWEDEN AD - TIANJIN MUNICIPAL RES INST FAMILY PLANNING, TIANJIN 300191, PEOPLES R CHINA AD - TONGJI MED UNIV, WUHAN 430030, PEOPLES R CHINA WHO, SPECIAL PROGRAMME RES DEV & RES TRAINING HUMAN RE, CH 1211 GENEVA 27, SWITZERLAND AD - WHO, SPECIAL PROGRAMME RES DEV & RES TRAINING HUMAN RE, CH 1211 GENEVA 27, SWITZERLAND SO - HUM REPROD 1995;10(2):308-314 11- UI - QR733 AU - Delgado R, Rojas A, Glaria LA, Torres M, Duarte F, Shill R, Nafeh M, Santin E, Gonzlez N, Palacios M TI - Ca2+-Independent Nitric-Oxide Synthase Activity in Human Lung After Cardiopulmonary Bypass. LA - English SH - Note RF - 10 AD - CTR PHARMACEUT CHEM, DEPT PHARMACOL & TOXICOL, POB 16042, HAVANA, CUBA AD - HERMANOS AMEIJEIRAS HOSP, CARDIOSURG UNIT, HAVANA, CUBA SO - THORAX 1995;50(4):403-404 12- UI - RZ827 AU - Ferrandiz R, Casas R, Dreborg S, Einarsson R, Fernndez B TI - Cross-Reactivity Between Dermatophagoides Siboney and Other House-Dust Mite Allergens in Sensitized Asthmatic- Patients. LA - English SH - Article RF - 21 AD - LINKOPING UNIV HOSP, DEPT PAEDIAT, S 58185 LINKOPING, SWEDEN AD - NATL CTR BIOPROD, DEPT ALLERGENS, HAVANA, CUBA SO - CLIN EXPERIMENT ALLERGY 1995;25(10):929-934 13- UI - UE028 AU - Gonzlez Abru E, Pon JA, Hernndez P, Rodrguez J, Mendoza E, Hernndez M, Cuevas E, Gonzlez AB TI - Serological Reactivity to a Synthetic Analog of Phenolic Glycolipid-I and Early Detection of Leprosy in an Area of Low Endemicity. LA - English SH - Article RF - 19 AD - INST PEDRO KOUR, APARTADO 601, ZONA POSTAL 13, HAVANA,

CUBA AD - DIRECC MUNICIPAL SALUD, SANCTI SPIRITUS, CUBA CTR PROV HIGIENE & EPIDEMIOL, SANCTI SPIRITUS, CUBA AD - CTR PROV HIGIENE & EPIDEMIOL, SANCTI SPIRITUS, CUBA SO - LEPROSY REV 1996;67(1):4-12 14- UI - VT779 AU - Coutinho EM, Athayde C, Barbosa I, lvarez F, Brache V, Gu ZP, Emuveyan EE, Adekunle AO, Devoto L, Deacosta OM, Mati J, Ladipo OA TI - Results of a User Satisfaction Study Carried Out in Women Using Uniplant Contraceptive Implant. LA - English SH - Article RF - 13 AD - UNIV FED BAHIA, MATERN CLIMERIO DE OLIVEIRA, RUA LIMOEIRO 1, BR 40055150 SALVADOR, BA, BRAZIL AD - PROFAMILIA, SANTO DOMINGO, DOMINICAN REP SHANGHAI INST MAT MED, SHANGHAI, PEOPLES R CHINA UNIV LAGOS, COLL MED, DEPT OBSTET & GYNECOL, LAGOS, NIGERIA UNIV COLL IBADAN HOSP, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV CHILE, FAC MED, DEPT OBSTET & GYNECOL, SANTIAGO 7, CHILE INST NACL ENDOCRINOL, HAVANA, CUBA KENYA GOVT MED RES CTR, REPROD HLTH RES UNIT, NAIROBI, KENYA S TO S COOPERAT REPROD HLTH, SALVADOR, BA, BRAZIL AD - SHANGHAI INST MAT MED, SHANGHAI, PEOPLES R CHINA UNIV LAGOS, COLL MED, DEPT OBSTET & GYNECOL, LAGOS, NIGERIA UNIV COLL IBADAN HOSP, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV CHILE, FAC MED, DEPT OBSTET & GYNECOL, SANTIAGO 7, CHILE INST NACL ENDOCRINOL, HAVANA, CUBA KENYA GOVT MED RES CTR, REPROD HLTH RES UNIT, NAIROBI, KENYA S TO S COOPERAT REPROD HLTH, SALVADOR, BA, BRAZIL AD - UNIV LAGOS, COLL MED, DEPT OBSTET & GYNECOL, LAGOS, NIGERIA UNIV COLL IBADAN HOSP, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV CHILE, FAC MED, DEPT OBSTET & GYNECOL, SANTIAGO 7, CHILE INST NACL ENDOCRINOL, HAVANA, CUBA KENYA GOVT MED RES CTR, REPROD HLTH RES UNIT, NAIROBI, KENYA S TO S COOPERAT REPROD HLTH, SALVADOR, BA, BRAZIL AD - UNIV COLL IBADAN HOSP, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA AD - UNIV CHILE, FAC MED, DEPT OBSTET & GYNECOL, SANTIAGO 7, CHILE AD - INST NACL ENDOCRINOL, HAVANA, CUBA KENYA GOVT MED RES CTR, REPROD HLTH RES UNIT, NAIROBI, KENYA S TO S COOPERAT REPROD HLTH, SALVADOR, BA, BRAZIL AD - KENYA GOVT MED RES CTR, REPROD HLTH RES UNIT, NAIROBI, KENYA AD - S TO S COOPERAT REPROD HLTH, SALVADOR, BA, BRAZIL SO - CONTRACEPTION 1996;54(5):313-317 15- UI - TU687 AU - Coutinho EM, Desouza JC, Athayde C, Barbosa IC, lvarez F, Brache V, Gu ZP, Emuveyan EE, Adekunle AO, Devoto L, Shaaban MM, Salem HT, Affandi B, Deacosta OM, Mati J, Ladipo OA TI - Multicenter Clinical-Trial on the Efficacy and Acceptability of a Single Contraceptive Implant of Nomegestrol Acetate, Uniplant. LA - English SH - Article RF - 7 AD - UNIV FED BAHIA, MATERN CLIMERIO OLIVEIRA, RUA LIMOEIRO 1, BR 40055150 SALVADOR, BA, BRAZIL AD - PROFAMILIA, SANTO DOMINGO, DOMINICAN REP SHANGHAI INST MAT MED, SHANGHAI, PEOPLES R CHINA UNIV LAGOS, COLL MED, DEPT OBSTET & GYNECOL, LAGOS, NIGERIA UNIV IBADAN, UNIV COLL HOSP, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV CHILE, FAC MED, DEPT OBSTET & GYNECOL, SANTIAGO 7, CHILE UNIV ASSIUT, SCH MED, DEPT OBSTET & GYNECOL, ASSIUT, EGYPT UNIV INDONESIA, FAC MED, DEPT OBSTET & GYNECOL, JAKARTA, INDONESIA SOUTH SOUTH COOPERAT REPROD HLTH, SALVADOR, BA, BRAZIL INST NACL ENDOCRINOL, HAVANA, CUBA KENYA GOVT MED RES

