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Bioscience Industry
A F A C T S H E E T F O R B U S I N E S S E S
Percent Change
¢ Catheter technologies (Medtronic; St. Jude Medical; Boston
Scientific, Inc.; Smith’s Medical). 20 39.4%
¢ Drug delivery systems (3M; Cima Labs, Inc.; Medtronic;
Smith’s Medical). 10
¢ Dialysis products (Minntech). 4.2%
¢ Impotence products (American Medical Systems). 0
¢ Electrotherapy (Medtronic; St. Jude Medical; Compex Minnesota United States
Technologies, Inc.; Empi Inc.). * NAICS 334510, 334517 and 3391.
¢ Spinal implants (Sulzer Spine-Tech). Source: U.S. Department of Labor, Bureau of Labor Statistics, Quarterly Census of
Employment and Wages (ES-202).
¢ Warming products for hypothermia (Arizant, Inc.).
¢ Hearing aids (Starkey Laboratories; Miracle Ear).
¢ Eyewear lenses (BMC Industries; Soderberg Opthalmic Services). N Minnesota’s medical technology industry employment:
¢ Medical device contract manufacturing (ev3, Inc.; Lake Region ¢ Increased 43 percent between 1994 and 2004 to over 23,800
Manufacturing; Medsource Technologies; Surgical Technologies). people.
¢ Drug-eluting coating process for medical devices (SurModics). ¢ Had a concentration of employment over three times the nation’s.
¢ Drug-coated stents (Boston Scientific, Inc.; Medtronic). ¢ Ranks second only to California in the medical device
industry.
Top Medical Technology N A number of medical technology companies have appeared on the
Manufacturers Operating in Minnesota prestigious Fast 500 list prepared by Deloitte and Touche.
¢ MGI Pharma revenues grew more than 700 percent and Vital
Annual Sales*
Company (millions) Images revenues tripled between 2001 and 2005.
Medtronic, Inc. $11,292 N Synovis Life Technologies, ASV, and Possis Medical were among
3M – Health Care 4,373 Fortune magazine’s 100 Fastest-Growing Companies for 2004.
Boston Scientific Scimed, Inc. 3,551
St. Jude Medical, Inc. 2,915 N Minnesota companies and research institutions have been first in
American Medical Systems, Inc. 263 developing many important medical devices:
* Sales for Minnesota headquarters or Minnesota-based operations ¢ Implantable cardiac pacemaker.
Source: Corporate Report Factbook 2007, Dun & Bradstreet , Reference USA, company annual reports.
¢ Artificial heart valves.
¢ Implantable drug transfusion pump.
N There are 585 FDA approved medical device establishments ¢ Anesthesia monitor.
currently in Minnesota. ¢ Blood pumps.
N About 2,500 medical device related patents were registered to ¢ Artificial urinary sphincter.
Minnesota companies between 2001 and 2005. ¢ In-the-ear hearing aid.
¢ Wireless cardiac monitoring system.
N According to the Milken Institute, Minnesota has the nation’s
highest number of investigational medical devices and FDA pre- N Minnesota medical technology companies have been involved in
market approvals of medical devices per 100,000 residents . numerous mergers and acquisitions.
¢ Medtronic, Inc. announced the acquisition of four companies
Outstanding ¢ Mayo Clinic: world’s best known health care facility in 2002, including California-based MiniMed and Medical
opportunities also collaborates with health care and medical Research Group, Inc. (MRG). Medtronic made acquisitions
for technology companies. totaling nearly $13.9 billion between 1996 and 2002.
collaboration ¢ Industrial Partnership for Research in Interfacial
¢ Since 2002, ev3, Inc. has acquired Appriva Medical, Inc. of
and Materials Engineering (IPRIME): Facilitates the
California and Minnesota’s Intra Therapeutics.
use of University of Minnesota equipment and staff
for its members, which include businesses such as ¢ Medsource Technologies acquired Cycam, Inc. of
Medtronic, SurModics, and 3M (www.iprime.umn.edu). Pennsylvania, while American Medical Systems acquired
¢ The University of Minnesota’s Biomedical California-based CryoGen, Inc. in 2002.
Engineering Institute combines engineering and
health sciences to create new medical devices.
Minnesota’s pharmaceutical industry is vibrant
Pharmaceuticals: and fast growing.
N Minnesota’s human health microbiology industry supplies a diverse N About 1,600 biological and life sciences degrees were awarded in
range of products that include: Minnesota between 2003 and 2004.
¢ Contract R&D laboratories (ATG Laboratories, ViroMed, N Minnesota is home to about 1,300 biological scientists and
Apptec Laboratory Services) technicians, as well as more than 2,800 life scientists and other
¢ Cell culture products (ViroMed, Apptec Laboratory Services) science technicians.
