PY TEST SERIES-XIV PRE GPAT-II

Duration: 2.00 hours

Max Marks: 120

1. 2. 3. 4. 5. 6. 7.

This question paper contains 50 objective type questions. Q. 1 to 50 carry 2 marks each. Q. 51 and 60 are common data based question, each carry two marks. In case of wrong answer 0.5 marks will be deducted. Using HP pencil, darken the appropriate double under each digit of your registration number and the letters corresponding to your paper code. Calculator is allowed in the examination hall. charts, graph sheets or tables are NOT allowed in the examination hall Rough work can be done on the question paper itself. Additionally blank pages are given at the end of the question paper for work.

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PRE GATE - II
1. 2. 3. 4. 5. 6. Highest temperature will be obtained by following mixture (a) Hydrogen + air (b) Hydrogen + oxygen (c) Acetylene + oxygen (d) Propane + oxygen Straight portion of curve in polarography is (a) Migration current (b) Limitimg current (c) Faradic current (d) Diffusion current Which of the following nuclei can not be studied by NMR 79 11 (a) Br (b) B 12 35 (c) C (d) Cl Rotameter is used to measure (a) Flow rate of carrier gas (b) Pressure of carrier gas (c) Temperature of carrier gas (d) All Ortho, meta, para isomers can be differentiated on the basis of (a) Chemical shift (b) Coupling constant (c) Both (d) None Substances that are ..soluble in the mobile phase will migrate greater distance in normal chromatography (a) More (b) Less (c) Intermediate (d) None Migration of colloidal particle through a solution under the influence of an electric field is depend on (a) Mass : charge ratio (b) Properties of electrical fields (c) Temperature (d) All List of disease and ailment which a drug may not purport to prevent or cure or make claims to prevent or cure under the drug and cosmetics rule 1945 is given under (a) Schedule J (b) Schedule K (c) Schedule M (d) Schedule P The chairman of the drug technical advisory boared is (a) The drug controller of India (b) The director, central drug laboratory, kolkata (c) The president, pharmacy council of India (d) The director general of health service Which one of the following is used as a preservative in ophthalmic preparation a) Benzalkonium chloride (b) Phenol (c) Benzoic acid (d) Chlorocresol The type of glass which could be exclusively employed for the solution having the pH less than 7 (a) Type I (b) Type II (c) Type III (d) Type IV LAL test is employed for the detection of (a) Bacterial level (b) Endotoxin level (c) Exotoxin level (d) Pyrogen level All are anticancer antibiotic EXCEPT (a) Vancomycin (b) Actinomycin D (c) Bleomycin (d) Mithramycin The drug which is tuberculostatic but not tuberculocidal is (a) Rifampin (b) Isoniazid 2

7.

8.

9.

10. 11.

12. 13. 14.

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(c) 15.

Ethambutol

(d)

Pyrizinamide

16. 17. 18. 19. 20. 21. 22.

23.

24. 25.

26. 27.

Leprostatic, anti-inflammatory dye which acts by interfering with DNA template functioning. The drug is (a) Dapsone (b) Clofazimine (c) Rifampicin (d) None X-ray spectral lines K doublet arises from the transition electron from (a) M to K shell (b) L to K shell (c) L to M shell (d) M to L shell The methods of expression of magnetic field strength is (a) Cycle/ sec (b) Debey (c) Guass (d) Per sec When the liquid is removed from the jelly and only the framework remains, it is called as (a) Dry gel (b) Anhydrous gel (c) Xerogel (d) All ACE inhibitor generally contain 2-S aminophenyl butyric acid ethyl ester EXCEPT (a) Benzapril (b) Enalpril (c) Eosinopril (d) Ramapril According to Vaughan Williams classification of antiarrthmic agents class IC drugs (a) Lengthen refractory period (b) Slows conduction (c) Shortens duration of action potential (d) All Sesquiterpens mainly composed of . No of carbon atoms (a) 5 (b) 10 (c) 15 (d) 20 HETP is equal to a) Length of the column / no. of theoretical plate b) Area of the column / no. of theoretical plate c) no. of theoretical plate / Area of the column d) no. of theoretical plate / Length of the column Chemically ibuprofen is a) RS(-4 butyl phenyl )propionic acid b) RS-2-(-4 isobutyl phenyl )acetic acid c) RS-2-(-4isobutyl phenyl )propionic acid d) RS(-4 butyl phenyl )acetic acid Terpens which are mainly composed volatile in nature (a) Mnoterpens (b) Diterpens (c) Sesqueterpens (d) Sterols All the following are true for methtrexate EXCEPT (a) Methtrexate inhibit DHFRase (b) Non proliferative cells are resistant to methotrexate (c) Folinic acid enhances the acton of methotrexate (d) Methotrexate is used in the treatment of psoriasis Which of the following shows frequency dependent calcium channel blockade (a) Verapamil (b) Amlodipine (c) Felodipine (d) Diltiazem The 3 adrenoceptor differs from the other subtype of receptor in that it (a) Is not blocked by the conventional doses of propanolol (b) Is located primarily in the heart (c) Regulate blood sugar level (d) Is not coupled to G proteins 3

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28.

