Pubmed

<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.or g/TR/xhtml1/DTD/xhtml1-transitional.dtd">  <html><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8">< /head><body><pre>PMID- 23970596 OWN - NLM STAT- Publisher DA - 20130823 IS - 1758-1052 (Electronic) IS - 0956-4624 (Linking) DP - 2013 Jul 19 TI - Chest radiographic findings in patients with HIV/AIDS and pulmonary tuberc ulosis. AB - The study describes the main chest radiographic changes in people living w ith HIV/AIDS and pulmonary tuberculosis, confirmed by sputum culture. This was a descriptive study involving a total of 42 sputum tests from 42 people livi ng with HIV/AIDS and a clinical suspicion of pulmonary tuberculosis. All patients attended two referral hospitals in Recife-PE, Brazil, between August 2009 and January 2012. The most common isolated radiological change was parenchymal consolidation, encountered in six (14.3%) patients, followed by patterns o f interstitial infiltrate, diffuse micronodular (miliary), and an associatio n between interstitial infiltrate and parenchymal consolidation, each being encountered in five (11.9%) patients. No statistically significant differe nce was observed between the radiological findings and CD4T-cell counts, p = 0.680 . AD - Tropical Medicine Post-graduation, Universidade Federal de Pernambuco - UF PE, Recife-PE, Brasil. FAU - Albuquerque, Yvana Maria Maia de AU - Albuquerque YM FAU - Lima, Ana Luiza Magalhaes de Andrade AU - Lima AL FAU - Silva, Ana Carolina Brandao E AU - Silva AC FAU - Filho, Eolo Santana de Albuquerque AU - Filho ES FAU - Falbo, Ana Rodrigues AU - Falbo AR FAU - Magalhaes, Vera AU - Magalhaes V LA - ENG PT - JOURNAL ARTICLE DEP - 20130719 TA - Int J STD AIDS JT - International journal of STD & AIDS JID - 9007917 OTO - NOTNLM OT - HIV/AIDS OT - Pulmonary tuberculosis OT - chest X-ray OT - radiography EDAT- 2013/08/24 06:00 MHDA- 2013/08/24 06:00
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2013/08/24 06:00 0956462413484010 [pii] 10.1177/0956462413484010 [doi] aheadofprint Int J STD AIDS. 2013 Jul 19. 23485388 NLM MEDLINE 20130314 20130830 1815-7920 (Electronic) 1027-3719 (Linking) 17 4 2013 Apr Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Cli
Trials Group Protocol A5253. PG - 532-9 LID - 10.5588/ijtld.12.0737 [doi] AB - BACKGROUND: Improved tuberculosis (TB) screening is urgently needed for hu man immunodeficiency virus (HIV) infected patients. METHODS: An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic evaluation (SDE) for TB with standard of care (SOC ). SOC evaluations included TB symptom review (current cough, fever, night sweats and/or weight loss), sputum Ziehl-Neelsen staining and chest radiography. SDE scr eening added extended clinical signs and symptoms and fluorescent microscopy (FM) . All participants underwent all evaluations. Mycobacterium tuberculosis on sput um culture was the primary outcome. RESULTS: A total of 801 participants were enrolled from Botswana, Malawi, South Africa, Zimbabwe, India, Peru and Br azil. The median age was 33 years; 37% were male, and median CD4 count was 275 cells/mm(3). Thirty-one participants (4%) had a positive culture on Lowenstein-Jensen media and 54 (8%) on MGIT. All but one positive culture came from sub-Saharan Africa, where the prevalence of TB was 54/445 (12%). SOC screening had 54% sensitivity (95%CI 40-67) and 76% specificity (95%CI 7280). Positive and negative predictive values were respectively 24% and 92%. No elements of the SDE improved the predictive values of SOC. CONCLUSIONS: Symptom-based screening with smear microscopy was insufficiently sensitive . More sensitive diagnostic testing is required for HIV-infected patients. AD - Department of Internal Medicine, University of Nebraska Medical Center, Om aha, Nebraska 68198-8106, USA. sswindells@unmc.edu FAU - Swindells, S AU - Swindells S FAU - Komarow, L AU - Komarow L FAU - Tripathy, S AU - Tripathy S FAU - Cain, K P