¢ Immunoassay testing (Beckman Coulter) N Firms in Minnesota are exploring new advances in microbiology:
¢ Cytokine-related reagents (R&D Systems) ¢ R&D Systems-Techne Corp. manufactures purified cytokines
¢ Hematology controls and calibrators (R&D Systems) (proteins), antibodies, and assay kits as well as whole-blood
¢ Immunoassay and conjugate stablilizers (SurModics) hematology controls and calibrators. The company has been
¢ cGMP manufacturing services (Apptec Laboratory Services) listed among the Top 25 Medical Technology Companies as of
¢ Occupational health testing (Medtox Scientific Inc.) 2003 by The Business Journal.
N Minnesota Partnership for Biotechnology and Medical Genomics: ¢ Beckman Coulter Inc. manufactures in vitro immunodiagnostic
Leverages the scientific leadership of the University of Minnesota systems for allergies, infectious diseases, immunology,
and the Mayo Clinic into a powerful research collaboration to position hormones, and serum proteins.
Minnesota as a world leader in biotechnology and medical genomics. ¢ Protein Design Labs, Inc. has antibodies in clinical development
(www.minnesotapartnership.info) for autoimmune and inflammatory conditions, asthma and cancer.
N Mayo Clinic is using IBM’s Blue Gene supercomputer to advance
work in molecular modeling for disease research. Exceptional ¢ The University of Minnesota provides state-of-the-
Biological art imaging and advanced genetic analysis facilities
Research to companies through the “Biotech Mall” known as
Top Human Health Microbiology Facilities “Biodale”.
Companies in Minnesota ¢ Nearly $500 million has been invested in genomics
Annual Sales* and biotechnology by the University of Minnesota
Company (millions) and the Mayo Clinic.
R&D Systems – Techne Corp. $203 ¢ The University of Minnesota has the Biotechnology
PDL BioPharma 90** Institute, Developmental Biology Center, Biomedical
Medtox Scientific, Inc. 64 Engineering Institute, and the Biomedical Genomic
AppTec Laboratory Services 35** Center. The Mayo Clinic has the Genomics
Viromed Laboratories - LabCorp 10** Research Center.
*Sales for Minnesota headquarters or Minnesota-based operations. ¢ University Enterprise Laboratory is a biotech
**Estimate. incubator launched in 2003 and has landed $24
Source: Corporate Report Factbook 2007, Dun & Bradstreet, Reference USA,
company annual reports.
million from investors.
N Minnesota’s Agricultural and Industrial Biotechnology industries N Cargill Dow LLC manufactures biodegradable packaging and
supply a diverse range of products that include: fibers using corn starch and a special fermentation process that
¢ Agricultural chemicals (Cargill Inc., Cenex Harvest States) requires 20 to 50 percent less fossil resources. CEO Randy
¢ Specialty cleaning and sanitation preparations (Ecolab) Howard was named to the 2002 Scientific American 50, a list of
¢ Sanitary products (H.B. Fuller) visionary contributors to science and technology.
¢ Prepared feed and feed ingredients (Land O’Lakes N Minnesota Corn Processors is the second largest domestic
Agricultural Services, Archer Daniels Midland, Cargill Inc.) producer of ethanol, and merged with Archer Daniels Midland in
¢ Crop services (Land O’Lakes Agricultural Services, 2002.
Syngenta Seeds, Cenex Harvest States) N Land O’Lakes provides farmers with:
¢ Biofuels (Cargill Dow LLC, Minnesota Corn ¢ Genetically engineered seeds through its seed company
Producers – ADM) Croplan Genetics that produce higher yields through crop
¢ Biopesticides (Syngenta) inputs and agricultural services.
¢ Soybean processing (ADM, Cenex Harvest States, Ag ¢ Specialty corn products for animal feeds and consumer food
Processing Inc.) markets developed in conjunction with Novartis Seeds.
¢ Plant biopolymers/fibers (Cargill Dow) N Using a solvent process, Cenex Harvest States manufactures
¢ Industrial lubricants (Cargill Inc.) soy products including edible refined oil, ink, flour, soy meal,
fatty acids and lecithin. In 2003, Cenex Harvest States opened its
second soybean crushing facility in Fairmont, Minnesota.
Top Agricultural and Industrial N Ecolab operates in 40 countries worldwide and manufactures products
such as cleaners and hand sanitizers.
Biotechnology Companies in Minnesota
N H.B. Fuller has developed water-based adhesives and non-woven
Annual Sales*
hygienic technology used in the fabrication of diapers, adult
Company (millions)
Cargill $75,210
incontinence devices, feminine and disposable medical products.
Land O’Lakes 7,560 N In 2003, Minnesota Soybean Processors built a new soybean
Ecolab 4,535 processing plant in Brewster, Minnesota and announced the addition
CHS, Inc. 3,500 of a biodiesel refinery.
H. B. Fuller 1,472 N A project of Positively Minnesota, the Department of Agriculture
* Sales for Minnesota headquarters or Minnesota-based operations and the University of Minnesota’s Department of Wood and Paper
Source: Corporate Report Factbook 2007, Dun & Bradstreet, Reference USA, Science, the Minnesota Biofiber Consortium brings together leaders
company annual reports.
of industry, research and agriculture to promote agricultural crops and
residues as industrial feedstocks.