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Woodhead Publishing

Biomedicine and
Biomaterials
2014 Catalogue
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Contents
Biomedicine
Bioengineering, biotechnology
Bioinformatics, computing and life sciences
Genetics and genomics
Intellectual property, regulation
Life science, molecular and cellular biology
Management and business
Manufacturing and processing
Medical science and technology, cancer research
Nanoscience and technology in medicine
Pharmaceutical science/technology, drug delivery
Regenerative medicine
Stem cell sciences
Biomaterials
Applications
Clinical techniques
Materials
Medical textiles
Technologies and performance
Title index
Author index
Order form
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Elseviers Acquisition of Woodhead Publishing
In August 2013, Elsevier acquired Woodhead Publishing Limited, an award-winning, UK-based publisher
known for its high-quality content in the felds of materials science, food science, engineering, energy &
environmental technology, textile technology and biomedicine. The acquisition of Woodhead Publishing
also includes Chandos Publishing, known for its strong publishing program in library information science
and Asian studies.
The acquisition of Woodhead Publishing helps Elsevier achieve its objective to improve research
outcomes and researcher productivity. Woodheads high-quality, global publishing program is
complementary to Elseviers books portfolio.
Martin Woodhead built Woodhead Publishing into a successful business over 24 years. Now Elsevier will
maintain Woodheads more than 1,500 published titles and strong front list program, taking the books to
new levels in both the print and electronic markets.
Woodhead Publishing was recognized for international achievement at the 2012 Independent Publishing
Awards, sponsored by the London Book Fair, being called active and innovative in whatever country it
targets.
Woodhead and Chandos titles are available on the ScienceDirect platform and via online retailers.
2
BIOENGINEERING,
BIOTECHNOLOGY
NEW
An introduction to biotechnology
The science, technology and medical
applications
W T Godbey, Tulane University, USA
Woodhead Publishing Series in Biomedicine
No. 24
An introduction to biotechnology is
a biotechnology textbook aimed at
undergraduates. It covers the basics of cell
biology, biochemistry and molecular biology,
and introduces laboratory techniques specifc
to the technologies addressed in the book. It
addresses specifc biotechnologies at both the
theoretical and application levels.
CONTENTS
Part 1 The cell: Plasma membrane - phospholipids, proteins,
cholesterol: Prokaryotic outer barriers - cell wall (NAMs,
NAGs, crosslinking); The cytoplasm - more proteins: Enzymes
(enzymes are catalysts, enzymes depend on proper protein
folding, enzymes used in science, enzymes used in industry);
The nucleus - organization of the genome (chromosomes,
DNA fbers, nucleosomes, DNA strands, RNA); Prokaryotic
genome organization - circular genome, attached to inner
plasma membrane; The central dogma - transcription
(Mrna); The life of a cell - the cell cycle (synthesis (S)
phase, mitosis (M), gap phases, cell cycle control). Part
2 Biotechnology: Applications to and of the cell; Genetic
engineering - genes (exons, introns, promoters, enhancers);
Gene delivery models - viral (adenovirus, adeno-associated
virus, herpesvirus, lentivirus/retrovirus); Gene delivery cargo
- DNA, RNA, siRNA; Fluorescence - quantum yield, Stokes
shift, brightness; Recombinant Proteins; Biofuels - from
cellulose degradation (biochemistry of cellulose); Stem cells
- cells with potential (totipotent, pluripotent, multipotent);
Transgenics; Cloning.
500 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 28 2 E-ISBN: 978 1 908818 48 5

NEW
Electroporation-based therapies
for cancer
From basics to clinical applications
Edited by R Sundararajan, Purdue University,
USA
Woodhead Publishing Series in Biomedicine
No. 49
Electroporation-based therapies for cancer
provides a comprehensive overview of
electroporation-based clinical studies in
the hospitals for various cancer treatments,
including melanomas, head and neck cancers,
chest wall breast carcinomas and colorectal
cancers, and also looks at research studies
in the lab using cell lines, primary cells, and
animals.
CONTENTS
Clinical electro-chemo-therapy for advanced superfcial
melanoma; Effective electro-chemo-therapy for chest wall
recurrence of breast carcinoma; Electrochemotherapy
- aspects of clinical experience; Low and high voltage
electro-chemo-therapy for breast cancer: An in vitro model
study; Electrically-enhanced proliferation control of cancer-
stem-cell-like adult human mesenchymal stem cells a novel
modality of treatment; Why electroporation is a useful
technique for cancer treatments; Electro-endocrine therapy
for breast cancer; Electroporation of cervical and leukemia
cancer cells; Targeted delivery of siRNA and other diffcult to
transfect molecules using electroporation; Nanosecond, low
voltage pulses for electro-endocrine therapy; Low and high
voltage electroporation of ovarian cancer cells; Irreversible
electroporation; Electric feld distribution study of malignant
tumors.
250 pages 234 x 156mm (6 x 9) hardback Q1 2015
ISBN: 978 1 907568 15 2 E-ISBN: 978 1 908818 29 4
MATLAB

in bioscience and
biotechnology
L Burstein, Technion, Haifa University, Israel
Woodhead Publishing Series in Biomedicine
No. 3
MATLAB

in bioscience and biotechnology


presents an introductory Matlab course
oriented towards various collaborative
areas of biotechnology and bioscience. It
concentrates on Matlab fundamentals and
gives examples of its application to a wide
range of current bioengineering problems in
computational biology, molecular biology,
bio-kinetics, biomedicine, bioinformatics,
and biotechnology. In this book, Matlab is
presented with examples and applications
to various school-level and advanced
bioengineering problems.
CONTENTS
MATLAB

basics; MATLAB

graphics; Script, function fles


and some useful MATLAB

functions; Ordinary and partial


differential equation solvers; Bioinformatics tool for
sequence analysis.
248 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 907568 04 6 E-ISBN: 978 1 908818 03 4
NEW
From plant
genomics to plant
biotechnology
Edited by S P Poltronieri,
Italian National Research
Council, Italy, N Burbulis,
Aleksandr Stulginskis
University, Lithuania and C Fogher, Catholic
University, Italy
Woodhead Publishing Series in Biomedicine
No. 53
From plant genomics to plant biotechnology
reviews the recent advancements in the
post-genomic era, discussing how different
varieties respond to abiotic and biotic
stresses, understanding the epigenetic
control and epigenetic memory (RNAs, DNA
methylation, histone modifcations and
polycomb complexes), the roles of non-
coding RNAs, applicative uses of RNA silencing
and RNA interference in plant physiology
and in experimental transgenics and plants
modifed to specifc aims (biofuels, production
of high-value pharmaceutical proteins in
plants, abiotic stress resistant wood trees
and ornamental plants). In the forthcoming
years these advancements will support the
production of plant varieties better suited to
resist biotic and abiotic stresses, for food and
non-food applications.
CONTENTS
From plant genomics to -omics technologies; Plant
microRNAs; Epigenetic control by plant Polycomb proteins:
New perspectives and emerging roles in stress response;
Metabolite profling for plant research; The uniqueness of
conifers; Cryptochrome genes modulate global transcriptome
of tomato; Genomics of grapevine: From genomics research
on model plants to crops and from science to grapevine
breeding; Grapevine genomics and phenotypic diversity
of bud sports, varieties and wild relatives; Peach ripening
transcriptomics unveils new and unexpected targets
for the improvement of drupe quality; Application of
doubled haploid technology in breeding of Brassica napus;
Plant biodiversity and biotechnology; Natural resveratrol
bioproduction.
274 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 29 9 E-ISBN: 978 1 908818 47 8

Bioengineering, biotechnology
3
A biotech managers
handbook
A practical guide
Edited by M ONeill, Eolas
Biosciences Limited and M
M Hopkins, University of
Sussex, UK
Woodhead Publishing Series
in Biomedicine No. 9
A biotech managers handbook lays out - in
a simple, straightforward manner - for the
manager or would-be entrepreneur the basic
principles of running a biotech company.
Most managers in biotechnology companies
are working in their frst company or in their
frst managerial role. Their expertise and
experience in the scientifc part of the work
can be taken as a given but there is a whole
range of other skills to be learned and areas
of expertise to come to terms with. Small
companies do not have big budgets to hire
people or time to become an expert in so
many areas. The book starts by outlining the
state of the biopharmaceutical industry and
goes on to explain the importance of planning
(no matter what the size of the company).
Succeeding chapters deal with the basics of
intellectual property, perspectives from a
university technology transfer offce and how
to raise some initial funding from an investor
and entrepreneur.
CONTENTS
The bioscience sector: Challenges and opportunities;
Academic innovation: So you want to be a bio-entrepreneur?
Leadership and you; Managing self, situations and stress;
Its all in the plan; Exploring funding routes for therapeutics
frms; Raising funds and managing fnances; Introduction to
intellectual property; Managing projects and portfolios in
R&D: Why and how; Successful registration of new therapies;
Clinical trials: Design and practice; Business development:
Starting out; Business development: To the deal and beyond;
Conclusions and fnal thoughts.
414 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 14 5 E-ISBN: 978 1 908818 15 7
BIOINFORMATICS, COMPUTING
AND LIFE SCIENCES
NEW
Bioinformatics for biomedical
science and clinical applications
K-H Liang, LinKo Medical Center, Chang Gung
Memorial Hospital, Taiwan R.O.C.
Woodhead Publishing Series in Biomedicine
No. 20
Contemporary biomedical and clinical research
is undergoing constant development thanks
to the rapid advancement of various high
throughput technologies at the DNA, RNA
and protein levels. These technologies can
generate vast amounts of raw data, making
bioinformatics methodologies essential in
their use for basic biomedical and clinical
applications. Bioinformatics for biomedical
science and clinical applications demonstrates
what these cutting-edge technologies can do
and examines how to design an appropriate
study, including how to deal with data and
address specifc clinical questions.
CONTENTS
Genomics; Transcriptomics; Proteomics; Systems biomedical
science; Clinical developments.
170 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 44 2 E-ISBN: 978 1 908818 23 2
NEW
Deterministic versus stochastic
modelling in biochemistry and
systems biology
P Lecca, The Microsoft Research University of
Trento, COSBI, Italy, I Laurenzi, ExxonMobil,
USA and F Jordan, The Microsoft Research
University of Trento, COSBI, Italy
Woodhead Publishing Series in Biomedicine
No. 21
Deterministic versus stochastic modelling in
biochemistry and systems biology introduces
and critically reviews the deterministic and
stochastic foundations of biochemical kinetics,
covering applied stochastic process theory
for application in the feld of modelling and
simulation of biological processes at the
molecular scale.
CONTENTS
Deterministic chemical kinetics; The stochastic approach
to biochemical kinetics; The exact stochastic simulation
algorithms; Modelling in systems biology; The structure of
biochemical models; Reaction-diffusion systems; KInfer: A
tool for model calibration; Modelling living systems with
BlenX; Simulation of ecodynamics: Key nodes in food webs.
390 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 62 6 E-ISBN: 978 1 908818 21 8

NEW
Computer-aided
applications in
pharmaceutical
technology
Edited by J Djuris, University
of Belgrade, Serbia
Woodhead Publishing Series in Biomedicine
No. 52
Computer-aided applications in
pharmaceutical technology covers the
fundamentals of experimental design
application and interpretation in
pharmaceutical technology and chemometric
methods, with emphasis on their application
in process control, neural computing (artifcial
neural networks, fuzzy logic and decision
trees, evolutionary computing and genetic
algorithms, self-organizing maps) computer-
aided biopharmaceutical characterization,
as well as application of computational fuid
dynamics in pharmaceutical technology.
All of these techniques are essential tools
for successful building of quality into
pharmaceutical products and processes from
the early stage of their development to
selection of the optimal ones. In addition to
theoretical aspects of various methods, the
book provides numerous examples of their
application in the feld of pharmaceutical
technology.
CONTENTS
Quality-by-design in pharmaceutical development;
Computer-aided formulation development; Experimental
design application and interpretation in pharmaceutical
technology; Chemometric methods application in
pharmaceutical products and processes analysis and
control; Neural computing in pharmaceutical products and
process development; Computer-aided biopharmaceutical
characterization: Gastrointestinal absorption simulation;
Computational fuid dynamics: Applications in
pharmaceutical technology.
300 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 27 5 E-ISBN: 978 1 908818 32 4

Bioinformatics, computing and life sciences
4
NEW
Computer-aided vaccine design
J C Tong, A*STAR Institute for Infocomm
Research, Singapore and S Ranganathan,
Macquarie University, Australia
Woodhead Publishing Series in Biomedicine
No. 23
Computational pre-screening of antigens is
now routinely applied to the discovery of
vaccine candidates. Computer-aided vaccine
design is a comprehensive introduction to
this exciting feld of study. The book is a
textbook for researchers and for courses
in bioinformatics, as well as a laboratory
reference guide. It is written for biologists
who want to understand the current methods
of computer-aided vaccine design. The
contents are designed to help biologists
appreciate the underlying concepts and
algorithms used, as well as limitations of the
methods and strategies for their use. The
book is of interest to computational biologists
who would like to understand more about
the biological concepts related to the feld of
computational immunology.
CONTENTS
MHC and T cell responses; Immunoglobulins and B cell
responses; Scientifc publications and databases; Database
design; Computational T cell vaccine design; Computational
B cell vaccine design; Infectious disease informatics;
Vaccine safety and quality assessments; Vaccine adjuvant
informatics.
164 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 41 1 E-ISBN: 978 1 908818 41 6

Annotating new genes
From in silico screening to experimental
validation
S Uchida, Max-Planck-Institute, Germany
Woodhead Publishing Series in Biomedicine
No. 15
In Annotating new genes the author
considers his teams approach as applied
to evolutionary-conserved, heart-enriched
genes with unknown functions. All the above
mentioned methods have been validated by
students working in the feld of bioinformatics
and developmental biology to provide a
step-by-step methodology to obtain highly
publishable data as well as knowledge creation
that will aid the development of products
which can be used in the feld of regenerative
medicine.
CONTENTS
Databases and software to make your research life easier;
How to program like a bioinformatician? Case study: C-It,
knowledge database for screening evolutionarily conserved,
tissue-enriched, uncharacterized genes; Experimental
validation: Concepts and practice; Further application: Adult
stem cells and tissue regenerations; Conclusion.
196 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 68 8 E-ISBN: 978 1 908818 12 6

Open source
software in life
science research
Practical solutions to
common challenges in the
pharmaceutical industry
and beyond
Edited by L Harland, Pfzer
and M Forster, Syngenta, UK
Woodhead Publishing Series in Biomedicine
No. 16
The free/open source approach has grown
from a minor activity to become a signifcant
producer of robust, task-orientated
software for a wide variety of situations
and applications. Examples range from core
infrastructure platforms such as the apache
web-server, powerful document indexing and
search tools such as Lucene, through to major
user-orientated systems such as Mediawiki
(which powers Wikipedia) and Drupal (which
powers many diverse websites). To life science
informatics groups, these systems present an
appealing proposition - high quality software
at a very attractive price. Open source
software in life science research considers
how industry and applied research groups have
embraced these resources, discussing practical
implementations that address real-world
business problems.
CONTENTS
Building research data handling systems with open source
tools; Interactive predictive toxicology with Bioclipse
and OpenTox; Utilizing open source software to facilitate
communication of chemistry at RSC; Open source software
for mass spectrometry and metabolomics; Open source
software for image processing and analysis: Picture this with
ImageJ; Integrated data analysis with KNIME; Investigation-
Study-Assay, a toolkit for standardizing data capture
and sharing; GenomicTools: An open source platform for
developing high-throughput analytics in genomics; Creating
an in-house omics data portal using EBI Atlas software;
Setting up an omics platform in a small biotech; Squeezing
big data into a small organisation; Design Tracker: An easy
to use and fexible hypothesis tracking system to aid project
team working; Free and open source software for web-based
collaboration; Developing scientifc business applications
using open source search and visualisation technologies;
Utopia Documents: Transforming how industrial scientists
interact with the scientifc literature; Semantic MediaWiki
in applied life science and industry: Building an Enterprise
Encyclopaedia; Building disease and target knowledge with
Semantic MediaWiki; Chem2Bio2RDF: A semantic resource for
systems chemical biology and drug discovery; TripleMap: A
web-based semantic knowledge discovery and collaboration
application for biomedical research; Extreme scale clinical
analytics with open source software; Validation and
regulatory compliance of free/open source software; The
economics of free/open source software in industry.
582 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 97 8 E-ISBN: 978 1 908818 24 9

Protein folding in
silico
Protein folding versus
protein structure
prediction
Edited by I Roterman-
Konieczna, Jagiellonian
University Medical College,
Poland
Woodhead Publishing Series in Biomedicine
No. 22
Protein folding is a process by which a protein
structure assumes its functional shape of
conformation, and has been the subject of
research since the publication of the frst
software tool for protein structure prediction.
Protein folding in silico approaches this
issue by introducing an ab initio model that
attempts to simulate as far as possible the
folding process as it takes place in vivo, and
attempts to construct a mechanistic model on
the basis of the predictions made. The opening
chapters discuss the early stage intermediate
and late stage intermediate models, followed
by a discussion of structural information
that affects the interpretation of the folding
process. The second half of the book covers a
variety of topics including ligand binding site
recognition, the fuzzy oil drop model and
its use in simulation of the polypeptide chain,
and misfolded proteins. The book ends with
an overview of a number of other ab initio
methods for protein structure predictions and
some concluding remarks.
CONTENTS
The early-stage intermediate; The late-stage intermediate;
Structural information involved in the interpretation of the
stepwise protein folding process; The divergence entropy
characterizing the internal force feld in proteins; Ligand-
binding-site recognition; Use of the fuzzy oil drop model
to identify the complexation area in protein homodimers;
Simulation of the polypeptide chain folding process using
the fuzzy oil drop model; Misfolded proteins; A short
description of other selected ab initio methods for protein
structure prediction; Conclusion.
240 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 17 6 E-ISBN: 978 1 908818 25 6

