Knowledge-Enabled and Human-Centered Computing

(aka Knucomp)

Knowledge-Enabled and Human-Centered Computing

(aka Knucomp)

Table of Content

Summary ..............................................................................................................................1 1. Concept ............................................................................................................................2 2. Outside Collaborators ......................................................................................................4 3. Supporting Science, Scholarship or Creative Activity ....................................................5 Research Labs and Infrastructure...................................................................................7 4. Extramural Funding .........................................................................................................8 5. Management Plan.............................................................................................................9 6. Funding Plan ..................................................................................................................11 7. Economic Development .................................................................................................12 8. Graduate Programs.........................................................................................................15 9. Undergraduate Programs ...............................................................................................17 10. Faculty..........................................................................................................................18 11. Summary of Metrics ....................................................................................................19 Appendix 1: Faculty Profile ...............................................................................................20 Appendix 2: Major Research Synergies ............................................................................21 Appendix 3: Economic Development Metrics and Data ...................................................25 Appendix 4: Support Letters ..............................................................................................27

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USO Center of Excellence (COE) on

Knowledge-Enabled and Human-Centered Computing (aka Knucomp)

Summary Knucomp is a logical next step to the successful outcomes from the Third Frontier award in 2003 to develop the Wright Center of Innovation for Advanced Data Management and Analysis now operating as daytaOhio, Ohios Wright Center for Data and the related grant from the Ohio Board of Regents for an Ohio Eminent Scholar, the LexisNexis Eminent Scholar in Advanced Data Management and Analysis which in turn led to the development of the Kno.e.sis Center.1 Kno.e.sis has already established itself as an exceptionally well funded and internationally recognized center of research in important information and knowledge management areas that enable creation of knowledge services, while daytaOhio has leveraged its world class data management and visualization infrastructure for regional economic development. Together, these centers have extensive academic, industrial and public sector collaborations (principally with the Air Force Research Laboratory (AFRL) located at Wright Patterson Air Force Base (WPAFB) that focus on three of the four important development clusters in the Dayton region: human sciences and healthcare, aerospace & defense R&D, and information technology. Knucomp represents an exceptional opportunity to further promote economic development by combining the strengths of these centers along with eight additional faculty collaborators across five departments that in turn leverage world class research of fifteen faculty members, high quality graduate students, international recognition in key areas of research relevant to the proposed center, and capacity to grow on its own. The potential to grow, realize continued commitment within the University System of Ohio, and achieve the impact of its work in the region will be significantly enhanced by its recognition as Center of Excellence. Near term and primary graduate programs involved in this Center are: Computer Science and Engineering (CSE) graduate programs -MS and PhD Biomedical Sciences (BMS) Ph.D. program Human Factors and Industrial/Organizational Psychology (HFIOP) Ph.D. program Secondary beneficiaries of the Knucomp would be the Department of Community Health, the Department of Information Systems & Operations Management, Community Based and Health Professions Education and the Biomedical Engineering Program. Knucomp faculty are members of, advise students in and/or teach courses to the students from these departments and programs.

Knowledge enabled Information & Services Science Center, http://knoesis.wright.edu

1. Concept Todays post-industrial, post-service economy is transitioning to a knowledge economy. 2 A large percentage of the current growth in todays industrial and services sectors is coming from knowledge services.3 4 5 Consequently, Ohios future economic success will, to a great extent, hinge upon how well we succeed in the emerging knowledge- and idea-based economy. To compete successfully, Ohio must invest in preparing professionals skilled in the capture, management, analysis, and delivery of information, as identified in Ohios Knowledge Economy Awareness Initiative. 6 A timely strategic investment in research-driven innovation will equip our state with the facilities and manpower to excel in the knowledge marketplace. 7 To this end, the Center of Excellence on Knowledge-Enabled and Human-Centered Computing (Knucomp) will provide a cutting-edge, world-class resource within the state of Ohio for the development, implementation, and strategic deployment of knowledge services to enhance the competitiveness of Ohio industries and workers. The concept of knowledge services reflects a new view of managing data and complex systems as well as a new view of the nature of cognitive systems. These problems are no longer framed in terms of data or information processing, but rather in terms of semantics, meaning processing and insights. The measures of success shift from indices of storage capacity and processing speed, to indices of productive thinking (i.e., measures of the degree to which the data can be used effectively, discovery of actionable knowledge, and enhance decision making and creativity) and enhancing human experiences and effectiveness. Consider, by way of illustration, the following example:
A pharmaceutical company has a significant body of heterogeneous, proprietary knowledge. Experimental results, whitepapers, chemical formulas, and clinical trials results are only a few examples. Taken together with public-domain knowledge such as that found in the PubMed database of biomedical publications, this information may contain a wealth of undiscovered knowledge. Some of this knowledge, such as evidence that a particular drug might have efficacy against a new pathogen, may have significant fiscal value. With appropriate knowledge services that enable experts to visually interact with and analyze data, information and knowledge from chemical, molecular, cellular, functional and medical levels, researchers are more able to identify and capitalize upon this value.8

2 3

Wikipedia: Knowledge Economy: http://en.wikipedia.org/wiki/Knowledge_economy H. Kujath, Knowledge-intensive services as a key sector for processes of regional economic innovation : Leapfrogging and path dependency, in Rethinking Regional Innovation and Change, Springer, 2005, pp. 85-106. 4 Knowledge-based services ...grew by almost 177 per cent in the period 1995 - 2005, compared to growth of 52 per cent for non-knowledge services (Knowledge Economy in the UK: http://www.esrcsocietytoday.ac.uk/ESRCInfoCentre/facts/index4.aspx 5 The fastest-growing part of the service sector consists of knowledge- and information-related services such as education, R&D, modern communications (telephones and Internet), and business services: Beyond Economic Growth, The World Bank Group. http://www.worldbank.org/depweb/english/beyond/global/chapter9.html 6 Ohios Knowledge Economy Awareness Initiative: http://regents.ohio.gov/kea/ 7 The Knowledge Economy: Is United States Losing its Competitive Edge, the Task Force on the Future of American Innovation, February 2005: http://www.futureofinnovation.org 8 This example conceptually extends the research being done in NHLBI R01 grant to Kno.e.sis/ WSU (PI: Sheth) in collaboration with UGA and Stanford, that is about discovering vaccine candidates for a human parasite.

Thus, this example illustrates not only the promise of information technology for improving access to data, but also cost of this technology that sometimes overwhelms us with data. The challenge is to integrate and organize information in ways that enhance understanding and that inspire innovation. The meaning and ultimately the value of data rest on our ability to use it to answer questions arising from complex problems. In respect to this example, the specific goal would be to build knowledge tools that help the pharmaceutical industry to discover improved models of health and disease and ultimately to improve health care. Knucomp researchers will conduct cutting-edge research with the goal of developing new tools and technologies that will enable our industrial and government partners to employ knowledgeenabled and human-centered computing to use data information and knowledge productively. Specific examples of activities that support knowledge-enabled computing include creation of ontologies (i.e., domain models or knowledge bases), scalability, high performance computing (including cloud computing), and multivariate data analysis. Additionally, human-centered computing focuses on developing tools to support direct perception and direct manipulation of information (e.g., visualization tools, virtual reality, and synthetic task environments). That is, we want to present information in a way that takes maximum advantage of humans superior cognitive ability to integrate over multiple modalities, to recognize patterns, and to chunk information in order to achieve deeper understanding. The ultimate goal of both initiatives is to mine data in ways that enhance peoples ability to productively think about complex problems. In sum, the intellectual merit of this center reflects a paradigm shift from the age of information processing toward an age of meaning processing. Our goal is to stand on the shoulders of the innovators of the information age and to push toward the horizons of the meaning age. The focus is no longer simply to accumulate data, but also to explore how to put this data to work to address complex problems. In the spirit of Pasteurs Quadrant, the Knucomp Center will attack the issues of meaning processing in a way that will contribute to basic theory about computation and cognitive systems and in a way that will address pressing practical problems associated with productive thinking in the face of an explosion of data.