CTR, REPROD HLTH RES UNIT, NAIROBI, KENYA AD - SHANGHAI INST MAT MED, SHANGHAI, PEOPLES R CHINA UNIV LAGOS, COLL MED, DEPT OBSTET & GYNECOL, LAGOS, NIGERIA UNIV IBADAN, UNIV COLL HOSP, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV CHILE, FAC MED, DEPT OBSTET & GYNECOL, SANTIAGO 7, CHILE UNIV ASSIUT, SCH MED, DEPT OBSTET & GYNECOL, ASSIUT, EGYPT UNIV INDONESIA, FAC MED, DEPT OBSTET & GYNECOL, JAKARTA, INDONESIA SOUTH SOUTH COOPERAT REPROD HLTH, SALVADOR, BA, BRAZIL INST NACL ENDOCRINOL, HAVANA, CUBA KENYA GOVT MED RES CTR, REPROD HLTH RES UNIT, NAIROBI, KENYA AD - UNIV LAGOS, COLL MED, DEPT OBSTET & GYNECOL, LAGOS, NIGERIA UNIV IBADAN, UNIV COLL HOSP, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV CHILE, FAC MED, DEPT OBSTET & GYNECOL, SANTIAGO 7, CHILE UNIV ASSIUT, SCH MED, DEPT OBSTET & GYNECOL, ASSIUT, EGYPT UNIV INDONESIA, FAC MED, DEPT OBSTET & GYNECOL, JAKARTA, INDONESIA SOUTH SOUTH COOPERAT REPROD HLTH, SALVADOR, BA, BRAZIL INST NACL ENDOCRINOL, HAVANA, CUBA KENYA GOVT MED RES CTR, REPROD HLTH RES UNIT, NAIROBI, KENYA AD - UNIV IBADAN, UNIV COLL HOSP, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA AD - UNIV CHILE, FAC MED, DEPT OBSTET & GYNECOL, SANTIAGO 7, CHILE AD - UNIV ASSIUT, SCH MED, DEPT OBSTET & GYNECOL, ASSIUT, EGYPT UNIV INDONESIA, FAC MED, DEPT OBSTET & GYNECOL, JAKARTA, INDONESIA SOUTH SOUTH COOPERAT REPROD HLTH, SALVADOR, BA, BRAZIL INST NACL ENDOCRINOL, HAVANA, CUBA KENYA GOVT MED RES CTR, REPROD HLTH RES UNIT, NAIROBI, KENYA AD - UNIV INDONESIA, FAC MED, DEPT OBSTET & GYNECOL, JAKARTA, INDONESIA AD - SOUTH SOUTH COOPERAT REPROD HLTH, SALVADOR, BA, BRAZIL INST NACL ENDOCRINOL, HAVANA, CUBA KENYA GOVT MED RES CTR, REPROD HLTH RES UNIT, NAIROBI, KENYA AD - INST NACL ENDOCRINOL, HAVANA, CUBA KENYA GOVT MED RES CTR, REPROD HLTH RES UNIT, NAIROBI, KENYA AD - KENYA GOVT MED RES CTR, REPROD HLTH RES UNIT, NAIROBI, KENYA SO - CONTRACEPTION 1996;53(2):121-125 16- UI - UH487 AU - Rovet J, lvarez M TI - Thyroid-Hormone and Attention in Congenital Hypothyroidism. LA - English SH - Article RF - 6 AD - UNIV TORONTO, HOSP SICK CHILDREN, DEPT PSYCHOL, 555 UNIV AVE, TORONTO, ON M5G 1X8, CANADA AD - UNIV HAVANA, FAC PSYCHOL, HAVANA, CUBA SO - J PEDIATR ENDOCRINOL METAB 1996;9(1):63-66 17- UI - UX510 AU - Pestana ES, Bjorklund G, Larsson R, Nygren P, Nilsson K, Bergh J TI - Effects of Interferons and Tumor-Necrosis-Factor-Alpha on Human Lung-Cancer Cell-Lines and the Development of an Interferon-Resistant Lung-Cancer Cell-Line. LA - English SH - Article RF - 32 AD - UNIV UPPSALA HOSP, DEPT PATHOL, S 75185 UPPSALA, SWEDEN UNIV UPPSALA HOSP, DEPT CLIN PHARMACOL, UPPSALA, SWEDEN UNIV UPPSALA HOSP, DEPT ONCOL, S 75185 UPPSALA, SWEDEN NATL INST ONCOL & RADIOBIOL, HAVANA, CUBA AD - UNIV UPPSALA HOSP, DEPT CLIN PHARMACOL, UPPSALA, SWEDEN UNIV UPPSALA HOSP, DEPT ONCOL, S 75185 UPPSALA, SWEDEN NATL INST ONCOL & RADIOBIOL, HAVANA, CUBA AD - UNIV UPPSALA HOSP, DEPT ONCOL, S 75185 UPPSALA, SWEDEN NATL INST ONCOL & RADIOBIOL, HAVANA, CUBA AD - NATL INST ONCOL & RADIOBIOL, HAVANA, CUBA

