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http://www.nlm.nih.gov/medlineplus/ency/article/003344.htm
Coombs test
The Coombs' test looks for antibodies that may stick to your red blood cells and cause red blood cells to die too early.
Normal Results
A normal result means there were no clumping of cells (agglutination), meaning you have no antibodies to red blood cells. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.
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http://www.nlm.nih.gov/medlineplus/ency/article/003344.htm
Infectious mononucleosis Mycoplasmal infection Syphilis Systemic lupus erythematosus Transfusion reaction, such as one due to improperly matched units of blood The test may also be abnormal without any clear cause, especially among the elderly. An abnormal (positive) indirect Coombs' test means you have antibodies that will act against red blood cells your body views as foreign. This may suggest: Autoimmune or drug-induced hemolytic anemia Erythroblastosis fetalis hemolytic disease Incompatible blood match (when used in blood banks)
Risks
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others. Other risks associated with having blood drawn are slight but may include: Excessive bleeding Fainting or feeling light-headed Hematoma (blood accumulating under the skin) Infection (a slight risk any time the skin is broken)
Alternative Names
Direct antiglobulin test; Indirect antiglobulin test
References
Powers A, Silberstein LE. Autoimmune hemolytic anemia. In: Hoffman R, Benz EJ Jr., Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingston Elsevier; 2008: chap 47. Schrier SL, Price EA. Extrinsic nonimmune hemolytic anemias. In: Hoffman R, Benz EJ Jr., Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingston Elsevier; 2008: chap 48. Schwartz RS. Autoimmune and intravascular hemolytic anemias In: Goldman L, Schafer AI, eds.Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 163.
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