ERYTHROPOIESIS

Erythropoiesis constitute 10-30% of hemopoietic cells in the bone m rro!" The m ture erythrocyte is #eri$e# from the stem cell% !hich #ifferenti te to erythroi# colony formin& cells '()*-E% +)*-E,% n# ne-t to the proerythrobl st% the first morpholo&ic lly reco&ni. ble cell of the series" The proerythrobl st m tures to the b sophilic normobl st% then the polichrom tic normobl st% !here synthesis of hemo&lobin is st rte#" /t the en#% the polychrom tophilic normobl st m tures to the orthochrom tic normobl st" The orthochrom tic normobl st loses its nucleus n# #e$elopes into reticulocyte% !hich fter 0-1 # ys #e$elops into m ture erythrocyte" The m ture erythrocyte st ys for c " 1 months in the bloo#"

2R/3*4OPOIESIS
2r nulopoiesis constitutes 10-50% of the h emopoietic cells in the norm l bone m rro!" The myelobl st is the first reco&ni. ble cell of the &r nulopoiesis" The myelobl st enl r&es n# #ifferienti tes to the promyelocyte" /t this st &e specific &r nules be&in to ppe r 'eosinophilic &r nules in the eosinophilic leucocytes% b sophilic &r nules in the b sophilic &r nulocytes n# neutrophilic &r nules in the neutrophilic leucocytes," The promyelocytes m ture n# become the myelocytes n# then met myelocytes" In the en# of the m tur tion process met myelocytes become b n# neutrophil n# then se&mente# neutrophil" These cells mo$e from the m rro! to the bloo#" The m 6ority of &r nulopoiesis in the norm l m rro! consists of neutrophilic leucocytes"The percent &e of eosinophilic leucocytes n# b sophilic leucocytes shoul# not e-cee# 7% n# 1% respecti$ely"

8O3O+YTI+ SERIE
8onocytes n# their precursors constitute sm ll percent &e of the hemopoietic cells 'less th n 0%," *su lly they ppe r s m ture cells 'monocytes,% r rely precursors of the monocytes 'monobl sts% promonocytes, re obser$e#"

4Y8PHOPOIESIS
4ymphopoiesis constitute 7-00% of the bone m rro! cells" The lymphocytes - s ll hemopoietic cells re #eri$e# for the stem cell% !hich #ifferenti tes into cells common for the t!o lymphocytic series '( n# Tcells," The cell #i$i#es into precursors pro-( n# pre-T cells% !hich #e$elop into the st &e of the m ture (- n# T-lymphocyte" /fter nti&en e-position the m ture lymphocytes #iffer nti te into intensi$e prolifer ti$e lymphocytes" They re c p ble of synthesis immuno&lobulins n# immunolo&ic l memory cells"

THRO8(OPOIESIS
The me& 9 ryobl st is the first morpholo&ic lly #istin&uish ble cell of the series" The ne-t st &e of m tur tion is the prome& 9 ryocyte% !hich #ifferenti te to the me& 9 ryocyte" The me& 9 ryocyte #et ches l r&e number of pl telets" :ue to their si.e n# the ten#ency to rem in insi#e the bone m rro! fr &ments it is $ery #ifficult to #etermine their percent &e in the bone m rro!" Therefore to ssess the series #escripti$e form is use# !h t is $ery sub6ecti$e n# #epen#s on p tholo&ist;s e-perience"