PMID- 12151508 OWN - NLM STAT- MEDLINE DA - 20020801 DCOM- 20020903 LR - 20131121 IS - 1529-2401 (Electronic) IS - 0270-6474 (Linking) VI - 22 IP - 15 DP - 2002

Aug 1 TI - Caffeine induces dopamine and glutamate release in the shell of the nucleu s accumbens. PG - 6321-4 AB - An increase in the extracellular concentration of dopamine in the nucleus accumbens (NAc) is believed to be one of the main mechanisms involved in t he rewarding and motor-activating properties of psychostimulants such as amphetamines and cocaine. Using in vivo microdialysis in freely moving rat s, we demonstrate that systemic administration of behaviorally relevant doses of caffeine can preferentially increase extracellular levels of dopamine and glutamate in the shell of the NAc. These effects could be reproduced by th e administration of a selective adenosine A1 receptor antagonist but not by a selective adenosine A2A receptor antagonist. This suggests that caffeine, because of its ability to block adenosine A1 receptors, shares neurochemical prope rties with other psychostimulants, which could contribute to the widespread cons umption of caffeine-containing beverages. FAU - Solinas, Marcello AU - Solinas M AD - Section of Preclinical Pharmacology, Behavioral Neuroscience Branch, Natio nal Institute on Drug Abuse, National Institutes of Health Intramural Research Program, Baltimore, Maryland 21224, USA. FAU - Ferre, Sergi AU - Ferre S FAU - You, Zhi-Bing AU - You ZB FAU - Karcz-Kubicha, Marzena AU - Karcz-Kubicha M FAU - Popoli, Patrizia AU - Popoli P FAU - Goldberg, Steven R AU - Goldberg SR LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - J Neurosci JT - The Journal of neuroscience : the official journal of the Society for Neuroscience JID - 8102140 RN - 0 (5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c

)pyrimi dine) RN - 0 (Purinergic P1 Receptor Antagonists) RN - 0 (Pyrimidines) RN - 0 (Receptor, Adenosine A2A) RN - 0 (Triazoles) RN - 35873-49-5 (8-cyclopentyl-1,3-dimethylxanthine) RN - 3G6A5W338E (Caffeine) RN - 3KX376GY7L (Glutamic Acid) RN - C137DTR5RG (Theophylline) RN - VTD58H1Z2X (Dopamine) SB - IM MH - Animals MH - Behavior, Animal/drug effects MH - Caffeine/*pharmacology MH - Dopamine/analysis/*metabolism MH - Dose-Response Relationship, Drug MH - Extracellular Space/chemistry/metabolism MH - Glutamic Acid/analysis/*metabolism MH - Injections, Intraperitoneal MH - Male MH - Microdialysis MH - Motor Activity/drug effects MH - Nucleus Accumbens/*drug effects/*metabolism MH - Purinergic P1 Receptor Antagonists MH - Pyrimidines/pharmacology MH - Rats MH - Rats, Sprague-Dawley MH - Receptor, Adenosine A2A MH - Theophylline/*analogs & derivatives/pharmacology MH - Triazoles/pharmacology MH - Wakefulness/drug effects/physiology EDAT- 2002/08/02 10:00 MHDA- 2002/09/11 10:01 CRDT- 2002/08/02 10:00 AID - 20026640 [doi] AID - 22/15/6321 [pii] PST - ppublish SO - J Neurosci. 2002 Aug 1;22(15):6321-4.