Figure 1: Impact: from research and applications to workforce and economic development relevant to competitive industry clusters

With demonstrated expertise in complementary research areas, rapidly growing research portfolio including a history of multidisciplinary research attacking increasingly complex problems, international recognition of a number of participating faculty, proven leadership, exceptional investments and facilities, and the ability to transfer academic research into economic development in most relevant industry sectors through collaborations, workforce development and technology transfer, the Knucomp team is ready to realize the new exciting vision (Figure 1). 3

2. Outside Collaborators Kno.e.sis has current collaborations with a number of international, national and state institutionsacademic, commercial and government. These include a number of National Institute of Health (NIH) and National Science Foundation (NSF) funded projects between a faculty in Kno.e.sis and other WSU collaborators identified and part of this center, including collaborations with the Nationwide Health Information Network Collaborative through the Office of the National Coordinator in the US Department of Health and Human Services, National Center for Biomedical Ontologies at the Stanford University, University of Georgia (two), Cincinnati Children's Hospital Medical Center (CCHMC), University of MarylandBaltimore County (UMBC), SAIC, IBM Research, Microsoft Research, and HP Research. Appendix 2 identifies a subset of these collaborations. We also have two projects funded by Air Force Research Lab (AFRL) Sensor (AFRL-Sensor) and Human Effectiveness (AFRL-HE) Directorates, and we are a significant partner in AFRL/WPAFB funded $10+million funded Adaptive Multi-Layered Sensing Architectures (AMSA) initiative that is led by SAIC. Additionally pending or in progress proposals to NIH or NSF include partners such as CCHMC, Ohio State University, University of California- Irvine, Purdue University, UES Inc. (Xenia), and REI Technologies (Dayton). In all except three of the funded projects, faculty in Knucomp serve as the PI, in the rest, a faculty of Knucomp serves as a co-PI. Our collaboration not involving funding includes National Library of Medicine, University of Melbourne, CSIROAustralia, DERI-Ireland, and Yahoo! We are also an official member of World Wide Web Consortium (W3C). 9 To this extensive list, daytaOhio adds its academic, public organizations, non profits, industry partners and collaborators. It has invested in facilities at four other Ohio universities (Kent State, Ohio State, University of Cincinnati and University of Dayton) and the Ohio Supercomputer Center. It works with the AFRL (both AFRL-Sensor and AFRL-HE), the Ohio Department of Natural Resources, the Dayton Development Coalition, and Online Computer Library Center (OCLC). daytaOhios commercial partners include LexisNexis, General Dynamics, SAIC, Siemens PLM and Medical, Ball Aerospace, Kettering Health Network, Schlumberger, Hess Petroleum, Western Geco and CDO Technologies plus technology vendors like TechViz, Presagis and Barco Inc. Letters of support from renowned researchers attest to the academic excellence of faculty and students associated with Knucomp, while letters from AFRL-HE, large and small companies, and Dayton Development Corporation attest to our current collaborations as well as our future role in economic development (Appendix 4).

Prof. Sheth serves as an advisory member since 2003, co-chairs two activities, and our work has already resulted in a W3C recommendation/standard

3. Supporting Science, Scholarship or Creative Activity Kno.e.sis was formed in January 2007 by Prof. Sheth, when he moved to the Wright State University as the LexisNexis Ohio Eminent Scholar. Despite its youth, it has remarkable achievements and the following summarize what has made the Kno.e.sis Center an international leader. Top quality graduate students and graduates. Currently, approx. 20 PhD students are funded as GRAs. Graduates routinely do internship at top institutions such as Microsoft Research, IBM Research (Almaden, Watson), HP Research, National Library of Medicine, Yahoo! Labs, UC-Berkeley, DERI-Ireland, etc., serve on program committees of international conferences and workshops, and publish in high quality conferences and journals. With average record of over 10 publications (accompanied by an unusual record of highly cited publications) and 4 program committee memberships (including selective international conferences with less than 20% acceptance rate) prior to graduation, recent advisees of our faculty have been highly sought after and have joined high quality institutions in academia (e.g., North Carolina State University) and industry with salaries and responsibilities that significantly exceed averages. These statistics demonstrate the current pipeline: six of the senior PhD students (those who will graduate within 2 years) have published 84 papers and served on 43 program committees of international conferences and workshops. Seven faculty members who have proven successful records including funding, highly cited research publications, awards, major professional activities, etc. During past 20 months, they have received new competitive funding from NSF (four), NIH (lead for R01, with Stanford and Univ. of Georgia as subcontractors to WSU), AFRL (three), State of Ohio, Microsoft Research, HP Research, IBM Research, Google, etc. During last recruiting season, our ability to hire a top quality candidate was also demonstrated; Dr. Pascal Hitzer, hired as an assistant professor, comes from the top European research institute in Semantic Web (an area in which Kno.e.sis is the largest group in USA) and is already an internationally recognized researcher. Currently active (funded) collaborations with other world class organizations (details in collaboration section). We also play an important role in the World Wide Web Consortium (W3C) which has included the successful adoption of an international standard based on our proposal. In Semantic Web, an important new area of the next generation of the Web, we are the largest academic research group in the US and one of the top 5 in the world. Our work in Services Computing and the associated area of Workflows is among the best cited in the world (e.g., seven publications with over 200 citations each). Leadership by Prof. Sheth. He is an Ohio Eminent Scholar, an IEEE Fellow, is among the best cited authors in Computer Science (he is among the 25 most cited authors in CS10, 29 of around 250+ publications with 100+ citations each, 15,400+ total citations), has a history of extensive funding (approx. $14.5 million in research funding from NSF, NIH, NIST, DARPA, AFRL, NRL, ARDA, industry, etc. mostly in leadership role,11 plus
10 11

http://www.cs.ucla.edu/~palsberg/h-number.html For example, Kno.e.sis $1.5+ million NHLBI R01 led by Sheth as PI, for which Stanford University and University of Georgia are subawardee.

over $5million in R&D/ commercialization funding), is an internationally known leader (EIC/co-EIC for two international journals, editor of two Springer book series, chair/organizer of 60+ international conferences/workshops, member of 160 PCs), and has been a successful entrepreneur (including founding/managing two companies). His research has resulted in several products and services as well as operationally deployed applications in biomedicine, health care, financial services, telecommunications, and defense R&D. Knucomp will extend Kno.e.sis from seven faculty members in one center of the Computer Science & Engineering (CSE) department to fifteen accomplished faculty members across five departments, encompassing two centers and twelve research labs in addition to daytaOhio. The faculty members support 46 active PhD advisees (practically all full time PhD advisees are funded as GRAs). These faculty members have published 830 refereed publications among 1,300 total publications, have over 30,000 citations (on Google scholar) to their publications, have served on approx. 388 program committees and have served as leaders (primarily as chair/cochair) of 100+ international events. The expansion will facilitate extensive multidisciplinary collaborations integrating areas of research identified in Appendix 2. Both Ohio Eminent Scholars position (and hence Kno.e.sis) and daytaOhio were created with the same Third Frontier award in Information Technology, one of Ohios five development areas identified by a Battelle study in 2002. The two groups have collaborated since 2007 when Kno.e.sis was established. This has included work on the AFRL funded Sensor Vigilance (SaVIG) program. More recently both have been exploring use of daytaOhios world class visualization environment for defense/intelligence application of sensors as well as human effectiveness application of importance to WPAFB. The joining of two additional faculty members in visualization from the CSE as well as the faculty in cognitive sciences will further enhance this collaboration. Kno.e.sis largest funding is in multidisciplinary projects involving CS and human science (biomedicine), one of its labs focuses on bioinformatics, and three faculty members are members of the interdisciplinary Biomedical Sciences PhD program, which is a strength the center intends to build upon. The proposed center includes 9 CSE faculty (7 Kno.e.sis faculty plus two faculty in visualization), three faculty in Cognitive Science from the College of Science and Math as well as one faculty each from Information Systems and Operations Management in the Raj Soin College of Business, and Biochemistry and Molecular Biology and Community Health from the Boonshoft School of Medicine. See Appendix 1 (Knucomp Faculty Profile [affiliations, technical strengths, awards]). Kno.e.sis currently has extensive collaborations with researchers outside WSU, an explicit objective of the proposed center is to increase collaborative funding within the campus, especially by combining strengths with other important organizations such as Comprehensive Neuroscience Center Comprehensive Neuroscience Center (CNC; http://www.med.wright.edu/cnc/) and Center for Intervention, Treatment, and Addictions Research (CITAR; http://www.med.wright.edu/citar/). We already have collaboration with the Center for Healthy Communities (CHC; http://www.med.wright.edu/chc).

