PY TEST SERIES-XIII PRE GPAT-I

Duration: 2.00 hours

Max Marks: 120

1. 2. 3. 4. 5. 6. 7.

This question paper contains 50 objective type questions. Q. 1 to 50 carry 2 marks each. Q. 51 and 60 are common data based question, each carry two marks. In case of wrong answer 0.5 marks will be deducted. Using HP pencil, darken the appropriate double under each digit of your registration number and the letters corresponding to your paper code. Calculator is allowed in the examination hall. charts, graph sheets or tables are NOT allowed in the examination hall Rough work can be done on the question paper itself. Additionally blank pages are given at the end of the question paper for work.

CENTRE - LIC BUILDING, 3rd FLOOR, CIVIL LINES, SAGAR (M.P.) Mob.: 9753030576, 9907039445, 9981779766
Sunil mokati

PY-TEST SERIES-XIII
1. Reapeated administration of tyramine results in its decreasing effectiveness (a) gets detoxicated easily (b) Displaces nor-adrenaline from nerve ending binding site (c) Displaces adrenaline from nerve ending (d) None binding site Atropine on hydrolysis with barium hydroxide gives (a) Tropanol and tropic acid (b) Scopine and tropic acid (c) Ecgonine and benzoic acid (d) Benzyl ecgonine and methanol The concentration of sucrose in simple syrup BP is (a) 85% w/w (b) 60.70% w/w (c) 66.70% w/w (d) 40.74% w/w Stratified cork and forked fibre are the characteristic diagnostic features of (a) Apocynaceae (b) Scrophulariaceae (c) Gentiaceae (d) Polygonaceae C17- unsaturated lactone ring is a common feature in (a) Digitalis and squill glycoside (b) Digitalis and strophanthus glycoside (c) Digitalis and senna glycoside (d) Digitalis and amygdalin For drying blood plasma the following technique is used (a) Spray drying (b) Freeze drying (c) Vaccum drying (d) Fluid bed drying C3 O glycoside digitoxin is used for (a) Cadiac action (b) Hypotensive action (c) Precipitating steroids from solution (d) precipitating The HLB value of sodium lauryl sulphate is (a) 6.5 (b) 13.8 (c) 25.0 (d) 40.0 Claviceps purpuria yields after infecting ovaries of graminaceous plants (a) Digitoxin (b) Lysergic acid derivative (c) Reserpine (d) Polypetides In the official bioassay of erythromycine, the strain used is a) Bacillus subtilus (b) Mmicrcoccus luteus (c) Salmonella typhii (d) Escherichia coli The disintegration time for sugar coated tablet is (a) 30 minutes (b) 45 minutes (c) 60 minutes (d) 120 minutes Idioblast of crystal layer of calcium oxalate is a diagonostic feature of (a) Hyoscymus nigar leaves (b) Deadly nightshade leaves (c) Cinchona bark (d) Senna leaves Antibiotic which interacts with calcium ion is (a) Erythromycin (b) Strephomycin (c) Tetramycin (d) Ampicillin Flow rate of granule from the hopper can be improved by adding (a) Disintegrant (b) Glidant (c) Binder (d) Lubricant Silicon carbide rod heated to a high temperature is used as a (a) Detector in IR spectroscopy (b) Source of light in IR spectroscopy (c) Source of light in fluorimetry (d) Detector in gas chromatography

2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15.

Sunil mokati

16. 17. 18. 19. 20.

21. 22.

23.

24. 25.

26. 27.

28.

