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w
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iabl
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Contents
. - . . . .
-........
..

*.,.%

&
.
.
-

..... .......

. . .

I,

I,,..

I.

9. Muscarinic ~eceptor~ ~ o r f i ' g k' , .

..
' ,. ; , -. ,
and Antagonists....:;.r!?!:l.,
....1...
,

'

- .

I,

, 1
, .

;.:1q223
1 .

.....
.....239
.
.

10. Anticholinesterslse Agents..............,....

4,

. ,

Joan Hetler Brown and Nora Laiken

reface t o the First Edition xix

'

'

- - ,

. I

Palmer Taylor

1 1. Agents Acting at the Neuromusculor

Junction and Autonomic Gangh
255
Ryan E. tlibbs and A k n d e r C Zambon
12. Admergic Agonists and Antagonists ...................277

..........................

I I . Drug invention and the Pharmaceutical

Thomas C. Weiffatl and Oarid P. WestFall

13.5-Hydroxy try ptamine (Seraonin)

and Dapamine ...................................................

Suzanne M. Rivera and Alfred Goodman Gilman

&.~pharmaookipe~cs:
The Dynamics of Drug
!
Absorption, Distribution, Metabolism,
.,andElimination .......................................................

17

'Pain L. 0.Buxton and Leslie Z. Benet

I--.

..
prug Toxicity and Poisoning............... ................... 73
Kevin C. Osterhoudt and Trwor M. Penning

5. Membrme Transporters and

........................................................

w u g Response
ka~lleenM. Giammini and Yuichi Sugiyam

i 6.

'

I -

Drug Metalmlism .................................................

Frank J. Gonzalez, MichaelCoughtrie,

? a n d Robert H. Tukey
I . , ! , ..

-335
.

7. Phnrrnacogenetics., ....;..,. .;..<>

.....;..............
Mary V. Relling and Kathleen M. Giacomini

89
123

...........145

Peny B. Molinoff
, *,
,: : . i i m K r i i;,+l:',
15. Drug Therapy of Depression
...
and Anxiety D k d e r s ...........
..................... 2 7
James M. O'DonneU and Richard C. Shdton
16. Pharmacotherapy of Psychosis
and Mania ............................................................... 417
I,.,

>

;
.
.
,
d
.

h
m ,

Jonathan H. Meyer

17. Hypnotics and Sedatives ....................................... 457

S. John Mihic and R Admn ktarris
18. Opioids, Analgesia, and Pain
Management .....................................~...........~, .....481
Tony 1. Yaksh and Hark S. W a k e

1 8. General Anesthetics and Therapeutic Gnst

Piyurh M. PateL Hemal H.
'and David M. Roth

......527

Patel,

20. Local Anesthetics ..................................................

William A. CattewU and Kbnneth b d d e

beurottansmission:The Autonomic
grid Somatic Motor Nervous Systems ................... 17 1
Thomas C. westfall and David P. Westfall

.,

....i,.;:.i&;*:t~;~,~.363

Nervous System ..;k~c~::4j:;.:.~;.,;,?.;

, -

Phannadynamics: MoIeeular Mechanisms

of Dmg Action ..................................
..................41
.Donald IC Bhmenthal and ;lam6 C. Garrison

EIaine Sanders-Bush and Lisa H a x e l w d

14. Neurotransrnission and the Central

565

ZJ,, PRannacotherapy of the Epilepsies .......................583

;James 0. McNamara

viii 22. Treatment of Central Nervous System

Degenerative Disorders
David G. Standaert and Erik D. Roberson
23. Ethanol and Methanol .........................................

........................................,
609
629

Hormones and Hormone

Antagonists

649

38. Introduction To Endmrinology:

The ~ypohhmi~l'ituitaryxis ...................... .I 103

Marc A. Schuckit

24. Drug Addiction......................................................

Chades P. (r8rien

Modutation of Caaiwascular

Function

669

25. Regulation of Renal Function

and Vascular VoIume ...................................

1......... 671

Robert F. Reilly and Edwin K. Jackson

26. Renin and Angiotensin ..........................................
Randa Hilal-Dandan

27. Tkatment of Mymadial Ischemia

and Hypertension

............................,..,.,.

72 1

Thomas Michel and Brian B, Hoffman

28. Phamacotherapy of Coagestive

Heart Failure.,

....,..,.....,...,.......,...,,......,...,.a.-,

............ 789

Bradley A. Maron and Thomas P, Rocco

29. Anti-Arrhytfmic Drugs ......................................... 8 15

Keith L Parker and Bernard P. Sd-hrnmer

39. Thyroid and Anti-Thyroid Drugs

..