Research Labs and Infrastructure: The twelve research labs directed by Knucomp faculty members are: Bioinformatics Research, Data Intensive Analysis and Computing, Machine Learning, Data Mining, e-Science, Formal Semantics & Rules, Intelligent Systems, NMR Spectroscopy Lab (WSU School of Medicine), Medical Data Analysis, Metadata and Languages, Semantic Web, Services Science, and Visualization. Examples of extensive research and teaching infrastructure include a cloud with 16 nodes (64 cores), a 16 node cluster, a number of powerful servers, a Medtronic Surgical Simulation System, a whole-body laser range scanner, and a visualization lab with large-screen stereoscopic display systems, VERITAS facility,12 multiple TB-sized data storage solutions, high-performance and large memory graphics workstations, a workstation equipped with dual Tesla Teraflop many-core processors, a 360 NMR system, and a Varian INOVA 600 system. daytoOhios advanced visualization infrastructure in the Appenzeller Visualization Lab (AVL) was developed in collaboration with Barco Inc. whose North American center for Virtual and Augmented Reality is located in Xenia, Ohio. The specific components include a large, rear projection screen (iWALL) supporting multiple inputs using Barcos XDS-1000 display management system and a 4 sided immersive environment (i-Space) with two tracking channels. To support the applications that use these environments, daytaOhio has a multiple terabyte data storage system with high-performance servers and large memory graphics workstations. All of the elements are networked and administered from a central facility in the AVL. daytaOhio has also collaborated with four other Ohio universities (Kent State University, Ohio State, and the Universities of Cincinnati and Dayton) and the Ohio Supercomputer Center to make investments in visualization and processing facilities that can be leveraged by Knucomp under joint use agreements. daytaOhio also has a Teradata 5400E installation with 2TB of capacity and applications to support genetics and logistics analysis projects. Kno.e.sis Center faculty already have a shared computing infrastructure and equipment; the same strategy will span Knucomp. daytaOhio facilities are structured to support multiple projects and users.

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The Virtual Environment Research, Interactive Technology, and Simulation (VERITAS) Facility is owned and operated by Wright State University, but housed in the Air Force Research Laboratory (AFRL) at Wright-Patterson Air Force Base (WPAFB). The facility is centered around a 5-walled CAVE, a room-sized virtual environment presentation system. Additional equipment includes a DataWall, head-mounted displays, haptic feedback devices, head trackers, and associated software. The facility emphasizes the development and evaluation of 3D audio displays.

4. Extramural Funding Knucomps fifteen faculty members have lifetime research funding of $47.3 million as PIs and over $20 million as co-PIs, including currently active research funding of $8.7 million as PIs and $6 million as co-PIs. Academic personnel (not including daytaOhio personnel) include 15 faculty members, approx. 46 funded Postdocs and PhD students advised by faculty members, one administrative staff, and a number of MS and BS students. Faculty members have been PIs for funding from most major federal funding sources such as NIH (several institutes), NSF, National Institute of Standards & Technology (NIST), DARPA, Advanced Research Development $4,275 Authority (ARDA), Air Force Research Lab $4,025 $3,775 (AFRL), Army Research Lab (ARL), Air $3,525 Force Office of Scientific Research $3,275 (AFOSR), and Office of Naval Research $3,025 (ONR). $2,775 The Kno.e.sis funding record, accounting for six of its seven faculty members, is shown in Figure 2. 13 A significant majority (approx. 70%) of these funds are from highly competitive federal sources (e.g., NSF, NIH), with smaller percentage (approx. 19%) from state sources, and about 11% from highly prestigious and desirable unrestricted gifts and innovation grants from Industry.14
Thousands $2,525 $2,275 $2,025 $1,775 $1,525 $1,275 $1,025 $775 $525 $275 $25 Jan-07 Jan-08 Jan-09
Federal Industry State Total

daytaOhio was initially funded by the Ohio Department of Development (ODOD) as a Figure 2: Funding record in thousands for six of Wright Center of Innovation with $11.1M in the seven Kno.e.sis faculty members capital funding in October 2003 and an additional $1.5M in operating funds in September 2005. Since then, daytaOhio has generated a return of close to $60M with $39M in co-investment, $16M in new investments in Ohio based on the capital investments that were made, and $4.6M in grants/contracts to support its ongoing operations. The assets acquired using the states capital grant and current staff are currently projected to generate continuing contract and grant incomes in excess of $1M per year, and it is anticipated that the participation in the Knucomp will increase that income. Starting with current active research funds of approx. $8.7 million15, we plan for active research funds of $13 million in 5 years and $19.5 million in 10 years reflecting 50% increase each five years. Correspondingly, academic staffing level for Knucomp (not including daytaOhio staff) conservatively plans for 50% increase each 5 year period.
13 14

Seventh colleague joins in Fall 2009, and has substantial funding record not included in this figure. Kno.e.sis faculty received unrestricted gifts/grants from Microsoft Research, HP Research, IBM Research and Google within last 12 months. 15 Over $4million of this corresponds to the currently active research funds associated with six Kno.e.sis faculty as shown in Figure 2, and the rest is associated with Knucomp faculty that are currently not in Kno.e.sis.

5. Management plan Knucomps management plan primarily focuses on four aspects: providing an environment for carrying out world class research, defining and managing large multidisciplinary projects such as those outlined in Synergies Table (Appendix 2), supporting economic development through the commercialization of intellectual property and developments of a skilled workforce. Our management plan takes advantage of the existing models for both Kno.e.sis and daytaOhio and the personnel that support these. For example, daytaOhio has for-profit spin offs that can support the creation of new companies or joint ventures. While Knucomp will have a coordinated agenda, the operating plan will accommodate specific interests of the partnering organizations. Our expectations for support from USO and WSU are modest, and initially there will be no dedicated COE staff. However, based on the actual success in funding and collaborations, and when USO and WSUs strategic funding permit, we will add additional administrative and shared technical personnel. These include the following: a post-doc (who will specifically help faculty to do preliminary research and demonstrate existing collaborations which are necessary to win sizable grants) a programmer (who will help polish the tools and technologies developed by center participants so that they can be better utilized by the community, bringing visibility, helping market technology for potential licensing, and managing comprehensive Web portal for presence and branding); and a dedicated business manager once funding reaches the $10 million level who can deal with increased funding and budgetary issues. Support for matching funds when required by a sponsor of a major grant may also be solicited. daytaOhio will seek independent funding for a CTO position whose activity in part will support Knucomp objectives. In a number of areas, such as technology transfer and research involving human and animal subjects, we will continue to use the existing groups at Wright State University, including the Office of Technology Transfer IRB and the Office of Research and Sponsored Programs. Prof. Sheth will serve as the director of Knucomp and provide primary leadership for research aspects. Terry Rapoch will serve as the co-director, leading its activities related to the economic development. Within this overall structure, Mike Raymer will direct the centers education activities. For each of the industry clusters we seek to impact, technical leadership will be provided as follows: Kate Cauley for healthcare, Nicholas Reo on human sciences, Guozhu Dong on information technology, and Arthur Goshtasby on Defense/Aerospace R&D. daytaOhio is already structured to focus on its key target markets in Medicine, Energy and Defense and will build on this as it works with the Knucomp team. The COE will have an Advisory Board (AB) that will conduct its annual review. It will set and modify as needed the evaluation matrix discussed later in this proposal. Members of the committee are world-renowned leaders in academia as well as industry or entrepreneurship (all have accepted to serve on the Advisory Board): Prof. Ramesh Jain (Chair of Advisory 9

Committee), Prof. Gerhard Weikum, Prof. Ahmed Elmagarmid, and Mr. Krishna Joshi (Founder & Chairman, UES, Dayton; benefactor). Table 1 outlines the qualifications and relevance of renowned research leaders on the proposed Advisory Board. Their letters along with those of regional organizations appear in Appendix 4. daytaOhio will consider opportunities for joint membership on its Board of Directors to further enhance collaboration.
Table 1: Members of the Initial Advisory Board