SO - ACTA ONCOL 1996;35(4):473-478 18- UI - VK620 AU - Castano G, Tula L, Canetti M, Morera M, Mas R, Illnait J, Fernndez L, Fernndez JC TI - Effects of Policosanol in Hypertensive Patients with Type-II Hypercholesterolemia. LA - English SH - Article RF - 29 AD - NATL CTR SCI RES, CTR NAT PROD, HAVANA 6880, CUBA NATL CTR SCI RES, MED SURG RES CTR, HAVANA 6880, CUBA NATL CTR SCI RES, LUIS DIAZ SOTO HOSP, HAVANA 6880, CUBA NATL CTR SCI RES, SALVADOR ALLENDE HOSP, HAVANA 6880, CUBA AD - NATL CTR SCI RES, MED SURG RES CTR, HAVANA 6880, CUBA NATL CTR SCI RES, LUIS DIAZ SOTO HOSP, HAVANA 6880, CUBA NATL CTR SCI RES, SALVADOR ALLENDE HOSP, HAVANA 6880, CUBA AD - NATL CTR SCI RES, LUIS DIAZ SOTO HOSP, HAVANA 6880, CUBA NATL CTR SCI RES, SALVADOR ALLENDE HOSP, HAVANA 6880, CUBA AD - NATL CTR SCI RES, SALVADOR ALLENDE HOSP, HAVANA 6880, CUBA SO - CURR THER RES 1996;57(9):691-699 19- AU - Canetti M AU - Moreira M, Mas R, Illnait J, Fernndez L, Fernndez J, Daz E, Castano G TI - A 2-Year Study on the Efficacy and Tolerability of Policosanol in Patients with Type-II Hyperlipoproteinemia. LA - English SH - Article RF - 29 AD - NATL CTR SCI RES, CTR NAT PROD, HAVANA, CUBA CTR MED & SURG RES, HAVANA, CUBA SALVADOR ALLENDE HOSP, HAVANA, CUBA AD - CTR MED & SURG RES, HAVANA, CUBA SALVADOR ALLENDE HOSP, HAVANA, CUBA AD - SALVADOR ALLENDE HOSP, HAVANA, CUBA SO - INT J CLIN PHARM RES 1995;15(4):159-165 20- UI - WQ362 AU - Castano G, Mas R, Fernndez JC, Illnait J TI - Comparative Effects of 2 Once-Daily Regimens of Policosanol in Patients with Type-II Hypercholesterolemia. LA - English SH - Article RF - 31 AD - NATL CTR SCI RES, CTR MED SURG RES, HAVANA, CUBA NATL CTR SCI RES, CTR NAT PROD, HAVANA, CUBA AD - NATL CTR SCI RES, CTR NAT PROD, HAVANA, CUBA SO - CURR THER RES 1997;58(3):154-162 21- UI - WW589 AU - Rovet J, Alvarez M TI - Attentional Functioning in Children and Adolescents with IDDM. LA - English SH - Article RF - 70 AD - UNIV TORONTO, TORONTO, ON, CANADA NATL INST NEUROL & NEUROSURG, HAVANA, CUBA AD - NATL INST NEUROL & NEUROSURG, HAVANA, CUBA SO - DIABETES CARE 1997;20(5):803-810

