Sunteți pe pagina 1din 2

2010 UpToDate Drug regimens for prophylaxis against malaria in adults "nitiation Drug Tablet size Dose Frequen

n y! #time before first exposure to malaria$ Dis ontinuation #time after last exposure$ Use in pregnan y

%reas &ith hloroquine'resistant (lasmodium fal iparum %to)aquone'proguanil #*alarone$ *efloquine hydro hloride #0ariam and generi agents$ Doxy y line hy late #6ibramy in7 6ibra'Tabs7 other brands7 and generi agents$/ doxy y line monohydrate #*onodox7 %doxa7 and generi agents$ 2+0 mg ato)aquone and 100 mg proguanil 2+0 mg salt #221 mg base$ ,ne tablet orally ,ne tablet orally ,n e daily ,n e &ee2ly 1'2 days 3 &ee2s preferable/ 1'2 &ee2s a eptable - days 4 &ee2s .o/ insuffi ient data on use in pregnan y 5es/ limited data a)ailable on first trimester use

100 mg

,ne tablet orally

,n e daily

1'2 days

4 &ee2s

.o/ teratogeni

%reas &ith hloroquine'sensiti)e (lasmodium fal iparum 8hloroquine phosphate #%ralen and generi agents$ 9ydroxy hloroquine sulfate #(laquenil$ %to)aquone'proguanil #*alarone$ *efloquine hydro hloride #0ariam and generi agents$ Doxy y line hy late #6ibramy in7 6ibra'Tabs7 other brands7 and generi agents$/ doxy y line monohydrate #*onodox7 %doxa7 and generi agents$ +00 mg salt #300 mg base$ 400 mg salt #310 mg base$ 2+0 mg ato)aquone and 100 mg proguanil 2+0 mg salt #221 mg base$ ,ne tablet orally ,ne table orally ,ne tablet orally ,ne tablet orally ,n e &ee2ly ,n e &ee2ly ,n e daily ,n e &ee2ly 1'2 &ee2s 1'2 &ee2s 1'2 days 3 &ee2s preferable/ 1'2 &ee2s a eptable 4 &ee2s 4 &ee2s - days 4 &ee2s 5es 5es .o/ insuffi ient data on use in pregnan y 5es/ limited data a)ailable on first trimester use

100 mg

,ne tablet orally

,n e daily

1'2 days

4 &ee2s

.o/ teratogeni

(rimaquine phosphate!!

2:;3 mg salt #1+ mg base$

T&o tablets orally

,n e daily

1'2 days

- days

.o/ ontraindi ated be ause of potential toxi ity for fetal erythro ytes

%reas &ith (; )i)ax (rimaquine phosphate #appropriate prophylaxis for short duration tra)el to areas &ith prin ipally (; )i)ax$ 8hloroquine phosphate #%ralen and generi agents$ 9ydroxy hloroquine sulfate #(laquenil$ %to)aquone'proguanil #*alarone$ *efloquine hydro hloride #0ariam and generi agents$ Doxy y line hy late #6ibramy in7 6ibra'Tabs7 other brands7 and generi agents$/ doxy y line monohydrate #*onodox7 %doxa7 and generi agents$ 2:;3 mg salt #1+ mg base$ +00 mg salt #300 mg base$ 400 mg salt #310 mg base$ 2+0 mg ato)aquone and 100 mg proguanil 2+0 mg salt #221 mg base$ .o/ ontraindi ated be ause of potential toxi ity for fetal erythro ytes 5es 5es .o/ insuffi ient data on use in pregnan y 5es/ limited data a)ailable on first trimester use

T&o tablets orally

,n e daily

1'2 days

- days

,ne tablet orally ,ne tablet orally ,ne tablet orally ,ne tablet orally

,n e &ee2ly ,n e &ee2ly ,n e daily ,n e &ee2ly

1'2 &ee2s 1'2 &ee2s 1'2 days 3 &ee2s preferable/ 1'2 &ee2s a eptable

4 &ee2s 4 &ee2s - days 4 &ee2s

100 mg

,ne tablet orally

,n e daily

1'2 days

4 &ee2s

.o/ teratogeni

(resumpti)e antirelapse therapy #to pre)ent relapse due to (; )i)ax or (; o)ale$ 2:;3 mg salt #1+ mg base$ %s soon as possible follo&ing exposure for &hi h another prophyla ti drug ta2en .o/ ontraindi ated be ause of potential toxi ity for fetal erythro ytes

(rimaquine phosphate

T&o tablets orally

,n e daily

14 days

! Drugs administered on e daily should be ta2en at the same time ea h day/ drugs administered on e &ee2ly should be ta2en on the same day ea h &ee2; !! (rimaquine has tissue s hizonti idal a ti)ity but la 2s blood s hizonti idal a ti)ity against (; fal iparum; "t is less effe ti)e than ato)aquone'proguanil7 mefloquine or doxy y line7 but is a eptable as a se ond'line agent for pre)ention of (; fal iparum if other drugs annot be administered; 1; 9ill7 D<7 =ri sson7 8D7 (earson7 <D7 et al; The (ra ti e of Tra)el *edi ine> ?uidelines by the "nfe tious Diseases @o iety of %meri a; 8lin "nfe t Dis 200:/ 43>14AA; 2; Freedman7 D,; 8lini al pra ti e; *alaria pre)ention in short'term tra)elers; . =ngl B *ed 2001/ 3+A>:03':12;

2010 UpToDate7 "n ; %ll rights reser)ed; C @ubs ription and 0i ense %greement 0i ensed to> Do tors "n ;

S-ar putea să vă placă și