AU - Cain KP FAU - MacGregor, R R AU - MacGregor RR FAU - Achkar, J M AU - Achkar JM FAU - Gupta, A AU - Gupta A FAU - Veloso, V G AU - Veloso VG FAU - Asmelash, A AU - Asmelash A FAU - Omoz-Oarhe, A E AU - Omoz-Oarhe AE FAU - Gengiah, S AU - Gengiah S FAU - Lalloo, U AU - Lalloo U FAU - Allen, R AU - Allen R FAU - Shiboski, C AU - Shiboski C FAU - Andersen, J AU - Andersen J FAU - Qasba, S S AU - Qasba SS FAU - Katzenstein, D K AU - Katzenstein DK CN - AIDS Clinical Trials Group 5253 Study Team LA - eng PT - Journal Article PT - Multicenter Study PL - France TA - Int J Tuberc Lung Dis JT - The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease JID - 9706389 SB - IM MH - Adult MH - Africa South of the Sahara/epidemiology MH - Algorithms MH - Bacteriological Techniques MH - Brazil/epidemiology MH - CD4 Lymphocyte Count MH - Clinical Protocols MH - *Coinfection MH - Cough/microbiology MH - Cross-Sectional Studies MH - Female MH - Fever/microbiology MH - HIV Infections/*diagnosis/epidemiology MH - Humans MH - India/epidemiology MH - Male MH - *Mass Screening/methods MH - Microscopy, Fluorescence MH - Mycobacterium tuberculosis/isolation & purification MH - Peru/epidemiology MH - Predictive Value of Tests MH - Prevalence
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Prospective Studies Radiography, Thoracic Sputum/microbiology Standard of Care Sweating Tuberculosis, Pulmonary/*diagnosis/epidemiology/microbiology Weight Loss 2013/03/15 06:00 2013/08/31 06:00 2013/03/15 06:00 10.5588/ijtld.12.0737 [doi] ppublish Int J Tuberc Lung Dis. 2013 Apr;17(4):532-9. doi: 10.5588/ijtld.12.0737. 23175897 NLM MEDLINE 20121126 20121211 0189-2657 (Print) 0189-2657 (Linking) 21 4 2011 Oct-Dec Chest X- ray findings in HIV patients in relation to the CD4 count. 306-11 BACKGROUND: CD4 count measures the degree of immunosupression in HIV-infec
patients. Immunosupression results in lack of ability of the body to fight infections thus predisposing the individual to infection; lung is one of t he most susceptible organs. An important diagnostic tool in assessing the respirat ory complications as well as the manifestations of HIV infection is the chest radiograph. OBJECTIVE: This study is aimed at determining the radiological features seen on chest radiographs of HIV/AIDS patients in relation to the ir corresponding CD4 count which is a measure of immunosupression. METHODS: T his study was conducted at Lagos State University Teaching Hospital (LASUTH) H IV clinic between September 2009 and August 2010 amongst all consenting regis tered HIV/AIDS patients. A total of one hundred and six consenting participants were recruited consecutively into the study, their blood samples were collected for CD4 count assay, and all the participants were sent for chest xray in the radiology department. They were asked to fill the structured questionnaire to obtain demographic data. RESULTS: More than three-quarters, 87(82.1%) had a normal chest radiographs. The abnormal findings included 13 cases of (12.3 %) pulmonary tuberculosis, 3(2.8%) having bronchopneumonia, and 3(2.8%) lobar pneumonia. Majority, 32 of 87 of those with normal chest-x ray had CD4 cou nt <100 cells/il while about half of the patients with pulmonary tuberculosis (5 o f 13) had CD4 count >350 cells/il. All the three patients who had lobar pneum
onia had CD4 count between 200-350 cells/il, while 2 of 3 patients with bronchopneu monia had CD4 counts between 200-350 cells/il, only 1 of them had CD4 of 100-200 cells/il CONCLUSION: About three-quarters of HIV-infected patients had nor mal chest radiographs, majority of those with normal chest x-ray were severely immunocompromised. While almost half of those with pulmonary tuberculosis had CD4 count >350 cells/il. The CD4 count level may not be an indicator of pul monary infection. AD - Department of Haematology and Blood Transfusion, Lagos State University Co llege of Medicine. ajoke_clinic@yahoo.co.uk FAU - Akinbami, A A AU - Akinbami AA FAU - Adegboyega, A O AU - Adegboyega AO FAU - Oshinaike, O O AU - Oshinaike OO FAU - Adebola, P A AU - Adebola PA FAU - Enabulele, C AU - Enabulele C FAU - Dosunmu, O A AU - Dosunmu OA FAU - Adediran, A AU - Adediran A LA - eng PT - Journal Article PL - Nigeria TA - Nig Q J Hosp Med JT - Nigerian quarterly journal of hospital medicine JID - 9713944 SB - IM MH - AIDS-Related Opportunistic Infections/epidemiology MH - Adolescent MH - Adult MH - CD4 Lymphocyte Count MH - Female MH - HIV Infections/*epidemiology/immunology/*radiography MH - Humans MH - *Immunocompromised Host MH - Lung/*radiography MH - Male MH - Middle Aged MH - Pneumonia/*epidemiology/radiography MH - Sex Distribution MH - Tuberculosis, Pulmonary/*epidemiology/radiography MH - Young Adult EDAT- 2012/11/28 06:00 MHDA- 2012/12/12 06:00 CRDT- 2012/11/27 06:00 PST - ppublish SO - Nig Q J Hosp Med. 2011 Oct-Dec;21(4):306-11. PMID- 23077699 OWN - NLM STAT- MEDLINE
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20121018 20130308 20130711 1937-8688 (Electronic) 12 2012 Chest X-ray findings in HIV- infected Highly Active Antiretroviral Treatme
(HAART)-naive patients. PG - 78 AB - INTRODUCTION: Patients with human immunodeficiency virus (HIV) infection frequently present with a wide spectrum of pulmonary and cardiac complicat ions from the virus, opportunistic infections and neoplasms that may be associa ted with a high mortality rate. Diseases of the respiratory tract account for about half of deaths from AIDS, while cardiac diseases account for more than a q uarter of deaths from AIDS. This study aimed at determining the prevalence of pul monary and cardiac diseases using a chest radiograph in HAART-naive HIV-infected patients. METHODS: This study was conducted at Lagos State University Teac hing Hospital (LASUTH) HIV clinic between September 2010 and August 2011 amongs t all registered HAART-naive HIV/AIDS patients. Patients had posterior-anterior chest radiographs done in full inspiration. Participants were asked and aided to fill the structured questionnaires to obtain demographic data. RESULTS: Out of a total of one hundred and two recruited for the study, 54 ( 52.94%) had a normal chest radiograph, while 48 (47.06%) had abnormal chest radiograph .The abnormal findings included, 27.45% who had bronchopneumonia, 6.86% cardiomegaly, 5. 88% pulmonary tuberculosis, 5.88% radiological features of congestive cardiac failure, and 0.98% bronchitis. CONCLUSION: It appears that more than half of HAART-naive HIV-infected patients have normal chest radiographs. Bronchopn eumonia (27.5%) is the commonest pulmonary abnormality associated with HIV infecti on, while the prevalence of pulmonary tuberculosis is 5.88%. AD - Department of Haematology and Blood Transfusion, Lagos State University Co llege of Medicine, Nigeria. FAU - Akinbami, Akinsegun AU - Akinbami A FAU - Balogun, Babajide AU - Balogun B FAU - Balogun, Modupe AU - Balogun M FAU - Dosunmu, Owolabi AU - Dosunmu O FAU - Oshinaike, Olajumoke AU - Oshinaike O FAU - Adediran, Adewumi AU - Adediran A
FAU - Adegboyega, Kayode AU - Adegboyega K LA - eng PT - Journal Article DEP - 20120719 PL - Uganda TA - Pan Afr Med J JT - The Pan African medical journal JID - 101517926 SB - IM MH - Adult MH - Bronchopneumonia/epidemiology/*radiography/virology MH - Cardiomegaly/epidemiology/radiography/virology MH - Female MH - HIV Infections/complications/*radiography MH - Hospitals, University MH - Humans MH - Male MH - Middle Aged MH - Prevalence MH - Tuberculosis, Pulmonary/epidemiology/*radiography/virology MH - Young Adult PMC - PMC3473964 OID - NLM: PMC3473964 OTO - NOTNLM OT - Chest X-ray OT - HAART-nave OT - HIV-infected EDAT- 2012/10/19 06:00 MHDA- 2013/03/09 06:00 CRDT- 2012/10/19 06:00 PHST- 2011/03/24 [received] PHST- 2012/05/07 [accepted] PHST- 2012/07/19 [epublish] PST - ppublish SO - Pan Afr Med J. 2012;12:78. Epub 2012 Jul 19. </pre></body></html>

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