BIOCHEMISTRY(AIPG) 5. 2013 no questions Gout is disorder of A. Purine metabolism B. C.

Pyrimidine metabolism Ketone metabolism

D. Protein metabolism Ref: Harrison 17/e p. 2444

2010 2012 1. What is the most sensitive indicator of cellular energy? A. ATP B. C. ADP Phosphocreatine 32. Most LIPOGENIC carbohydrate A. Fructose B. C. Glucose Ribose

D. AMP

D. Sucrose Ref: Harper 22/e p 193 2011 33. Denaturation of DNA A. Fragmentation of DNA molecules B. C. Reversible separation of DNA Irreversible separation of DNA

1.

Which of the following is not present in basal lamina A. Rhodopsin B. C. Entactin Laminin

D. Coagulation of DNA Ref: Aynes 2/e p. 427 34. Cereals are deficient in A. Vitamin C B. Vitamin B Complex Iron C.

D. Integrin Ref: James 3/e p. 294 2. Shingomyelinse deficiency is seen in A. Niemann pick disease B. C. Garber disease Tay sachs disease

D. Calcium Ref: Lippincott 2/e 15 35. ATP are store house of?

D. Krabbes disease Ref: Satyanarayan 3/E, 307 3. Decreased BMR is seen in A. Obesity B. C. Hyperthyroidism Feeding Harper 22/e 337 36. During Ref: Ganong 22/e p. 462 4. Somatomedin mediate A. Chondritin sulfate deposition B. C. Lipolysis Gluconeogenesis 37. FSH, LH, TSH acts through Ref: Ganong 22/e p. 382 A. Cyclic AMP phagocytes respiratory burst involves A. Energy B. C. Phosphate Protein

D. Glucose

D. Exercise activation of A. Oxidases B. C. Hydrolase Peroxidase

D. All

D. Decreased rate of glucose uptake by cells

B. C.

Cyclic GMP Both

D. Transcription activators Ref: Harper 26/e, p. 458 44. Insulin causes lipogenesis by all EXCEPT? A. Increasing acetyl CoA carboxylase activity B. C. Increase the transport of glucose into the cell Inhibit pyruvate dehydrogenase

D. None Harper 22/e 427 38. The Highest percentages of polyunsaturated fatty acids are present in? A. Ground nut oil B. C. Palm oil Margarine

D. Decrease intracellular cAMP level

D. Soyabean oil Park 19/e 481 39. ___ is not a transcription factors A. Insulin B. C. Estrogen Vitamin D

45. True about G protein coupled receptors is A. G protein bind to hormones on the cell surface B. C. All the three subunits alpha, beta & Gamma should bind to each other for G protein to act G proteins acts as inhibitory and excitatory because of difference in alpha sub unit D. G protein bound to GTP in resting stage Ref: Harper 26/e, p. 458 46. Thiamine deficiency causes decreased energy

D. Glucocoticoid 40. Ist clinical sign of vitamin A deficiency is A. Night blindness B. C. Bitots spots Xerostomia

production because A. It is required for the process of transamination B. C. It is co factor in exudative reduction It is co - enzyme for transketolase in pentose phosphate pathway

D. Conjunctival dryness Davidson 19/e 318 41. The reducing equivalent for fatty acid synthesis is derived from A. Glycolysis B. C. Krebs cycle Urea cycle

D. It is co enzyme for pyruvate dehydrogenase Ref: Harper 26/e, p. 488 47. All are true about glutathione EXCEPT A. It is a tripeptide B. C. It converts Hb to met Hb It conjugates xenobiotics

D. Pentose phosphate pathway

D. It scavenges free radicals and superoxide ions Harper 22/e 202 42. Compared A. Lactose B. C. Fat Protein to cows milk, mothers milk has Ref: Harper 26/e, p. 629 48. In molecular cloning Blue White screening is used for A. To screen for recombinant vectors B. C. To detect gene mutation To identify desired chromosomal DNA insert in plasmid vectors D. To detect host DNA in Situ Park 19/e 500 2009 43. Steroid hormone receptors have attachment site for all EXCEPT A. Steroid hormone B. C. Transcription repressors Hormone responsive element 2008 49. Amino acid which is used in transportation of ammonia and helps in urea synthesis is A. Arginine B. C. Glutamate Aspirtate

abundance of

D. All

D. Glycin Ref: Lippincotts 2/e, p. 286, 240-241 50. Which of the following enzyme is stable at acidic pH? A. Pepsin B. C. Trypsin Chemotrypsim