22- UI - 135DC AU - Iznagaescobar N, Arocha LAT, Morales AM, Suzarte MR, Mesa NR, Rodrguez RP TI - Technetium-99m-Antiepidermal Growth Factor-Receptor Antibody in Patients with Tumors of Epithelial Origin - Part II - Pharmacokinetics and Clearances. LA - English SH - Article RF - 54 AD - CTR MOL IMMUNOL, POB 16040, HAVANA 11600, CUBA CLIN RES CTR, HAVANA 11600, CUBA MED SURG RES CTR, HAVANA 11600, CUBA AD - CLIN RES CTR, HAVANA 11600, CUBA MED SURG RES CTR, HAVANA 11600, CUBA AD - MED SURG RES CTR, HAVANA 11600, CUBA SO - J NUCL MED 1998;39(11):1918-1927 23- UI - YR214 AU - Iznagaescobar N, Torres LA, Morales A, Ramos M, lvarez I, Prez N, Fraxedas R, Rodrguez O, Rodrguez N, Prez R, Lage A, Stabin MG TI - Tc-99m-Labeled Anti-EGF-Receptor Antibody in Patients with Tumor of Epithelial Origin - I Biodistribution and Dosimetry for Radioimmunotherapy. LA - English SH - Article RF - 50 AD - ORTHOPED FRANK PAIS, CTR MOL IMMUNOL CLIN RES & MED SURG RES, INST NEPHROL, HAVANA, CUBA AD - RADIAT INTERNAL DOSE INFORMAT CTR, OAK RIDGE, TN, USA SO - J NUCL MED 1998;39(1):15-23 24- UI - YZ964 AU - Bentez J, Palenzuela D, Rivero J, Gavilondo JV TI - A Recombinant Protein-Based Immunoassay for the Combined Detection of Antibodies to HIV-1, HIV-2 and HTLV-I. LA - English SH - Article RF - 19 AD - CTR GENET ENGN & BIOTECHNOL, IMMUNOTECHNOL & DIAGNOST DIV, 31 AVE & 190 CUBANACAN, POB 6162, HAVANA, CUBA AD - SANTIAGO VEGAS SANAT, HAVANA, CUBA SO - J VIROL METH 1998;70(1):85-91 25- UI - ZQ404 AU - Bello I, Prez A, Torres AM, Hernndez MV, Saura PL TI - High-Levels of Soluble IFN-Gamma Receptor-Alpha Chain in the Plasma of Rheumatoid-Arthritis Patients. LA - English SH - Article RF - 31 AD - CTR INVEST BIOL, POB 6996, HAVANA, CUBA UNIV HAVANA, FAC FARM & ALIMENTOS, HAVANA, CUBA INST REUMATOL, HAVANA, CUBA AD - UNIV HAVANA, FAC FARM & ALIMENTOS, HAVANA, CUBA INST REUMATOL, HAVANA, CUBA AD - INST REUMATOL, HAVANA, CUBA SO - BIOTHERAPY 1998;11(1):53-57 26- UI - 111CY AU - Espino AM, Daz A, Prez A, Finlay CM

TI - Dynamics of Antigenemia and Coproantigens During a Human Fasciola-Hepatica Outbreak. LA - English SH - Article RF - 20 AD - INST MED TROP PEDRO KOURI IPK, DEPT PARASITOL, APTDO 601, ZONA 13, HAVANA, CUBA AD - INST MED TROP PEDRO KOURI IPK, SUBDIRECC EPIDEMIOL, HAVANA, CUBA SO - J CLIN MICROBIOL 1998;36(9):2723-2726 27- UI - 130KK AU - Castano G, Mas R, Fernndez JC, Pontigas V, Suazo M, Fernndez L TI - Open-Label Study of the Efficacy, Safety, and Tolerability of Policosanol in Patients with High Global Coronary Risk. LA - English SH - Article RF - 39 AD - NATL CTR SCI RES, CTR NAT PROD, HAVANA 6880, CUBA NATL CTR SCI RES, CTR MED SURG RES, HAVANA 6880, CUBA AD - NATL CTR SCI RES, CTR MED SURG RES, HAVANA 6880, CUBA SO - CURR THER RES 1998;59(10):737-745 28- UI - 130KK AU - Fernndez L, Mas R, Illnait J, Fernndez JC TI - Policosanol - Results of a Postmarketing Surveillance Study of 27,879 Patients. LA - English SH - Article RF - 37 AD - NATL CTR SCI RES, CTR NAT PROD, HAVANA, CUBA SO - CURR THER RES 1998;59(10):717-722 29- UI - 139CD AU - Estradaparra S, Nagaya A, Serrano E, Rodrguez O, Santamara V, Ondarza R, Chvez R, Correa B, Monges A, Cabezas R, Calva C, Estradagarcia I TI - Comparative-Study of Transfer-Factor and Acyclovir in the Treatment of Herpes-Zoster. LA - English SH - Article RF - 33 AD - NATL POLYTECH INST, NATL SCH BIOL SCI, DEPT IMMUNOL, PROL CARPIO Y PLAN DE AYALA, MEXICO CITY 11340, DF, MEXICO AD - DERMATOL CTR L PASCUA SS, MEXICO CITY, DF, MEXICO CIMEQ, HAVANA, CUBA AD - CIMEQ, HAVANA, CUBA SO - INT J IMMUNOPHARMACOL 1998;20(10):521-535 30- UI - 136HW AU - Garca Milin R, Hernndez H, Panad L, Rodrguez C, Gonzlez N, Valenzuela C, Arana MD, Perea SE TI - Detection and Typing of Human-Papillomavirus DNA in Benign and Malignant-Tumors of Laryngeal Epithelium. LA - English SH - Article RF - 25 AD - BIOL RES CTR, DEPT CELLULAR BIOL, 134 ST & 25 AVE, POB 6996, HAVANA, CUBA AD - FAC MED SCI, HAVANA, CUBA HOSP CLIN QUIRURG 10 OCTOBRE, DEPT OTORHINOLARYNGOL, HAVANA, CUBA NATL CTR ONCOL & RADIOBIOL, DEPT HEAD &