Bioinformatics, computing and life sciences
5
MATLAB

in
bioscience and
biotechnology
L Burstein, Technion, Haifa
University, Israel
Woodhead Publishing Series
in Biomedicine No. 3
MATLAB

in bioscience and biotechnology


presents an introductory Matlab course
oriented towards various collaborative
areas of biotechnology and bioscience. It
concentrates on Matlab fundamentals and
gives examples of its application to a wide
range of current bioengineering problems in
computational biology, molecular biology,
bio-kinetics, biomedicine, bioinformatics,
and biotechnology. In the last decade
Matlab has been presented to students as
the frst computer program they learn.
Consequently, many non-programmer
students, engineers and scientists have
come to regard it as user-friendly and
highly convenient in solving their specifc
problems. Numerous books are available
on programming in Matlab for engineers in
general, irrespective of their specialization,
or for those specializing in some specifc area,
but none have been designed especially for
such a wide, interdisciplinary, and topical
area as bioengineering. Thus, in this book,
Matlab is presented with examples and
applications to various school-level and
advanced bioengineering problems - from
growing populations of microorganisms and
population dynamics, reaction kinetics and
reagent concentrations, predator-prey models,
mass-transfer and fow problems, to sequence
analysis and sequence statistics.
CONTENTS
MATLAB

basics; MATLAB

graphics; Script, function fles


and some useful MATLAB

functions; Ordinary and partial


differential equation solvers; Bioinformatics tool for
sequence analysis.
248 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 907568 04 6 E-ISBN: 978 1 908818 03 4
GENETICS AND GENOMICS
NEW
Gene expression analysis in the
RNA world
J Q Clement, Texas Southern University, USA
Woodhead Publishing Series in Biomedicine
No. 61
Gene expression analysis in the RNA world
is a practical guide to the principles and
techniques that are essential to RNA-based
gene expression analysis. Key features include
a detailed presentation of the procedures
and methods for triplicates, time course,
and recovery studies involving the use of
multiple microarrays and correlation analysis
between microarray results, RT-PCR, and
Northern blotting. Each step of the microarray
experimental process from bench work of
RNA isolation through to computational and
bioinformatics analysis is described in detail.
CONTENTS
Gene expression regulation - the concept and practice
of a Rnase-Free Lab; Total RNA isolation through
ultracentrifugation versus commercial kits, RNA integrity
assessment; Using total RNA for gene-specifc expression
studies using RT-PCR and Northern Analysis; Using total
RNA for genome-wide expression studies using microarray
analysis; Critical comments on bioinformatics software and
web-based resources.
220 pages 234 x 156mm (6 x 9) hardback Q3 2015
ISBN: 978 1 907568 30 5 E-ISBN: 978 1 908818 43 0
NEW
Gene therapy
Potential applications of
nanotechnology
S Nimesh, Health Canada /
Sant Canada, Canada
Woodhead Publishing Series
in Biomedicine No. 57
Gene therapy is emerging as a new class of
therapeutics for the treatment of inherited
and acquired diseases. However, poor
cellular uptake and instability of DNA in the
physiological milieu limits its therapeutic
potential, hence a vector which can protect
and effciently transport DNA to the target
cells must be developed. Nanotechnology-
based non-viral vectors have been proposed
as potential candidates. Various polymeric
nanoparticles have been shown to be
suitable, with high cellular uptake effciencies
and reduced cytotoxicity. These delivery
vectors form condensed complexes with DNA
which result in shielding against enzymatic
degradation and enhanced cellular targeting.
Advantages including easy manipulatibility,
high stability, low cost and high payload,
mean that nanoparticles from various
polymers have been exploited. Gene therapy
gives a systematic account of the many
aspects of nanotechnology mediated gene
therapy, from the preparation of nanoparticles
to physicochemical characterization, and
follows with applications in in vitro and
in vivo models. This book emphasizes the
various aspects of nanotechnology-based gene
therapy, with initial chapters detailing the
tools and techniques available for preparation
and in vitro and in vivo characterization
of nanoparticles. Later chapters provide
exhaustive details on polymeric systems
employed for gene therapy.
CONTENTS
Nanotechnology: An introduction; Methods of nanoparticles
preparation; Tools and techniques for physicochemical
characterization of nanoparticles; In vitro and in vivo
characterization of nanoparticles; Theory and limitations
to gene therapy; Targeted gene delivery mediated by
nanoparticles; Polymeric nanoparticles for gene delivery;
Poly-L-lysine; Chitosan; Polyethylenimine; Atelocollagen;
Protamine; Dendrimers; Cyclodextrin-containing polymers;
PLGA based nanoparticles; Nanomaterials and metallic
nanoparticles.
384 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 40 4 E-ISBN: 978 1 908818 64 5

Genetics and genomics
6
Annotating new
genes
From in silico screening to
experimental validation
S Uchida, Max-Planck-
Institute, Germany
Woodhead Publishing Series
in Biomedicine No. 15
In Annotating new genes the author
considers his teams approach as applied
to evolutionary-conserved, heart-enriched
genes with unknown functions. All the above
mentioned methods have been validated by
students working in the feld of bioinformatics
and developmental biology to provide a
step-by-step methodology to obtain highly
publishable data as well as knowledge creation
that will aid the development of products
which can be used in the feld of regenerative
medicine.
CONTENTS
Databases and software to make your research life easier;
How to program like a bioinformatician? Case study: C-It,
knowledge database for screening evolutionarily conserved,
tissue-enriched, uncharacterized genes; Experimental
validation: Concepts and practice; Further application: Adult
stem cells and tissue regenerations; Conclusion.
196 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 68 8 E-ISBN: 978 1 908818 12 6

Concepts and
techniques in
genomics and
proteomics
N Saraswathy and P
Ramalingam, Kumaraguru
College of Technology, India
Woodhead Publishing Series
in Biomedicine No. 5
Concepts and techniques in genomics and
proteomics covers the important concepts
of high-throughput modern techniques used
in the genomics and proteomics feld. Each
technique is explained with its underlying
concepts, and simple line diagrams and fow
charts are included to aid understanding and
memory. A summary of key points precedes
each chapter within the book, followed by
detailed description in the subsections. Each
subsection concludes with suggested relevant
original references.
CONTENTS
Introduction to genes and genomes; The human genome
project; Genomes of model organisms; High capacity
vectors; DNA sequencing methods; Genome mapping;
Genome sequencing methods; Genome sequence assembly
and annotation; Functional genomics; Introduction to
proteomics; Two-dimensional gel electrophoresis of proteins;
Mass spectrometry for proteomics; Protein Identifcation
by Peptide Mass Fingerprinting (PMF); Protein sequencing
techniques; Phosphoproteomics; Glycoproteomics.
268 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 907568 10 7 E-ISBN: 978 1 908818 05 8

INTELLECTUAL PROPERTY,
REGULATION
NEW
The impact of regulation on drug
development
G H Hennings, hgh regulatory sciences,
Germany
Woodhead Publishing Series in Biomedicine
No. 36
The impact of regulation on drug development
provides the reader with a basic understanding
of the evolution of global regulatory standards
relevant to the research and development
process of medicinal products and the role
regulatory science plays, i.e. the science
of developing new tools, standards and
approaches to assess the safety, effcacy,
quality and performance of regulated
products. This book provides practical
guidance on how to obtain such advice
effciently and how it is incorporated in global
regulatory planning and strategies.
CONTENTS
Developing effective medicines - a contribution to public
health; Evolution and maintenance of global regulatory
standards; Current regulatory issues of research and
development pipelines; The value chain from discovery
to post-authorisation research; Health authorities provide
scientifc (and regulatory) advice; Strategic regulatory plans
and planning.
200 pages 234 x 156mm (6 x 9) hardback Q1 2015
ISBN: 978 1 907568 70 1 E-ISBN: 978 1 908818 59 1
NEW
Quality assurance
Problem solving and
training strategies
for success in the
pharmaceutical and life
science industries
G Welty, Adelphi University,
USA
Woodhead Publishing Series in Biomedicine
No. 55
Quality assurance is necessary to maintain
quality and services in the pharmaceutical
and life science industries. Quality assurance
demonstrates that the logic and practice of
problem solving can integrate both program
effcacy and regulatory compliance. This
title is divided into three parts; the frst part
discusses the process by which a problem in
regulated industry is identifed, for example
a manufacturing deviation that leads to an
adulterated drug product, and reviews the
decision-making steps involved in remedying
the problem. The second part delves into
the staff training requirements of revised
procedures. The third part expands on this
discussion by considering piloting the proposed
module, preparing assessments of trainee
profciency, evaluating the training module,
including integrating rigorous evaluative
designs with formative program improvement,
and documenting the entire effort.
CONTENTS
Part 1 A systematic approach to problem solving: Framework
for continuous improvement; Investigations, root cause
analyses and CAPAs; The role of critical review in the
revision of procedures; Working with standard operating
procedures (SOPs). Part 2 Designing and developing training
materials: The design phase of the program improvement
model; Content development: A new employee orientation
program; Content development: A continuing cGMP training
program; Content development: Qualifcation of employees.
Part 3 Using the training materials: Assessing trainee
profciency; Pilot implementation; Training record- keeping;
Formative evaluation; Final implementation.
374 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 36 7 E-ISBN: 978 1 908818 62 1

Intellectual property, regulation
7
NEW
Biobanks
Patents or open science?
A De Robbio, University of
Padova, Italy
Woodhead Publishing Series
in Biomedicine No. 13
Biobanks represent an invaluable research
tool and, as a result of their intrinsic and
extrinsic nature, may be looked upon as
archives or repositories largely made up of
libraries, or collections of content where
the content is the biological material
derived from different individuals or species,
representing valuable tangible assets.
Biobanks analyses aspects of the commons
and common intellectual property relating
to the concepts of private property, not only
concerning data but biological materials as
well, and the advantages and disadvantages
of patents in scientifc research. Several
recent initiatives in biomedical research have
attempted to make their data freely available
to others, so as to foster innovation. Many
of these initiatives have adopted the open
source model, which has gained widespread
recognition in the computer industry. This title
is structured into eight chapters and begins
with an introduction, which is followed by
chapters that discuss how the term biobank
came about in scientifc literature; legal
matters relating to biobanks; and intellectual
and physical property. Later chapters
comprehensively analyse the intellectual
property of biobanks within the sphere of
copyright; biotechnological inventions and
research patentability; open data sharing in
biobanks; and biobanks as commons or vault.
CONTENTS
How the term biobank came about in scientifc literature;
Legal matters relating to biobanks: Privacy, confdentiality
and informed consent; Intellectual and physical property;
The intellectual property of biobanks within the sphere
of copyright; Biotechnological inventions and research
patentability; Open data sharing in biobanks: Open science
and its impact on society; Biobanks: Commons or vault?
70 pages 234 x 156mm (6 x 9) paperback 2013
ISBN: 978 1 907568 34 3 E-ISBN: 978 1 908818 61 4

Patently innovative
How pharmaceutical frms
use emerging patent law
to extend monopolies on
blockbuster drugs
R A Bouchard, Intellectual
Property Lawyer and Scholar,
Canada
Woodhead Publishing Series in Biomedicine
No. 7
Patently innovative provides a review
of the importance of traditional patent
law and emerging linkage regulations for
pharmaceutical products on the global stage,
with a focus on the linkage regime in Canada.
The primary focus is on how innovation in
the pharmaceutical sector can be strongly
regulated and how government regulation can
either stimulate or inhibit development of
breakthrough products.
CONTENTS
Drug approval, drug patenting, pharmaceutical linkage, and
public health policy; Empirical analysis of drug approval;
Empirical analysis of pharmaceutical innovation and drug
approval-drug patenting linkage; Empirical analysis of drug
patenting in multiple high-value cohorts; Implications of
empirical data: Are pharmaceutical linkage regulations
a success? Future directions: Testable hypotheses and
evolution toward global pharmaceutical linkage.
296 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 12 1 E-ISBN: 978 1 908818 08 9

Contract research and
manufacturing services (CRAMS)
in India
The business, legal, regulatory and tax
environment in the pharmaceutical and
biotechnology sectors
Edited by M Antani and G Gokhale, Nishith
Desai Associates, India
Woodhead Publishing Series in Biomedicine
No. 19
Contract research and manufacturing
services (CRAMS) in India provides a detailed
account of the current scenario in India and
the advantages that the Indian outsourcing
industry can offer in the feld of CRAMS.
Following an overview of the services and
their emergence in India, chapters in the book
begin by discussing the legal and regulatory
scenario and major concerns and issues. In the
latter part of the book, topics covered include
service agreements, dispute resolution and
contract negotiations, followed by a discussion
of the outlook for CRAMS in India.
CONTENTS
Overview of CRAMS; Legal and regulatory scenario; Issues
and concerns; Tax environment and related issues; Service
agreements; Negotiating a contract; Outlook and conclusion.
248 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 19 0 E-ISBN: 978 1 908818 16 4

LIFE SCIENCE, MOLECULAR AND
CELLULAR BIOLOGY
NEW
Fed-batch fermentation
A practical guide to scalable recombinant
protein production in Escherichia coli
G G Moulton
Woodhead Publishing Series in Biomedicine
No. 42
Fed-batch fermentation is primarily a practical
guide for recombinant protein production in E.
coli using a fed-batch fermentation process.
Ideal users of this guide are teaching labs and
R&D labs that need a quick and reproducible
process for recombinant protein production.
It may also be used as a template for the
production of recombinant protein product
for use in clinical trials. The guide highlights a
method whereby a medium cell density - fnal
Ods = 30-40 (A600) - fed-batch fermentation
process can be accomplished within a single
day with minimal supervision. This process
can also be done on a small (2L) scale that is
scalable to 30L or more. All reagents (media,
carbon source, plasmid vector and host cell)
used are widely available and are relatively
inexpensive. This method has been used to
produce three different protein products
following cGMP guidelines for Phase I clinical
studies.
CONTENTS
Introduction to fermentation; Typical recombinant E. coli
host cells and plasmids used; Generation of recombinant
clone and working cell bank; Generation of inoculants for
fed-batch culture; Fed-batch culture method; Analysis
of growth and production data; Parametric analysis for
periplasmic soluble production of recombinant product.
270 pages 234 x 156mm (6 x 9) hardback Q2 2014
ISBN: 978 1 907568 92 3 E-ISBN: 978 1 908818 33 1

Life science, molecular and cellular biology
8
NEW
Gene expression analysis in the
RNA world
J Q Clement, Texas Southern University, USA
Woodhead Publishing Series in Biomedicine
No. 61
Gene expression analysis in the RNA world
is a practical guide to the principles and
techniques that are essential to RNA-based
gene expression analysis. Key features include
a detailed presentation of the procedures
and methods for triplicates, time course,
and recovery studies involving the use of
multiple microarrays and correlation analysis
between microarray results, RT-PCR, and
Northern blotting. Each step of the microarray
experimental process from bench work of
RNA isolation through to computational and
bioinformatics analysis is described in detail.
CONTENTS
Gene expression regulation - the concept and practice
of a Rnase-Free Lab; Total RNA isolation through
ultracentrifugation versus commercial kits, RNA integrity
assessment; Using total RNA for gene-specifc expression
studies using RT-PCR and Northern Analysis; Using total
RNA for genome-wide expression studies using microarray
analysis; Critical comments on bioinformatics software and
web-based resources.
220 pages 234 x 156mm (6 x 9) hardback Q3 2015
ISBN: 978 1 907568 30 5 E-ISBN: 978 1 908818 43 0
NEW
Ultrafltration for bioprocessing
H Lutz, Millipore Corporation, USA
Woodhead Publishing Series in Biomedicine
No. 29
Ultrafltration (UF) is a key process in the
bioprocessing area and is used in almost every
bioprocess. Ultrafltration for bioprocessing
is written by a leading worker in the area and
includes many practical applications and case
studies. It is key reading for all those involved
in the biotechnology and biopharmaceutical
areas.
CONTENTS
Fundamentals; Membranes; Modules; Process confgurations;
Processing; Recovery; Cleanup; Manufacturing systems;
Trouble shooting.
200 pages 234 x 156mm (6 x 9) hardback Q1 2015
ISBN: 978 1 907568 46 6 E-ISBN: 978 1 908818 53 9

NEW
An introduction to biotechnology
The science, technology and medical
applications
W T Godbey, Tulane University, USA
Woodhead Publishing Series in Biomedicine
No. 24
An introduction to biotechnology is
a biotechnology textbook aimed at
undergraduates. It covers the basics of cell
biology, biochemistry and molecular biology,
and introduces laboratory techniques specifc
to the technologies addressed in the book. It
addresses specifc biotechnologies at both the
theoretical and application levels.
CONTENTS
Part 1 The cell: Plasma membrane - phospholipids, proteins,
cholesterol: Prokaryotic outer barriers - cell wall (NAMs,
NAGs, crosslinking); The cytoplasm - more proteins: Enzymes
(enzymes are catalysts, enzymes depend on proper protein
folding, enzymes used in science, enzymes used in industry;
The nucleus - organization of the genome (chromosomes,
DNA fbers, nucleosomes, DNA strands, RNA); Prokaryotic
genome organization - circular genome, attached to inner
plasma membrane; The central dogma - transcription
(Mrna); The life of a cell - the cell cycle (synthesis (S)
phase, mitosis (M), gap phases, cell cycle control). Part
2 Biotechnology: Applications to and of the cell; Genetic
engineering - genes (exons, introns, promoters, enhancers);
Gene delivery models - viral (adenovirus, adeno-associated
virus, herpesvirus, lentivirus/retrovirus); Gene delivery cargo
- DNA, RNA, siRNA; Fluorescence - quantum yield, Stokes
shift, brightness; Recombinant Proteins; Biofuels - from
cellulose degradation (biochemistry of cellulose); Stem cells
- cells with potential (totipotent, pluripotent, multipotent);
Transgenics; Cloning.
500 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 28 2 E-ISBN: 978 1 908818 48 5
NEW
Marine enzymes for biocatalysis
Sources, biocatalytic characteristics and
bioprocesses of marine enzymes
A Trincone, Istituto di Chimica Biomolecolare
(I.C.B.), Italy
Woodhead Publishing Series in Biomedicine
No. 38
Marine enzymes for biocatalysis initially
examines the nature and level of interest
in marine biological diversity, and outlines
the fundamentals of biocatalysis. It goes
on to detail sources of marine enzymes and
analyses examples from both chemical and
stereochemical viewpoints of catalysis,
including microbial enzymes and animal or
plant sources. The book goes on to explore the
future potential of marine bioprospecting in
biocatalysis.
CONTENTS
Source of marine enzymes; Processes and biocatalytic
characteristics; Bioprocesses; Biocatalytic characteristics.
576 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 80 0 E-ISBN: 978 1 908818 35 5

NEW
From plant
genomics to plant
biotechnology
Edited by S P Poltronieri,
Italian National Research
Council, Italy, N Burbulis,
Aleksandr Stulginskis
University, Lithuania and C Fogher, Catholic
University, Italy
Woodhead Publishing Series in Biomedicine
No. 53
From plant genomics to plant biotechnology
reviews the recent advancements in the
post-genomic era, discussing how different
varieties respond to abiotic and biotic
stresses, understanding the epigenetic
control and epigenetic memory (RNAs, DNA
methylation, histone modifcations and
polycomb complexes), the roles of non-
coding RNAs, applicative uses of RNA silencing
and RNA interference in plant physiology
and in experimental transgenics and plants
modifed to specifc aims (biofuels, production
of high-value pharmaceutical proteins in
plants, abiotic stress resistant wood trees
and ornamental plants). In the forthcoming
years these advancements will support the
production of plant varieties better suited to
resist biotic and abiotic stresses, for food and
non-food applications.
CONTENTS
From plant genomics to -omics technologies; Plant
microRNAs; Epigenetic control by plant Polycomb proteins:
New perspectives and emerging roles in stress response;
Metabolite profling for plant research; The uniqueness of
conifers; Cryptochrome genes modulate global transcriptome
of tomato; Genomics of grapevine: From genomics research
on model plants to crops and from science to grapevine
breeding; Grapevine genomics and phenotypic diversity
of bud sports, varieties and wild relatives; Peach ripening
transcriptomics unveils new and unexpected targets
for the improvement of drupe quality; Application of
doubled haploid technology in breeding of Brassica napus;
Plant biodiversity and biotechnology; Natural resveratrol
bioproduction.
274 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 29 9 E-ISBN: 978 1 908818 47 8

