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This antibody reacts primarily with gastric and intestinal epithelium, urothelium, and Merkel cells.

Anti-cytokeratin 20 is useful in the differentiation of specific types of simple epithelial cells of the urinary tract as well as normal and malignantly transformed epithelia. Studies have identified the presence of cytokeratin 20 in adenocarcinomas of the colon, stomach, pancreas, and biliary system. Additionally, mucinous ovarian tumors, transitional-cell, and Merkel cell carcinomas have shown reactivity. In contrast, squamous cell carcinomas and adenocarcinomas of the breast, lung and endometrium, non-mucinous tumors of the ovary, and small cell carcinomas are non-reactive.
Bladder: Dysplasia vs. Reactive Carcinoma-in-situ Reactive Atypia Normal Urothelium Carcinomas Lund Adenocarcinoma Colorectal Adenocarcinoma Transitional Cell Carcinoma Squamous Cell Carcinoma Cutaneous Neoplasm CD10 Basal Cell Carcinoma Trichoepithelioma Merkel Cell Carcinoma Microcystic Adnexal Carcinoma Sebaceous Carcinoma Sebaceous Adenoma + - +/+/Androgen Receptor + - + + CK 20 - + + CD34 - + Ber-EP4 + + + -/+ + + bcl-2 + + + + +/+ - - CK 19 + + + CK Cocktail + + + + CK 7 + + CK 20 + + CD10 + + B-Catenin + CK 5 + + p63 + + CEA + + CDX-2 + Villin + CK 20 + + p53 + CD44 + +(basal layer) Ki-67 + + -

Reactivity Control Stability Isotype Protocols

Paraffin, Frozen Cytoplasmic

Visualization

Colon Carcinoma Up to 36 mo. at 2-8C IgG2a/K

Pretreatment: EDTA/Trilogy Incubation Time: 30-60 min. RT or 16-32 min. at 37 C

References
1. Moll R, et al. Am j Pathol 1992;427-47 2. Moll R, et al. J Cell Biol 1990;111:567580 3. Moll R, et al. Cell 1982;31:11-24 4. Nan Ping Wang, et al. Appl Immuno 1995;3(2):99-107

Mouse Monoclonal Clone: Ks20.8


0.1 ml, concentrate. . . . . . . . 320M-14 0.5 ml, concentrate. . . . . . . . 320M-15 1 ml, concentrate. . . . . . . . . 320M-16 1 ml, prediluted. . . . . . . . . . . 320M-17 7 ml, prediluted. . . . . . . . . . . 320M-18 Positive control slides. . . . . 320S

Mouse Monoclonal Clone: Ks20.8


Ventana 50 Test Dispenser

IVD IVD IVD RUO IVD 1 800.665.7284 (N. America) +1 916.746.8900 (direct) +1 916.746.8989 (fax) service@cellmarque.com www.cellmarque.com

760-2635
Dispenser orders: 1 800.227.2155 +1 520.887.2155 or visit www.ventanamed.com

* Ventana is a registered trademark of Ventana Medical Systems, Inc. Cell Marque antibodies are developed, manufactured and distributed by Cell Marque Corporation and their sale through Ventana Medical Systems Inc. does not imply approval, endorsement, or any guarantee of quality or performance of those Cell Marque antibodies by Ventana.

Cell Marque Immunohistochemistry Reference Guide Vol. 9 Rev. 0.1

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