NECK, HAVANA, CUBA CTR GENET ENGN & BIOTECHNOL, DIV CLIN TRIALS, HAVANA, CUBA AD - HOSP CLIN QUIRURG 10 OCTOBRE, DEPT OTORHINOLARYNGOL, HAVANA, CUBA AD - NATL CTR ONCOL & RADIOBIOL, DEPT HEAD & NECK, HAVANA, CUBA CTR GENET ENGN & BIOTECHNOL, DIV CLIN TRIALS, HAVANA, CUBA AD - CTR GENET ENGN & BIOTECHNOL, DIV CLIN TRIALS, HAVANA, CUBA SO - ACTA OTO-LARYNGOL 1998;118(5):754-758 31- UI - KK066 AU - Coutinho EM, De Souza JC, Da Silva AR, De Acosta OM, lvarez F, Brache V, Flores JG, Vsquez Estrada L, Santo R, Bassol S, Alvarado G, Gu ZP, Ladipo OA, Adekunle AO, Otolorin EO, Mati JKG, Maggwa ABN, Shaaban MM, Sayed EH, Abdelaleem H, Sikazwe NC, Segal SJ TI - Comparative-Study on the Efficacy and Acceptability of 2 Contraceptive Pills Administered by the Vaginal Route - An International Multicenter Clinical-Trial. LA - English SH - Article RF - 11 AD - FED UNIV BAHIA, MATERNIDADE CLIMERIO OLIVEIRA, RUA LIMOEIRO 1, BR 40055 SALVADOR, BA, BRAZIL AD - CINSERHA PROFAMILIA, SANTO DOMINGO, DOMINICAN REP ROCKEFELLER FDN, NEW YORK, NY 10036, USA UNIV ASSIUT, DEPT OBSTET & GYNECOL, ASSIUT, EGYPT UNIV ZAMBIA, DEPT OBSTET & GYNECOL, LUSAKA, ZAMBIA SHANGHAI INST MAT MED, SHANGHAI, PEOPLES R CHINA INST NACL NUTR SALVADOR ZUBIRAN, DEPT REPROD BIOL, MEXICO CITY 14000, DF, MEXICO INST NACL ENDOCRINOL, HAVANA, CUBA UNIV IBADAN, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV NAIROBI, DEPT OBSTET & GYNECOL, NAIROBI, KENYA AD - ROCKEFELLER FDN, NEW YORK, NY 10036, USA UNIV ASSIUT, DEPT OBSTET & GYNECOL, ASSIUT, EGYPT UNIV ZAMBIA, DEPT OBSTET & GYNECOL, LUSAKA, ZAMBIA SHANGHAI INST MAT MED, SHANGHAI, PEOPLES R CHINA INST NACL NUTR SALVADOR ZUBIRAN, DEPT REPROD BIOL, MEXICO CITY 14000, DF, MEXICO INST NACL ENDOCRINOL, HAVANA, CUBA UNIV IBADAN, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV NAIROBI, DEPT OBSTET & GYNECOL, NAIROBI, KENYA AD - UNIV ASSIUT, DEPT OBSTET & GYNECOL, ASSIUT, EGYPT UNIV ZAMBIA, DEPT OBSTET & GYNECOL, LUSAKA, ZAMBIA SHANGHAI INST MAT MED, SHANGHAI, PEOPLES R CHINA INST NACL NUTR SALVADOR ZUBIRAN, DEPT REPROD BIOL, MEXICO CITY 14000, DF, MEXICO INST NACL ENDOCRINOL, HAVANA, CUBA UNIV IBADAN, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV NAIROBI, DEPT OBSTET & GYNECOL, NAIROBI, KENYA AD - UNIV ZAMBIA, DEPT OBSTET & GYNECOL, LUSAKA, ZAMBIA SHANGHAI INST MAT MED, SHANGHAI, PEOPLES R CHINA INST NACL NUTR SALVADOR ZUBIRAN, DEPT REPROD BIOL, MEXICO CITY 14000, DF, MEXICO INST NACL ENDOCRINOL, HAVANA, CUBA UNIV IBADAN, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV NAIROBI, DEPT OBSTET & GYNECOL, NAIROBI, KENYA AD - SHANGHAI INST MAT MED, SHANGHAI, PEOPLES R CHINA INST NACL NUTR SALVADOR ZUBIRAN, DEPT REPROD BIOL, MEXICO CITY 14000, DF, MEXICO INST NACL ENDOCRINOL, HAVANA, CUBA UNIV IBADAN, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV NAIROBI, DEPT OBSTET & GYNECOL, NAIROBI, KENYA AD - INST NACL NUTR SALVADOR ZUBIRAN, DEPT REPROD BIOL, MEXICO CITY 14000, DF, MEXICO AD - INST NACL ENDOCRINOL, HAVANA, CUBA UNIV IBADAN, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV NAIROBI, DEPT OBSTET & GYNECOL, NAIROBI, KENYA AD - UNIV IBADAN, DEPT OBSTET & GYNECOL, IBADAN, NIGERIA UNIV NAIROBI, DEPT OBSTET & GYNECOL, NAIROBI, KENYA AD - UNIV NAIROBI, DEPT OBSTET & GYNECOL, NAIROBI, KENYA SO - CLIN PHARMACOL THER 1993;53(1):65-75 32- UI - KU275 AU - Pons P, Jimnez A, Rodrguez M, Illnait J, Mas R, Fernndez L, Fernndez JC

