XAVIER UNIVERSITY Dr. Jose P.

Rizal College of Medicine Third Bimonthly Exam Set A

1. The following are true of heme biosynthesis, EXCEPT: A. begins with succinyl-CoA and glycine B. Glycine is activated by pyridoxal phosphate C. The rate limiting step is catalyzed by dehydratase D. Does not occur in red blood cell 2. Which is not true of erythroietic protoporphyria? A. Enzyme involved is a Uroporphyrinogen III cosynthase B. Photosensitivity is a major complaint C. Presence of fecal and red cell protoporhyrin D. Happens when ceonversion of protoporphyrin to heme is blocked 3. The following are true of bilirubin transport EXCEPT: A. Bilirubin bound to albumin is transported from peripheral tissue to the liver B. Binding with albumin makes more soluble in plasma C. In 100mL of plasma, about 75mg of bilirubin can tightly bound to albumin D. Antibiotic may compete with bilirubin for binding site in albumin 4. Which of the following is not true of conjugated bilirubin? A. It is water soluble B. Secreted into bile by facilitated diffusion C. Most bilirubin secreted into bile are in the form of bilirubin diglucoronide D. B-glucoronidases in terminal ileum removes the diglucoronide from bilirubin 5. The rate limiting step in the metabolism of bilirubin is the A. Uptake of bilirubin by the liver parenchymal cells B. Conjugation of bilirubin in the SER C. Secretion of conjugated bilirubin into the bile D. Conversion of glucoronides into urobilinogens in the intestine 6. The following statements are true regarding the properties of Lipids EXCEPT: A. Lipids are insoluble in water B. Lipids are soluble in inorganic solvents like dilute acids and dilute alkali C. The melting point of even-numbered carbon fatty acids increases with chain length D. Triglycerol containing all saturated fatty acids of 12 C or more is solid at body temperature.

7. Gastric lipids acts on triglycerides to produce: A. Diglyceride and fatty acids B. Cholesterol and fatty acids C. Lysophospholipid and fatty acids D. Monoglycerides and fatty acids 8. The following phospholipases are involved in the degradation of phospholipids A.

9. The glycerol backbone in phospholipids is derived from A. Glycerol phosphate B. Phosphatidic acid C. Dihydroxyacetone phosphate D. Diacyl glycerol 10. The following are true of VLDL, EXCEPT: A. Most plasma VLDL is formed by liver cells B. It is the precursor of intermediate-density lipoprotein (IDL) C. Its density is greater than that of chylomicrons D. Transports primarily cholesterol from liver to extrahepatic tissues 11. The main apolipoprotein of LDL is A. apo A B. apo B C. apo C D. apo E 12. The following are descriptive of Acetyl-CoA carboxylase EXCEPT: A. Rate limiting enzyme in FA B. It is inhibited by citrate C. Palmitoyl-CoA prevents its polymerization D. Regulated by phosphorylation 13. Which of the following paired enzymes catalyze the first 2 reactions in ketogenesis A. carnitine acyltransferase and acetyl-CoA carboxylase B. cholesterol acyltransferase and HMG-CoA reductase C. thiolase and HMG-CoA synthase D. ferrochelatase and UDPG-transferase

14. The following are descriptive of mechanisms of homeostatic glucose regulation, EXCEPT: A. almost all of the extrahepatic tissue cells are relatively impermeable to glucose B. hexokinase phosphorylates glucose that may enter extrahepatic tissue C. negative feedback is executed by inhibition of hexokinase by glucose-6phosphate D. insulin causes glycogenolysis by activating phosphorylase 15. The following enxymes catalyzed irreversible reactions which prevent reversal of glycolysis, EXCEPT: A. pyruvate carboxylase B. PEP carboxylase C. Fructose 1-6 biphosphatase D. Glucose 6-phosphatase 16. If a patient is glycosuric his blood glucose is A. >9.5 10 mmol/L B. 8 10 mmol/L C. <10 mmol/L D. 6 10 mmol/L 17. (no submitted question)

18. The luminal phase of carbohydrate digestion starts in the mouth and involves this step: A. cleavage of the OH group from the C atoms B. cleavage of the C to C double bonds C. hydrolysis of 1,4 glycosidic bonds D. hydrolysis of 1,6 glycosidic bonds 19. The most common form of dissacharide deficiency is: A. galactose deficiency B. lactase deficiency C. fructose deficiency D. biphosphatase deficiency 20. (no question submitted)