Life science, molecular and cellular biology
9
NEW
Bacterial cellular
metabolic systems
Metabolic regulation
of a cell system with
13
C-metabolic fux analysis
K Shimizu, Kyushu Institute
of Technology and Institute
of Advanced Biosciences of Keio University,
Japan
Woodhead Publishing Series in Biomedicine
No. 18
Bacterial cellular metabolic systems focuses
on this highly topical subject in relation to
culture environment and provides a detailed
analysis from gene level to metabolic level
regulation, as well as offering a discussion of
the most recent modelling approaches. The
book begins with an introduction to metabolic
mechanisms and to the metabolic regulation
of a cell, before moving on to discussing the
action of global regulators in response to a
specifc culture environment. The second
half of the book examines conventional
fux balance analysis and its applications,
13
C-metabolic fux analysis, and the effect of a
specifc gene knockout on the metabolism.
CONTENTS
Main metabolism; Brief overview of metabolic regulation of
a bacterial cell; Metabolic regulation by global regulators in
response to culture environment; Conventional fux balance
analysis and its applications;
13
C-metabolic fux analysis
and its applications; Effect of a specifc-gene knockout on
metabolism.
496 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 01 5 E-ISBN: 978 1 908818 20 1

Human papillomavirus infections
From the laboratory to clinical practice
F Cobo, Hospital de Poniente, Spain
Woodhead Publishing Series in Biomedicine
No. 14
This succinct review of the various facets of HPV
invection and disease will be very useful for the
intended audiences interested in this subject.
Doodys Reviews
Human papillomavirus (HPV) is one of the
most common causes of sexually transmitted
diseases worldwide, both in men and women.
Human papillomavirus infections provides the
scientifc background needed to understand
the natural history and pathogenesis of HPV
infection and offers discussion of its clinical
features, diagnosis, treatment and prevention.
CONTENTS
Introduction and epidemiological data; Basic virology:
Structure and nomenclature; Natural history and
transmission: Anatomic distribution; Pathogenesis and
clinical features; HPV infection and association with cancer;
Diagnosis of HPV infection; Clinical utility of HPV testing;
Treatment; Prevention: HPV vaccines.
168 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 74 9 E-ISBN: 978 1 908818 17 1

Therapeutic
antibody engineering
Current and future
advances driving the
strongest growth area
in the pharmaceutical
industry
W R Strohl, Johnson &
Johnson Biotechnology
Center of Excellence and L M Strohl, Medical
Illustrator, USA
Woodhead Publishing Series in Biomedicine
No. 11
An excellent balance between readability and depth of
material.... The book is well referenced and provides
plentiful opportunities to continue subject-specifc
learning.
mAbs Journal
An excellent book describing many aspects of
therapeutic antibody generation and the current market
share of these drugs. It is an up-to-date evaluation of
their production and clinical utility.
Doodys Reviews
Therapeutic antibody engineering examines
all aspects of engineering monoclonal
antibodies and analyses the effect that various
genetic engineering approaches will have
on candidates of the future. Chapters in the
frst part of the book provide an introduction
to monoclonal antibodies, their discovery
and development and the fundamental
technologies used in their production. In the
following chapters, the book covers a number
of specifc issues relating to different aspects
of antibody engineering, including variable
chain engineering, targets and mechanisms
of action, classes of antibody and the use
of antibody fragments, among many other
topics. The last part of the book examines
development issues, the interaction of human
IgGs with non-human systems, and cell line
development, before a conclusion looking at
future issues affecting the feld of therapeutic
antibody engineering.
CONTENTS
Introduction to biologics and monoclonal antibodies; Value
proposition for therapeutic monoclonal antibodies and Fc
fusion proteins; Antibody structurefunction relationships;
Fundamental technologies for antibody engineering; Sources
of antibody variable chains; Variable chain engineering
humanization and optimization approaches; Antibody
interactions with the immune system; Monoclonal antibody
targets and mechanisms of action; Therapeutic antibody
classes; Antibody Fc engineering for optimal antibody
performance; IgG glycans and glyco-engineering; Antibody
fragments as therapeutics; Multiple antibody and multi-
specifcity approaches; FcFPs and similar constructs using
Fc; Antibody-drug conjugates; Development issues: Antibody
stability, developability, immunogenicity, and comparability;
Interactions of human IgGs with non-human systems; Cell
line development; Issues facing therapeutic monoclonal
antibodies for the future.
696 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 37 4 E-ISBN: 978 1 908818 09 6

Therapeutic protein
drug products
Practical approaches
to formulation in
the laboratory,
manufacturing, and the
clinic
Edited by B K Meyer, Merck
Research Laboratories (MRL),
USA
Woodhead Publishing Series in Biomedicine
No. 8
Therapeutic protein drug products provides
a comprehensive overview of therapeutic
protein drug products, with an emphasis
on formulation beginning in the laboratory,
followed by manufacturing and administration
in the clinic. A list of many commercial
therapeutic drug products are described
and include the product name, dosages,
active concentration, buffer, excipients, Ph,
container type and route of administration.
The laboratory formulation sections focus on
the most common buffers, excipients, and Ph
ranges that are commonly tested in addition
to systematic approaches. Properties of
therapeutic protein formulations are described
and include opalescence, phase separation,
color, and subvisible particles. The drug
product manufacturing process, which includes
the process of compounding to flling, is also
covered. Methods of delivery in the clinic
are addressed, as well as delivery strategies.
Finally, a perspective on the regulatory
requirements for therapeutic protein
formulations is discussed.
CONTENTS
Commercial therapeutic protein drug products; A formulation
method to improve the physical stability of macromolecular-
based drug products; Properties of protein formulations;
Material and process compatibility testing; Compounding
and flling: Drug substance to drug product; Administration
in the clinic; Regulatory guidelines for the development of a
biotechnology drug product.
200 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 18 3 E-ISBN: 978 1 908818 10 2

Concepts and techniques in
genomics and proteomics
N Saraswathy and P Ramalingam, Kumaraguru
College of Technology, India
Woodhead Publishing Series in Biomedicine
No. 5
CONTENTS
Introduction to genes and genomes; The human genome
project; Genomes of model organisms; High capacity
vectors; DNA sequencing methods; Genome mapping;
Genome sequencing methods; Genome sequence assembly
and annotation; Functional genomics; Introduction to
proteomics; Two-dimensional gel electrophoresis of proteins;
Mass spectrometry for proteomics; Protein Identifcation
by Peptide Mass Fingerprinting (PMF); Protein sequencing
techniques; Phosphoproteomics; Glycoproteomics.
268 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 907568 10 7 E-ISBN: 978 1 908818 05 8

Life science, molecular and cellular biology
10
Open source
software in life
science research
Practical solutions to
common challenges in the
pharmaceutical industry
and beyond
Edited by L Harland, Pfzer
and M Forster, Syngenta, UK
Woodhead Publishing Series in Biomedicine
No. 16
The free/open source approach has grown
from a minor activity to become a signifcant
producer of robust, task-orientated
software for a wide variety of situations
and applications. Examples range from core
infrastructure platforms such as the apache
web-server, powerful document indexing and
search tools such as Lucene, through to major
user-orientated systems such as Mediawiki
(which powers Wikipedia) and Drupal (which
powers many diverse websites). To life science
informatics groups, these systems present an
appealing proposition - high quality software
at a very attractive price. Open source
software in life science research considers
how industry and applied research groups have
embraced these resources, discussing practical
implementations that address real-world
business problems.
CONTENTS
Building research data handling systems with open source
tools; Interactive predictive toxicology with Bioclipse
and OpenTox; Utilizing open source software to facilitate
communication of chemistry at RSC; Open source software
for mass spectrometry and metabolomics; Open source
software for image processing and analysis: Picture this with
ImageJ; Integrated data analysis with KNIME; Investigation-
Study-Assay, a toolkit for standardizing data capture
and sharing; GenomicTools: An open source platform for
developing high-throughput analytics in genomics; Creating
an in-house omics data portal using EBI Atlas software;
Setting up an omics platform in a small biotech; Squeezing
big data into a small organisation; Design Tracker: An easy
to use and fexible hypothesis tracking system to aid project
team working; Free and open source software for web-based
collaboration; Developing scientifc business applications
using open source search and visualisation technologies;
Utopia Documents: Transforming how industrial scientists
interact with the scientifc literature; Semantic MediaWiki
in applied life science and industry: Building an Enterprise
Encyclopaedia; Building disease and target knowledge with
Semantic MediaWiki; Chem2Bio2RDF: A semantic resource for
systems chemical biology and drug discovery; TripleMap: A
web-based semantic knowledge discovery and collaboration
application for biomedical research; Extreme scale clinical
analytics with open source software; Validation and
regulatory compliance of free/open source software; The
economics of free/open source software in industry.
582 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 97 8 E-ISBN: 978 1 908818 24 9

MANAGEMENT AND BUSINESS
NEW
Successful biopharmaceutical
operations
Driving change
C Driscoll, Driscoll Consulting Group, USA
Woodhead Publishing Series in Biomedicine
No. 48
Successful biopharmaceutical operations
provides a practical guide to transforming
biopharma companies into industry leaders
through a focus on driving change. The
industry has a blind spot concerning this
kind of work, because successful change
management comes from a focus on people,
while our technically-minded ranks invariably
prefer a technical focus. This cognitive bias
causes us to pick up the tools we like the best
and to swing them enthusiastically - whether
they are working or not. This book provides
new tools, and readers gain an understanding
of how biopharma organizations developed
into the cultures we see currently.
CONTENTS
Part 1 The need for change: Something isnt right?; The
problem of smart people; The ease of fundamentalism; The
silo skyline; Integrating the appearance of improvement; Call
it what it is: Cost reduction; When you turn the wheel and
nothing happens; When you take public opinion polls to see
whats wrong; When you realize you run a daycare center.
Part 2 The change process: Change management framework;
Cognitive bias; The compliance card; Simplicity vs.
complexity; Accountability vs. innocent bystander; Bringing
it all together: Engagement, gameplan, sustainability. Part
3 Noise (youll want to read this): Lessons from Oobleck;
Theyre under too much pressure; We need to give them
time; They dont feel comfortable bringing things up.
270 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 13 8 E-ISBN: 978 1 908818 42 3

NEW
The impact of regulation on drug
development
G H Hennings, hgh regulatory sciences,
Germany
Woodhead Publishing Series in Biomedicine
No. 36
The impact of regulation on drug development
provides the reader with a basic understanding
of the evolution of global regulatory standards
relevant to the research and development
process of medicinal products and the role
regulatory science plays, i.e. the science
of developing new tools, standards and
approaches to assess the safety, effcacy,
quality and performance of regulated
products. This book provides practical
guidance on how to obtain such advice
effciently and how it is incorporated in global
regulatory planning and strategies.
CONTENTS
Developing effective medicines - a contribution to public
health; Evolution and maintenance of global regulatory
standards; Current regulatory issues of research and
development pipelines; The value chain from discovery
to post-authorisation research; Health authorities provide
scientifc (and regulatory) advice; Strategic regulatory plans
and planning.
200 pages 234 x 156mm (6 x 9) hardback Q1 2015
ISBN: 978 1 907568 70 1 E-ISBN: 978 1 908818 59 1

Therapeutic risk management of
medicines
S J Mayall and A K Banerjee, Pope Woodhead
& Associates, UK
Woodhead Publishing Series in Biomedicine
No. 30
Legislation has evolved rapidly over the last
decade and Therapeutic risk management of
medicines is an authoritative, yet practical,
guide on planning, writing, implementing
and evaluating risk management plans for
medicines globally. The book also includes
chapters on the historical development,
lessons from other industries, the regulatory
and health authority perspective and public
communication of beneft risk. This topic
is of critical importance not only to the
pharmaceutical and biotechnology industry,
but also prescribers, pharmacists, regulators
and healthcare policymakers.
CONTENTS
Introduction and historical background of risk management
plans; EU-RMP (Risk Management Plan); USA REMS
(Risk Evaluation and Mitigation Strategies); Safety
specifcation; Pharmacovigilance planning; Assessing
the need for risk minimization; Risk minimization tools;
Implementation of RMPs and REMS; Evaluation of RMPs
and REMS; Developmental risk management plans;
Effectively negotiating with the health authorities; Public
communication of beneft risk.
250 pages 234 x 156mm (6 x 9) hardback 2014
ISBN: 978 1 907568 48 0 E-ISBN: 978 1 908818 27 0

Management and business
11
NEW
CAPA in the pharmaceutical and
biotech industries
How to implement an effective nine step
program
J Rodriguez, Monarch Quality Systems
Solutions, USA
Woodhead Publishing Series in Biomedicine
No. 33
CAPA in the pharmaceutical and biotech
industries contains the most current
information on how to implement, develop
and maintain an effective Corrective Action
and Preventive Action (CAPA) and investigation
program using a nine step closed-loop process
approach for medical device, pharmaceutical
and biologic manufacturers, as well as any
company or institution, which has to maintain
a quality system.
CONTENTS
Step-by-step basics on how to build a comprehensive CAPA
program; How to use a nine step CAPA process to effectively
handle any product or quality system failures; How to
effectively use failure investigations and CAPA in order to
handle, and process complaints investigations in a timely
manner; How to effectively use risk management concepts
to assign a risk level to failure investigations in order to
prioritize based on risk; How to use Failure Mode and Effect
Analysis to identify potential failure modes; How to review
data from post production, and post market in order to
determine the need for changes as well as new mitigations
activities; Responding effectively to non-conformances,
failures, deviations and complaints by identifying root causes
and implementing corrective and preventative actions;
Effcient use of root cause analysis tools; Optimizing CAPA
and RCA documentation procedures; Essential SOPs and
other documentation; Review areas of common FDAs 483
inspection observations; How to effectively identify and
track deviations and non-conformances; Learning to analyse
and trend data to identify existing and potential causes of
non-conformance; Gathering, organizing and managing the
correct data required to conduct an effective Root Cause
Investigation; Review the elements of a good investigation;
Integrating RCA and CAPA with other systems such as:
Internal auditing, deviations, Out Of Specifcation (OOS)
and complaint handling; Performing trend analysis and using
effective RCA tools; How to use of statistical methodologies
when performing Root Cause Analysis; CAPA and the linkage
to effective management review and annual product reviews;
Step-by-step basics on how to build your own comprehensive
CAPA program; Most important: Review of the real benefts
of an effective CAPA system.
270 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 58 9 E-ISBN: 978 1 908818 37 9

NEW
The application of
statistical process control
in the pharmaceutical and
biotechnology industries
A practical approach
T Cochrane, Napp Pharmaceutical Group, UK
Woodhead Publishing Series in Biomedicine
No. 28
The application of statistical process control
in the pharmaceutical and biotechnology
industries is a starting point for anyone
interested in or tasked with introducing these
new pharma initiatives. This book is a practical
guide on how to apply statistical process
control or SPC within the pharmaceutical
industry. It considers the various areas where
SPC thinking can be applied and demonstrates
the benefts that can be achieved by its use. It
encourages all those involved in the industry
- whether it be production, quality or the
regulatory bodies - to start assessing data in a
different way.
CONTENTS
History of statistical process control; Why now in the
pharmaceutical and biotech industry; Getting the culture
right; The pharmaceutical industry; The system; SPC theory;
Raw materials and supplier development; Key parameters;
Auditing; Manufacturing processes; Training; Finished
product testing; Critical quality attributes; Validation;
Continuous verifcation; The annual product review; Putting
all the information together; Reducing the risk in the system;
Continuous improvement teams; Sales; Case studies.
220 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 33 6 E-ISBN: 978 1 908818 36 2
NEW
The funding of biopharmaceutical
research and development
D R Williams, Appalachian State University,
USA
Woodhead Publishing Series in Biomedicine
No. 43
The funding of biopharmaceutical research
and development provides a comprehensive
critical review of the funding of research
and development (R&D) in the human
biopharmaceutical market sector. It addresses
both private and public funding sources
available in the US and internationally.
CONTENTS
Introduction to the biopharmaceutical market; Synopsis
of theories of the frm and valuation methods; Innovation
and the merging of the pharmaceutical and biotechnology
industries; The funding of basic research and publicprivate
partnerships; Strategic alliances; Angel and venture capital;
The initial public offering; Conclusion.
284 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 94 7 E-ISBN: 978 1 908818 38 6

NEW
Lean
biomanufacturing
Creating value through
innovative bioprocessing
approaches
N J Smart, Smart Consulting
Group, USA
Woodhead Publishing Series in Biomedicine
No. 37
The objective of this book is to re-visit
lean principles and then apply them
sympathetically - in a highly practical
approach - to the specifc needs of
pharmaceutical processes, which present
signifcantly different challenges to more
mainstream manufacturing processes.
CONTENTS
An introduction to lean biomanufacturing; Lean technologies/
methods to be applied to biomanufacturing; Creation,
execution and implementation of the Transition Plan; Issues
and problems for the biopharmaceutical industry that make
the situation challenging; Developing a lean approach to
biopharmaceutical processes; The contribution of simulation
models in the development of lean biopharmaceutical
processes; Integration of biomanufacturing with lean
laboratory operations; Lean compliance and considerations
connected with enabling lean manufacturing; Ready to use
technologies and their role in lean biomanufacturing.
384 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 78 7 E-ISBN: 978 1 908818 40 9
NEW
Orphan drugs
Understanding the rare disease market
and its dynamics
E Hernberg-Stahl, Late Phase Solutions Europe
AB, Sweden and M Reljanovic
Woodhead Publishing Series in Biomedicine
No. 46
There are between 5,000 and 7,000 rare
diseases and the number of patients
suffering from them is estimated to be more
than 50 million in the US and Europe. This
authoritative and comprehensive book makes
the reader familiar with the processes of
bringing orphan drugs to the global market.
Orphan drugs provides a comprehensive
overview of strategy, key activities and
considerations of how to bring an orphan
drug from concept to the market and make it
available to patients. It is a source of updated
information, news and trends for those who
are already active in this fast-moving feld.
CONTENTS
Orphan drugs and orphan drug legislation; Characteristics
of rare diseases; Patient network and advocacy groups;
Organisations and networks dedicated to rare diseases and
orphan drugs; Policies and research funding; Designing robust
clinical trials for orphan drugs; Market access procedures for
orphan drugs.
334 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 09 1 E-ISBN: 978 1 908818 39 3