Ref: Guyton 8/e p. 870-81 56. A small Ca2+ binding protein that modifies the activity of many enzymes and other proteins in response of changes of Ca2+ concentration is known as A. Cycline B. C. Calmodulin Collagen

D. Carboxypeptidase Ref: Harper27 / e p. 485 51. Type of collage found in hyaline cartilage is A. Type I B. C. Type II Type III

D. Kinesin Ref: Harper 27/E p. 482 57. Which of the following has low glycemic index? A. Whole wheat bread B. C. Brown rice Ice cream

D. Type IV Ref: Harper 27/E p. 561, 546 52. Protein purification and separation can be done by all EXCEPT A. Centrifugation B. C. Electrophoresis Densitometry

D. Potato Ref: Harper 27/E p. 482 58. Keton bodies are utilized by all EXCEPT A. RBC B. C. Brain Heart

D. Muscles Ref: Harper 27/E p. 191-192

D. Chromatography Ref: Harper 27/E p. 21-24 59. Which of the following is a good sources of saturated fatty acids 53. All of the following processes are involved in the detection of mRNA expression EXCEPT A. Northern blot B. C. RT PCR Microarray Ref: lippincotts 2/e, p 314 60. All are good sources of n e poly unsaturated fatty acids EXCEPT 54. All of the following are the components of basement membrane EXCEPT A. Rhodopsin B. C. Laminin Entactin A. Groundnut oil B. C. Mustard oil Corn oil Ref: Harper 27/E p. 123 61. Which of the following maskes hydrophobic to Ref: Harper 27/E p. 550-571 55. Which of the following is the most active form of calcium in the circulation? A. Ionized calcium B. C. Complexed with phosphate Complexed with oxalates Ref: Harper 27/E p. 633-637 hydrophilic? A. Methylation B. C. Acetylation Glucuronidation A. Palm oil B. C. Sunflower oil Ground nut oil

D. Olive oil

D. RNA sequencing Ref: Harper 27/E p. 409-410

D. Fish oil

D. Dystroglycan

D. Hydroxylation

D. Bound to albumin

62. The conversion of ethanol to aldehyde is mediated by A. Alcohol dehydrogenase B. C. Aldehyde dehydrogenase Xenthine oxidase 68. The most abundant protein present in body is A. Globulin B. Ref: Harper 27/E p. 225, 95,96 C. Albumin Collagen 2007

D. Catalase

D. Hemoglobin 63. Which of the following participates in transamination reaction? A. Thiamine pyrophosphate B. C. Pyridoxal phosphate Cyanocobalamine 69. All of the following types of collagen EXCEPT one are present in cartilage A. 2 B. C. Ref: Harper 27/E p. 247 64. Regarding pentose phosphate pathway all of the following are true EXCEPT A. Occurs in the cytosol B. C. No ATP is produced in the cycle It is active in adipose tissue, liver, and gonads nonoxidative phase generates pyruvate Ref: Harper 27/E p. 177, 180 70. All of the following are sarcolemmal proteins EXCEPT A. Syntrophin B. C. Dystrophin Dystrobrevin 4 6 Ref: Harper 27/E p 88

D. Niacin

D. 9 Ref: Harper 27/E p 561

D. The oxidative phase generates NADPH and the

D. Dysmorphin Ref: Harper 27/E p 575 71. High content of cholesterol is present in

65. All of the following are precursor of adrenaline EXCEPT A. Noradrenalin B. C. Phenylalanine Isoprenaline

A. Coconut oil B. C. Egg yolk Hydrogenated fat

D. Ghee (unsaturated) Ref: Harper 27/E p. 230 72. Fatty acids help in synthesis of all EXCEPT A. Glucose B. C. Cholesterol Ketone bodies

D. Dopamine Ref: Harper 27/E p. 276, 455 66. Intrinsic factor A. Is a polysaccharide B. C. Is a glycoprotein Helps in foliate absorption

D. Fat Ref: Harper 27/E p. 134 73. Increase in pyruvate and lactate is seen in which of the following deficiency? A. Thiamine B. C. Pyridoxine Niacin

D. Helps in blood coagulation Ref: Harper 27/E p 499-500 67. Which of the following is true about vitamin K ? A. Vitamin K1 is synthesized in intestine by microbial flora B. C. Vitamin K2 exists in plants Vitamin K is fat soluble and require bile for its absorption D. Vitamin K absorbs because it is water soluble Ref: Harper 27/E p 495