Anomocytic stomata are found in the leaves of : (a) Fox glove (b) Urginea maritima (c) Cassia acutifolia (d) Atropa belladonna Liver microsomal enzyme are stimulated (enzyme induction) by (a) Cimetidine (b) Phenobarbitone (c) Procaine (d) Adrenaline Enteric coated is achieved by using (a) Hydroxyl propyl methyl cellulose (b) Carboxy methyl cellulose (c) Cellulose acetate phthalate (d) Providone Carr price reaction is app;ied for the photometric evaluation of (a) Vitamin D (b) Tocopherol (c) Nondrolone (d) Benzodiazepine Peroxidase enzyme present in acacia is identified by (a) Borntraggers test (b) Molishs test (c) Oxidation and extraction in benzene (d) Oxidation and treatment with benzidine Prostaglandins are a group of related (a) Alcohols (b) Aldehydes (c) Fatty acids (d) Alkaloids Most accepted mechanism for developing bacterial resistance to sulphonides is a) An increasing capacity to inactivate or destroy the drug b) An alternative metabolic pathway for synthesis of an essential metabolite c) An increased product of drug antagonist d) An alternation in enzyme that utilizes PABA Chemical name of amoxicillin is a) 6-[D-(-)-amino p-hydroxy phenyl acetamido ] penicillanic acid b) 4-[D-(-)-amino p-hydroxy phenyl acetamido ] penicillanic acid c) -hydroxy analogue of benzyl peniciline d) -carboxy analogue of benzyl pencillin Licence to sell drug specified in schedule C and C1 is given in form no (a) 19 (b) 18 (c) 21 (d) 24 Estrogenic and progestrogenic combination mainly (a) Inhibits the ovulation (b) Inhibit the implantation of the fertilized ovum (c) Inhibits the fertilization of ovum (d) Inhibit development of endometrium Liquid paraffin exhibits (a) Plastic flow (b) Newtonian flow (c) Pseudoplastic flow (d) Dilatant flow More of earthy matter in a rhizome is determined by (a) Total ash value (b) The earthy material is separated and then weighed (c) The rhizome is washed in water and then in hydrochloric acid finally it is weighed (d) Acid insoluble ash value Lidocaine is synthesized from (a) 2,6-dimethyl -5-amino methyl benzene (b) 2,6-dimethyl -5-nitro methyl benzene (c) 2,6-xylidine (d) 2-methyl-6-ethyl-5-amino methyl benzene 3

Sunil mokati

29. 30. 31. 32.

33. 34. 35. 36. 37. 38. 39. 40. 41. 42.

43.

44.

Sterilization temperature for aqueous solution in autoclave (moist heat) is (a) 720C (b) 1210C 0 (c) 147 C (d) 1600C Following combination is suggested in the treatment of leprosy (a) Dapsone + ampiciline + clofazimine (b) Dapsone + rifampine + clofazimine (c) Dapsone + rifampine + erythromycine (d) Dapsone+tetracycline+ streptomycin Renal clearace of insulin represents (a) Effective renal blood flow (b) Rate of renal drug excretion (c) Glomerular filtration rate (d) Active renal excretion For the synthesis of nitrofurantoin which one of the following combination of chemical are used (a) 5-nitro-2-furaldehyde-2-amino hydantoin (b) 5-nitro-2-furaldehyde and hydantoin (c) 5-amino-2-furaldehyde-2amino hydantoin (d) 5-amino-2-furaldehyde and barbituric acid The sugar moity of digitalis purpuria is (a) 2,6-deoxyallose (b) 2,6-deoxyglucose (c) 2,6-deoxyrhamnose (d) 2,6-deoxygalactose Addition of sodium chloride to sodium oleate, emulsion will (a) Stabilize emulsion (b) destabilize emulsion (c) Decrease the globule size of the emulsion (d) None Antihypertensive drug which inhibits the rennin angiotensin system is (a) Reserpine (b) Captopril (c) Methyl dopa (d) Propanolol Acidity of ascorbic acid is due to the presence of (a) Free carboxylic acid (b) A number of hydroxyl groups (c) Enolic group (d) None Progesterone injection BP is a sterile solution in (a) Water (b) Ethyloleate (c) Propylene glycol (d) Glycerol I = I010-ax is called (a) Lamberts law equation (b) Beers law equation (c) Planks equation (d) Einsteins equation The no of vibrational degree of freedom of carbon dioxide (a) 2 (b) 3 (c) 4 (d) 5 The strongly acidic cation exchanger among the following (a) CM-cellulose (b) SM-cellulose (c) DEAE-cellulose (d) TEAE-cellulose The centrifugation technique that employs homogenous medium for separation is (a) Preparative (b) Differential (c) Density gradient (d) Analytical Clinically significant drug interaction occurs between pyridoxine and all of the following drugs EXCEPT (a) Isoniazid (b) cyclosporine (c) levodopa (d) hydralazine The correct IUPAC name of clonazepam (a) 6-(2-chlorophenyl)-7-nitro-2,5-diazobicyclo[5,4,0]undeca-5,8,10,12-tetra-3-one (b) 6-(2-nitrophenyl)-7-chloro-2,5-diazobicyclo[5,4,0]undeca-5,8,10,12-tetra-3-one (c) 6-(2-chlorophenyl)-7-chloro-2,5-diazobicyclo[5,4,0]undeca-5,8,10,12-tetra-4-one (d) 6-(2-nitrophenyl)-7-nitro-2,5-diazobicyclo[5,4,0]undeca-5,8,10,12-tetra-3-one The drug having dual effect both as potassium channel opener and NO donar is (a) Diazoxide (b) Nicorandil 4

Sunil mokati

45. 46. 47.