Management and business
12
NEW
21st Century quality
management and good
management practices
Value added compliance for the
pharmaceutical and biotechnology
industry
S Williams, Consultant, Australia
Woodhead Publishing Series in Biomedicine
No. 31
21st Century quality management and good
management practices is a practical guide
on how to apply 21st century principles
in the pharmaceutical and biotechnology
workplace. The book includes simple
understandable examples and case studies
on modern compliance. The book serves as a
practitioners guide and is an ideal companion
for pharmaceutical and biotechnology industry
professionals and students studying quality
management and GMP compliance.
CONTENTS
International rules and regulations in the life science
industry; Pharmaceutical quality management and quality
systems (ICH Q10); Fundamentals of good manufacturing
practices (GMP); Validation; Pharmaceutical quality risk
management (ICH Q9); Building quality into products (ICH Q8
and QbD); Process control and process analytical technology;
CAPA, failure investigation and root cause analysis; Effective
training and education; Behavioural GMPs, deviations and
human error reduction; Supply chain integrity; Compliance
auditing and product reviews.
250 pages 234 x 156mm (6 x 9) hardback Q2 2015
ISBN: 978 1 907568 50 3 E-ISBN: 978 1 908818 56 0

Outsourcing biopharma R&D to
India
P R Chowdhury, J. Sagar Associates, India
Woodhead Publishing Series in Biomedicine
No. 2
Several global pharma-biotech majors
ascertained large market requirements within
India and capitalized on the advantage of
serving Indian customers. Strategies were
devised to optimize operational expenses
with the setting up of on-site R&D to develop
products for local requirements. In view
of this, this book seeks to explore various
nuances of the outsourcing sector with respect
to biopharma in India.
CONTENTS
Biopharma outsourcing in India: Its evolution; Indias core
competitive advantage in R&D in the biopharma sector: The
impetus for outsourcing; Different modes of outsourcing
biopharma R&D to India; The Indian regulatory environment:
A historical perspective; Implications of the changing
regulatory environment in India; Creating contracts for
outsourcing in the biopharma industry; Environmental,
health and safety guidelines and biopharma outsourcing: An
Indian perspective; Certifcations; The need for due diligence
of service providers.
130 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 907568 08 4 E-ISBN: 978 1 908818 01 0

Contract research
and manufacturing
services (CRAMS) in
India
The business, legal,
regulatory and tax
environment in the
pharmaceutical and
biotechnology sectors
Edited by M Antani and G Gokhale, Nishith
Desai Associates, India
Woodhead Publishing Series in Biomedicine
No. 19
Contract research and manufacturing
services (CRAMS) in India provides a detailed
account of the current scenario in India and
the advantages that the Indian outsourcing
industry can offer in the feld of CRAMS.
Following an overview of the services and
their emergence in India, chapters in the book
begin by discussing the legal and regulatory
scenario and major concerns and issues. In the
latter part of the book, topics covered include
service agreements, dispute resolution and
contract negotiations, followed by a discussion
of the outlook for CRAMS in India and some
concluding remarks. Several appendices are
included, offering a list of major players in
the feld and various forms for use in licence
applications.
CONTENTS
Overview of CRAMS; Legal and regulatory scenario; Issues
and concerns; Tax environment and related issues; Service
agreements; Negotiating a contract; Outlook and conclusion.
248 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 19 0 E-ISBN: 978 1 908818 16 4

Practical
leadership for
biopharmaceutical
executives
J Y Chin, Medical Science
Liaison (MSL) Institute, USA
Woodhead Publishing Series
in Biomedicine No. 1
CONTENTS
Leadership as a phenomenon; Seven managerial leadership
competencies; Three commitments of pharmaceutical
executives: Presence; Three commitments of pharmaceutical
executives: Stewardship; Three commitments of
pharmaceutical executives: Development; Self-concept
as leader; Conclusion: A new model of biopharmaceutical
executive leadership.
216 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 907568 06 0 E-ISBN: 978 1 908818 02 7

A biotech managers
handbook
A practical guide
Edited by M ONeill, Eolas
Biosciences Limited and M
M Hopkins, University of
Sussex, UK
Woodhead Publishing Series
in Biomedicine No. 9
A biotech managers handbook lays out - in
a simple, straightforward manner - for the
manager or would-be entrepreneur the basic
principles of running a biotech company. The
book starts with outlining the state of the
biopharmaceutical industry and goes on to
explain the importance of planning (no matter
what the size of the company).
CONTENTS
The bioscience sector: Challenges and opportunities;
Academic innovation: So you want to be a bio-entrepreneur?
Leadership and you; Managing self, situations and stress;
Its all in the plan; Exploring funding routes for therapeutics
frms; Raising funds and managing fnances; Introduction to
intellectual property; Managing projects and portfolios in
R&D: Why and how; Successful registration of new therapies;
Clinical trials: Design and practice; Business development:
Starting out; Business development: To the deal and beyond;
Conclusions and fnal thoughts.
414 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 14 5 E-ISBN: 978 1 908818 15 7
Commercializing the stem cell
sciences
O Harvey, University of Sydney, Australia
Woodhead Publishing Series in Biomedicine
No. 12
Commercializing the stem cell sciences offers
a comparative analysis of the commercial
methods adopted in the global stem cell
industries. It seeks to establish whether
there is an optimum commercial model and
to examine what emerging companies can
learn from their predecessors. Following an
introduction to stem cell sciences and the
problems involved in their commercialization,
the book begins with a discussion of stem cell
treatments from a global perspective, and the
role of innovation in the commercialization of
biotechnology in general. In the second half
of the book, chapters focus on the different
strategies that can be employed and their
relative risks and values, before a conclusion
that looks at potential new developments in
the feld.
CONTENTS
Introduction: Stem cell science, biotechnology and the
problem of commercialization; Stem cell treatments in a
global marketplace; The role of innovation systems in the
commercialization of biotechnology; Low-risk, low-value:
Adult stem cells; High-risk, high-value: Embryonic stem cells;
Low-risk, low-value: iPS cells; What does the future hold?
212 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 60 2 E-ISBN: 978 1 908818 14 0

Management and business
13
Patently innovative
How pharmaceutical frms
use emerging patent law
to extend monopolies on
blockbuster drugs
R A Bouchard, Intellectual
Property Lawyer and Scholar,
Canada
Woodhead Publishing Series in Biomedicine
No. 7
Patently innovative provides a review
of the importance of traditional patent
law and emerging linkage regulations for
pharmaceutical products on the global stage,
with a focus on the linkage regime in Canada.
The primary focus is on how innovation in
the pharmaceutical sector can be strongly
regulated and how government regulation can
either stimulate or inhibit development of
breakthrough products.
CONTENTS
Drug approval, drug patenting, pharmaceutical linkage, and
public health policy; Empirical analysis of drug approval;
Empirical analysis of pharmaceutical innovation and drug
approval-drug patenting linkage; Empirical analysis of drug
patenting in multiple high-value cohorts; Implications of
empirical data: Are pharmaceutical linkage regulations
a success? Future directions: Testable hypotheses and
evolution toward global pharmaceutical linkage.
296 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 12 1 E-ISBN: 978 1 908818 08 9

Clinical research in
Asia
Opportunities and
challenges
U Sahoo, Chiltern, India
Woodhead Publishing Series
in Biomedicine No. 10
An important contribution to the feld of global
research ethics
Doodys Book Reviews
Asia is increasingly taking on a leading role
in the felds of Good Clinical Practice (GCP)
and ethics, two areas that are central to
clinical research practices worldwide. Clinical
research in Asia examines the evolution of
these key sectors in the Asian countries where
the greatest developments are taking place,
offering valuable perspectives on a wide range
of issues affecting clinical research.
CONTENTS
Clinical research in Asia: A brief overview; Clinical research
in Japan; Clinical research in India; Clinical research in
China; Clinical research in South Korea; Clinical research in
Taiwan; Clinical research in Singapore; Clinical research in
Thailand; Clinical research in Malaysia; Clinical research in
Hong Kong; Clinical research in the Philippines, Indonesia
and Vietnam; Conclusions.
412 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 00 8 E-ISBN: 978 1 908818 13 3

MANUFACTURING AND
PROCESSING
NEW
Ultrafltration for bioprocessing
H Lutz, Millipore Corporation, USA
Woodhead Publishing Series in Biomedicine
No. 29
Ultrafltration (UF) is a key process in the
bioprocessing area and is used in almost every
bioprocess. Ultrafltration for bioprocessing
is written by a leading worker in the area and
includes many practical applications and case
studies. It is key reading for all those involved
in the biotechnology and biopharmaceutical
areas.
CONTENTS
Fundamentals; Membranes; Modules; Process confgurations;
Processing; Recovery; Cleanup; Manufacturing systems;
Trouble shooting.
200 pages 234 x 156mm (6 x 9) hardback Q1 2015
ISBN: 978 1 907568 46 6 E-ISBN: 978 1 908818 53 9
NEW
The application of
statistical process control
in the pharmaceutical and
biotechnology industries
A practical approach
T Cochrane, Napp Pharmaceutical Group, UK
Woodhead Publishing Series in Biomedicine
No. 28
The application of statistical process control
in the pharmaceutical and biotechnology
industries is a starting point for anyone
interested in or tasked with introducing these
new pharma initiatives. This book is a practical
guide on how to apply statistical process
control or SPC within the pharmaceutical
industry. It considers the various areas where
SPC thinking can be applied and demonstrates
the benefts that can be achieved by its use. It
encourages all those involved in the industry
- whether it be production, quality or the
regulatory bodies - to start assessing data in a
different way.
CONTENTS
History of statistical process control; Why now in the
pharmaceutical and biotech industry; Getting the culture
right; The pharmaceutical industry; The system; SPC theory;
Raw materials and supplier development; Key parameters;
Auditing; Manufacturing processes; Training; Finished
product testing; Critical quality attributes; Validation;
Continuous verifcation; The annual product review; Putting
all the information together; Reducing the risk in the system;
Continuous improvement teams; Sales; Case studies.
220 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 33 6 E-ISBN: 978 1 908818 36 2

CAPA in the pharmaceutical and
biotech industries
How to implement an effective nine step
program
J Rodriguez, Monarch Quality Systems
Solutions, USA
Woodhead Publishing Series in Biomedicine
No. 33
CAPA in the pharmaceutical and biotech
industries contains the most current
information on how to implement, develop
and maintain an effective Corrective Action
and Preventive Action (CAPA) and investigation
program using a nine step closed-loop process
approach for medical device, pharmaceutical
and biologic manufacturers, as well as any
company or institution, which has to maintain
a quality system.
CONTENTS
Step-by-step basics on how to build a comprehensive CAPA
program; How to use a nine step CAPA process to effectively
handle any product or quality system failures; How to
effectively use failure investigations and CAPA in order to
handle, and process complaints investigations in a timely
manner; How to effectively use risk management concepts
to assign a risk level to failure investigations in order to
prioritize based on risk; How to use Failure Mode and Effect
Analysis to identify potential failure modes; How to review
data from post production, and post market in order to
determine the need for changes as well as new mitigations
activities; Responding effectively to non-conformances,
failures, deviations and complaints by identifying root causes
and implementing corrective and preventative actions;
Effcient use of root cause analysis tools; Optimizing CAPA
and RCA documentation procedures; Essential SOPs and
other documentation; Review areas of common FDAs 483
inspection observations; How to effectively identify and
track deviations and non-conformances; Learning to analyse
and trend data to identify existing and potential causes of
non-conformance; Gathering, organizing and managing the
correct data required to conduct an effective Root Cause
Investigation; Review the elements of a good investigation;
Integrating RCA and CAPA with other systems such as:
Internal auditing, deviations, Out Of Specifcation (OOS)
and complaint handling; Performing trend analysis and using
effective RCA tools; How to use of statistical methodologies
when performing Root Cause Analysis; CAPA and the linkage
to effective management review and annual product reviews;
Step-by-step basics on how to build your own comprehensive
CAPA program; Most important: Review of the real benefts
of an effective CAPA system.
270 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 58 9 E-ISBN: 978 1 908818 37 9

Manufacturing and processing
14
NEW
21st Century quality
management and good
management practices
Value added compliance for the
pharmaceutical and biotechnology
industry
S Williams, Consultant, Australia
Woodhead Publishing Series in Biomedicine
No. 31
21st Century quality management and good
management practices is a practical guide
on how to apply 21st century principles
in the pharmaceutical and biotechnology
workplace. The book includes simple
understandable examples and case studies
on modern compliance. The book serves as a
practitioners guide and is an ideal companion
for pharmaceutical and biotechnology industry
professionals and students studying quality
management and GMP compliance.
CONTENTS
International rules and regulations in the life science
industry; Pharmaceutical quality management and quality
systems (ICH Q10); Fundamentals of good manufacturing
practices (GMP); Validation; Pharmaceutical quality risk
management (ICH Q9); Building quality into products (ICH Q8
and QbD); Process control and process analytical technology;
CAPA, failure investigation and root cause analysis; Effective
training and education; Behavioural GMPs, deviations and
human error reduction; Supply chain integrity; Compliance
auditing and product reviews.
250 pages 234 x 156mm (6 x 9) hardback Q2 2015
ISBN: 978 1 907568 50 3 E-ISBN: 978 1 908818 56 0
NEW
Stem cell bioprocessing
For cellular therapy, diagnostics and drug
development
T G Fernandes, M M Diogo and J M S Cabral,
Instituto Superior Tcnico (IST), Technical
University of Lisbon, Portugal
Woodhead Publishing Series in Biomedicine
No. 40
Stem cell bioprocessing describes the main
large-scale bioprocessing strategies for both
stem cell culture and purifcation, envisaging
the application of these cells for regenerative
medicine and drug screening. Bioreactor
confgurations are described, including their
applications for stem cell expansion and/
or differentiation. Stem cell separation
techniques are also discussed, aiming towards
both isolation and purifcation of rare stem
cell populations.
CONTENTS
Stem cells; Stem cell culture; Bioreactors for stem cell
culture; Stem cell bioseparation; Micro-scale technologies
for stem cell culture and separation; Stem cells and
regenerative medicine.
236 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 88 6 E-ISBN: 978 1 908818 30 0

NEW
Lean
biomanufacturing
Creating value through
innovative bioprocessing
approaches
N J Smart, Smart Consulting
Group, USA
Woodhead Publishing Series in Biomedicine
No. 37
The objective of this book is to re-visit
lean principles and then apply them
sympathetically - in a highly practical
approach - to the specifc needs of
pharmaceutical processes, which present
signifcantly different challenges to more
mainstream manufacturing processes. A major
goal of the book is to highlight those problems
and issues that appear more specifc or unique
to biopharmaceutical manufacturing situations
and to provide some insights into what
challenges are the important ones to solve
and what techniques, tools and mechanisms
to employ to be successful. The emphasis of
the book is to approach the subject from a
pharmaceutical practitioners point of view,
rather than to create another generic treatise
on lean manufacturing, of which there are
ample editions in the marketplace already.
CONTENTS
An introduction to lean biomanufacturing; Lean
technologies/methods to be applied to biomanufacturing;
Creation, execution and implementation of the Transition
Plan; Issues and problems for the biopharmaceutical
industry that make the situation challenging; Developing
a lean approach to biopharmaceutical processes; The
contribution of simulation models in the development
of lean biopharmaceutical processes; Integration of
biomanufacturing with lean laboratory operations; Lean
compliance and considerations connected with enabling lean
manufacturing; Ready to use technologies and their role in
lean biomanufacturing.
384 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 78 7 E-ISBN: 978 1 908818 40 9

MEDICAL SCIENCE AND
TECHNOLOGY, CANCER
RESEARCH
NEW
Innovative brain tumor therapy
Nanoparticle-based therapeutic strategies
G Caruso, L Merlo and M Caffo, University of
Messina, Italy
Woodhead Publishing Series in Biomedicine
No. 67
Despite recent advances, therapeutic efforts
have not been successful establishing a
defnitive strategy of treatment for brain
gliomas, because of the presence of the
blood-brain barrier. Innovative brain
tumor therapy presents a synopsis of the
studies on nanoparticles as ideal devices for
brain tumor treatment. Their nanometric
size, electrostatic charge, and lipophilic
characteristics allow them to penetrate into
the brain tissue freely. Promising in-vitro
results have been reported, but remain to be
validated in humans. This title focuses on the
blood-brain barrier pathophysiology in brain
tumors, and the possibilities of overcoming
this with nanoparticle-based systems. Relevant
patents of nanoparticles used as drug delivery
carriers are also reported, as well as future
scenarios in nanoparticles and stem cells.
CONTENTS
Brief introduction on brain tumor epidemiology and state of
the art in therapeutics; Blood brain barrier pathophysiology
in brain tumors; Brain drug delivery attempts; Nanoparticles
potential: Types, mechanisms of action, actual in vitro
and animal studies, recent patents; Future scenarios:
Nanoparticles and stem cells.
200 pages 234 x 156mm (6 x 9) hardback Q4 2014
ISBN: 978 1 907568 59 6 E-ISBN: 978 1 908818 74 4

Medical science and technology, cancer research
15
NEW
Imported infectious diseases
The impact in developed countries
F Cobo, Hospital de Poniente, Spain
Woodhead Publishing Series in Biomedicine
No. 66
The increase of immigrant population in
developed countries (mainly in Europe and
North America) together with an important
increase of international travel worldwide
are the two most important causes that
have contributed to the introduction and
diagnosis of imported/tropical infectious
diseases in these countries. These factors
have had an important impact in developed
countries in both social and economic aspects.
Imported infectious diseases focuses not
only on describing the infections, but also
in evaluating the current epidemiology, the
economic and social impact and the possibility
to apply immunization measures and vaccines.
The main purpose of this book is to give
an overview of the current most important
and frequent imported infectious diseases
in developed countries. The frst chapter
informs about the medical services that are
being offered to the immigrants in the main
developed countries depending on the legal
situation. Following chapters describe the
main surveillance systems for these kinds of
diseases, mainly in Europe and North America.
Finally, remaining chapters contain sections on
epidemiology, pathogenesis, clinical features,
diagnosis, treatment and prevention.
CONTENTS
Epidemiology; Surveillance systems in developed
countries; Febrile syndrome in immigrants and travelers;
Diarrhoea Syndrome; Current status of malaria;
Filariasis; Schistosomiasis: Bilharziasis; Strongyloidiasis;
Trypanosomiasis; Taeniasis and neurocysticercosis;
HIV infection; Syphilis; Tuberculosis: The problem of
multirresistance; Viral hepatitis; Leishmaniasis; Main causes
of viral hemorrhagic fever; Arthropod-borne viruses affecting
the central nervous system; Impact of imported infections
in health care providers; Prophylaxis, immunisation and
vaccination.
200 pages 234 x 156mm (6 x 9) hardback Q4 2014
ISBN: 978 1 907568 57 2 E-ISBN: 978 1 908818 73 7