AB member
Prof. Ramesh Jain http://ngs.ics.uci.edu/

Description
First Bren Professor in Bren School of Information and Computer Sciences, UC-Irvine. Founder of four companies (including a public company). Chairman of ACM SIG Multimedia, founding Editor-inChief of IEEE Multimedia. Fellow of ACM, IEEE, IAPR, AAAI, and SPIE. Research Director, Max-Planck Institute for Informatics, Saarbruecken, Germany; Chair, Department on Databases and Information systems. Spokesperson of the International Max-Planck Research School for Computer Science. Member of the German Academy of Science and Engineering, ACM Fellow, CIDR 2005 Timeless Idea Award, VLDB 10-Year Award 2002, ACM SIGMOD Conference 1998 Best Paper Award. Professor, Computer Science; Director, Cyber Center; Director of the Indiana Center for Database Systems, Purdue University. Presidential Young Investigator award from the National Science Foundation. Distinguished alumni awards from Ohio State University. Earlier served as a chief scientist in the Office of Strategy and Technology at Hewlett-Packard. Krishna Joshi founded UES Inc., an employee owned company, in 1973 in Dayton. It provides Support to DoD, EPA, DoE, NASA, NSF, is a leader in the State of Ohio SBIR Awards, and has recently expanded competencies into Nanotechnology and Biotechnology Disciplines. Mr. Joshi has been a prominent entrepreneur and benefactor of the Miami Valley. Kno.e.sis and daytaOhio are housed in the Joshi Research Center named after Krishna and Vicky Joshi.

Prof. Gerhard Weikum http://www.mpiinf.mpg.de/~weikum/

Prof. Ahmed Elmagarmid http://www.cs.purdue.ed u/people/faculty/ake/

Krishna Joshi

The management plan includes the development of a suitable teaming agreement between Kno.e.sis, daytaOhio, Wright State University and other parties that will provide additional detail on how issues such as IP, funding splits, performance management and use of shared facilities will be addressed.

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6. Funding Plan Kno.e.sis faculty, as well as those collaborating in Knucomp have strong track records for winning sizable grants (see Section on extramural funding) and this will be one of the sustaining elements in the funding plan, as will daytaOhios continuing development of contract and grant revenue. To this continuing activity, Knucomp will significantly enhance funding in two additional ways: lead an increasing number of larger collaborative proposals, and expanding state and regional opportunities. To date, Knucomp faculty members have participated in several large multi-institutional, multimillion dollar proposals but these have typically been led by internationally reputed research groups at large US universities. However, establishment of Knucomp will create the following new funding opportunities that we expect to lead in significant majority of cases. Federal funding targets include the following. Air Force's Center of Excellence (co-funded by AFRL and AFOSR)16 DoDs Multi-University Research Initiative (MURI) NSFs Partnerships for International Research and Education (PIRE), Partnership for Innovation (PFI) and Science & Technology Centers (STC) NIHs National Center for Research Resources (NCRR), starting with a P20 grant proposal for a NIH Exploratory Center Collaboration on NIH program grants with CITAR, CNC, and CHC Expanded state and regional opportunities: Having the center in place will also facilitate proposals for other funding with higher relevance to economic development such as: Third Frontier grants involving Knucomp faculty, daytaOhio and/or IDCAST STTR/SBIR grants with industry partners WPAFB and AFRL

16

Air Force COE funding is $1.5 million per year for five years, of which AFOSR contributes $500K, AFRL contributes $500K, and Knucomp with the help of the university will need to come up with a match of $500K.

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7. Economic Development The goals for the center as defined by the USO focus on the creation of a world-class research capability that attracts and retains outstanding faculty and student talent. The matching metrics from USO are focused on the economic outcomes from realizing these goals in terms of new investment, business development, job creation and the development and retention of new talent. These measures are reflected in Appendix 3. To accomplish these results, Knucomp builds on the regional strengths that drove the formation of both Kno.e.sis and daytaOhio. The center aligns with the framework (Fig. 3) that underpins the technology driven economic development agenda for the region. As depicted in the diagram, the following four development sectors form the core of the regional strategy17: Information Technology, Human Sciences and Healthcare, Aerospace Research and Development and Advanced Materials and Manufacturing. As shown in the Research Synergies table in Appendix 2, Knucomps interests and activities are aligned with three of the four development sectors. In addition, the commercialization framework identified in Figure 3 visually demonstrates how innovations developed through research at regional universities and other organizations are moved to industry through commercialization channels and incubators such as daytaOhio.

Figure 3: Collaborative Framework for Commercialization developed by Dayton Development Coalition (DDC) 17 Dayton Development Coalition Industry Clusters: http://www.getmidwest.com/industryClusters/index.cfm?sectionID=ic

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Knucomp will be a significant new contributor within this framework, leveraging the confluence of strengths in highly relevant research and technology development. The center will work to match market pull from businesses and employers in the Dayton region with technology push from the internationally recognized Kno.e.sis Center, daytaOhio and its industrial and academic collaborators. The pull aspect of Knucomp originates from the research and knowledge services needs of many of the regions key employers, including SAIC, Ball Aerospace, UES, REI Technologies, and LexisNexis, as well as WPAFB, the largest single site employer in Ohio, and the Dayton regions globally competitive industry strengths in three sectors of the collaborative framework. The push aspect derives from exceptional strengths in STEM education and research of centers and the labs of fifteen accomplished faculty across five colleges of the Wright State University and daytaOhios four partner universities and the Ohio Supercomputing Center. Knucomp will be the core for a new competitive cluster in the Dayton region. It will be centered around innovative knowledge services that use knowledge-enabled and human-centered computing involving advanced visualization and presentation techniques that improve the ability of users to take advantage of the vast amounts of information that currently exist and are being created every day on the Internet and the World Wide Web. This cluster will bring new products and services to market generating new revenues and investment for the region to support business and workforce growth opportunities. To make companies within the region and Ohio aware of its research and how it can be incorporated within their product and services, Knucomp through existing relationships with daytaOhio will work with existing regional and state level economic development organizations focusing on the Information Technology sector, including Technology First (http://www.technologyfirst.org/), formerly the Greater Dayton IT Alliance, and the Ohio IT Alliance(OhioITA: http://ohioITA.org). Investment in the center through grants and contracts will contribute to the development of wellqualified professionals and an effective supporting infrastructure. The funds from federal and private agencies will support its work and help to transfer and commercialize its technologies. Four of the participating faculty members have been involved in founding start ups. Prof. Sheths Venture Capital funded company quickly grew to 35 employees before it was acquired. 18 Based on the existing track record of Kno.e.sis and daytaOhio, and new Knucomp partners it is reasonable to anticipate that cumulative investments and funding over the next 10 years will be in the $20-34M range19. The changes in size and organization of the traditional pillar companies of the Dayton area mean that the continuing prosperity of the region will become even more dependent on the viability and success of small and medium-sized businesses. In addition to startups, the center will focus on infusing its technologies into these existing companies, providing the opportunity to restart their growth by allowing them to enter and compete in new markets and expand
18

Prof. Sheth founded Taalee by licensing technology from his university research and managed it as the CEO/COB until its acquisition/merger (subsequently served as Exec. VP/CTO/Chief Scientists in resulting companies Voquette and Semagix, which now survives as Fortent). This company invested over $7 million in local payroll while he managed it, paid university $100K in cash license fees in addition to equity, and provided high paying high-tech employments before it moved following the latest merger. 19 Sum of funding from research, daytaOhio cost share and contracts, capital invested, additional investments based on Knucomp activities, and SBIR/STTR, see Appendix 3 for details.

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existing ones. The center will also have a particular interest in supporting companies with SBIR and STTR funding which are a recognized mechanism for growing new and existing companies by bringing new technologies of interest and importance to defense programs. The goal is to realize a combined impact from these activities directly impacting 8-12 companies within the region, see Appendix 3 for details. The result of expanding the regions research and business infrastructure is in the growth of new and sustainable job opportunities. Some of these will be within the academic sector as new research funds become available and new programs are offered that require teaching and other support. Within the academic community as identified, it is anticipated that the overall job impact would be in the order of 10-15 FTEs per year over the next 10 years. The FTE measure is used to properly account for the transient nature of graduate students, research assistants, postdocs and other positions associated with and supported by the work of the Center. With respect to the industry opportunity, and based on the assessment of the growth and business infrastructure, it is expected that the center would create 80- 100 jobs over the next 10 years within the private sector in the region, not considering the centers role preparing workers for opportunities at WPAFB from the growth anticipated as a result of the BRAC legislation. Appendix 3 summarizes the anticipated cumulative economic impact of Knucomp over the next 5 and 10 years in terms of changes in investment, business infrastructure, employment and talent development.