TI - Effects of Policosanol in Elderly Hypercholesterolemic Patients. LA - English SH - Article RF - 7 AD - PLAZA POLICLIN CTR, HAVANA, CUBA NATL CTR SCI RES, HAVANA, CUBA AD - NATL CTR SCI RES, HAVANA, CUBA SO - CURR THER RES 1993;53(3):265-269 33- AU - Ramos-Suzarte M, Rodriuez N, Oliva JP, Iznaga Escobar N, Perera A, Morales A, Gonzlez N, Cordero M, Torres L, Pimentel G, Borron M, Gonzlez J, Torres O, Rodrguez T, Prez R TI - Tc-99m-labeled antihuman epidermal growth factor receptor antibody in patients with tumors of epithelial origin: Part III. Clinical trials safety and diagnostic efficacy LA - English SH - Article AD - Ctr Mol Immunol, Havana, Cuba AD - Ctr Med Surg Res AD - Natl Inst Oncol & Radiobiol, Havana 11600, Cuba AD - Clin Res Ctr, Havana 11600, Cuba SO - JOURNAL OF NUCLEAR MEDICINE. May 1999; 40 (5) : 768-775. 34- AU - Torrens I, Reyes O, Ojalvo AG, Seralena A, Chinea G, Cruz LJ, de-la-Fuente J TI - Mapping of the antigenic regions of streptokinase in humans after streptokinase therapy LA - English SH - Article AD - Ctr Ing Genet & Biotechnol, Div Pharmaceut, Havana, Cuba AD - Ctr Ing Genet & Biotechnol, Div Phys Chem, Havana, Cuba SO - BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. May 27, 1999: 259 (1) : 162-168. 35- AU - Castao G, Mas R, Fernndez JC, Lpez LE, Fernndez L TI - A long-term, open-label study of the efficacy and tolerability of policosanol in patients with high global coronary risk LA - English SH - Article AD - Natl Ctr Sci Res, Havana 6880, Cuba AD - Med Surg Res Ctr SO - CURRENT THERAPEUTIC RESEARCH CLINICAL AND EXPERIMENTAL. Jul 1999; 60 (7) : 379-391. 36- AU - Gamonal J, Acevedo A, Bascones A, Jorge O, Silva A TI - Levels of interleukin-1 beta. -8 and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment LA - English SH - Article AD - CSIC, Ctr Invest Biol, Dpt Immunol, E-28006 Madrid, Spain AD - Univ Chile, Fac Odontol, Area Periodoncia, Dept Odontol Conservadora, Santiago, Chile AD - Hosp Univ Princesa, Madrid, Spain AD - Ctr Nacl Biopreparados, La Habana, Cuba SO - JOURNAL OF PERIODONTOLOGY. Oct 2000; 71 (10) : 1535-1545. 37- AU - Palomino A, Hernndez-Bernal F, Haedo W, Franco S, Mas JA, Fernndez JA, Soto G, Alonso A, Gonzlez T, Lpez-Saura P TI - A multicenter, randomized, double-blind clinical trial examining the effect of oral human recombinant

eoidermal growth factor on the healing of duodenal ulcers LA - English SH - Article AD - Biol Res Ctr, Clin Trials Division, Havana, Cuba AD - Carlos J Finlay Hosp, Havana, Cuba AD - Gastroenterol Inst, Havana, Cuba AD - Luis Daz Soto Hosp, Havana, Cuba AD - Hermanos Ameijeiras Hosp, Havana, Cuba AD - Miguel Enrquez Hosp, Havana, Cuba AD - Natl Ctr Coordinat Clin Trials, Havana, Cuba SO - SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. Oct 2000; 35 (10) : 1016-1022. 38- AU - Calnan DP, Fagbemi A, Berlanga-Acosta J, Marchbank T, Sizer T, Lakhoo K, Edwards AD, Playford RJ TI - Potency and stability of C terminal truncated human epidermal growth factor LA - English SH - Article AD - Univ London Imperial Coll Technol & Med, Sch Med, Dept Gastroenterol, London W12 ONN, England AD - Leicester Gen Hosp, Univ Div Gastroenterol, Leics, England AD - Ctr Genet Eng & Biotechnol, Havana, Cuba SO - GUT. Nov 2000; 47 (5) : 622-627. 39- AU - Menndez R AU - Mas R, Amor AM, Fernndez JC, AU - Gonzlez RM TI - Effects of policosanol on the susceptibility of low-density lipoprotein isolated from hipercholesterolemic patients at high coronary risk to in vitro copper-mediated lipid peroxidation: a randomized, double-blind pilot study LA - English SH - Article AD - Natl Ctr Sci Res, Ctr Nat Prod, Havana, Cuba SO - CURRENT THERAPEUTIC RESEARCH CLINICAL AND EXPERIMENTAL. Sep 2000; 61 (9) : 609-620. 40- AU - Prez JL, Garca L, Talavera A, Oliva R, Valmaseda T, Ano G, Prez O, Sierra G TI - Passive protection of serum from volunteers inoculated with attenuated strain 638 of Vibrio cholerae O1 in animal models LA - English SH - Article AD - Finlay Inst, Ctr Res Vaccines & Sera, Havana, Cuba SO - VACCINE. Sep 15, 2000; 19 (2-3) : 376-384. 41- AU - Marcello S, Gladstein J, Tesone P, Mas R TI - Effects of bezafibrate plus policosanol or placebo in patients with combined dyslipidemia: a pilot study LA - English SH - Article AD - Natl Ctr Sci Res, Ctr Nat Prod, Havana 6880, Cuba AD - Ramon Ramos Mejias Hosp, Buenos Aires, DF, Argentina SO - CURRENT THERAPEUTIC RESEARCH CLINICAL AND EXPERIMENTAL. Jun 2000; 61 (6) : 346-357. 42- AU - Castao G, Mas R, Fernndez JC, Fernndez L, lvarez E, Lezcay M TI - Efficacy and tolerability of policosanol compared with lovastatin in patients with type II

