DRUG STUDY

Drug Data Classification

Mechanism of
Action
Indication Contraindications Adverse Reaction Nursing Responsiilities
Generic Name
biperiden
Trade Name
Akineton

!atients Dose
2g tab OD PO

Minimum
Dose
6mg/day


Ma"imum
Dose
16mg/day

Contents
biperiden

Availailit#
and color
Talets$ 2mg,
4mg, 8mg
Routes of
administration
PO
Therapeutic$
Antiparkinson
agents
!harmacologic$
Anticholinergics
!regnanc#
Categor#
C
Is a tertiary amine
antimscarinic !ith
central and peripheral
actions" It stimlates
and then depresses
the #$%, it also has
antispasmodic
actions on smooth
mscle and redces
secretions, esp
sali&ary and bronchial
secretions"
!harmaco%ineti
cs
A $ 'eadily Absorbed
(rom the )I tract"
D$ *nkno!n
M&'$ +,tensi&e (irst-
pass e((ect"
(nset
nkno!n
!ea%
nkno!n

Duration
nkno!n

Drug )alf *ife
Abot 2. hrs"
General
Indications

Ad/ncti&e treatment
o( all (orms o(
Parkinson disease,
inclding drg-
indced
e,trapyramid e((ects
and acte dystonic
reactions"
!atients Actual
Indication
0o pre&ent drg
indced
e,trapyramid e((ects
and acte dystonic
reactions






1ypersensiti&ity2
Angleclosre glacoma2
3o!el obstrction2
4egacolon20ardi&e
dyskinesia"
!recaution
Prostatic enlargement2
%ei5re
disorders2#ardiac
arrhythmias2
O3, 6actation7 %a(ety
not established2
)eri7 Increased risk o(
ad&erse reactions2
lo!er doses may be
necessary"
.Drug interaction
+drug to drug
Amantadine 4ay
increase
anticholinergic ad&erse
reactions"
Digo"in 4ay increase
digo,in serm le&els,
especially !ith slo!-
dissoltion oral digo,in
tablets"
)aloperidol 4ay
!orsen schi5ophrenic
symptoms2 may
decrease haloperidol
serm le&els2 tardi&e
dyskinesia may
de&elop" 4ay decrease
action o(
phenothia5ines" 4ay
increase incidence o(
anticholinergic ad&erse
reactions"
CNS$ con(sion,
depression, di55iness,
hallcinations,
headache, sedation,
!eakness"
''NT$ blrred &ision,
dry eyes, mydriasis"
C,$ arrhythmias,
hypotension,
palpitations,
tachycardia"
GI$ constipation, dry
moth, iles, nasea"
GU$ hesitancy, rinary
retention"
Misc$ decreased
s!eating"
-efore
1" Asses patient8s
diagnosis"
2" Assess patient8s mental
stats"
9" Assess patient8s &isal
acity"
4" #on(irm medication (rom
doctor8s orders"
:" Assess blood pressre"

During

1" #on(irm patient8s
identity"
2" Administer medication
at the right prescribed
rote"
9" 4st administer
medication !ith (ood"
4" Practice aseptic
techni;e"
:" Administer medication
at the prescribed time"

After

1" Obser&e proper
docmentation o(
administered
medication"
2" +nsre that patient has
(lly s!allo!ed oral (orm
o( medication"
9" Obser&e patient8s
beha&ior closely (or
atleast 1:-9. mintes
a(ter administration"
4" Instrct patient to mo&e
slo!ly to pre&ent
di55iness"
:" +ncorage patient to
increase (lid intake to
pre&ent drying o( moth"
Source$
Deglin, <" et" Al" 2..=" Da&is8s Drg )ide (or $rses" 12
th
ed" >"A" Da&is" pp 192.