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Modified grf 1-29 was originally sold under the name tetrasubstitued grf (1-29). Some research facilities may still be using this name for the sake of consistency with re!ious research which can cause some confusion for buyers. "oth of these identifiers are used to refer to a 29 amino acid e tide. #his is a modified !ersion of this functional fragment that is ty ically abbre!iated to growth releasing factor or grf 1-29. $t is also marketed under the name sermorelin. Mod grf is designed to re lace the 2nd% &th% 1'h and 2(th amino acids in this e tide se)uence. #hese amino acids in the grf 1-29 se)uence will yield a modified grf (1-29) se)uence% with an a e tide is a rece tors.
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structure with those that would be more resistant to the ine!itable en3ymatic clea!age. 5dditional substitution has allowed grf 1-29 to be altered to crease a !ariety of half-life conditions that can be customi3ed to address the needs of the s ecific animal in which the synthesi3ed amino acid is being a lied. 4rf 1-29 was first mentioned in the use of tetrasubtitued research during a 2,,' study which was designed to better understand the structures of this e tide. #he s ecific notations referred to the structure of grf 1-29 when the 2nd% &th% 1'th and 2(th amino acids had been re laced with alternati!e structures. $n 2,,&% 6at"true created the official term modified grf 1-29 to refer to tetrasubstitued grf in articles that would be ublished for the ublic. Since this time% this has become the standard reference on both ublic and ri!ate nomenclature. Modified grf (1-29) is designed to act as a synthetic modification of factors with substitutions of gln% d-ala% ala and leu. #hese allow the e tide an increased stability% which encourages additional chemical synthesis. #his e tide is soluble in water or in 1 ercent acetic acid for intra!enous a animal test sub1ects. #he increased stability of the synthetic e tide allows for storage at 2-& degrees Celsius but those that lan to use this e tide for long term research a lications should desiccate the e tide and store it at -2, degrees Celsius.
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