NEW
Medical education, training and
care delivery in a virtual world
K Kahol, Arizona State University, USA
Woodhead Publishing Series in Biomedicine
No. 64
Medical education, training and care delivery
in a virtual world provides a one-stop shop
for educators, universities and researchers
looking to employ virtual worlds for delivering
medical education, training and employ virtual
worlds for clinical purposes. The book provides
theoretical basis and practical resources for
virtual-environment-driven medical education
and healthcare.
CONTENTS
Introduction to virtual worlds; Virtual worlds: Some
examples; Techniques; Setting the virtual universe; Setting
your avatars; Setting the interactions; Meetings in virtual
worlds; Applications; Training for technical and cognitive
skills in virtual worlds; Team training in virtual environments;
Validating virtual world training; Delivery of clinical
care through virtual worlds: Guidelines, challenges and
opportunities; Ethical and fnancial issues of virtual worlds.
220 pages 234 x 156mm (6 x 9) hardback Q3 2015
ISBN: 978 1 907568 03 9 E-ISBN: 978 1 908818 52 2
NEW
Translational biology in medicine
M Montano, Boston Medical Center, USA
Woodhead Publishing Series in Biomedicine
No. 41
The recent emphasis in biomedical research
on translational biology and personalized
medicine is revolutionizing conceptual and
experimental approaches to understanding
and improving human health. Translational
biology in medicine begins with an introduction
to experimental model systems for disease,
such as cell lines, primary cells, stem cells
and animal models for disease, followed by a
systematic description of genetic and genomic
profling and biomarker validation currently
used in biomedical research. Examples of
translation studies that have used these models
and methods are presented, including studies
in aging, tissue repair and chronic infection,
each with an emphasis on how personalized
medicine is transforming biomedicine.
CONTENTS
Model systems for disease: C.elegans; Mouse; Rhesus
macaque; Mammalian cell lines; Primary cells; Adult stem
cells and induced pluripotent stem (iPS) cells; Genomic
and genetic profling: Signatures for infection; Chronic
infammatory disease; Cancer risk; Accelerated aging and
longevity; Blood biomarkers: An overview of existing serum
test strategies for disease severity; Risk for progression;
Therapeutic benchmark targets; Examples of translational
models and methods in studies of human aging, muscle tissue
repair, and chronic infection; Bioethical considerations in
translational study design and bioethical considerations in
biomedical research; Concluding remarks and the future of
personalized medicine.
200 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 42 8 E-ISBN: 978 1 908818 65 2

NEW
Electroporation-based therapies
for cancer
From basics to clinical applications
Edited by R Sundararajan, Purdue University,
USA
Woodhead Publishing Series in Biomedicine
No. 49
Electroporation-based therapies for cancer
provides a comprehensive overview of
electroporation-based clinical studies in
the hospitals for various cancer treatments,
including melanomas, head and neck cancers,
chest wall breast carcinomas and colorectal
cancers. It also looks at research studies in the
lab using cell lines, primary cells, and animals.
CONTENTS
Clinical electro-chemo-therapy for advanced superfcial
melanoma; Effective electro-chemo-therapy for chest wall
recurrence of breast carcinoma; Electrochemotherapy
- aspects of clinical experience; Low and high voltage
electro-chemo-therapy for breast cancer: An in vitro model
study; Electrically-enhanced proliferation control of cancer-
stem-cell-like adult human mesenchymal stem cells a novel
modality of treatment; Why electroporation is a useful
technique for cancer treatments; Electro-endocrine therapy
for breast cancer; Electroporation of cervical and leukemia
cancer cells; Targeted delivery of siRNA and other diffcult to
transfect molecules using electroporation; Nanosecond, low
voltage pulses for electro-endocrine therapy; Low and high
voltage electroporation of ovarian cancer cells; Irreversible
electroporation; Electric feld distribution study of malignant
tumors.
250 pages 234 x 156mm (6 x 9) hardback Q1 2015
ISBN: 978 1 907568 15 2 E-ISBN: 978 1 908818 29 4

NEW
Bioinformatics for biomedical
science and clinical applications
K-H Liang, LinKo Medical Center, Chang Gung
Memorial Hospital, Taiwan R.O.C.
Woodhead Publishing Series in Biomedicine
No. 20
Contemporary biomedical and clinical research
is undergoing constant development thanks
to the rapid advancement of various high
throughput technologies at the DNA, RNA
and protein levels. These technologies can
generate vast amounts of raw data, making
bioinformatics methodologies essential in
their use for basic biomedical and clinical
applications. Bioinformatics for biomedical
science and clinical applications demonstrates
what these cutting-edge technologies can do
and examines how to design an appropriate
study, including how to deal with data and
address specifc clinical questions.
CONTENTS
Genomics; Transcriptomics; Proteomics; Systems biomedical
science; Clinical developments.
170 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 44 2 E-ISBN: 978 1 908818 23 2

Medical science and technology, cancer research
16
NEW
NMR metabolomics
in cancer research
M Cuperlovic-Culf, National
Research Council of Canada
Institute for Information
Technology, Canada
Woodhead Publishing Series
in Biomedicine No. 63
NMR metabolomics in cancer research presents
a detailed account of the NMR spectroscopy
methods applied to metabolomics mixture
analysis along with a discussion of their
advantages and disadvantages. The book
begins with an examination of the cancer
metabolic phenotype and experimental
methodology, before moving on to cover data
pre-processing and data analysis. Chapters in
the latter part of the book look at dynamic
metabolic profling, biomarker discovery,
and the application of NMR metabolomics for
different types of cancer.
CONTENTS
Biology Cancer metabolic phenotype; Experimental
methodology; Metabolomics NMR data pre-processing
Analysis of individual spectrum; Metabolomics data analysis
Processing and analysis of a dataset; Dynamic metabolic
profling and metabolite network and pathways modelling;
Biomarker discovery; NMR metabolomics application by
cancer type; Perspectives.
446 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 84 8 E-ISBN: 978 1 908818 26 3

Allergens and
respiratory
pollutants
The role of innate
immunity
Edited by M A Williams,
United States Environmental
Protection Agency, USA
Woodhead Publishing Series in Biomedicine
No. 4
CONTENTS
An introduction to allergic infammation and the innate
immune sensing of dangerous ambient pollutants by
the dendritic cell; Asthma: Primary immunomodulatory
pathways; Environmental lung injury and pattern recognition
receptors; Asthma exacerbations: A paradigm of synergy
between allergens, pollutants and viruses; Bronchial
hyperresponsiveness and lung infammation induced by
allergic immune response and oxidative stress: Role of innate
and adaptive immune responses; Effects of air pollutants on
allergic sensitization through the airway; Particulate matter
and oxidative stress: Dangerous partners in infammation,
vascular dysfunction and innate immunity; Diesel exhaust
particles and the airway epithelial celldendritic cell
interface in the control of immune homeostasis; Role of
macrophages in adverse pulmonary effects of particulate
pollutants; Particulate air pollution and vulnerability to
respiratory infections in children; The intersection of
respiratory syncytial virus infection, innate immunity and
allergic lung disease; Interactions between allergens and
dendritic cells: Pattern recognition receptors and their
function in the pathogenesis of allergic respiratory diseases.
312 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 907568 54 1 E-ISBN: 978 1 908818 06 5

Human
papillomavirus
infections
From the laboratory to
clinical practice
F Cobo, Hospital de
Poniente, Spain
Woodhead Publishing Series
in Biomedicine No. 14
This succinct review of the various facets of HPV
invection and disease will be very useful for the
intended audiences interested in this subject...There
are no comparable books.
Doodys Reviews
Human papillomavirus (HPV) is one of the
most common causes of sexually transmitted
diseases worldwide, both in men and women.
Human papillomavirus infections provides the
scientifc background needed to understand
the natural history and pathogenesis of HPV
infection and offers discussion of its clinical
features, diagnosis, treatment and prevention.
The book begins with chapters covering
the epidemiology, virology, history and
transmission of the infection, as well as its
pathogenesis and clinical features. Following
a discussion of the relationship between HPV
and cancer, chapters in the second half of the
book look at diagnosis, testing and treatment.
The book concludes with detailed coverage
of the prevention of HPV through worldwide
vaccination programmes.
CONTENTS
Introduction and epidemiological data; Basic virology:
Structure and nomenclature; Natural history and
transmission: Anatomic distribution; Pathogenesis and
clinical features; HPV infection and association with cancer;
Diagnosis of HPV infection; Clinical utility of HPV testing;
Treatment; Prevention: HPV vaccines.
168 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 74 9 E-ISBN: 978 1 908818 17 1

NANOSCIENCE AND
TECHNOLOGY IN MEDICINE
NEW
Nanoparticle-based approaches
to targeting drugs for severe
diseases
J L Arias, University of Granada, Spain
Woodhead Publishing Series in Biomedicine
No. 47
Nanoparticle-based approaches to targeting
drugs for severe diseases is devoted to the
analysis of the latest developments in the
use of passive and/or active targeting nano-
strategies for controlling the biodistribution
profles of pharmacotherapy agents and special
attention is given to recent advances in these
engineering approaches. This book provides
an in-depth and detailed analysis of the above
problems, and a comprehensive discussion of
the available solutions. It focuses on aspects of
the formulation of drug nanocarriers, alongside
characterisation techniques, toxicity issues,
regulatory aspects, and marketing.
CONTENTS
Integration of nanotechnology in pharmacotherapy;
Nanostructures in drug delivery; Nano-engineering strategies
for passive drug delivery and targeting; Nano-engineering
strategies for ligand-mediated drug delivery and targeting;
Nano-engineering strategies for stimuli-sensitive drug delivery
and targeting; Nano-engineering strategies in theragnosis;
Advanced nanomedicines against severe diseases.
300 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 11 4 E-ISBN: 978 1 908818 44 7
Nanoparticulate drug delivery
Perspectives on the transition from
laboratory to market
V Patravale, Institute of Chemical Technology,
India, P Dandekar and R Jain, Institute of
Chemical Technology, India
Woodhead Publishing Series in Biomedicine
No. 17
Nanoparticulate drug delivery highlights and
examines the transition of nanoparticulate
drug delivery systems, operating at scales of
billionths of a metre, from laboratory into a
commercially viable sector. The book describes
the need for various types of nanoparticulate
drug delivery systems in different application
areas, and assesses the challenges to society
associated with their advance.
CONTENTS
Nanoparticulate systems as drug carriers: The need;
Nanoparticles as drug carriers; Characterization techniques
for nanoparticulate carriers; Nanotoxicology: Evaluating
toxicity potential of drug-nanoparticles; Regulatory aspects
of nanoparticulate drug delivery systems; Clinical trials and
industrial aspects; Case studies: Nano-systems in the market.
244 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 98 5 E-ISBN: 978 1 908818 19 5

Nanoscience and technology in medicine
17
PHARMACEUTICAL SCIENCE/
TECHNOLOGY, DRUG DELIVERY
NEW
Clinical research in paediatric
psychopharmacology
A practical guide
P Auby, Corporate ICR France & Paediatrics,
France
Woodhead Publishing Series in Biomedicine
No. 27
Clinical research in paediatric
psychopharmacology covers ethical,
regulatory, clinical, scientifc, intercultural
and practical aspects of clinical research in
child and adolescent psychopharmacology.
The book is written and organised with the
aim of being a practical guide, providing both
an overview of clinical research in paediatric
psychopharmacology and practical points to
consider when developing clinical research in
this feld.
CONTENTS
Historical perspective; Regulatory changing environment
- US; EU; And WHO; Scientifc - state of the art - child
and adolescent psychopharmacology at the beginning of
the 21st century; Ethical aspects of research in paediatric
psychopharmacology; Clinical development; Patients
and family perspectives; Intercultural aspects; Future
methodological perspectives; Future of child and adolescent
psychopharmacological research.
220 pages 234 x 156mm (6 x 9) hardback Q4 2014
ISBN: 978 1 907568 24 4 E-ISBN: 978 1 908818 60 7

NEW
Controlled drug delivery
The role of self-assembling multi-task
excipients
M A Mateescu, P Ispas-Szabo and E Assaad,
University of Quebec, Canada
Woodhead Publishing Series in Biomedicine
No. 58
In complex macromolecules, minor
modifcations can generate major changes,
due to self-assembling capacities of
macromolecular or supramolecular networks.
Controlled drug delivery highlights how the
multifunctionality of several materials can be
achieved and valorized for pharmaceutical and
biopharmaceutical applications.
CONTENTS
The concept of self-assembling; Starch and derivatives
as pharmaceutical excipients; Chitosan and derivatives
as biomaterials and as pharmaceutical excipients;
Polyelectrolyte complexes as excipients for oral
administration; Natural semi-synthetic and synthetic
materials; Protein-protein associative interactions and their
involvement in bioformulations; Self-assembling materials,
implants and xenografts; Conclusions and perspectives.
200 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 45 9 E-ISBN: 978 1 908818 67 6
NEW
Advancement in carrier-based
drug delivery
S K Jain, Central University and A Jain, Adina
Institute of Pharmaceutical Sciences, India
Woodhead Publishing Series in Biomedicine
No. 56
Concerned with the scientifc and
technological aspects of the various drug
delivery systems. Pharmaceutics is one of
the most diverse areas in pharmaceutical
science. Advancement in carrier-based drug
delivery presents emerging trends in specifc
drug delivery, including advanced concepts
in the design and fabrication of new drug
delivery systems and targeting mechanisms.
This title includes the infuence of drug
properties, route of administration, and PK/
PD of drugs. The book is structured into four
sections, and discusses general considerations
in drug delivery, including physiological
and biochemical barriers to drug delivery;
carrier-based drug delivery systems, including
liposomes, niosomes and ethiosomes; drug
targeting approaches, including organ-based
drug targeting; and regulatory aspects for new
drug delivery techniques.
CONTENTS
Section 1 General considerations in drug delivery:
General considerations and biochemical concepts in drug
delivery; Physiological and biochemical barrier to drug
delivery; Infuence of drug properties and routes of drug
administration; Biopharmaceuticals and pharmacokinetics
considerations of drug delivery system; Applications of
pharmacokinetics and pharmacodynamics in design of drug
delivery system. Section 2 Carrier-based drug delivery
system: Liposomes; Niosomes; Ethiosomes; Pharmacosomes;
Phytosomes; Nanoparticles; Dendrimers; Carbon nanotubes;
Resealed erythrocytes; Aquasomes; Micro/ nanospheres;
Micro/nanoemulsions. Section 3 Drug targeting approaches:
Molecular consideration of drug targeting; Various
approaches of drug targeting including chemical and
physical approaches; Organ-based drug targeting. Section 4
Regulatory aspects for new drug delivery.
200 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 49 7 E-ISBN: 978 1 908818 69 0

NEW
Clinical trial management
An overview
U Sahoo, India for Chiltern and D Sawant,
Clinical Monitoring, India
Woodhead Publishing Series in Biomedicine
No. 35
Clinical trial management is designed to
show the various activities that are involved
in clinical trials and understand their
processes, which are essential for planning
and implementing a successful clinical trial.
This book also facilitates the understanding
of the importance of ethics in clinical studies
and the evolution of various guidelines, rules
and regulations for the management of a
clinical trial. Recruitment and retention of
valuable patients are critical to the success of
a clinical trial and hence pose a large number
of challenges for the management team to
complete the trial in multiple countries with
the desired number of patients enrolled in
time.
CONTENTS
Project management; Inspection and audits; Regulatory
affairs; Pharmacovigilance; Medical affairs; Patient
recruitment and retention; Ethics in clinical research.
250 pages 234 x 156mm (6 x 9) hardback Q3 2015
ISBN: 978 1 907568 66 4 E-ISBN: 978 1 908818 58 4
NEW
The life-cycle of pharmaceuticals
in the environment
R Braund and B M Peake, University of Otago,
New Zealand
Woodhead Publishing Series in Biomedicine
No. 51
The life-cycle of pharmaceuticals in the
environment identifes pathways of entry
of pharmaceuticals into the environment -
beginning with the role of global prescribing
and disposal practices. It then discusses
typical levels of common pharmaceuticals and
how they can be determined in natural waters
such as raw and treated sewage, and potable
water. Methods currently available to degrade
pharmaceuticals in the natural waters are
discussed and some of their ecotoxicological
impacts are reviewed. Future considerations
and the growing concept of product
stewardship are also examined.
CONTENTS
Prescribing practices of pharmaceuticals; Disposal practices
of pharmaceuticals; Pharmaceutical levels detected within
natural waters; Removal and degradation of pharmaceuticals
in natural waters; Environmental impact; Conclusions/future
policies.
270 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 25 1 E-ISBN: 978 1 908818 45 4
Pharmaceutical science/technology, drug delivery
18
NEW
Handbook of cosmeceutical
excipients
Y H Kwan, Duke-NUS Graduate Medical School
Singapore, Y K Tung and J S Kochhar, National
University of Singapore, A-L Poh, Parkway
Hospitals Singapore Pte Ltd and L Kang,
National University of Singapore, Singapore
Woodhead Publishing Series in Biomedicine
No. 65
Cosmeceuticals are the latest additions to the
health industry and have an ever-expanding
market. They are considered to be a marriage
between cosmetics and drugs and are defned
as preparations applied on the body that may
modify the physiological functions of the
skin. However, as more cosmeceuticals are
launched in the market and more types of
drugs are incorporated into the formulation,
the composition of cosmeceuticals is becoming
more complex. Handbook of cosmeceutical
excipients summarises the current evidence
relating to cosmeceuticals side effects and
highlights the important information that
practitioners and consumers need to know,
as well as ways to avoid the adverse effects
of the excipients. Handbook of cosmeceutical
excipients includes chapters covering topics
such as the history of cosmeceuticals and the
laws that regulate them, skin permeation,
carcinogenicity as a systemic adverse effect
and dermatitis as a topical adverse effect. It
concludes with an appendix that gives brief
information on the potency and permeability
of common ingredients in cosmeceuticals.
The appendix aims to highlight the maximum
allowable quantity of each ingredient to
ensure product safety for consumers. The
appendix was prepared by compiling the
ingredients of 257 products containing more
than 500 compounds, collected from a hospital
pharmacy in Singapore.
CONTENTS
History and opportunities: Historical background of
cosmeceuticals and its impact in current world; Concept
of excipient safety: Who coined the term?; How big is
the industry?; How many new products per year?; Law:
Regulation in US and Role of US FDA in cosmeceuticals;
Regulation in Europe; Regulation in ASEAN; A comparison
of their differences; Skin permeation: Overview of the
concept of fux; Translation of animal to human dose;
Calculating of limits of excipients to prevent related
adverse effects; Systemic effect: Cancer: Impact of
carcinogenicity of excipients; Evidences available in current
literature; Mechanism of carcinogenicity; Ways to prevent
carcinogenicity of excipients. Local effect: Dermatitis:
Impact of dermatitis of excipients; Evidences available in
current literature; Mechanism of dermatitis; Prevention;
Appendix: Brief description of each excipient.
200 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 53 4 E-ISBN: 978 1 908818 71 3