D. Vitamin C Ref: Harper 27/E p. 496-497

74. Exrahepatic cholestasis is associated with

A. Increased bilirubin in urine B. C. Increased urobilirubin in urine Increased bilirubin and increased urobilirubbin in serum D. Increased bilirubin in serum Ref: Harper 27/E p 290-292

A. Isocitrate dehydrogenase B. C. Homocysteine methyl transferase Glycogen synthase

D. G-6-P dehydrogenase Ref: Chetterjea Shindre, 6/E, P. 181 81. The ligand receptor complex dissociates in the

75. Dark color urine and clay stool is seen in A. Obstructive jaundice B. C. Hemolytic jaundice Hepatocellular jaundice

endosome because; A. Of its large size B. C. The vesicle looses its clathrin coat Of the acidic pH of the vesicle

D. Severe dehydration Ref: Harper 27/E p 292

D. Of the basic pH of the vesicle Ref: Chetterjea Shindre, 6/E, P. 19 82. The human plasma lipoprotein containing the highest

76. Which of the following is correct method for estimation of true serum creatinine? A. Jaffe reaction B. C. Kinetic jaffe reaction Enzyme immunoassay

percentage of triacylglycerol by weight is A. VLDL B. C. Chylomicrons Hdl

D. Ldl Ref: Lippioncott, 3/E, P. 225, 230 83. The sigma (s) subunit of prokaryotic RNA polymerase

D. Plasma gel filtration

77. For glucose estimation in blood the mode of transport from a primary health care center to laboratory is done by addition of A. Potassium oxalate + NaF B. C. Potassium oxalate + citrate EDTA

A. Binds the antibiotic rifampicin B. C. Is inhibited by a=amanitin Specifically recognizes the promoter site

D. Is part of the core enzyme 84. An affected male infant born to normal parent could be an example of all of the following except; A. mRNA B. C. tRNA rRNA

D. Sodium citrate Ref: Harper 27/E p 152 78. In all of the following RNA participates directly EXCEPT A. Post translational modification B. C. Post transcriptional modification DNA replication

D. snRNA Ref: Harper, 26/E, P. 356 85. proteins are linear polymers of amino acids, they fold into compact structures. Sometimes these folded structure associate to form homo-or hetero-dimers. Which one of the following refers to this associated from? A. Denatured state B. C. Molecular aggregation Precipitation

D. Splicing Ref: Harper 27/E p 38 79. All of the following procedure can be used to detect the chromosomal mutation EXCEPT A. Single stranded length polymorphism B. C. Agarose gel electrophoresis Protein gradient electrophoresis

D. Quaternary structures Ref: Harper, 26/E, P. 34 86. The structural proteins are involed in maintaining the shape of cell or in the formation of matrices in the body. The shape of these point is A. Globular

D. Pulse field gel electrophoresis Ref: Harper 27/E p 24 2006 80. Vitamin B12 acts a coenzymes to which one of the following enzymes?Isocitrate dehydrogenase

B. C.

Fibrous Stretch of beads Ref: Harper, 26/E, P. 38

D. Planar

94. Differential expression of same gene depending on 87. Iron is present in all of the following except; A. Myoglobin B. C. Cytochrome Catalase Ref: Harpers, 25/E, P. 360 88. During phagocytosis, the metabolic process called respiratory burst involves the activation of; A. Oxidase B. C. Hydrolase Peroxidase parent of origin is referred to as: A. Genomic imprinting B. C. Mosaicism Anticipation

D. Pyruvate kinase

D. Non penetrance Ref: Robbins, 7/E, P. 186 95. Fluoride used in collection of blood samples for glucose elimation, inhibits the enzyme A. Glucokinase B. C. Hexokinase Enolose

D. Dehydrogenase Ref: Robbins, 7/E, P. 60 2005

D. Glucose 6 phosphtase Ref: Harper, 26/E, P. 137

2004 89. The cell component that is genetically continuous from one cell generation to the next is A. Nuclear membrane B. C. Golgi complex Central Bodies 96. Shine Dalgarno sequence in bacterial mRNA is near: A. ANUG codon B. C. UAA codon AUG codon

D. Chromatin 90. Golgi bodies are responsible for: A. Synthesis of plypeptides B. C. Formation of glycoproteins only Modification and sorting of glycoproteins

