MEDISCA INC.

661 Route 3, Unit C, Plattsburgh, New York, 12901 Tel.: (800) 665-6334 Fax: (518) 563-5047

Material Safety Data Sheet

I - Product Identification: Product Name: Empirical Formula: Chemical Name: Uses: II - Toxicological Information: Irritancy: Adverse Effects: Desoximetasone, USP (Micronized) C22H29FO4 Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, (11,16)-. Corticosteroid. Code: 0479 CAS#: 382-67-2

Toxicity Data: III - Physical Data: Physical State: Liquid Solid X Gas Description: White to practically white, odourless, crystalline powder. Solubility: Insoluble in water; freely soluble in alcohol, in acetone, and in chloroform. Other Physical Properties: mw: 376.46 mp: N/A USP Specifications: Identification: Conforms to the std tests (A,B) Residue on ignition<281>: NMT 0.2% Melting range<741>: 206-218C Specific rotation<781S>: +107 to +112 Loss on drying<731>: NMT 1.0% Assay (on dried basis): 97.0-103.0% Heavy metals<231>II: NMT 0.002% Packaging and storage: Preserve in well-closed containers. IV - Fire And Explosion Hazards: Flammability: N/A Flash Point: N/A Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol or polymer foam. Fire-Fighting: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. V - Reactivity Data: Stability: Stable Hazardous Decomp. Products: Toxic fumes of hydrogen fluoride gas, carbon monoxide and carbon dioxide. Hazardous Polymerization: Will not polymerize. VI - Preventive Measures: Preventive Measures: Do not breathe vapour or dust. Avoid contact with skin and eyes. Avoid prolonged or repeated contact. Wash thoroughly after handling. Personal Protective Equipment: NIOSH/MSHA approved respirator, chemical resistant gloves, safety goggles, other protective clothing. Specific Engineering Controls: Adequate mechanical ventilation with chemical fumehood. Eyewash stations, and shower should be readily available. Spill And Leak: Evacuate area. Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves. Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pick up is complete. Waste Disposal: Dissolve in a combustible solvent. Burn in a chemical incinerator equipped with afterburner and scrubber according to local laws and regulations. Storage: Preserve in well-closed containers. DESOXIMETASONE, USP (MICRONIZED) AUGUST 2004

Causes eye, skin, mucous membrane and upper respiratory tract irritation. May cause disturbances in electrolyte balance, oedema, hypertension, increased excretion of potassium, hypokalaemic alkalosis, cardiac failure, mobilisation of calcium and phosphorous, osteoporosis, spontaneous fractures, nitrogen depletion, hyperglycaemia, increase in insulin requirements, increased appetite, delayed wound healing, increased susceptibility to infection, atrophy of the adrenal cortex, growth defects, Cushingoid symptoms or Cushing's syndrome, amenorrhoea, hyperhidrosis, skin thinning, ocular changes, mental and neurological disturbances, intracraneal hypotension, acute pancreatitis, aseptic necrosis of bone, increase in coagulability of the blood, peptic ulceration, and muscle weakness and wasting. Hypersensitivity reactions may occur. N/A

MEDISCA INC.
661 Route 3, Unit C, Plattsburgh, New York, 12901 Tel.: (800) 665-6334 Fax: (518) 563-5047

VII- First Aid Measures: Eyes:

Flush with copious amounts of water for 15 minutes, separating eyelids with fingers. Call a physician. Skin: Wash with soap & water for 15 minutes. Ingestion: Call a physician. Wash out mouth with water. Inhalation: Remove to fresh air. If breathing becomes difficult, call a physician. NOTE: If victim is unconscious, never induce vomiting nor give liquids. Place victim in a stable side position and keep warm. Ecological Data: N/A Hazardous Ingredients: N/A References: Available on request

DESOXIMETASONE, USP (MICRONIZED)

AUGUST 2004