Fibrinolytic, and Antiplatelet Dmgs.. .......,,. ......-849

Jeffrey I. Weitz
3 1. Drugmerapy f ~ Hypercholesterolemia
r
and Dyslipidemia .......................................... %..
......37'7

................... ....1129

Gregory A. Brent and Ronald J. Kwnig

40. Esbgens and Progestins. . . . . . . . . ~ ~ ~ ~ ~

1163
~~~~

ms R. Lwin and Stephen R. Hamines

41. Androgens ...........................................................
Peter 3. Snyder
42. ACTH, Adrenal Steroids, and Pharmacology
of the Adrenal Cortex...................
...

1195

..............1209

Bernard P. Schimmr and John W. Funder

43. Endocrine Pancreas and Phmacotherapy

of Diabetes Mellitus and Hypoglycemia ............. 1 237
Alvin C. Powers and David W A k m

44. Agents Affecting Mineral Ion

Homeostasis and Bone Turnover.........................

1275

Peter A. Friedman

BECT~ONVI-.-

Kevin 3. Sampson,and Robert S. Kass

30:Blood Coagulation qnd AnticqqgNant,

3 101

.
.-

Drugs Affecting Gastrointestinal

~undon

1307

45. fiarmacotherapy of Gastric Acidity, Peptic

Ulcers, and GastroesophagealReflux Disease.... I309
John L. Wallace and Keith A. Sharkey

46. Treatment-of Disorders of Bowel Motility and

Water Hux;:Anti-Emetics;Agents Used in
Biliary and Pandrkatic ,Disease............................1323

Thomas P. +ot

Keith A. Sharkey and John L. Wallace

and Hematopoiesis

909

32. Histamine, Bradykinin, and Their

Antagoaists...........................................................
.91i
Randal A. Skid& AUen P. &plan, and Elvin G. Erdiis
33. Lipid-Derived Autacoids: Eicmmoids
and Platelet-Activ&tingFactor............................... 937

.......

959

Tilo Gmsser, Emr M. Smyth, a d Garret A. FibGerald

35. Tmmunosuppressants, Tolerogens, and

Imrnunostimulants..................... ,..................... 1 005
Alan M. Krensky, William H. enn nett, and wo Yfncenti
36.Plllrnonary Pharmacology ..................................
.1M1
Peter 3. Barnes
37. Hematopoietic Agents: GrowthF
,
Minerals, and Vitamins........................................
1067
Kenneth thushandy and Thomas J. Kipps

1351

John L. Wallace and Keith A, Sharkey

Diseases

Emer M. Smyth, Tilo Grosser, and Ga>r@ A. FibGerald

34. Anti-inflammatbry, Antipyreti4 and Analgesic

Agents; ~harrnacothqai~
of Gout........................

47. Phmacotherapy df Inflammatory

Bowel Wsease
.........................................

1363

48. General Principles of Anti microbial

Therapy .............,.,.
...................................1365
Tawanda Gumbo
49. Chemothempy of Malaria .................................13 83
Joseph M. Vinetr, Jbrbme Ctain, Vlengngeun Bounkeua,
b A v ylrH
Wchard T. Eastman, and David Fidock

50. Chemotherapy of Protozoal Infections:

Amebiasis, Gidiasis, Trichomoniasis,

a!as

.Trypanosomiasis. Leishmaniasis, and Other

Protoml Infections ............................................

Margaret A. PhiUipr and Samuet L Stanley, Jr.

14 19

62, Targeted Therapies: Qmine Kinase Inhibitors,

Monoclonal Antibodies, and Cytokines .............. 173 1
Bruce A. Chabner, Jeffrey Barnes, Joe\ Neal, Erin O h n ,
Harnza Plyfagic. Lecia Sequist, Wynham Wilson, Dan L. Longo,
Constantine Mitsiad~,and Paul Richardson

63.Natural Products in Cancer Chemotherapy :

Hormones and Related Agents ............................1755
Bwerly Moy, Richard J. Lee,
and Matthew Smith

, M i s c e b u sAntibackriaJAgents.. ....,............ 1521

Conan'MacOou~alladHenry F. Chambers
-56.,Chemoth~rapyof Tubermlosjs I&cobacteriw
Avium Oomplex Disease, and Leprosy
1549
Taw3nda Gumbo
57. htifungal Agents .......................................
2
1

............,

John E. Bennett
J$8.iiAhti#ird&g&nki7(Nbmm~iral)
r ~EdwarcPP:~'costaundXharlesfletter
$9: AhtbtroviraPAgehb~md:

...,.....................1593

'I

,t

.,...............,,..,........,.1623

Tdatment of
" l9fia*s'"&,&
1

:.

Iqfection.
.I

'

64.Ocular Pharmacology

1771

..,....,. ............................ 1773

JefFrey D. Henderer and Christopher 3. Rapuano

65. Dermatological PharmamIogy............................ 1803

Craig Burkhart, Dean MornU,
and Lowdl Goldsmith
66. Contraqtion and Pharmacotherapy of

Obstetrical and Gynecological Disorders............ 1833

Bernard P. Schimmer and Keith L Parker

67. Environmental Toxicology;
Carcinogens and Heavy Metals...........................

1853

Michael C. Byms and Trevor M. Penniy

,.
I. Principles of Prescription Order
Writing and Patient Compliance .........................

'

'Chemotherapy of Neoplasnc
Diseases

1665

cib. General Principles of Cancer Chemotherapy ...... 1667

Bruce A. Chabner

Special Systems Pharmacolog

61. Cytotoxic Agents .................................................

I 677
Bruce A. Chabner, Jowph Bertino, Jams Ckary, Taylor Ortiz,
Andrew Lane, Jeffrey 6. Supko, and David Ryan

1879

Iain L 0. Bwrton

II. Design and Optimization of Dosage

Regimens: PBarmacokineric Data

....................... 1891

Kenneth E. Thummet, Dany O. Shen, and Nina

Isoherranen

Index

1991