D. UGA codon Ref: Lippincotts Biochemistry, 2/E, P. 395 97. A segment of Eukaryotic gene that is not represented in the mature mRNA is known as: A. Intron B. C. Exon Plasmid

D. Lipid and steroid synthesis Ref: Garlands Publishing Company, 1/E, P. 355 361 91. Enzymes that move a molecular group from one molecule to another are known as: A. Ligases B. C. Oxidoreductases Transerases

D. TATA Box Ref: Harper, 26/E, P. 253 98. An enzyme that makes a double stranded DNA copy form a single stranded RNA template molecule is known as: A. DNA polymerase B. C. 92. The amino acid residue having an imino side chain is: A. Lysine B. C. Histidine Tyrosine 99. The transmemebrane region of protein is likely to have: A. A stretch of hydrophilic amino acids 93. Vitamin A A. Is water soluble B. C. Deficiency causes impaired vision Maintains normal plasma of clotting factors B. C. A stretch of hydrophobic amino acids A disulphide loop acids Ref: Harper, 26/E, P. 450 100. Which of the following group of proteins assist in the folding of other proteins: Ref: Harper, 25/E, P. 407 RNA polymerase Reverse transcriptase

D. Dipeptidases Ref: Mathews, 3/E, P. 392

D. Phosphokinase

D. Proline Ref: Harpers, 25/E, P. 29

D. Alternating hydrophilic and hydrophobic amino

D. Is required for formation of clotting factors Ref: Biochemistry by Devlin , 5/E, P. 1140, 1141

A. Proteases B. C. Proteosomes Templates 2003 107. Enzymes concerned with the citric acid cycle are found in the: A. Nucleus B. C. Ribosomes Mitochondria

D. Chaperones Ref: Harper, 26/E, P. 507 101. Which of the following is membrane bound enzyme that catalyses the formation of cyclic AMP from ATP: A. Tyrosine kinase B. C. Polymerase ATP synthase

D. Adenylate cyclase Ref: Ganong, 19/E, P. 41

D. Non particulate cytoplasm Ref: Harper 25/e p. 230

102. To which of the following family of chemical mediators of inflammation, the lipoxins belong: A. Kinin system B. C. Cytokines Chemokines 108. Which cell organelle contains DNA A. Mitochondrion B. C. Golgi body Endoplasmic reticulum

D. Arachidonic acid metabolites 103. The most abundant glycoproteins present in the basement membrane is A. Laminim B. C. Fibronectin Collagen type 4

D. Centriole Ref: Harper 26/e p.322, 323 109. The code world of which proteins is also an initiation code for proteins: A. Leucine B. C. Isoleucine Methionine

D. Heparin sulphate Ref: Tencates 5/e p. 366, 368 104. A person on fat free carbohydrate rich diet continues to grow obese, which of the following lipoproteins is likely to be elevated in his blood? A. Chylomicrons B. C. VLDL LDL Ref: Harper, 26/E, P. 211 105. Which of the following elements is known to influence the bodys ability to handle oxidative stress: A. Calcium B. C. Iron Potassium

D. Lysine Ref: Lehninger 2/e p. 898 110. The main enzyme responsible for activation of Xenobiotics is: A. Cytochrome P 450 B. C. Glutathione S- transferase NADPH cytochrome P 450

D. HDL

D. Glucuronyl transferase Ref: Harper 25/e 780 2002 111. In oxidative phosphorylation, the ATP production and respiratory chain are linked by: A. Chemical methods B. C. Physical methods Chemiosmotic methods

D. Selenium Harrison 15/e 469 106. The most common condition of inherited blindness due to mitochondrial chromosomal anomaly is: A. Retinopathy of prematurity B. C. Lebers hereditary optic neuropathy Retinitis pigmentosa

D. Confirmational changes Ref: Lippincott 2/e p 70 112. Substrate level phosphorylation is seen in the conversion of: A. Acetoaccatate to alpha ketoglutarate B. Succinyl CoA to succinate

D. Retinal detachment Harrison 15/e 1711, 405

C.

Fumarate to malate

D. Succinate to funarate Ref: Harper 25/e 192, 185 2001 113. The nitrogen of the body is supplied by: A. Triacyl glycerol B. C. Proteins Glucose

D. Lipids

114. Collagen is rich in: A. Glutamate and glycine B. C. Alanine and glycine Proline and glycine

D. Glutamate and proline

Ref: Harper 25/e 696, 697