NEW
Therapeutic risk management of
medicines
S J Mayall and A K Banerjee, Pope Woodhead
& Associates, UK
Woodhead Publishing Series in Biomedicine
No. 30
Legislation has evolved rapidly over the last
decade and Therapeutic risk management of
medicines is an authoritative, yet practical,
guide on planning, writing, implementing
and evaluating risk management plans for
medicines globally. The book also includes
chapters on the historical development,
lessons from other industries, the regulatory
and health authority perspective and public
communication of beneft risk. This topic
is of critical importance not only to the
pharmaceutical and biotechnology industry,
but also prescribers, pharmacists, regulators
and healthcare policymakers.
CONTENTS
Introduction and historical background of risk management
plans; EU-RMP (Risk Management Plan); USA REMS
(Risk Evaluation and Mitigation Strategies); Safety
specifcation; Pharmacovigilance planning; Assessing
the need for risk minimization; Risk minimization tools;
Implementation of RMPs and REMS; Evaluation of RMPs
and REMS; Developmental risk management plans;
Effectively negotiating with the health authorities; Public
communication of beneft risk.
250 pages 234 x 156mm (6 x 9) hardback Q2 2014
ISBN: 978 1 907568 48 0 E-ISBN: 978 1 908818 27 0
NEW
Oral delivery of
insulin
T A Sonia and C P Sharma,
Sree Chitra Tirunal Institute
for Medical Sciences and
Technology, India
Woodhead Publishing Series
in Biomedicine No. 41
Diabetes Mellitus, a syndrome of disordered
metabolism, characterised by abnormal
elevation in blood glucose level, has become
a life-threatening condition for many people.
Current means of therapy for Diabetes
Mellitus do not mimic the normal physiological
pattern of insulin release. Oral delivery is the
preferred route of administration due to its
non-invasive nature. Oral delivery of insulin
presents an overview of Diabetes Mellitus,
and discusses the strategies and techniques
adopted for oral delivery of insulin.
CONTENTS
Diabetes Mellitus; Different routes of administration of
insulin; Oral insulin delivery: Challenges and strategies;
Experimental techniques involved in the development of oral
insulin carrier; Lipids; Inorganic nanoparticles and polymers
in oral insulin delivery; Summary and future perspectives for
oral delivery of insulin.
270 pages 234 x 156mm (6 x 9) hardback Q1 2015
ISBN: 978 1 907568 47 3 E-ISBN: 978 1 908818 68 3

NEW
Orphan drugs
Understanding the rare disease market
and its dynamics
E Hernberg-Stahl, Late Phase Solutions Europe
AB, Sweden and M Reljanovic
Woodhead Publishing Series in Biomedicine
No. 46
There are between 5,000 and 7,000 rare
diseases and the number of patients
suffering from them is estimated to be more
than 50 million in the US and Europe. This
authoritative and comprehensive book makes
the reader familiar with the processes of
bringing orphan drugs to the global market.
Orphan drugs provides a comprehensive
overview of strategy, key activities and
considerations of how to bring an orphan
drug from concept to the market and make it
available to patients. It is a source of updated
information, news and trends for those who
are already active in this fast-moving feld.
CONTENTS
Orphan drugs and orphan drug legislation; Characteristics
of rare diseases; Patient network and advocacy groups;
Organisations and networks dedicated to rare diseases and
orphan drugs; Policies and research funding; Designing robust
clinical trials for orphan drugs; Market access procedures for
orphan drugs.
334 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 09 1 E-ISBN: 978 1 908818 39 3

An introduction
to pharmaceutical
sciences
Production, chemistry,
techniques and technology
J Roy, Mississippi University
for Women, USA
Woodhead Publishing Series
in Biomedicine No. 6
This textbook is written as a unifed approach
to various topics, ranging from drug discovery
to manufacturing, techniques and technology,
regulation and marketing.
CONTENTS
Career prospects in the pharmaceutical industry; Drugs,
medicines, and regulatory authorities; Bulk drugs or active
pharmaceutical ingredients; Formulated drugs 1; Formulated
drugs 2; The stability of medicines; Quality assurance in
medicines; Pharmacological concepts and drugs; The top
fve most common or long-selling drugs; Life-style drugs,
statins, and COX-2 drugs; Counterfeit drugs and drug abuse;
New pharmaceutical technology and pharmaceuticals; Future
prospects for the pharmaceutical industry; Pharmaceutical
case studies.
446 pages 234 x 156mm (6 x 9) paperback 2011
ISBN: 978 1 907568 52 7 E-ISBN: 978 1 908818 04 1
Pharmaceutical science/technology, drug delivery
19
NEW
Nanoparticle-based approaches
to targeting drugs for severe
diseases
J L Arias, University of Granada, Spain
Woodhead Publishing Series in Biomedicine
No. 47
Nanoparticle-based approaches to targeting
drugs for severe diseases is devoted to the
analysis of the latest developments in the
use of passive and/or active targeting nano-
strategies for controlling the biodistribution
profles of pharmacotherapy agents
and special attention is given to recent
advances in these engineering approaches:
specifcally, to target nanomedicines against
severe diseases, and to the development
of multifunctional nanoplatforms for
combined selective diagnosis and effective
pharmacotherapy. This book provides an
in-depth and detailed analysis of the above
problems, and a comprehensive discussion of
the available solutions. It focuses on aspects
of the formulation of drug nanocarriers,
alongside characterisation techniques, toxicity
issues, regulatory aspects, and marketing.
CONTENTS
Integration of nanotechnology in pharmacotherapy;
Nanostructures in drug delivery; Nano-engineering strategies
for passive drug delivery and targeting; Nano-engineering
strategies for ligand-mediated drug delivery and targeting;
Nano-engineering strategies for stimuli-sensitive drug
delivery and targeting; Nano-engineering strategies in
theragnosis; Advanced nanomedicines against severe
diseases.
300 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 907568 11 4 E-ISBN: 978 1 908818 44 7

NEW
Ocular transporters and
receptors
Their role in drug delivery
Edited by A K Mitra, University of Missouri,
USA
Woodhead Publishing Series in Biomedicine
No. 39
Ocular transporters and receptors contains
detailed descriptions of major transporters
and receptors expressed in the eye, with
special emphasis on their role in drug
delivery. The complex anatomy and the
existence of multiple barriers in the eye pose
a considerable challenge to successful drug
delivery to the eye. Hence ocular transporters
and receptors are important targets for drug
delivery. A signifcant advancement has been
made in the feld of ocular transport research
and their role in drug delivery. In this book the
cutting edge research being carried out in this
feld is compiled and summarized. The book
focuses on key areas, including the anatomy
and physiology of the eye, biology of ocular
transporters and receptors, techniques in
characterization of transporters and receptors,
transporters and receptors in the anterior
and posterior segment in the eye, the role
of ocular transporters and receptors in drug
delivery, and transporter-metabolism interplay
in the eye.
CONTENTS
Eye: Anatomy, physiology and barriers to drug
delivery; Biology of ocular transporters and receptors;
Characterization of ocular transporters and receptors;
Transporters and receptors in the anterior segment of
the eye; Transporters and receptors in the posterior
segment of the eye; Transporters in subcellular organelles:
Regulation, characterization and role in ocular drug delivery;
Transporters in drug discovery and delivery: A new paradigm
in ocular drug design; Transporter-metabolism interplay in
the eye.
250 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 86 2 E-ISBN: 978 1 908818 31 7

NEW
Transporters in drug discovery
and development
Detailed concepts and best practice
Y Lai, A major US pharmaceutical company,
USA
Woodhead Publishing Series in Biomedicine
No. 50
Written by a leading researcher in the
feld, Transporters in drug discovery and
development provides a comprehensive and
practical guide to drug transporter families
that are the most important for drug discovery
and development.
CONTENTS
Membrane transporters and the diseases corresponding
to functional defects; P-glycoprotein (P-gp/MDR1)/
ABCB1; Multidrug resistance- associated protein 2 (MRP2/
ABCC2); Breast cancer resistance protein (BCRP)/ABCG2;
The bile salt export pump (BSEP/ABCB11); Organic anion-
transporting polypeptides (OATPs/SLCOs); Organic anion,
organic cation and zwitterion transporters of the SLC22 and
SLC47 superfamily (OATs, OCTs, OCTNs and MATEs); Drug
transporters in drug discovery and development; Transporter
study methodologies.
780 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 21 3 E-ISBN: 978 1 908818 28 7
NEW
Drug-biomembrane interaction
studies
The application of calorimetric techniques
Edited by R Pignatello, University of Catania,
Italy
Woodhead Publishing Series in Biomedicine
No. 45
Drug-biomembrane interaction studies is
written by scientists renowned for their
work in the feld of DSC applications to drug
development and delivery, and especially
to drug-biomembrane interaction studies.
The issues above are clarifed, and any areas
where uncertainties remain are highlighted
and assessed. The book combines insights
from biochemistry and physiology with those
from structural biology, nanotechnology and
bio-thermodynamics, to obtain a complete
depiction of cell membranes and their
functions.
CONTENTS
Biological membranes and their role in physio- pathological
conditions; Biomembrane models; Analytical methods
for studying drugbiomembrane interactions; Differential
scanning calorimetry (DSC): Theoretical fundamentals; DSC:
History, instruments and devices; DSC in drugbiomembrane
interaction studies; DSC applications: Macromolecules; DSC
applications: Nucleic acids and membrane interactions; Non-
steroidal anti- inf ammatory drugs; Antimicrobial agents;
Drug delivery systems: Drug nanocarriers.
440 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 05 3 E-ISBN: 978 1 908818 34 8

Pharmaceutical science/technology, drug delivery
20
NEW
Sterility,
sterilisation and
sterility assurance
for pharmaceuticals
Technology, validation
and current regulations
T Sandle, Bio Products
Laboratory, UK
Woodhead Publishing Series in Biomedicine
No. 32
Failure to adequately control any microbial
challenge associated within process or
product by robust sterilisation will result
in a contaminated marketed product, with
potential harm to the patient. Sterilisation is
therefore of great importance to healthcare
and the manufacturers of medical devices
and pharmaceuticals. Sterility, sterilisation
and sterility assurance for pharmaceuticals
examines different means of rendering a
product sterile by providing an overview
of sterilisation methods including heat,
radiation and fltration. The book outlines
and discusses sterilisation technology and
the biopharmaceutical manufacturing
process, including aseptic flling, as well
as aspects of the design of containers
and packaging, as well as addressing the
cleanroom environments in which products are
prepared. Consisting of 18 chapters, the book
comprehensively covers sterility, sterilisation
and microorganisms; pyrogenicity and
bacterial endotoxins; regulatory requirements
and good manufacturing practices; and gamma
radiation. Later chapters discuss e-beam;
dry heat sterilisation; steam sterilisation;
sterilisation by gas; vapour sterilisation;
and sterile fltration, before fnal chapters
analyse depyrogenation; cleanrooms; aseptic
processing; media simulation; biological
indicators; sterility testing; auditing; and new
sterilisation techniques.
CONTENTS
Sterility, sterilisation and microorganisms; Pyrogenicity
and bacterial endotoxins; Regulatory requirements and
good manufacturing practices; Gamma radiation; E-beam;
Dry heat sterilisation; Steam sterilisation; Sterilisation by
gas; Vapour sterilisation; Sterile fltration; Depyrogenation;
Cleanrooms; Aseptic processing; Media simulation; Biological
indicators; Sterility testing; Auditing; New sterilisation
techniques.
362 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 38 1 E-ISBN: 978 1 908818 63 8
NEW
Formulation tools
for pharmaceutical
development
Edited by J E Aguilar
Woodhead Publishing Series
in Biomedicine No. 44
The range of innovative tools described
in this book permit the evaluation of the
proposed formulation which provides data for
a better understanding of the process and the
product which supports the development of
medicines according to recent new strategies
of Quality by Design and New Strategy for
Process Validation Guidelines. The tools
included in this book are: expert systems;
artifcial intelligence tools, neuro-fuzzy tools,
multimedia tools, artifcial neural networks,
neurofuzzylogic and genetic programming,
plus other mathematical tools.
CONTENTS
Artifcial neural networks technology to model, understand,
and optimize drug formulations; ME_expert 2.0: A heuristic
decision support system for microemulsions formulation
development; Expert system for the development and
formulation of pushpull osmotic pump tablets containing
poorly water- soluble drugs; SeDeM Diagram: An expert
system for preformulation, characterization and optimization
of tablets obtained by direct compression; New SeDeM-
ODT expert system: An expert system for formulation of
orodispersible tablets obtained by direct compression;
3-D cellular automata in computer-aided design of
pharmaceutical formulations: Mathematical concept and
F-CAD software; OXPIRT: Ontology- based eXpert system
for Production of a generic Immediate Release Tablet;
Optimisation of compression parameters with AI-based
mathematical models.
304 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 99 2 E-ISBN: 978 1 908818 50 8
NEW
Computer-aided
applications in
pharmaceutical
technology
Edited by J Djuris, University
of Belgrade, Serbia
Woodhead Publishing Series in Biomedicine
No. 52
Computer-aided applications in
pharmaceutical technology covers the
fundamentals of experimental design
application and interpretation in
pharmaceutical technology and chemometric
methods, with emphasis on their application
in process control, neural computing (artifcial
neural networks, fuzzy logic and decision
trees, evolutionary computing and genetic
algorithms, self-organizing maps) computer-
aided biopharmaceutical characterization,
as well as application of computational fuid
dynamics in pharmaceutical technology.
All of these techniques are essential tools
for successful building of quality into
pharmaceutical products and processes from
the early stage of their development to
selection of the optimal ones. In addition to
theoretical aspects of various methods, the
book provides numerous examples of their
application in the feld of pharmaceutical
technology.
CONTENTS
Quality-by-design in pharmaceutical development;
Computer-aided formulation development; Experimental
design application and interpretation in pharmaceutical
technology; Chemometric methods application in
pharmaceutical products and processes analysis and
control; Neural computing in pharmaceutical products and
process development; Computer-aided biopharmaceutical
characterization: Gastrointestinal absorption simulation;
Computational fuid dynamics: Applications in
pharmaceutical technology.
300 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 27 5 E-ISBN: 978 1 908818 32 4

Pharmaceutical science/technology, drug delivery
21
Therapeutic
antibody engineering
Current and future
advances driving the
strongest growth area
in the pharmaceutical
industry
W R Strohl, Johnson &
Johnson Biotechnology
Center of Excellence and L M Strohl, Medical
Illustrator, USA
Woodhead Publishing Series in Biomedicine
No. 11
An excellent balance between readability and depth of
material.... The book is well referenced and provides
plentiful opportunities to continue subject-specifc
learning.
mAbs Journal
An excellent book describing many aspects of
therapeutic antibody generation and the current market
share of these drugs. It is an up-to-date evaluation of
their production and clinical utility.
Doodys Book Reviews
Therapeutic antibody engineering examines
all aspects of engineering monoclonal
antibodies and analyses the effect that various
genetic engineering approaches will have
on candidates of the future. Chapters in the
frst part of the book provide an introduction
to monoclonal antibodies, their discovery
and development and the fundamental
technologies used in their production. In the
following chapters, the book covers a number
of specifc issues relating to different aspects
of antibody engineering, including variable
chain engineering, targets and mechanisms
of action, classes of antibody and the use
of antibody fragments, among many other
topics. The last part of the book examines
development issues, the interaction of human
IgGs with non-human systems, and cell line
development, before a conclusion looking at
future issues affecting the feld of therapeutic
antibody engineering.
CONTENTS
Introduction to biologics and monoclonal antibodies; Value
proposition for therapeutic monoclonal antibodies and Fc
fusion proteins; Antibody structurefunction relationships;
Fundamental technologies for antibody engineering; Sources
of antibody variable chains; Variable chain engineering
humanization and optimization approaches; Antibody
interactions with the immune system; Monoclonal antibody
targets and mechanisms of action; Therapeutic antibody
classes; Antibody Fc engineering for optimal antibody
performance; IgG glycans and glyco-engineering; Antibody
fragments as therapeutics; Multiple antibody and multi-
specifcity approaches; FcFPs and similar constructs using
Fc; Antibody-drug conjugates; Development issues: Antibody
stability, developability, immunogenicity, and comparability;
Interactions of human IgGs with non-human systems; Cell
line development; Issues facing therapeutic monoclonal
antibodies for the future.
696 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 37 4 E-ISBN: 978 1 908818 09 6

Clinical research in
Asia
Opportunities and
challenges
U Sahoo, Chiltern, India
Woodhead Publishing Series
in Biomedicine No. 10
An important contribution to the feld of global
research ethics
Doodys Book Reviews
Asia is increasingly taking on a leading role
in the felds of Good Clinical Practice (GCP)
and ethics, two areas that are central to
clinical research practices worldwide. Clinical
research in Asia examines the evolution of
these key sectors in the Asian countries where
the greatest developments are taking place,
offering valuable perspectives on a wide range
of issues affecting clinical research. Following
an introduction that provides an overview of
the topic and its strengths and weaknesses,
each chapter of the book is devoted to clinical
research in a specifc country, focusing on
issues including the history and evolution of
clinical research, clinical trials and regulatory
aspects. The chapters also offer a perspective
on future trends in clinical research in each
country. The book concludes with a discussion
of the importance of political, economic,
socio-cultural, technological, legal and
environmental factors (PESTLE analysis).
CONTENTS
Clinical research in Asia: A brief overview; Clinical research
in Japan; Clinical research in India; Clinical research in
China; Clinical research in South Korea; Clinical research in
Taiwan; Clinical research in Singapore; Clinical research in
Thailand; Clinical research in Malaysia; Clinical research in
Hong Kong; Clinical research in the Philippines, Indonesia
and Vietnam; Conclusions.
412 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 00 8 E-ISBN: 978 1 908818 13 3
Therapeutic protein
drug products
Practical approaches
to formulation in
the laboratory,
manufacturing, and the
clinic
Edited by B K Meyer, Merck
Research Laboratories (MRL),
USA
Woodhead Publishing Series in Biomedicine
No. 8
Therapeutic protein drug products provides
a comprehensive overview of therapeutic
protein drug products, with an emphasis
on formulation beginning in the laboratory,
followed by manufacturing and administration
in the clinic. A list of many commercial
therapeutic drug products are described
and include the product name, dosages,
active concentration, buffer, excipients, Ph,
container type and route of administration.
The laboratory formulation sections focus
on the most common buffers, excipients,
and Ph ranges that are commonly tested in
addition to systematic approaches. A brief
section on biophysical and analytical analysis
is also provided. Properties of therapeutic
protein formulations are described and include
opalescence, phase separation, color, and
subvisible particles. An emphasis is placed on
material and process testing to ensure success
during manufacturing. The drug product
manufacturing process, which includes the
process of compounding to flling, is also
covered. Methods of delivery in the clinic
are addressed, as well as delivery strategies.
Finally, a perspective on the regulatory
requirements for therapeutic protein
formulations is discussed.
CONTENTS
Commercial therapeutic protein drug products; A formulation
method to improve the physical stability of macromolecular-
based drug products; Properties of protein formulations;
Material and process compatibility testing; Compounding
and flling: Drug substance to drug product; Administration
in the clinic; Regulatory guidelines for the development of a
biotechnology drug product.
200 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 18 3 E-ISBN: 978 1 908818 10 2