21. The reaction that allows glycolysis to proceed in the absence of oxygen is catalyzed by A. lactate deH B. oxidation of FFA C. enzyme that forms NaOH D. none of the above 22. Which of these enzyme facilitates the transfer of TCA intermediate oxaloacetate into the main gluconeogenetic pathway A. pyruvate carboxykinase B. pyruvate carboxylase C. fructose 1,6 bisphosphatase D. PEP carboxykinase 23. Glycolysis results in the net yield of ___ATPs per mole of glucose A. one B. two C. three D. four 24. (no question submitted)

25. This disease is characterized by a deficiency of glucose-6-phosphate A. Hers disease B. Tarauis disease C. Pompes disease D. Von Gierkes disease 26. The reaction that is common to glycolysis and glycogenesis is: A. phosphorylation of glucose to glucose-6-phosphate B. conversion of glucose to glucose-1-phosphate C. glucose 1-phosphate reacts with uridine triphosphate D. hydrolysis of pyrophosphate to inorganic phosphate 27. (no question submitted)

28. Which of the following integrates the regulation of glycogenolysis by simultaneous activation of phosphorylase and inhibition of glycogen synthase A. Ca++ B. Calmodulin C. cAMP D. glucokinase

29. The phosphorylitic cleavage of the 1 4 linkages of glycogen to yield glucose 1phosphate is catalyzed by: A. glucokinase C. phosphoglucomutase B. glycogen synthase D. glycogen phosphorylase 30. In the liver, phosphorylase b is rephosphorylated to active phosphorylase a. This reaction is catalyzed by: A. phosphorylase kinase B. protein phosphatase-1 C. glucose-6-phosphatase D. glucomutase 31. Phosphorylase in muscle differs from that in liver because in muscle: A. phosphorylase exists in two forms B. phosphorylase is active C. phosphorylase b is dephosphorylated D. phosphorylase is activated by cAMP 32. Which the enzyme in glycogenolysis exposes the 16 branch point A. transglucosidase B. glucan transferase C. branching enzyme D. glucose-6-phosphatase 33. In hemolytic anemia which enzyme is commonly deficient A. phosphofructokinase B. hexokinase C. glucokinase D. glucomutase 34. This is defined as the polypeptide backbone made up of a unique sequence of amino acids joined by peptide bonds in a protein: A. primary backbone B. primary structure C. polypeptide structure D. none of the above 35. These enzymes catalyze the cleavage of bonds by the addition of water: A. isomerases B. hydrolases C. transferases D. oxidoreductases

36. The following are the general properties of enzymes, EXCEPT: A. most active sites interact with substrate B. most if not all are proteins C. accelerate rate of reaction D. consumed in overall process 37. True of pepsin, EXCEPT: A. precursors are called pepsinogen B. precursors are activated by gastric HCL C. immediate product of peptide digestion are amino acid D. alkaline pancreatic juice in duodenum and ileum 38. The following associations between amino acids and their catabolic end products are correct, EXCEPT: A. proline -ketoglutarate B. arginine oxaloacetate C. threonine pyruvate D. phenylalanine fumarate 39. The following are descriptive of protein degradation, EXCEPT A. all proteins with short half lives follow the PEST sequence B. all of the nitrogen form urea C. excess proteins are degraded not stored D. ubiquitin is needed for degradation of short-lived proteins 40. Which of the following happens first in amino acid metabolism A. transamination C. translation B. deamination D. hydration 41. Which of the following enzymes 5phosphoribosylamine in purine synthesis A. glutamine PRPP amidotransferase B. ribonucleotide reductase C. thioredoxin reductase D. carbamoylphosphate synthase catalyzes the formation of

42. (no submitted question)

43. Nucleosides are different from nucleotides because of the absence of this: A. carboxyl group B. pentose sugar C. purine/pyrimidine bases D. phosphate group

44. In replication, which of the these steps/stages follows elongation of the daughter strand A. termination of replication B. rewinding of the DNA molecule C. primase creates temporary complementary RNA primase D. DNA binding protein binds tightly to separated strands 45. (no submitted question)

46. In translation, which of these steps/stages follows elongation A. fragments of DNA attached to as initiation component B. fragments of continuous DNA which are eventually joined to form DNA C. fragments of DNA that are copied in direction away from the replication fork D. synthesized from 5 to 3 and proceed in same direction as replication fork 47. The enzyme responsible for unwinding of duplex DNA segment is A. helicase C. DNA polymerase B. ligase D. DNA topoisomerase 48. As regards transcription, the following are true, EXCEPT: A. builds RNA in 5 to 3 direction B. follows the Watson-Crick base pairing C. phosphodiester bonds link adjacent nucleotides D. builds RNA in the direction parallel to that of DNA template 49. (no submitted question)

50. Which posttranscriptional processing prevents 3 exonuclease or polypeptide A. poly A tail B. splicing reaction C. addition of extra COOH group D. methyl guanosine triphosphate cap