14

8. Graduate Programs Knucomp will interact with and draw student talent from several graduate programs at Wright State University. The M.S. and Ph.D. programs in Computer Science and Engineering will provide a body of student researchers interested in extending the frontiers of computation and knowledge-based computing. These students will work on interdisciplinary teams with our government, industry and other academic partners to design and implement domain-specific solutions to targeted problems in science and business. This cross-disciplinary training will produce graduates that are well prepared to continue to perform innovative and exciting research in industrial and government partnerships. In addition, Knucomp will be closely associated with the BMS and HFIOP PhD programs. BMS program already has several tracks that emphasize computational modeling, analysis, and visualization, including: Genomics and Proteomics Computational and Theoretical Biology Cellular Dynamics and Engineering Structural Biology Biomedical Imaging In only 15 years, the HFIOP program has awarded 23 Ph.D.s and has grown to a steady state of approximately 50 full time graduate students. The program now attracts top students from throughout the world, and our alumni have been hired by research universities (e.g., Colorado State University, University of Tulsa), national and local corporations (e.g., General Dynamics, Intel, Lexis-Nexis, Proctor & Gamble, SAIC), US government laboratories (AFRL, NAVAIR, NIOSH) and international research centers (Max Plank Institute in Germany). Knucomp will strengthen the ties between the BMS program, HFIOP program and the other center participants. Four of the Knucomp faculty members (Goshtasby, Reo, Raymer, Sheth) are currently faculty members in BMS; their students take BMS courses and BMS students are advised/coadvised by them. Three of the Knucomp faculty members (Bennet, Gilkey, Flach) are associated with HFIOP program. Graduates from the College of Engineering & Computer Science (CECS) and the BMS program will work together to develop computational solutions to challenging problems in the human sciences. CECS and HFIOP collaborations can target applications in all three industry sectors of our relevance. Our students will be well prepared to tackle research problems that require computational skills, modeling shills, and extensive domain knowledge. Additionally, one of the Knucomp faculty is associated with Masters in Information Systems program which will gain secondary benefit through cross listing of courses. Broader impacts of our activities are likely to influence the Biomedical Engineering Program. Two Knucomp faculty members (Reo and Ghostaby) teach courses that are routinely taken by Biomedical Engineering (BME) program students and often advise and fund BME students. The bioinformatics research group within Kno.e.sis, together with the statewide Ohio Consortium for Bioinformatics, was awarded a Choose Ohio First (COF) grant by the Ohio Department of Development in 2008. For each year from 2008 to 2013, ten graduate and undergraduate students will receive tuition scholarships from this award. While the award 15

covers approximately one-half of student tuition each quarter, the School of Graduate Studies at Wright State has agreed to provide matching funds covering the rest of the tuition costs of graduate students participating in the program. For the first year of projects grant support, we have utilized nine of the ten available scholarship opportunities. In addition, WSU is the lead institution in a COF award supporting students in STEM (Science, Technology, Engineering and Mathematics) fields. WSU is ranked 4th in the nation for scholarly productivity among small research universities per the Chronicle of Higher Education. Our graduate programs in Computer Science and Engineering have an average enrollment of 98 Masters and 37 Doctoral students over the period of 2003 through 2008. An average of 51 M.S. and 5 Ph.D. degrees were awarded by these programs from 2002 through 2007. Knucomp associated faculty have authored a number of highly-utilized textbooks used in graduate and undergraduate teaching, including Multimedia Data Management (Sheth), Management of Heterogeneous and Autonomous Database Systems (Sheth), Semantic Web (Hitzler), Fundamental Concepts of Bioinformatics (Raymer), and Control Theory for Humans (Flach). Kno.e.sis is already attracting a majority of the graduate students applying to CECS programs. In 2006, we did not have enough highly qualified applicants for all the graduate assistantship (GTA and GRA) positions we had available. In contrast, in 2009, the number of highly qualified applicants exceeded the number of available Kno.e.sis positions. We anticipate that future selectivity will reach 50% in 5 years, and 25% in 10 years. Students graduating from Kno.e.sis as well as those advised by all Knucomp faculty members have 100% employment. An informal survey indicated that Prof. Sheths recent advisees have consistently received salaries that approach the highest available in their initial jobs (e.g., $75K in Atlanta to $90K in California for M.S. graduates, $120K for Ph.D. recipients). We will target similar pay for all Knucomp graduates. Although graduate students in CSE Department are not required to participate in internships, a majority of Kno.e.sis students have two to three internships, typically at the best industry and national labs. We would like to achieve a rate of 75% of Knucomp Ph.D. students attaining at least one internship position with the best industry research labs in 5 years, and 90% in 10 years. A number of advisees of Knucomp faculty have chosen to stay in Ohio (choosing employers20). Current retention rate is approx. 50% for graduates. Closer collaboration with local industry partners and higher recruiting of local students who are U.S. citizens and hence qualify for some of the government or government contract related jobs will help us raise the retention rate to 60% and 70% in 5 and 10 years, respectively.

20

Example companies chosen by former advisees of Knucomp faculty include CCHMC, P&G, Kettering Medical Center, WPAFB, and LexisNexis.

16

9. Undergraduate Programs Knucomp will provide training and professional preparation for undergraduate students in conjunction with several WSU undergraduate programs, including the Bachelor of Science program in Computer Science, the Bachelor of Science program in Computer Engineering, and the Bachelor of Arts program in Computer Science. These three CSE programs at WSU have a strong history of producing well-trained undergraduate students. The Department of CSE enrolls more than 400 undergraduate students in computer science and engineering each year. Psychology Undergraduate Program (BS, BA) is another key undergraduate program that will be associated with Knucomp. With well over 600 majors, it is the largest major in the College of Science and Mathematics. The program has a strong emphasis on research and scientific method. For example, a laboratory research component is integrated in the first introductory course (Psy105), all majors are required to take a 3-course methods sequence, and the honors research program was the first in the university, pre-dating the university honors program. Many undergraduates from this program go on to obtain graduate degrees in Psychology, Neuroscience, Medicine, Law, and other fields. In fact, two of our undergrads who obtained Ph.D.s in Psychology have returned to become faculty in our department. We will seek to add computational element to this program through this collaboration. Collectively, Knucomp faculty have developed at least 10 new courses for undergraduate students in CSE. In addition, our past experiences in cross disciplinary research and education in bioinformatics will make Knucomp particularly well suited to involve students from programs outside of these tightly-coupled programs. Specifically, undergraduate students studying biology, biochemistry, biomedical engineering, industrial and systems engineering and cognitive psychology will be targeted for cross-disciplinary research and training opportunities. Knucomp faculty have already been involved in a number of highly successful pedagogical development efforts related to cross-disciplinary undergraduate studies. By way of example, the nations first NSF-funded undergraduate program in bioinformatics was led by a current Kno.e.sis faculty member (Raymer). This program has served as a model for similar programs throughout Ohio and the Midwest and demonstrates our ability to develop effective programs for recruiting, retaining, and engaging undergraduate student both in and out of the classroom. Undergraduate professional training will be accomplished through a variety of new programs and extensions to existing programs at WSU, including: A new undergraduate and graduate mixed seminar series on knowledge services and knowledge-based computing An undergraduate research program tied to our current Choose Ohio First awards in STEM and bioinformatics. Students participating in these programs will be invited to join Knucomp associated research meetings and to pursue multi-term research projects within these research groups A summer internship and co-op program that provides course credit for students engaging in summer work related to their studies Development of new undergraduate courses and study tracks in data visualization, pattern recognition, web and cloud computing, and other areas related to knowledge services 17

10. Faculty Significant majority of publications and presentations from Kno.e.sis Center faculty and students use Kno.e.sis name, Web sites, emails, logos and appropriate branding material, and we anticipate near 100% use by the next year (Figure 4). With over 650 items, Kno.e.sis library21 already hosts publications from all its faculty and students. Its faculty provide among the largest array of advanced courses offered in the areas of its focus anywhere in the world. They also give many keynotes, tutorials and professional courses.