Which of the following leaf shows activity against staphylococcus aureus and ranikhet disease (a) Aconite (b) Punarnava (c) Ashwagandha (d) Vasaka A bipyridine derivative also called as iondilator used for maintanence of CHF is (a) Spironolactone (b) Prazosin (c) Amrinone (d) Sod. Nitriprusside Chemical shift measured in (a) Ppm (b) Hz (c) Both (d) um Inhibition of squalene synthetase leads to accumulation of (a) Fernasyl diphosphate (b) Geranyl diphosphate (c) Isopentyl diphosphate (d) None The leaf is dorsiventral, epidermis have numerous glandular trichomes. Anisocytic stomata are present on epidermal layer,midrib shows many bicollateral vascular bundle. The drug is (a) Hyocymus (b) Stramonium (c) Belladona (d) Datura Sumatriptane, an antimigrane drugs acts by (a) 5HT 1A (b) 5HT 1B/1D (c) 5HT 2A (d) 5HT3 An example of directly acting muscle relaxant is (a) Quinine (b) Chloroxazone (c) Baclofen (d) Diazepam A drug solution has a half life of 21 days. Assuming that the drug undergoes first order kinetics, how long will it take for the potency to drop to 90% of the initial potency (a) 3.2 days (b) 9.6 days (c) 16 days (d) 6.4 days Local anesthetic acts by inhibiting (a) Efflux of K+ (b) Infflux of K+ + (c) Influx of Na (d) Efflux of Na+ 2,6-dimethyl aniline is reacted with the chlorylacetyl chloride, to form the chloroamide, which is reacted with a reagent P to form a local anesthetic drug. The reagent P is (a) Dimethylamine (b) Diethylamine (c) Methylmethylamine (d) Ammonia solution Aquateric is (a) Aqueous non enteric coating material (b) Aqueous enteric coating material (c) Nonaqueous enteric coating material (d) Aqueous non enteric coating material Bradykinin is (a) A steroidal hormone (b) Serotonin derivative (c) A nonapeptide (d) A lipoprotein A common organism that causes meningitis belongs to the genus (a) Candida (b) Neisseria (c) Pseudomonas (d) Clostridium Source of vitamin B12 (a) Clostridium butilicum (b) Clostridium acetobutilicum (c) Pseudomonas dentrificance (d) Pseudomonas aureginosa Which constituets of rauwolfia gives violet red color is produced when treated with vanillin in acetic acid solution (a) reserpine (b) rescinnamine 4

29. 30. 31. 32.

33. 34. 35.

36. 37.

38.

39. 40. 41. 42.

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43.

44. 45. 46. 47.

48.

49. 50.

51. 52.

53.

(c) yohimbine (d) ajmaline Natural camphor is (a) An optically inactive aldehyde obtained from cinnamomum camphora (b) A white dextrorotatory ketone obtained from the wood of cinnamomum camphora (c) a white optically inactive ketone obtained from the bark of cinnamomum camphora (d) A white volatile aldehyde obtained from the bark of cinnamomum camphora 5 chloro 2,4 disulphamoyl aniline on condensation with formic acid produces a well known diuretic (a) Chlorthiazide (b) Acetazolamide (c) Furocemide (d) Ethacrynic acid max of o-chlorobenzaldehyde in nm is (a) 275 (b) 265 (c) 255 (d) 250 Opium cantains not less than . Per cent of morphine (a) 2 (b) 3 (c) 5 (d) 9.5 Sennoside A differ from sennoside C in A) trans COOH gp in place of trans CH2OH B ) meso COOH gp in place of trans CH2OH C) trans NH2 gp in place of trans CH2OH D) meso NH2 gp in place of trans CH2OH Select the drug which affords faster and greater symptomatic relief in benign hypertrophy of prostate (a) Terazosin (b) Desmopressin (c) Finasteride (d) Sildenafil The following receptor has an intrinsic ion channel (a) Histamine H1 receptor (b) Histamine H2 receptor (c) Adrenergic alfa receptor (d) GABA-benzodiazepine receptor Addiction and habituation (a) Are fundamentlly different phenomenon (b) Are produced by different set of drug/substances (c) Differ from one another in the degree of attendant psychological dependence (d) Differ from one another by the presence or absence of physical dependence DATA FOR 51-52 Nafarelin is (a) Hexokinase (b) Antiandrogen (c) GnRH agonist (d) None Such compound acts by (a) Inhibiting conversion of (b) Antagonizing androgen action dihydrotestosterone (c) Inhibition of FSH and LH secretion (d) None DATA FOR 53-54 Barbiturate are drugs that act as central nervous system depressant, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia. Some are also used as anticonsulsants. The long acting barbiturate is among the following (a) Mephobarbiturate (b) Secobarbiturate (c) Pentobarbiturate (d) Hexobarbitone Its IUPAC name is (a) 5- phenyl-5-ethyl-3-methylbarbituric acid (b) 5-(1-methylbutyl)-5-prop-2-enylhexahydropyrimidine-2,4,6-trione 5

54.

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(c)

5-ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)pyrimidinetrione

(d)

5-(1-cyclohexenyl)-1,5-dimethylhexahydropyrimidine-2,4,6-trione

55.

LINKED QUESTION 55-56 A fruit have yellow coloured five primary ridges , and a bifid stylopod at the top and T.S. of fruits show 2 commissural vittae and 4 dorsal vittae have anomocytic stomata The chief constituents of this fruits (a) Borneol (b) Fenchone (c) Myristicin (d) Carvone This are mainly adultrated by (a) With orange seed (c) Myristica orgentea (b) (d) Exhausted fruits of same plant None

56.

57.

LINKED QUESTION 57-58 Certain drugs show the ptimal therapeutic effect over a narrow range of plasma drug concentration . the effect decline if the doses are increased or decreased from a limit This is called as (a) Ceiling effect (b) Therapeutic window phenomenon (c) Desensitization (d) Non receptor mediated action This is exhibited by (a) Captopril (c) Diazepam (b) (d) Furosemide Glipizide

58.

59. 60.

DATA FOR 59-60 When a film (coating ) may shrink and pull away from the sharp corners of an intagliation What can happened in above condition (a) Hazing (b) Filling (c) Bridging (d) Roughness How can be remove that (a) Reducing processing temp. (b) Add additional solvent (c) Increase plasticizer content (d) Reduced rate of drying

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