Pharmaceutical science/technology, drug delivery
22
REGENERATIVE MEDICINE
Developments in
tissue engineered
and regenerative
medicine products
A practical approach
J Basu and J W Ludlow,
Tengion Inc, USA
Woodhead Publishing Series
in Biomaterials No. 48
Developments in tissue engineered and
regenerative medicine products summarizes
recent developments in tissue engineering and
regenerative medicine with an emphasis on
commercialization and product development.
Features of current cell therapy and tissue
engineered products which have facilitated
successful commercialization are emphasized.
Roadblocks to successful product development
are also highlighted. Preclinical and clinical
testing of tissue engineered and regenerative
medicine products, regulatory, quality
control, manufacturing issues, as well as
generating and securing intellectual property
and freedom to operate considerations are
presented. This book represents a complete
how-to manual for the development of
tissue engineered and regenerative medicine
products from conceptualization to clinical
trial to manufacturing.
CONTENTS
Overview of tissue engineering/regenerative medicine;
Cells; Biomaterials for TE/RM products; Neo-Bladder:
A foundational technology platform for tubular organ
regeneration; Neo-Urinary Conduit; Tissue engineering
of non-bladder tubular organs; Tissue engineering of solid
organs; Regulatory and quality control; Pre-clinical and
clinical evaluation of TE/RM products; Manufacturing;
Intellectual property.
226 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 76 3 E-ISBN: 978 1 908818 11 9

STEM CELL SCIENCES
NEW
Stem cell bioprocessing
For cellular therapy, diagnostics and drug
development
T G Fernandes, M M Diogo and J M S Cabral,
Instituto Superior Tcnico (IST), Technical
University of Lisbon, Portugal
Woodhead Publishing Series in Biomedicine
No. 40
Stem cell bioprocessing describes the main
large-scale bioprocessing strategies for both
stem cell culture and purifcation, envisaging
the application of these cells for regenerative
medicine and drug screening. Bioreactor
confgurations are described, including their
applications for stem cell expansion and/
or differentiation. Stem cell separation
techniques are also discussed, aiming towards
both isolation and purifcation of rare stem
cell populations.
CONTENTS
Stem cells; Stem cell culture; Bioreactors for stem cell
culture; Stem cell bioseparation; Micro-scale technologies
for stem cell culture and separation; Stem cells and
regenerative medicine.
236 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 907568 88 6 E-ISBN: 978 1 908818 30 0

Commercializing the stem cell
sciences
O Harvey, University of Sydney, Australia
Woodhead Publishing Series in Biomedicine
No. 12
Commercializing the stem cell sciences offers
a comparative analysis of the commercial
methods adopted in the global stem cell
industries. It seeks to establish whether
there is an optimum commercial model and
to examine what emerging companies can
learn from their predecessors. Following an
introduction to stem cell sciences and the
problems involved in their commercialization,
the book begins with a discussion of stem cell
treatments from a global perspective, and the
role of innovation in the commercialization of
biotechnology in general. In the second half
of the book, chapters focus on the different
strategies that can be employed and their
relative risks and values, before a conclusion
that looks at potential new developments in
the feld.
CONTENTS
Introduction: Stem cell science, biotechnology and the
problem of commercialization; Stem cell treatments in a
global marketplace; The role of innovation systems in the
commercialization of biotechnology; Low-risk, low-value:
Adult stem cells; High-risk, high-value: Embryonic stem cells;
Low-risk, low-value: iPS cells; What does the future hold?
212 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 60 2 E-ISBN: 978 1 908818 14 0

APPLICATIONS
NEW
Joint replacement technology
Second edition
Edited by P A Revell, UCL, UK
Woodhead Publishing Series in Biomaterials
No. 80
Joint replacement has brought improved
quality of life to millions of patients and
is regarded a standard procedure for the
treatment of joint degradation, particularly
as a result of osteoarthritis. Its continued
success depends on effective collaboration
between clinicians and researchers across
many different areas in science and medicine.
In response to ongoing demand a great deal
of research is continually being undertaken,
resulting in signifcant improvements in both
the biomaterials and design of implants.
This second edition provides an updated
comprehensive review of recent developments
in joint replacement technology. This book
covers the most pertinent materials science
and engineering issues in depth, in addition to
a review of the specifc joints, biological and
mechanical issues and fxation techniques.
CONTENTS
Part 1 Introduction to joint replacement technology:
Biomechanics of joints; Tribology in joint replacement;
Biomaterials and the chemical environment of the body. Part
2 Materials and techniques in joint replacement: Metals for
joint replacement; Ceramics for joint replacement; Joint
bearing surfaces and replacement joint design; Cementless
fxation techniques in joint replacement; Bone cement
fxation: Acrylic cements. Part 3 Biological and mechanical
issues in joint replacement: The healing response to implants
used in joint replacement; Biological causes of prosthetic
joint failure; Failure mechanisms in joint replacement;
Tribology and corrosion in metal-on metal hip joint
replacements; Predicting the lifetime of joints; Imaging of
joint replacements. Part 4 Replacing specifc joints: Hip
replacement: Clinical perspectives; Knee replacement:
clinical perspectives; Intervertebral disc joint replacement
technology; Overview of total replacement of the frst
metatarso-phalangeal joint; Replacing shoulder joints;
Replacing elbow joints; Replacing fnger and toe joints with
pyrolytic carbon.
630 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 0 85709 841 2 E-ISBN: 978 0 85709 847 4

Regenerative medicine Stem cell sciences Applications
23
NEW
Cardiac regeneration and repair
Volume 1: Pathology and therapies
Edited by R-K Li and R D Weisel, University of
Toronto, Canada
Woodhead Publishing Series in Biomaterials
No. 71
Heart disease is the leading cause of death
in the UK and the United States. For those
people who survive heart disease, few victims
recover completely. Cell therapies, tissue
engineering and biomaterials technologies
have advanced and now offer the potential to
reverse the damage caused by heart disease.
Volume 1 provides readers with comprehensive
information on the pathology of heart disease
and the cell therapies available. Opening
chapters look at cardiac pathology and current
therapies. Further chapters present gene
and protein therapies for regeneration. The
text then discusses cell therapies for cardiac
regeneration whilst fnal chapters review
clinical considerations of stem cell therapies.
CONTENTS
Part 1 The pathogenesis of congestive heart failure:
Cardiac matrix remodeling and heart failure; Cardiac
biomechanics and heart dysfunction; Modifying matrix
remodeling to prevent heart failure. Part 2 Cell therapy
for cardiac regeneration and repair: Optimal cells for
cardiac repair and regeneration; Cell delivery routes for
cardiac stem cell therapy; Cell therapy to regenerate the
ischemic heart; Cell therapy for cardiac repair bench to
bedside and back; Recent advances in cardiac stem cell
therapy to restore left ventricular function; Monitoring
myocardial functional regeneration following cardiac stem
cell application; Feasibility of allogeneic stem cells for heart
regeneration; Bone marrow cells and their role in cardiac
repair after myocardial infarction. Part 3 Stem cells for
cardiac regeneration and repair: Cardiac cell therapy to
restore contracting elements; Human embryonic stem cells
(hESCs) for heart regeneration; Human pluripotent stem
cells (hPSCs) for heart regeneration; Cardiac cell therapy:
Current status and future trends. Part 4 Gene therapy for
cardiac regeneration and repair: Stem cell and gene therapy
for cardiac regeneration; Ultrasound-targeted cardiovascular
gene therapy.
448 pages 234 x 156mm (6 x 9) hardback Q1 2014
ISBN: 978 0 85709 658 6 E-ISBN: 978 0 85709 670 8
NEW
Cardiac regeneration and repair
Volume 2: Biomaterials and tissue
engineering
Edited by R-K Li and R D Weisel, University of
Toronto, Canada
Woodhead Publishing Series in Biomaterials
No. 72
Volume 2 of this important set provides
readers with comprehensive information
on biomaterials and tissue engineering as
strategies for the repair and regeneration
of the heart. The book begins with an
introduction to the feld. A frst set of
chapters look at biomaterials for regeneration
and repair of the heart. Further chapters
discuss tissue engineering strategies for the
regeneration and repair of the heart, whilst
the fnal chapters review vascular modelling
and regeneration.
CONTENTS
Part 1 Biomaterials for cardiac regeneration and repair:
Nanotechnology and nanomaterials for cardiac repair;
Hydrogels for cardiac repair; Injectable biomaterials for
cardiac regeneration and repair; Biomaterials for enhancing
endothelial progenitor cell (EPC) therapy for cardiac
regeneration; Endothelial progenitor cell (EPC)-seeded
intravascular stents. Part 2 Tissue engineering for cardiac
regeneration and repair: Biomaterials and cells for cardiac
tissue engineering; Decellularized biologic scaffolds for
cardiac repair and regeneration; Biomaterial scaffolds
for cardiac regeneration and repair derived from native
heart matrix; Cell sheet engineering for cardiac repair
and regeneration; Maturation of functional cardiac tissue
patches; Vascularizing engineered tissues for in vivo and in
vitro applications; Clinical considerations for cardiac tissue
engineering. Part 3 Vascular remodelling for regeneration
and repair: Aortic extra cellular matrix (ECM) remodelling;
Cell-biomaterial interactions for blood vessel formation;
Stem cells in tissue-engineered blood vessels for cardiac
repair; Tissue-engineered cardiovascular grafts and novel
applications of tissue engineering by self-assembly (TESA).
528 pages 234 x 156mm (6 x 9) hardback Q1 2014
ISBN: 978 0 85709 659 3 E-ISBN: 978 0 85709 671 5

Biomaterials and
devices for the
circulatory system
Edited by T Gourlay and
R Black, University of
Strathclyde, UK
Woodhead Publishing Series
in Biomaterials No. 27
CONTENTS
Part 1 Physiological responses to biomaterials: Tissue
responses to implanted materials; Blood interface
biomaterials; Biocompatibility of cardiovascular devices.
Part 2 Clinical application of biomaterials: Developments
in cardiovascular valve technology; Percutaneous
cardiovascular valve replacement; Cardiopulmonary bypass
technologies; Cardiovascular stents; Vascular implants for
peripheral arterial bypass and aortic aneurysm repair. Part 3
Future developments: Nanotechnology and nanomedicine in
cardiovascular therapy; Biomaterials in cardiac restoration
therapy; Biosensor technology in the treatment of
cardiovascular disease; Vascular tissue engineering.
400 pages 234 x 156mm (6 x 9) hardback 2010
ISBN: 978 1 84569 464 7 E-ISBN: 978 0 85709 055 3

NEW
Silk biomaterials for tissue
engineering and regenerative
medicine
Edited by S Kundu, Indian Institute of
Technology Kharagpar, India
Woodhead Publishing Series in Biomaterials
No. 74
Silk has been used for centuries in medicine as
sutures. The unique mechanical and chemical
properties of this material and the ability to
genetically tailor the protein has meant that
this material is now being used increasingly
for biomaterials and tissue engineering
applications. This book discusses the properties
and applications of silk for medical purposes.
CONTENTS
Part 1 Fundamentals and properties of silk for biomedical
applications: The history and origin of silk; Processing
of Bombyx mori silk for biomedical applications; Silk
nanostructures based on natural and self engineered
assembly; Biochemical and biophysical properties of native
Bombyx mori silk for tissue engineering applications;
Structure and properties of Spider and silkworm silk for
tissue scaffolds; Bio-response to silk sericin; Biodegradation
of silk. Part 2 Silk for biomaterials, tissue engineering and
regenerative medicine applications: Silk based biomaterials in
tissue engineering and regenerative medicine; Non-mulberry
Silk biomaterials in tissue engineering and regenerative
medicine; Silk powder for regenerative medicine; Silk
scaffolds for 3D tumour modelling; Silk hydrogels for tissue
engineering and dual drug delivery; Silk biomaterials for
Intervertebral disc tissue engineering; Silk scaffolds for dental
tissue engineering; Silk for cardiac tissue engineering; Silk
for dermal tissue engineering; Capillary growth in porous silk
flms; Pharmaceutical and Cosmeceutical Applications of Silk.
570 pages 234 x 156mm (6 x 9) hardback Q2 2014
ISBN: 978 0 85709 699 9 E-ISBN: 978 0 85709 706 4
NEW
Biomedical foams for tissue
engineering applications
Edited by P Netti, University of Naples and
Italian Institute of Technology, Italy
Woodhead Publishing Series in Biomaterials
No. 76
This book provides readers with a
comprehensive review of biomedical foams.
Part one discusses the fundamentals of
biomedical foams such as properties, structure
and materials. Part two reviews tissue
engineering applications of biomedical foams.
CONTENTS
Part 1 Fundamentals of biomedical foams: Properties
of biomedical foams; Biomedical foam pore structure;
Polymeric biomedical foams; Glass biomedical foams;
Composite biomedical foams. Part 2 Tissue engineering
applications of biomedical foams: Injectable biomedical
foams for bone regeneration; Biomedical glass and
glass-ceramics foam-like scaffolds for bone tissue
restoration; Polylactic acid (PLA) biomedical foams for
tissue engineering; Biomedical foam scaffolds for nerve
regeneration; Development of hydrogel biomedical foam
scaffolds for tissue repair; Titanium biomedical foams for
tissue attachment; Biodegradable biomedical foam scaffolds.
390 pages 234 x 156mm (6 x 9) hardback Q1 2014
ISBN: 978 0 85709 696 8 E-ISBN: 978 0 85709 703 3

Applications
24
NEW
Novel biomaterials for bone
regeneration
Novel techniques and applications
Edited by P Dubruel and S V Vlierberghe,
University of Ghent, Belgium
Woodhead Publishing Series in Biomaterials
No. 75
Biomaterials for bone regeneration is a
large and important area of research for
biomaterials scientists and engineers.
This feld continues to beneft from many
technological developments and will
continue to be a vital area of research for
scientists. This book will provide readers
with a comprehensive publication covering
novel materials, techniques and applications
of biomaterials for bone regeneration. The
frst section of this book provides readers
with vital information on the various types
of materials used in this arena. Chapters in
part two discuss processing, modifcation and
evaluation techniques of biomaterials. The
fnal section of the book will look at cellular
approaches and stimulation of biomaterials for
bone regeneration.
CONTENTS
Part 1 Materials for bone regeneration: Calcium phosphate
cements for bone regeneration; Injectable calcium
phosphate cements for bone repair; Hydrogels for bone
regeneration; Biopolymer and synthetic polymer composites
for bone regeneration; Polymeric scaffolds for bone
regeneration. Part 2 Processing, surface modifcation and
evaluation of biomaterials for bone regeneration: Rapid
prototyping techniques for the development of porous
polymeric scaffolds; Non-thermal plasma treatment for bone
regeneration biomaterials; In vitro analysis of magnesium
corrosion in orthopaedic biomaterials; Evaluation of
mechanical properties of biomaterials for bone regeneration;
Assessment of immunological properties of biomaterials
for bone regeneration. Part 3 Cellular approaches and
physical stimulation of biomaterials for bone regeneration
applications: Nanocarriers for Controlled Drug Delivery;
Gene transfer vectors (DNA vehicles) and their incorporation
into biomaterials for bone repair; Stem cell technology
for in vitro bone repair; Stem cell technology for in vivo
bone repair; Potential of electromagnetic, ultrasound and
laser stimulation for bone regeneration; Shape memory
applications in mechanobiology and bone repair.
510 pages 234 x 156mm (6 x 9) hardback Q2 2014
ISBN: 978 0 85709 804 7 E-ISBN: 978 0 85709 810 8

NEW
Biomaterials for cancer
therapeutics
Diagnosis, prevention and therapy
Edited by K Park, Purdue University, USA
Woodhead Publishing Series in Biomaterials
No. 66
Cancer can affect people of all ages, and
approximately one in three people are
estimated to be diagnosed with cancer
during their lifetime. Numerous potential
new therapeutics are being researched by
many different institutions and biomaterials
technology is now being developed to target,
treat and prevent cancer. This unique book
discusses the role and potential biomaterials
have to treat this prevalent disease. The frst
part of the book discusses the fundamentals of
biomaterials for cancer therapeutics. Chapters
in part two discuss synthetic vaccines, proteins
and polymers for cancer therapeutics. Part
three focuses on theranosis and drug delivery
systems whilst the fnal set of chapters look
at biomaterial therapies and cancer cell
interaction.
CONTENTS
Part 1 Fundamentals of biomaterials for cancer therapeutics:
Introduction to biomaterials for cancer therapeutics; Cancer
cell biology; Targeted drug delivery for cancer therapy.
Part 2 Synthetic vaccines, proteins, and polymers for cancer
therapeutics: Chemical synthesis of carbohydrate-based
vaccines against cancers; Generating functional mutant
proteins to create bioactive anti-cancer biopharmaceuticals;
Polymer therapeutics for treating cancer. Part 3 Theranosis
and drug delivery systems for cancer therapeutics:
Nanotechnology for cancer screening and diagnosis;
Synergistically integrated nanomaterials for multimodal
cancer cell imaging; Hybrid nanocrystal as a versatile
platform for cancer theranostics; Embolisation devices from
biomedical polymers for intra-arterial occlusion and drug
delivery in the treatment of cancer; Small Interfering RNAs
(siRNAs) as Cancer Therapeutics; Reverse Engineering of Low
Temperature Sensitive Liposome (LTSL) for treating cancer;
Gold nanoparticles (GNPs) as multi-functional materials for
cancer treatment; Multifunctional nanosystems for cancer
therapy. Part 4 Biomaterial therapeutics and cancer cell
interaction: Biomaterial strategies to modulate cancer; 3D
cancer tumour models for evaluating chemotherapeutic
effcacy; Nanotopography of biomaterials for controlling
cancer cell function.
528 pages 234 x 156mm (6 x 9) hardback Q1 2014
ISBN: 978 0 85709 664 7 E-ISBN: 978 0 85709 676 0