Figure 4: The Kno.e.sis Center uses comprehensive artwork, tag line and logo for branding, and significant majority of its presentations and publications carry its name and branding artifacts already (see http://knoesis.wright.edu). Faculty and staff business cards carry Kno.e.sis logo and Web site URL, and all faculty offices and their labs carry Kno.e.sis logo. This practice will be adopted for Knucomp with revised branding and artwork.

Knucomp already has one Ohio Eminent Scholar; we envision at least one additional Ohio Scholar (under ORSP or equivalent program) for each of the first two five year periods. We expect the university to provide start up for new faculty as it has done in past proposals for ORSP. Since the third floor of the Joshi Research Center is fully occupied by Kno.e.sis faculty and their respective activities, additional space will be needed in Joshi or Russ Engineering when hiring Ohio Scholars, but we expect to be able to find adequate space for regular tenure-track hires. As our collaborations develop further, we anticipate more faculty members would choose to join the center. Thus majority of the growth in faculty will come from existing faculty members. Growth related to non-faculty members was discussed in the Management Plan section. Knucomp currently does not lack any major equipment it needs to achieve its objectives at this time. Some of the pending and planned collaborations (discussed in the section on Funding plan) are likely to add substantial additional equipment.

21

http://knoesis.wright.edu/library/

18

11. Summary of Metrics We have devised several measurable targets that can be used to judge the success of this COE and ensure its placement among the top centers in its area in the world. These include the following within first five years (all percentages with respect to comparable unit such as the department or college to which faculty belong to)22: Recognition: Kno.e.sis is recognized as the leader in the area of Semantic Web in US and top 5 in the world. It also holds high position in a number of Web 3.0 areas including services and sensor computing on the Web. Knucomp will increase the coverage of recognition and eminence areas to include more emerging areas and multidisciplinary research (See Appendix 2 for specific examples). Funding: Average funding for Knucomp faculty to exceed 150% of average funding among peers with a target of 200%, and support for an average of at least two GRAs per Knucomp faculty with a target of three GRAs. Achieve 100% increase in MS students selecting research oriented thesis option, and 50-100% increase in advisement and graduation rate for MS and PhD per Knucomp faculty. Achieve 100% increase in engagement with WPAFB as well as with local/regional industry. Acquire at least one large grant (over $1 million each) every 2.5 years and obtain one major project such as Air Force Center of Excellence or DoD MURI within first 4 years. Student Achievements: Offering of one or two innovative graduate studies focus streams for MS of particular relevance to regional industry clusters, building upon a large number of relevant multidisciplinary courses offered by COE faculty. Achieve measurably better placement and/or salary for our graduates (min. 15%, with a target of 20%, over national average or regional averages when available, for the discipline). Faculty Achievements: Average publication per COE faculty to be at least 150% with a target of 200%. Demonstrably higher citation record for publications and more success in publishing in high quality events (e.g., top 3 conferences in area, or A-ranked journals). Successful selection as a fellow of major professional society for any one Knucomp faculty and selection as senior member for two Knucomp faculty members by the end of 2013. Collaborations and other outcomes: Increase intra-campus collaboration involving faculty from more than one department to 30% total (from current less than 15%). Achieve min. 150% increase over current national and international collaborations which include World Wide Web Consortium, NLM, CCHMC, Stanford Univ., Univ. Georgia, IBM, Google, Microsoft and HP. Additional world class institutions we are likely to collaborate with include Cleveland Clinic, CMU, UC-Irvine, Purdue U., OSU, Univ. of Wisconsin-Madison, DERI-Ireland, Univ. of Melbourne, and CSIRO-Australia. Three positive outcomes involving local/regional companies engaging daytaOhio as appropriate are anticipated (including SBIR/STTR funds, technology licensing, products/services based on jointly developed technology). Economic Impact: as detailed in Appendix 3.
22

When reliable national measures in our area, such as those from National Research Council, are available (current data is well over a decade old), we will seek to be in top 10% of the range.

19

Appendix 1: Knucomp Faculty Profile (affiliations, technical strengths, awards)

20

Appendix 2: Major Research Synergies This important table identifies collaborative activity and faculty spanning research labs and departments with potential regional industry and public partners. In each case, existing funded research forms the basis of larger collaborations in the context of Knucomp. Here we identify some of the regional partners/industry that will be the Centers priority for economic impact in the region, but we have numerous current collaborations across the state and the country. Table 2: Major Synergies Table
Research Topics/ Labs/[Relevant Industry Cluster] Current Research and existing infrastructure; (Current or pending funding if applicable, investments) [collaborators] Enhanced collaboration to be enabled by Knucomp; (Example funding source);[Example regional beneficiary - Company or Govt. Org in addition to national or global significance]
Current computation for this work takes days. Data intensive analysis and computing Chens high performance computing on clouds can speed up computation 10x 100x faster (NSF). Collaboration with Wischgoll will enable visualization of this knowledge base and visual knowledge discovery capability. Wangs work on statistic learning techniques can improve knowledge extraction from scientific literature. Rapid and automatic taxonomy/ontology generation has numerous applications including improving specialized search strategies. UES has existing projects with AFRL-HE that can be expanded in using such a knowledge base. (NSF, ARL, AFRL) [UES, AFRL-HE] Extension of existing programs with AFRL on search and rescue to evaluate integration into emergency responder training Extension of existing work integrating Schillers expertise in Virtual Worlds, daytaOhios virtual environment support with WSU (Gilkey, Flach, Psychology), and Kno.e.sis knowledge model for human cognition will allow development of a next generation multi-cave training environment for pilots Extension of work on seismic analysis to include work in Ohio New collaboration with Warfighters Readiness Division of AFRL that will

KNOWLEDGE MANAGEMENT & VISUALIZATION New techniques in automatic ontology development and visualization High Performance Computing Labs - Data Intensive Analysis and Computing - daytaOhio AVL - Semantic Web -Formal Semantics and Rules [Human Sciences and Defense/Aerospace R&D] VIRTUAL REALITY Virtual and Augmented Reality Second Life and MUVEs Accelerated Education and Training Labs - Semantic Web - CECS Visualization - daytaOhio - AVL [Defense/Aerospace R&D, Human

Sheth and Krishnaprasad are developing a Human Performance Cognition Ontology. This involves taxonomy extraction from Wikipedia and complex entity/relationship extraction from biomedical corpus. This research supports advanced literature search and biomedical discovery in human performance effectiveness research at AFRL-HE. Taxonomy generation technology is already offered by HP as professional service (Current: AFRL-HE: $400K; HP Research: $50K) Flach and Bennett have long funded research on graphical design for process control, aviation, and military command and control (ARL, AFRL, AFOSR: $500K) daytaOhios collaboration with Wright State (Gilkey, Psychology) and AFRL/RH has developed a visualization platform linking multiple virtual environments to evaluate the impact of new technologies and communications methods to improve performance for combat search and rescue (Current- AFRL/RH and WSU $900K plus daytaOhio capital in facilities - $3.2M) daytaOhio working with WSU (Earth and Environmental Science), Hess, Schlumberger to develop enhanced visualizations of seismic data to accelerate the assessment and extraction of deposits with

21

Sciences &Health Care]

VIRTUAL PATIENT Virtualized patient care Smart house and patient sensors Medical data analysis Labs - Medical data analysis e-Sciences - daytaOhio AVL [Healthcare and Defense/Aerospace R&D]

application to Ohio subsurface geology. (Current - $100K) Schillers research on virtual worlds focuses on team and group behavior and social impacts in teams through virtual collaboration. Research is current being conducted on one full size island in Second Life. Current complementary but nonintegrated activities include: Goshtasbys extensive effort in medical imaging, Wischgolls detailed visualizations of organs such as hearts, Hitzler and Sheths extensive work on biomedical and health care ontologies; Cauley, Lawhorne and Center for Healthy Communities work on developing remote monitoring processes for geriatric patients. daytaOhio Simulation based training - $80K (NSF: $1m; NHLBIs R01: $1.5m)

relocate to WPAFB as part of BRAC. (AFRL, DARPA) [Ball Aerospace, SAIC, AFRL-HE]

ELECTRONIC MEDICAL RECORD + Advanced EMR and translational medicine Labs - Center for Healthy Medicine - e-Science Lab - Medical Data Analysis - Data Mining Lab - CECS VL - daytaOhio AVL [Healthcare, IT & Data Management]