48. 49. 50.

51. 52.

53.

(c) Minoxidil (d) None Non aquous titration of allopurinol is done using the titrant (a) 0.1 M HClO4 (b) 0.1 N HClO4 (c) 0.1 M (C4H9)4OH (d) 0.1 N (C4H9)4OH The microbiological assay of kenamycin sulphate is carried out on (a) Bacillus pumilis (b) Bacillus subtilis (c) Bacillus cervies (d) All Thiamine on treatment with sodium sulfate solution and sulfur dioxide yields A) pyridine and a thiazole derivative B ) pyrimidine and thiazole derivative C) 2,3,4-trihydropyridine and thiophen derivative D) none Ion exchange capacity of a resin is depend on (a) The total mol wt of the resin (b) The total no of ion active group (c) Length of ion exchange resin (d) Solubility of ion exchange resin Equivalence point of conductometric titration shows (a) Neutralization (b) Precipitation (c) Both a and b (d) None One of the following are correct for stability testing of pharmaceutical formulation (a) Long term stability testing is carried out at 25oC 2OC and 60 5% RH (b) Long term stability testing is carried out at 40oC 2OC and 70 6% RH (c) Accelerated stability testing is carried out at 25oC 2OC and 60 5% RH (d) Alternate stability testing is carried out at 40oC 2OC and 70 6% RH DATA FOR 51-52 Glucose metabolism involve following enxyme and steps: Glyceraldehyde-3-phosphate ------ dihydroacetone phosphate (a) Hexokinase (b) Triose phosphate isomerase (c) Glu-60phosphate dehydrogenase (d) None 2-phosphoglycerate ----- phosphoenol pyruvate (a) Phosphoglycerate mutase (b) Pyruvate kinase (c) Phosphoglycerate isomerase (d) Enolase DATA FOR 53-54 Caffeine has the U.V. absorption maximum at 272. 0.1316 gm of this drug was dissolved in enough water to make one liter exactly 10ml of this solution was dil. to 100 ml and the absorbance of this solution in 1.0 cm cell at 272was 0.854 . if the mol. Weight of caffeine is 194.2 then calculate Molar absorptivity of caffeine (a) 1.28 X 104 (b) 128 X 102 (c) 677 X 10-7 (d) 677X 10-4 Calculate the conc. of unknown solution of this drug which gave an absorbance of 1.022 in 2 cm cell (a) 0.07874 (b) 78.74 X 10-4 (c) 0.399 X 10-4 (d) 399 X 10-6 LINKED QUESTION 55-56 Flavonoids occur ubiquitously in ferns and ferns allies. They contains carbonyl group present in hetrocyclic ring. (a) Flavanol (b) Chalcones (c) Flavone (d) Flavonolignam Flavonols differs from flavoes in having 5

54.

55.

56.
Sunil mokati

(a) (c)

OH group at C-2 OH group at C-4

(b) (d)

OH group at C-3 OH group at C-5

57.

LINKED QUESTION 57-58 Chills, fever, urticaria and intense flushing are the symptom of a syndrome Called as (a) WPW syndrom (b) Stokes adams syndrom (c) Red man syndrom (d) Reyes syndrom The above syndrome is caused by (a) Aspirin (b) Vancomycin (c) uincomycin (d) Hypotensive drugs DATA FOR 59-60 Anextremly potent and very broad spectrum B-lactum antibiotic which is resistant to most Blactamase and inhibit penicillinase producing staphylococci. This drug is belong to (a) Cephalosporin (b) Imipenem (c) Penicillins (d) Aztreonam This drug is sensitive for (a) Oxidation (b) Reduction (c) Hydrolysis (d) Photolysis

58.

59. 60.

Sunil mokati