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Port-said University Faculty: Science Department: Chemistry Class Year: Diploma of Biochemistry
I.D.
Date: 27 /2/2013 Time: 2 hrs. Full mark: 120 marks
(I) Choose the correct answer: (90 Marks) 1. Lactate formed in muscles can be utilized through
(A) Rapoport-Luebeling cycle (B) Glucose-alanine cycle (C) Coris cycle (D) Citric acid cycle
4. The intermediate in hexose monophosphate shunt is 5. Glycogen synthetase activity is depressed by 6. Dihydroxyacetone phosphate and glyceraldehyde-3-phosphate are interconverted by
(A) Triose isomerase (B) Phosphotriose isomerase (C) Diphosphotriose isomerase (D) Dihydroxyacetone phosphorylase
15. Transfer of the carbamoyl moiety of carbamoyl phosphate to ornithine is catalyzed by a liver mitochondrial enzyme:
(A) Carbamoyl phosphate synthetase (B) Ornithine transcarbamoylase (C) N-acetyl glutamate synthetase (D) N-acetyl glutamate hydrolase
7. Under anaerobic conditions the glycolysis one mole of glucose yields __ moles of ATP.
(A) One (B) Two (C) Eight (D) Thirty
18. All of the following are required for synthesis of glutamine except
(A) Glutamate (C) Pyridoxal phosphate (B) Ammonia (D) ATP
9. The following is an enzyme required for glycolysis: 10. The number of molecules of ATP produced by the total oxidation of acetyl CoA in TCA cycle is
(A) 6 (B) 8 (C) 10 (D) 12
11. Fatty acids cannot be converted into carbohydrates in the body as the following reaction is not possible.
(A) Conversion of glucose-6-phosphate into glucose (B) Fructose 1, 6-bisphosphate to fructose-6- phosphate (C) Transformation of acetyl CoA to pyruvate (D) Formation of acetyl CoA from fatty acids
21. A compound serving a link between citric acid cycle and urea cycle is
(A) Malate (C) Succinate (B) Citrate (D) Fumarate
(C) Occurs more rapidly than the absorption of any other sugar (D) Is impaired in cases of diabetes mellitus
24. -Oxidation of fatty acids requires all the following coenzymes except
(A) CoA (B) FAD (C) NAD (D) NADP
37. How many ATP molecules will be required for conversion of 2-molecules of Lactic acid to Glucose?
(A) 2 (B) 4 (C) 8 (D) 6
27. All the following statements about carnitine are true except
(A) It can be synthesized in the human body (B) It can be synthesized from methionine and lysine (C) It is required for transport of short chain fatty acids into mitochondria (D) Its deficiency can occur due to haemodialysis
38. Out of 24 molecules of ATP formed in TCA cycle, 2 molecules of ATP can be formed at substrate level by which of the following reaction?
(A) Citric acid Isocitric acid (B) Isocitrate Oxaloacetate (C) Succinic acid Fumarate (D) Succinylcat Succinic acid
39. Which one of the following compounds cannot give rise to the net synthesis of Glucose?
(A) Lactate (C) -ketoglutarate (B) Glycerol (D) Acetyl CoA (B) reuse of glucose (D) Both (A) & (B)
41. How many ATPs are produced in the conversion of phosphoenol pyruvate to citrate?
(A) 1 (B) 2 (C) 4 (D) 6
43. Deamination is ______ of amino group. 44. The transaminase activity needs the coenzyme: 45. Transamination is a
(A) Irreversible process (C) Both (A) and (B) (B) Reversible process (D) None of these
33. The fatty acids containing even number and odd number of carbon atoms as well as the unsaturated fatty acids are oxidized by
(A) -oxidation (C) -oxidation (B) -oxidation (D) All of these
46. Oxidative conversion of many amino acids to their corresponding ketoacids occurs in mammalian:
(A) Liver and kidney (C) Pancreas (B) Adipose tissue (D) Intestine
47. Ammonia intoxication symptoms occur when brain ammonia levels are
(A) Slightly diminished (C) Increased (B) Highly diminished (D) All of these
Name:
48. Glutathione is a
(A) Dipeptide (A) 3 (A) Blood clotting (A) Trypsinogen (A) Oxygenesis (A) Mg++ (B) Tripeptide (B) 4 (B) Metabolic pathway (B) Lipase (B) Glyconeogenesis (B) Zn++ (C) Polypeptide (C) 5 (C) Digestion (C) Cholecystokinin (C) Glycogenolysis (C) Co++
I.D.
(D) None of these (D) 6 (D) Krebs cycle (D) Chymnotrypsinogen (D) Anaerobic fermentation (D) Ca++
49. Urea biosynthesis occurs mainly in the liver involving the number of amino acids: 50. Insulin is a protein which controls 51. Pancreatic juice contains all of the following except 52. During glycolysis of glucose the energy liberated in the absence of oxygen is known as 53. Rennin acts on casein of milk in infants in presence of 54. A result of each oxidation a long chain fatty acid is cleaved to give
(A) An acid with 3-carbon less and propionyl CoA (C) An acid with 1-carbon less and acetyl CoA (A) NAD+ and NADP+ (C) FAD and FMN (A) 1 (B) 2 (B) An acid with 2-carbon less and acetyl CoA (D) An acid with 4-carbon and butyryl CoA (B) FADH2 and NADH + H (D) FAD+ and NAD+ (C) 6 (D) 8
55. In -Oxidation of fatty acids, which of the following are utilized as coenzymes? 56. The net number of ATP formed per mole of glucose in anaerobic glycolysis is 57. The initial step of the citric acid cycle is
(A) Conversion of pyruvate to acetyl-CoA (C) Conversion of citrate to isocitrate (A) Insulin (A) Bile salts (A) Acetyl CoA (B) Glucagon (B) Cu++ (B) Lactate (B) Condensation of acetyl-CoA with oxaloacetate (D) Formation of -ketoglutarate catalyzed by isocitrate dehydrogenase (C) Epinephrine (C) K + (C) Pyruvate (D) ACTH (D) Na+ (D) CO2 and H2O
58. The hormone activating the glycogen synthase activity is 59. Pancreatic lipase is activated in the presence of 60. End product of aerobic glycolysis is
Carbohydrates
Lipids
HMP
c) Compare between carrier protein and glutathione transport system in protein absorption.