hypercholesterolemia and concomitant coronary risk factors LA - English SH - Article AD - Natl Ctr Sci Res, Ctr Nat Prod, Havana 6880, Cuba SO - CURRENT THERAPEUTIC RESEARCH CLINICAL AND EXPERIMENTAL. Mar 2000; 61 (3) : 137-146. 43- AU - Prez A, Dickinson F, Cinza Z, Ruiz A, Serrano T, Sosa J, Gonzlez S, Gutirrez Y, Nazabal C, Gutirrez O, Guzmn D, Daz M, Delgado M, Caballero E, Sardias G, lvarez A, Martn A, Guilln G, Silva R TI - Safety and preliminary immunogenicity of the recombinant outer membrane protein p64k of Neisseria meningitidis in human volunteers LA - English SH - Article AD - Inst Med Trop Pedro Kour, Autopista Novia Medioda, Habana, Cuba AD - Ctr Ing Genet y Biotecnol, Div Vacunas, Habana, 10 600, Cuba SO - BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY. Oct 2001; 34 Part 2: 121. 44- AU - Stern PL, Faulkner R, Veranes EC, Davidson EJ TI - The role of human papillomavirus vaccines in cervical neoplasia LA - English SH - Article AD - Christie Hosp NHS Trust, Paterson Inst Canc Res, Manchester, England AD - Univ Manchester, England AD - Inst Finlay, Dept Virol, Habana 11600, Cuba SO - BEST PRACTICE AND RESEARCH IN CLINICAL OBSTETRICS AND GYNAECOLOGY. Oct 2001; 15(5) : 783-799. 45- AU - Toledo H, Baly A, Castro O, Resik S, Laferte J, Rolo F, Navea L, Lobaina L, Cruz O, Miguez J, Serrano T, Sierra B, Prez L, Ricardo ME, Dubed M, Lubian AL, Blanco M, Millan JC, Ortega A, Iglesias E, Pentn E, Martn Z, Prez J, Daz M, Duarte CA TI - A phase I clinical trial of a multi-epitope polypeptide TAB9 combined with Montanide ISA 720 adjuvant in non-HIV-1 infected human volunteers LA - English SH - Article AD - Ctr Ing Genet & Biotecnol, Havana, Cuba AD - Inst Med Trop Pedro Kour Habana, Cuba AD - SIDA, Lab Infest, San Jos, Habana, Cuba SO - VACCINE. Jul 2001; 19 (30): 4328-4336. 46- AU - Crombet T AU - Torres O, Rodrguez V, Menndez A, Stevenson A, Ramos M, Torres F, Figueredo R, Veita I, Iznaga N, Prez R, Lage A TI - Phase I clinical evaluation of a neutralizing monoclonal antibody against epidermal growth factor receptor in advanced brain tumor patients: preliminary study LA - English SH - Article AD - Ctr Mol Immunol, Div Clin Immunol, Habana, Cuba AD - Natl Inst Neurol & Neurosurg, Havana, Cuba SO - HYBRIDOMA. Apr 2001; 20 (2): 131-136. 47- AU - Crombet T, Torres O, Nennger E, Catal M, Rodrguez N, Ramos M, Fernndez E, Iznaga N, Prez R, Lage A

TI - Phase I clinical evaluation of a neutralizing monoclonal antibody against epidermal growth factor receptor LA - English SH - Article AD - Ctr Mol Immunol, Habana, Cuba AD - Hermanos Ameijeiras Hosp, Havana, Cuba AD - Ctr Med & Surg Res, Havana, Cuba AD - Univ Havana, Inst Pharm & Food, Cuba SO - CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS. Feb 2001; 16 (1) : 93-102. 48- AU - Sechi LA, Lezcano I, Nez N, Espim M, Dupre I, Pinna A, Molicotti P, Fadda G, Zanetti S TI - Antibacterial activity of ozonized sunflower oil (Oleozon) LA - English SH - Article AD - Univ Sassari, Italy AD - Ctr Nacl Invest Cient, Habana, Cuba SO - JOURNAL OF APPLIED MICROBIOLOGY. Feb 2001; 90 (2): 279-284. 49- AU - Fernndez JC, Mas R, Castao G, Menndez R, Amor AM, Gonzlez RM, lvarez E TI - Comparison of the efficacy, safety and tolerability of policosanol versus fluvastatin in elderly hypercholesterolaemic women LA - English SH - Article AD - Natl Ctr Sci Res, Ctr Nat Prod, Havana, Cuba AD - Med Surg Res Ctr, Havana, Cuba SO - CLINICAL DRUG INVESTIGATION 2001; 21 (2): 103-113 50- AU - Rempleton A, Dhall GI, Calder A, Gmez-Alzugaray M, Ho PC, Pretnar A, Sikazwe C, Jun-Kang C, et,al TI - Lowering the doses of mifepristone and gemeprost for early abortion: a randomized controlled trial LA - English SH - Article AD - World Health Org, UNDP, Geneva, Switzerland AD - Natl Inst Endocrinol & Metab Diseases, Havana, Cuba; entre otras de USA, Zambia, China, Escocia, Singapur, Suecia, Hungra y Georgia SO - BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY. Jul 2001; 108 (7): 738-742. 51- AU - Carroli G, Villar J, Piaggio G, Khan D, Gulmezoglu M, Mugford M, Lumbiganon P, Farnot U, Bersgjo P TI - WHO systematic review of randomized controlled trials of routine antenatal care LA - English SH - Article AD - Centro Rosarino de Estudios Perinatales, Santa Fe, Argentina AD - World Health Organization, Geneva, Switzerland AD - Hosp Ginecobst Amrica Arias, Habana Cuba AD - Univ Khon Kaen, Thailand AD - Univ Bergen, Norway SO - LANCET. May 19, 2001; 357 (9268): 1565-1570. 52- AU - Mas R, Castao G, Fernndez L, Illnait J, Fernndez JC, lvarez E TI - Effects of policosanol on lipid profile and cardiac events in older hipercholesterolemic patients with coronary disease LA - English