SENSOR TRUST Semantic Sensor Web and Situational Awareness/Semantic Web Lab, Services Science Lab,

Sheth has developed Active Semantic EMR for cardiology that is deployed in Cardiology Practice. Cauley and Sheth have collaborated on disambiguating patient names from several sources of medical records required for health information exchange and data held in a central data repository. Cauley works with national data exchange through the Nationwide Health Information Network (Athens Health Center - direct investment in product); NIH/NLM through ONC, $200K). Flach has directed evaluation of the testing process in Family Medical practices comparing paper and electronic records (collaboration with UC Medical School: $30K). Sheth and Krishnaprasad are enhancing sensor data with automatics semantic annotation, integration and analysis/reasoning for explanation, trust and situational awareness. (AFRL-Sensor

Virtualized patient care model represent and simulate one or more health care processes and patients. Collaboration between all participants will lead to an advanced technology for Virtual Patients that will involve comprehensive integration of health care data, investigate techniques and training on patients on earth and space. Studies involving translational medicine as well as virtual monitoring of actual patients. Opportunities for collaboration with Emergency Medicine in association with Calamityville to look at emergency medical training and emergency operations centers (Flach) (DHHS, AFRL, AFOSR, NASA, NIH) [AFRL, Ohio Hospitals] Collaboration related to population based medicine, syndromic surveillance, response modeling, clinical decision support using Semantic Web and visualization, linking academic research lab data across the state, (DHHS, NIH) [Veterans Affairs Administration, McKesson (Relay Health)]

Collaboration with Wischgoll and use of daytaOhios visualization infrastructure can lead to comprehensive visual environment for supporting situational awareness on multi-level sensor data; Schiller

22

Metadata & Languages Lab, daytaOhios Appenzeller Visualization Lab/[Healthcare]

Directorate/SAIC: $426K; DAGSI: 120K current; pending: 67K)

ENERGY EFFICIENT IT Labs: - Data Intensive Analysis and Computing - Services Science Lab - daytaOhio [IT & Data Management]

BIOMARKERS Identification of Metabolomic Biomarkers of Toxicity Labs: - AFRL - NMR Spectroscopy Lab (WSU School of Medicine) - Bioinformatics Research Group/ [Pharmaceutical and Chemical Industries] LAYERED SENSING Visually Enhanced Decision Making in Layered Sensing/ - Metadata and Languages - Semantic Web lab - daytaOhios AVL [Defense & Aerospace R&D, IT & data management

Sheth is collaborating with IBM on developing middleware to allow computation on multiple clouds based on quality of service and cost. - daytaOhio is working with Ohio IT Alliance on Get IT Green Ohio initiative with key industry partners to evaluate techniques to improve data center efficiency and use alternative, i.e. green energy sources. daytaOhio is also working with Hawaii Renewable Energy Infrastructure Research Center (HREIRC) on a green data center plan (Ohio IT Alliance - $50K, HREIRC$350K) Reo and Raymer are working with the U.S. Air Force Research Lab (Dr. Nick DelRaso) to identify biomarkers of low level exposure to a variety of toxicants. Current work utilizes NMR spectroscopy with computational multivariate analysis to identify metabolomics biomarkers.

can provide virtual collaboration expertise. Collaborating with Teradata infrastructure on data analytics for syndromic and bio-surveillance and population medicine (AFRL, AFOSR, ONR, NSF, Third Frontier) [SAIC, Ball Aerospace, UES, REI Technologies, AFRLSensor] Collaboration involving Chen, Sheth, dayaOhio and Ohio based partners will develop a strategy to maximize utilization of private data centers and public clouds leading to better utilization and ROI for Ohio companies into their computing infrastructures. Datacenters are hugely energy intensive and this will directly benefit energy security and climate change issues. High Performance Computing required to support missions moving to WPAFB under BRAC Deployment of training for energy efficient data center operations using virtual environment (AFRL, Ohio IT Alliance, NSF) Collaborators at WSU and AFRL (Reo, Raymer, DelRaso, Sheth) will work together to develop a comprehensive analysis suite for management and analysis of highdimensionality data from LCMS, NRM spectroscopy, and gene expression microarrays. The suite will be used to identify pre-dose characteristics that are predictive of recovery or non-recovery from exposure to toxicant. (NIH, NSF) [UES] + Collaborations involving a number of faculty members (Krishnaprasad, Sheth, Wischgoll, Gilkey, Flach) and daytaOhio to develop high performance interactive interfaces using daytaOhio's world class visualization and a variety of sensors to support JDL level 2 comprehensions in support of foundational Intelligence, Surveillance, and Reconnaissance. An analyst will be able to graphically formulate complex decision support

AFRL funded SaVIG (Sensor Aided Vigilance) project o daytaOhio funded to evaluate approaches to sensor data integration. o Subcontract to Kno.e.sis to investigate effective automation of sensor data fusion requires ability to translate heterogeneous sensor data into a common format, to register data accurately within a common spatiotemporal reference frame, and to identify and associate cross-

23

for Energy]

modal phenomenal attributes. (AFRL- AMSA program- awarded with SAIC as lead: WSU share - few hundred thousands)

DATA MINING Large-scale data exploration, mining including privacy preserving mining, and understanding of patterns and models: algorithms and infrastructures Labs: - Data mining Lab; Data Intensive Analysis and Computing Lab -Visualization Lab [all areas] 10 MEDICAL KNOWLEDGE EXTRACTION Knowledge extraction from volumetric data [Human Sciences and Healthcare]

and analytical queries against massive amount of multi-layer sensing data managed over highly scalable cloud computing environment and visually explore results. + Integration of layered sensing within virtual environments for search and rescue and emergency response (SAIC, AFRL/ RH and RY) [Calamityille] Dong has developed algorithms and Combining Dong and Chens work techniques on OLAP, data with Wischgolls expertise in warehousing, clustering, visualization will support classification and pattern mining medical/healthcare data exploration Chen has developed a system on and understanding; potential interactive data cluster visualization, collaborations with WPFAB on and researched multiplicative data intrusion detection, system log mining, perturbation for privacy preserving anomaly detection from data streams. mining Chen can collaborate with Cauley on Dong and Chen have developed privacy preserving mining of algorithms on data stream processing healthcare data. and mining. Funding: pending (NSF, DFFS, AFRL) [SAIC, Ball Aerospace]

Wischgoll developed methodologies for extracting quantitative knowledge from volumetric data sets to analyze vascular health. Collaboration with IUPUI, Cleveland Clinic, Mayo Clinic, funded by NIH ($385K, NIH)

Collaborations involving Wischgoll, Sheth, and Hitzler can improve health care ontologies to study or identify drug effects on organs. In cooperation with Goshtasby, models of organs can be derived to improve the virtual patient model. (NIH, AFRL)

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Appendix 3: Economic Development Metrics and Data This appendix summarizes the anticipated cumulative economic impact of Knucomp over the next 5 to 10 years in terms of changes in investment, business infrastructure, employment, talent development, etc. The current figures represent the results for Kno.e.sis and daytaOhio since their startups in 2004 and 2007, respectively; some of the figures are cumulative as noted while others are active current. The table is divided into two sections consistent with the metrics used by the Ohio Department of Development. The first section or A metrics are based on outcomes ($s, startups, jobs), while the second or B metrics reflect tangible evidence engagements with partners or collaborators.23 Table 3: Economic Development Metric Current24 $8.7million $39M cost share; $4.6Mcontracts $11.1MdaytaOhio; $6M faculty25 $16M daytaOhio 1 2 3 daytaOhio Holdings 12 + 33 (Faculty)

5 years $13million (grants and contracts)

10 years $19.5million (grants and contracts)

A Metrics $ value of research (faculty serving as PI and/or co-PIs) by source federal versus private $ value of daytaOhio cost share and contracts $ value of capital invested

+ 2M

+ 4M

$ value of additional investments based on Knucomp activities [leverage]26 # SBIR/STTR projects $ value of SBIR/STTR projects # Technology transfers, patents (from Faculty activities) # Startups # of Faculty + actively funded researchers (incl. GRAs & Post docs
23

+4M

+8M

4 +$1M +2 +2 +5 faculty) +

8 +$2.5M +4 +2 24 + 75

It is hard to accurately estimate number of public sector jobs and hence those figures are not included, despite significant impact resulting from our collaborations with WPAFB. 24 This column presents a snapshot of distinct resources associated with faculty activities (majority associated with the Eminent Scholar and Kno.e.sis Center activities) and daytaOhio activities. For future years, we present a blended set of metrics. 25 $11.1 million is the capital grant for the Wright Center of Data from ODOD (TECH04-043); Faculty capital includes rough estimate of capital invested in support of Eminent Scholar and other faculty research [does not include over $10+million investment in Joshi Research Center and facilities of which approx. 75% of the space is allocated to Kno.e.sis Center, participating Knucomp faculty and daytaOhio] 26 Additional investment in research or infrastructure in the state (outside of Knucomp, eg industry partners and government) as a result of Knucomp activities. Example is relocation of high performance computing for AFRLs Warfighter Readiness Research Division from their Univ. of Arizona high performance computing to Dayton under Knucomp umbrella on WSU campus.