SH - Article AD - Natl Ctr Sci Res, Havana, Cuba AD - Med Surg Res Ctr SO - CLINICAL DRUG INVESTIGATION. 2001; 21(7): 485-497. 53- AU - Viloria-Petit A, Crombet T, Jothy S, Hicklin D, Bohlen P, Schlaeppi JM, Rak J, Kerbel RS TI - Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis LA - English SH - Article AD - Sunnybrook & Women Coll, Hlth Sci Ctr, Dept Anat Pathol, Toronto, Canada AD - Ctr Mol Immunol, Habana, Cuba SO - CANCER RESEARCH. Jul 1, 2001; 61(13): 5090-5101. 54- AU - Blanco CER, Len HO, Guthrie TB TI - Combined partial arthroscopic synovectomy and radiation therapy for diffuse pigmented villonodular synovitis of the knee LA - English SH - Article AD - Pk Ridge Orthoped PA, Fletcher, N C 28732 USA AD - Hosp Hermanos Ameijeiras, Habana, Cuba SO - ARTHROSCOPY. May-Jun 2001; 17(5): 527-531. 55- AU - Castao G, Mas R, Fernndez L, Illnait J, Gamez R, Fernndez JC TI - Comparison of two regimens of policosanol administered at 20 mg/d in patients with type II hypercholesterolemia: a randomized, double-blind, placebo-controlled study LA - English SH - Article AD - Natl Ctr Sci Res, Ctr Nat Prod, Havana, Cuba AD - Ctr Med Surg Res, Havana, Cuba SO - CURRENT THERAPEUTIC RESEARCH CLINICAL AND EXPERIMENTAL. Mar 2001; 62(3): 194-208. 56- AU - Garmenda G, Miranda N, Borroso S, Longchong M, Martnez E, Ferrero J, AU - Porrero P, Lpez Saura P TI: Regression of Infancy Hemangiomas with Recombinant IFN-alpha2b LA - English SH - Article AD - Centro de Investigaciones Biolgicas, Habana, Cuba AD - Centro de Ingeniera Gentica y Biotecnologa, Habana, Cuba SO - JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. Jan 2001; 20(1): 31-8. Referencias bibliogrficas 1. Oramas Daz J, Jimnez Miranda J. La Colaboracin Cochrane Iberoamericana en Cuba. ACIMED 2001;9(2):127-35. Disponible en: http://bvs.sld.cu/revistas/aci/vol9_2_02/aci05201.htm Acceso: 15 de enero del 2003. 2. Jimnez Miranda J, Oramas Daz J, Caedo Andalia R. La Colaboracin Cochrane en Cuba. II Parte. La bsqueda manual de ensayos clnicos en la literatura mdica cubana en el perodo 1999-2002. ACIMED. En prensa. 2003. 3. Arajo Ruiz JA, Arencibia Jorge R, Gutirrez Calzado C. Ensayos clnicos cubanos publicados en revista de impacto internacional: estudio bibliomtrico del perodo 1999-2001. Rev Esp Doc Cient 2002;25(3):254-66. Recibido: 16 de septiembre del 2003. Aprobado: 8 de octubre del 2003

Lic. Rubn Caedo Andalia. Licenciado en Informacin Cientfico-Tcnica y Bibliotecologa. Red Telemtica de Salud en Cuba (Infomed). Centro Nacional de Informacin de Ciencias Mdicas. Calle 27 No. 110 e/ N y M, El Vedado. Plaza de la Revolucin. Ciudad de La Habana. Cuba. Correo electrnico: ruben@infomed.sld.cu

1Licenciado en Informacin Cientfico-Tcnica y Bibliotecologa. Red Telemtica de Salud en Cuba (Infomed). 2Ingeniero en Telecomunicaciones. Jefe del Dpto de Informacin Cientfica. Centro Nacional de Investigaciones Cientficas (CNIC). 3Tcnico Medio en Informacin Cientfico-Tcnica y Bibliotecologa. Centro Nacional de Investigaciones Cientficas (CNIC). 4Doctor en Ciencias Mdicas. Director. Centro Nacional de Investigaciones Cientficas (CNIC).

2004 2000, Editorial Ciencias Mdicas Calle E No. 452 e/ 19 y 21, El Vedado, La Habana, 10400, Cuba.

acimed@infomed.sld.cu