25

FTE associated with Knucomp activity (cumulative) # jobs in industry (FTE equivalent) in Ohio % students doing internship at top 10% institutions in their area27 B Metrics # Active industry collaborations (supported by MOU, LOA, collaborative funding, etc) # Active university collaborations # Active public collaborations

27 (daytaOhio only) 191 - daytaOhio 60%

+ +30 75%

+ +50 90%

10- daytaOhio; 6 - Faculty

+5

+7

5 daytaOhio; 8- +5 faculty 2 daytaOhio; 4 - +4 Faculty

+5 +4

27

Sample top internship places for our current PhD students: Microsoft Research, IBM Research (Almaden, Watson, and Bangalore), Yahoo! labs (San Jose, CA and Barcelona), HP labs, National Library of Medicine, Accenture Labs, Amazon.

26

Appendix 4: Support Letters Academic/Research: Prof. Ramesh Jain, Donald Bren Professor in Information & Computer Sciences, Bren School of Information and Computer Sciences, University of California, Irvine, CA Prof. Gerhard Weikum, Research Director, Max-Planck Institute for Informatics (MPII), Saarbruecken, Germany Prof. Ahmed Elmagarmid, Director, Cyber Center at Discovery Park, Purdue University, IN

Public: Colonel (Ret.) Jack Blackhurst, Director, Human Effectiveness Directorate, 711th Human Performance Wing, Wright-Patterson Air Force Base, OH Joseph Zeis, Jr., Vice President, Aerospace, Defense and Technology, Dayton Development Corporation Industry: Dr. Nina Joshi, President/CEO, UES, Inc., Xenia, OH Michael Zywein, Vice President & Director of Programs, SAIC, Beavercreek, OH Al Herman, Vice President & General Manager, Avionics and Simulation Division, Barco, Inc., Xenia, OH

27

Credits Front cover art is the cover art of Springer Book Series on Semantic Web & Beyond: Computing for Human Experience (series editors: Profs. Ramesh Jain and Amit Sheth). Back cover is a photograph of the Joshi Research Center which houses daytaOhio on the second floor, Kno.e.sis Center with its seven faculty and Ohio Eminent Scholars activities on the third floor, and two more Knucomp faculty members on the fourth floor.

Cyber Center
April 8, 2009

Chancellor Dr. Eric Fingerhut University System of Ohio - Ohio Board of Regents 30 East Broad Street, 36th Floor Columbus, Ohio 43215

Dear Dr. Fingurhut: I enthusiastically support the proposal for Center of Excellence (COE) on KnowledgeEnabled and Human-Centered Computing (Knucomp) to the University Systems of Ohio. Factors that make a research center successful and deliver many fold on investments include among others, vision and relevance, qualifications and leadership, as well as infrastructure and institutional commitment. There are several reasons I feel I can reasonably comment on the quality and importance of this COE proposal. Having founded and directed Purdues Cyber Center and Indiana Center for Database Management, I have experience in the process of establishing and managing such centers. I have also known Prof. Amit Sheth for over 25 years, and we are joint Editor in Chief of Distributed & Parallel Databases Journal and a Springer Book Series on Advanced Database Systems. I have visited the Kno.e.sis Center (as Prof. Sheth has visited my center). Let me briefly comment on the above factors. Vision and Relevance Move from agriculture, manufacturing and services economy to knowledge economy is well on its way. A number of studies have also documented the largest growth in traditional industries is coming from the use of high-tech and value added knowledge services. This is coupled with the economic development trend that unlike in the 20th

` century where capital intensive industries attracted workforce, capital increasingly moves to locations with a highly educated workforce. In this context, the proposed center leverages the synergies between the researchers at WSU (Kno.e.sis Center and a number of its collaborators) along with technology infrastructures of daytaOhio, with the key industry clusters in the Southwestern region of Ohio, namely defense/aerospace R&D (with prominent presence of WPAFB), IT/data management, and health sciences & healthcare. This synergy can lead to educating and retaining the highly educated workforce of specific relevance to regional economic needs, as well as development and transfer of technologies based on the research conducted in the proposed center. In the Cyber Center at Purdue which I direct, we have extensive collaborations between Computer Scientists and Human Science researchers. This is because biology and many other fields are increasingly regarded as data driven sciences replacing lab sciences. The proposed center has excellent synergies of this type, which will likely bring significant funding (as has already been demonstrated by Prof. Sheth led NHLBI R01 with Stanford and UGA as partners) yield important results. Qualification and Leadership The ascendency of WSU in the field of information and knowledge management in a short two year period is a rare phenomenon in academia. This started with the establishment of the Kno.e.sis Center by Prof. Sheth who moved with 10 of his PhD students from University of Georgia in 2007, and quickly expanded with a number of active faculty members and their respective labs. The quality and prominence of Kno.e.sis and Prof. Sheths research can be observed by this one example for which I have a personal knowledge. In large ($20m budget) preproposals submitted during 2008 by Ohio State University and Purdue University to NSFs Datanets initiatives, both teams sought out the participation of Prof. Sheths team for their proposals in the areas of ontology/knowledge management, information integration, visualization and Semantic Web, despite the fact that both universities have much larger Computer Science departments than WSU. Recent hiring of Prof. Pascal Hitzler from AIFB Universitt Karlsruhe (the most prestigious research group in Europe in the area of Semantic Web), whose qualifications rivals most Associate Professors as an Assistant Professor demonstrates the international reach and prominence of the Kno.e.sis Center. Prof. Sheth brings world class leadership based on his rare experience of working in three large company research labs, starting two successful companies and highly successful academic research (on a list of most cited Computer Science authors based on h-index measure of citations, he is listed 20th at the time of this writing). Furthermore, the funding profile of Kno.e.sis and its collaborators is enviable and comparable to the very best research groups in the country. During my visit to WSU, I found Kno.e.sis infrastructure appropriate for carrying out world class research in its area of research, and I was very impressed with the visualization infrastructure of daytaOhio. Perhaps the most impressive thing I noticed was the quality of PhD students I met. No wonder they

` routinely do summer internships at the very best companies (e.g., Microsoft Research, IBM Research, HP labs) where only the brightest students from the world over get a chance to work. Based on my own experience of founding and directing Purdues Cyber Center, I can say with confidence that institutional commitment is a major factor in success. For example, our own Cyber Center would not have been possible without the $2.5M seed funds that were received. This is what we used to get started initially and to help us with administrative costs. The $2.5M was exempted from overhead so it really went a long ways to help us be sustainable in the initial growth phase. So, while I am not familiar with what type of institutional and state commitments are made for the Center of Excellence, I will underscore their importance. I have no doubt the Kno.e.sis Center and daytaOhio are unique resources for WSU. Kno.e.sis is an internationally known research center which has the largest groups in Semantic Web in the US, and the strongest group in information and knowledge management among universities in Ohio and perhaps the Midwest. My understanding is that this COE will allow the participating researchers to further formalize their collaboration and even more strongly interact with industry in the region and the Wright Patterson Air Force Base. I support it strongly and would be delighted to share my expertise in building and managing large centers with many researchers.

Sincerely,

Ahmed K. Elmagarmid Director, Cyber Center, Discovery Park Director, Indiana Center for Database Research Professor, Computer Science, Purdue University