NEW
Nanomaterials in
tissue engineering
Fabrication and
applications
Edited by A K Gaharwar,
Harvard Medical School and
Massachusetts Institute of
Technology, S Sant, University of Pittsburgh
and Harvard Medical School, M J Hancock,
Broad Institute and S A Hacking, Massachusetts
General Hospital, USA
Woodhead Publishing Series in Biomaterials
No. 56
Nanomaterial technologies can be used to
fabricate high-performance biomaterials with
tailored physical, chemical, and biological
properties. They are therefore an area of
interest for emerging biomedical technologies
such as scaffolding, tissue regeneration, and
controlled drug delivery. Nanomaterials in
tissue engineering explores the fabrication
of a variety of nanomaterials and the use
of these materials across a range of tissue
engineering applications. Part one focuses on
the fabrication of nanomaterials for tissue
engineering applications. Part two highlights
the application of nanomaterials in soft tissue
engineering, while the use of nanomaterials
in hard tissue engineering applications,
including bone, dental and craniofacial tissue
engineering is discussed in part three.
CONTENTS
Biomedical nanomaterials in tissue engineering. Part
1 Fabrication of nanomaterials for tissue engineering
applications: Synthesis of polymeric nanomaterials
for biomedical applications; Engineering nanoporous
biomaterials; Layer-by-layer self-assembly techniques for
nanostructured devices in tissue engineering; Synthesis
of carbon based nanomaterials for tissue engineering
applications; Fabrication of nanofbrous scaffolds for tissue
engineering applications; Fabrication of nanomaterials
for growth factor delivery in tissue engineering. Part 2
Application of nanomaterials in soft tissue engineering:
Nanomaterials for engineering vascularised tissues;
Nanomaterials for cardiac tissue engineering; Nanomaterials
for neural tissue engineering; Nanomaterials for cartilage
tissue engineering; Biomaterials and nano-scale features for
ligament regeneration. Part 3 Application of nanomaterials
in hard tissue engineering: Nanomaterials for hard-soft tissue
interfaces; Mineralization of nanomaterials for bone tissue
engineering; Nanomaterials for dental and craniofacial tissue
engineering.
488 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 0 85709 596 1 E-ISBN: 978 0 85709 723 1

Applications
25
NEW
Standardisation
in cell and tissue
engineering
Methods and protocols
Edited by V Salih, Plymouth
University Schools of
Medicine and Dentistry, UK
Woodhead Publishing Series in Biomaterials
No. 58
The increased use of biodegradable synthetic
or natural scaffolds combined with cells
and/or biological molecules in the area of
tissue engineering has led to the need for
the development of best practice methods
to help ensure the creation of safe, high
quality products. Standardisation in cell
and tissue engineering introduces concepts
and current practice in the feld and aims
to provide awareness of the importance of
standardisation in this area while suggesting
directions for further investigation. Part
one provides an overview of methods for
cell and tissue engineering. Part two begins
with a chapter exploring the methods and
protocols of standardisation in cell and tissue
engineering before moving on to highlight
issues of quality control in the area.
CONTENTS
Part 1 Methods for cell and tissue engineering: Fundamentals
of cell and matrix biology for tissue engineering; Three-
dimensional collagen biomatrix development and control;
Two- and three-dimensional tissue culture bioprocessing
methods for soft tissue engineering; Two- and three-
dimensional tissue culture methods for hard tissue
engineering; Vascularisation of tissue-engineered constructs.
Part 2 Standards and protocols in cell and tissue engineering:
Standards in cell and tissue engineering; Principles of
good laboratory practice (GLP) for in vitro cell culture
applications; Quality control in cell and tissue engineering;
Standardised chemical analysis and testing of biomaterials;
Sterilisation procedures for tissue allografts; Commercial
manufacture of cell therapies.
272 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 0 85709 419 3 E-ISBN: 978 0 85709 872 6

NEW
Inhaler devices
Fundamentals, design and
drug delivery
Edited by P Prokopovich,
University of Cardiff, UK
Woodhead Publishing Series
in Biomaterials No. 59
Given their direct impact on the health and
quality of life for millions, inhalers represent
a major turning point in the history of modern
medicine. Inhaler devices: Fundamentals,
design and drug delivery provides readers
with an introduction to the fundamentals,
with a comprehensive discussion of the
history of inhalers as well as a discussion on
current research and development. Part one
discusses the fundamentals of inhaler devices,
outlines drug formulations and provides an
historical overview of the development of
inhaler technology. Part two reviews recent
developments in drug formulations and
nanotechnology with applications to inhaler
devices, and provides an exposition of recent
innovations, emerging inhaler technology and
possible future trends.
CONTENTS
Part 1 Fundamentals and considerations of inhaler devices:
Anatomy and pathophysiology of the respiratory system;
History of inhaler devices; Tribology of inhaler devices and
components; Novel coatings and biotechnology trends in
inhaler devices; Microbial control and safety in inhalation
devices. Part 2 Drug formulations for inhaler devices:
Chitosan and inhalers: A bioadhesive polymer for pulmonary
drug delivery; Polyelectrolyte assemblies for drug storage
and delivery: Multilayers, nanocapsules, and multicapsules;
Functionalized core-shell nanoparticles for medical
applications.
192 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 0 85709 496 4 E-ISBN: 978 0 85709 869 6
Nanomedicine
Technologies and
applications
Edited by T J Webster, Brown
University, USA
Woodhead Publishing Series
in Biomaterials No. 49
Nanotechnology is at the forefront of advances
in medicine. Nanomedicine: Technologies
and applications provides an important
review of this exciting technology and its
growing range of applications. Part one
discusses key materials and their properties,
including nanocrystalline metals and alloys,
nanoporous gold and hydroxyapatite coatings.
Part two goes on to review nanomedicine
for therapeutics and imaging. Nanomedicine
for soft tissue engineering is discussed in
part three, including organ regeneration,
skin grafts, nanotubes and self-assembled
nanomaterials. Finally, nanomedicine for
bone and cartilage tissue engineering is the
focus of part four, with electrically active
biocomposites for smart scaffolds investigated
alongside cartilage and bone tissue
engineering, regeneration and replacement.
CONTENTS
Part 1 Materials, properties and considerations: Introduction
to nanomedicine; Trends in nanomedicine; Biomedical
nanocrystalline metals and alloys: Structure, properties and
applications; Nanoporous gold for biomedical applications:
Structure, properties and applications; Hydroxyapatite
(HA) coatings for biomaterials. Part 2 Nanomedicine for
therapeutics and imaging: Calcium-phosphate coated
magnetic nanoparticles for treating bone diseases;
Orthopaedic carbon nanotube biosensors for controlled drug
delivery; Nanostructured selenium anti-cancer coatings for
orthopaedic applications; Nanoparticulate targeted drug
delivery using peptides and proteins; Nanotechnology for
DNA and RNA delivery; Gold nanoshells for imaging and
photothermal ablation of cancer; Microfuidics for testing
and delivering nanomedicine; Zinc oxide nanowires for
biomedical sensing and analysis. Part 3 Nanomedicine
for soft tissue engineering: Nanotechnology and tissue
engineered organ regeneration; Rapid fabrication of
biomimetic nanofber-enabled skin grafts; Nanotubes
for tissue engineering; Self-assembled nanomaterials for
tissue engineering applications. Part 4 Nanomedicine
for bone and cartilage tissue engineering: Electrically
active biocomposites for smart scaffolds for bone tissue
engineering; Nanotechnology for cartilage and bone
regeneration; Nanostructured materials for bone tissue
replacement; Nanocomposites for cartilage regeneration.
704 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 0 85709 233 5 E-ISBN: 978 0 85709 644 9

Applications
26
Biomaterials in
plastic surgery
Breast implants
Edited by W Peters,
University of Toronto,
Canada, H Brandon, K L
Jerina, Washington University
in St Louis, C Wolf, formerly
Washington University in St
Louis and V L Young, BodyAesthetic Plastic
Surgery and Skincare Center, USA
Woodhead Publishing Series in Biomaterials
No. 42
For the academic surgeon who desires a grouping of
articles specifcally related to breast implants in one
place, this book flls the bill.
Doodys book reviews
Biomaterials in plastic surgery reviews the
history, materials and safety issues associated
with breast implants. Beginning with an
introduction to the history of biomaterials
used for breast augmentation, the book
goes on to discuss development issues. It
then discusses the chemistry and physical
properties of biomedical silicones before
reviewing cohesive gel and polyurethane foam
implants. The book concludes by analysing
the epidemiological evidence on the safety
issues relating to breast implants, followed
by a review of retrieval and analysis of breast
implants emphasizing strength, durability and
failure mechanisms.
CONTENTS
The history of biomaterials used for breast augmentation;
The development of breast implants; The chemistry and
physical properties of biomedical silicones; Cohesive gel
breast implants; Polyurethane foam breast implants; The
safety of breast implants: Recent epidemiological studies;
Retrieval and analysis of breast implants emphasizing
strength, durability, and failure mechanisms.
240 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 84569 799 0 E-ISBN: 978 0 85709 641 8
Biomaterials for
spinal surgery
Edited by L Ambrosio,
Universit di Napoli Federico
II, Italy and E Tanner,
University of Glasgow, UK
Woodhead Publishing Series
in Biomaterials No. 39
This is a good reference on biomaterials. It will be
of most interest to materials engineers, bioengineers
and spine surgeons. It is well written and provides an
extensive list of references.
Doodys Book Reviews
There have been important developments in
materials and therapies for the treatment
of spinal conditions. Biomaterials for spinal
surgery summarises this research and how it
is being applied for the beneft of patients.
After an introduction to the subject, part one
reviews fundamental issues such as spinal
conditions and their pathologies, spinal loads,
modelling and osteobiologic agents in spinal
surgery. Part two discusses the use of bone
substitutes and artifcial intervertebral discs
whilst part three covers topics such as the
use of injectable biomaterials like calcium
phosphate for vertebroplasty and kyphoplasty
as well as scoliosis implants. The fnal part
of the book summarises developments in
regenerative therapies such as the use of stem
cells for intervertebral disc regeneration.
CONTENTS
Introduction to biomaterials for spinal surgery. Part 1
Fundamentals of biomaterials for spinal surgery: An overview
of the challenges of bringing a medical device for the
spine to the market; Introduction to spinal pathologies and
clinical problems of the spine; Forces on the spine; Finite
element modelling of the spine; Osteobiologic agents in
spine surgery. Part 2 Spinal fusion and intervertebral discs:
Spine fusion: Cages, plates and bone substitutes; Artifcial
intervertebral discs; Biological response to artifcial discs.
Part 3 Vertobroplasty and scoliosis surgery: The use of
polymethyl methacrylate (PMMA) in neurosurgery; Optimising
the properties of injectable materials for vertebraplasty
and kyphoplasty; Injectable calcium phosphates for
vertebral augmentation; Composite injectable materials for
vertebroplasty; Scoliosis implants: Surgical requirements;
Shape memory, superelastic and low Youngs modulus
alloys. Part 4 Regenerative medicine in the spine: Cell-
based tissue engineering approaches for disc regeneration;
Angiogenesis control in spine regeneration; Stem cells for
disc regeneration; Nucleus regeneration; In vivo models of
regenerative medicine in the spine.
652 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 84569 986 4 E-ISBN: 978 0 85709 619 7
Advanced wound
repair therapies
Edited by D Farrar, Smith and
Nephew, UK
Woodhead Publishing Series
in Biomaterials No. 34
The book comprises a nice overview of various kinds
of therapies and a suffciently extensive discussion of
important (future) materials and treatments.
Birgit Stubbe, Biomaterials Network
CONTENTS
Part 1 Introduction to chronic wounds: Dysfunctional wound
healing in chronic wounds; The role of micro-organisms
and bioflms in dysfunctional wound healing; Scarring and
scarless wound healing; The discovery and development of
new therapeutic treatments for the improvement of scarring;
Monitoring chronic wounds and determining treatment.
Part 2 Biomaterial therapies for chronic wounds: Functional
requirements of wound repair biomaterials; Tissue-
biomaterial interaction; Polymeric materials for chronic
wound and burn dressings; Dry wound healing concept
using spray-on dressing for chronic wounds; Assessing the
effectiveness of antimicrobial wound dressings in vitro;
Adhesives and interfacial phenomena in wound healing;
Wound healing studies and interfacial phenomena: Use and
relevance of the corneal model; Sulphonated biomaterials as
glycosaminoglycan mimics in wound healing. Part 3 Molecular
therapies for chronic wounds: Drug delivery dressings;
Molecular and gene therapies for wound repair; Antimicrobial
dressings; Avotermin: Emerging evidence of effcacy for the
improvement of scarring. Part 4 Biologically-derived and
cell-based therapies for chronic wounds: Engineered tissues
for wound repair; Commercialisation of engineered tissue
products; Biologically derived scaffolds; Stem cell therapies
for wound repair. Part 5 Physical stimulation therapies for
chronic wounds: Electrical stimulation for wound healing;
Negative pressure wound therapy; Debridement methods of
non-viable tissue in wounds.
672 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 84569 700 6 E-ISBN: 978 0 85709 330 1

Biomaterials for artifcial organs
Edited by M Lysaght and T J Webster, Brown
University, USA
Woodhead Publishing Series in Biomaterials
No. 29
Undoubtedly a useful resource, it would be well placed
in the biotechnology section of any university library.
Materials World
CONTENTS
Part 1 Commodity biomaterials: Membranes for oxygenators
and plasmaflters: Titanium and cobalt-chromium alloys
for hips and knees; Polymeric joint bearing surfaces for
total joint replacements; Biomaterials for pacemakers,
defbrillators and neurostimulators; Mechanical and
bioprosthetic valves. Part 2 Advanced and next generation
biomaterials: Small intestinal submucosa and other
decullarized matrix biomaterials for tissue repair; New
ceramics and composites for joint replacement surgery;
Biomaterials for improving the blood and tissue compatibility
of Total Artifcial Hearts (TAH) and Ventricular Assist Devices
(VAD); Nanostructured biomaterials for artifcial tissues and
organs; Matrices for tissue engineering and regenerative
medicine.
320 pages 234 x 156mm (6 x 9) hardback 2010
ISBN: 978 1 84569 653 5 E-ISBN: 978 0 85709 084 3

Applications
27
Regenerative
medicine and
biomaterials for the
repair of connective
tissues
Edited by C Archer and J
Ralphs, Cardiff University, UK
Woodhead Publishing Series
in Biomaterials No. 24
CONTENTS
Structure and regenerative capacity of synovial joint
tissues; The myofbroblast in connective tissue repair and
regeneration. Part 1 Cartilage repair and regeneration:
Structure of articular cartilage; Measuring the biomechanical
properties of cartilage cells; Understanding tissue response
to cartilage injury; Understanding osteoarthritis and other
cartilage diseases; Using animal models of cartilage repair
to screen new clinical techniques; Cartilage tissue repair:
Autologous osteochondral mosaicplasty; Cartilage tissue
repair: Autologous chondrocyte implantation; Cell sheet
technologies for cartilage repair; Cell therapies for articular
cartilage repair: Chondrocytes and mesenchymal stem
cells; Scaffolds for musculoskeletal tissue engineering;
Outcome measures of articular cartilage repair. Part 2 Repair
of tendons and ligaments: The structure of tendons and
ligaments; Tendon biomechanics; Tendon injury and repair
mechanisms; Tissue engineering for ligament and tendon
repair; Cell-based therapies for the repair and regeneration
of tendons and ligaments; Scaffolds for tendon and ligament
tissue engineering.
504 pages 234 x 156mm (6 x 9) hardback 2010
ISBN: 978 1 84569 417 3 E-ISBN: 978 1 84569 779 2

Biomaterials and
regenerative
medicine in
ophthalmology
Edited by T V Chirila,
Queensland Eye Institute,
Australia
Woodhead Publishing Series
in Biomaterials No. 23
CONTENTS
An introduction to ophthalmic biomaterials and their
application through tissue engineering and regenerative
medicine. Part 1 Applications in the anterior segment:
Advances in intraocular lens development; Opacifcation
and degradation of implanted intraocular lenses; Synthetic
corneal implants; Corneal tissue engineering versus synthetic
artifcial corneas; Tissue engineering of human cornea;
Engineering the corneal epithelial cell response to materials;
Reconstruction of the ocular surface using biomaterials;
Tissue engineering of the lens: Fundamentals; Bioinspired
biomaterials for soft contact lenses; Contact lenses: The
search for superior oxygen permeability; Extended wear
contact lenses. Part 2 Applications in the posterior segment:
Designing hydrogels as vitreous substitutes in ophthalmic
surgery; Retinal repair and regeneration; Development
of tissue-engineered membranes for the culture and
transplantation of retinal pigment epithelial cells. Part
3 Other applications: Hydrogel sealants for wound repair
in ophthalmic surgery; Orbital enucleation implants:
Biomaterials and design; Selected polymeric materials
for orbital reconstruction; Physicochemical properties of
hydrogels for use in ophthalmology.
560 pages 234 x 156mm (6 x 9) hardback 2009
ISBN: 978 1 84569 443 2 E-ISBN: 978 1 84569 743 3
Drug-device
combination
products
Delivery technologies and
applications
Edited by A Lewis,
Biocompatibles UK Ltd, UK
Woodhead Publishing Series
in Biomaterials No. 22
CONTENTS
Part 1 Overview: Drug-device combination products; Enabling
drug delivery from combination products; Nanomedical drug-
device combination products. Part 2 Areas of application:
Catheter-based drug-device combination products: An
overview; Catheter-based drug-device combination products:
The anti-infective 5-fuorouracil-coated central venous
catheter; Future outlook for drug eluting stents (DES);
Drug eluting beads (DEB) in the treatment of liver cancer;
Antibiotic-loaded bone cements; Glass-ionomer cements as
drug-device combination products; Bone graft substitutes as
drug-device combination products; Antibacterial releasing
dental restorative materials; Collagen-based dressings
as therapeutic agents for wound healing; Drug-device
combination products for occular applications. Part 3
Development of drug-device combination products: Safety
and effcacy issues in designing drug-device combination
products: The case of drug eluting stents (DES); Preclinical
testing of drug-device combination products; Sterilisation
of drug-device combination products; Innovation and patent
issues in the development of drug-device combination
products: The case of drug eluting stents (DES); Regulation
of drug-device combination products in Europe; (28a)
Regulation of drug-device combination products in the USA.
560 pages 234 x 156mm (6 x 9) hardback 2009
ISBN: 978 1 84569 470 8 E-ISBN: 978 1 84569 748 8

Materials science for dentistry
Ninth edition
B W Darvell, formerly University of Hong
Kong, Hong Kong and now Professor in Dental
Materials Science at Kuwait University,
Kuwait.
Woodhead Publishing Series in Biomaterials
No. 19
a truly excellent book that covers the topic in
greater depth and with greater authority than other
dental texts.
Professor Timothy F. Watson, Kings College
London, UK
There is no doubt it is the best in the feld.
Professor Nikhil K. Sarkar, Louisiana State
University, USA
688 pages 280 X 210mm (8 x 11) paperback 2009
ISBN: 978 1 84569 529 3 E-ISBN: 978 1 84569 667 2
Dental biomaterials
Imaging, testing and modelling
Edited by R V Curtis and T F Watson, Kings
College London, UK
Woodhead Publishing Series in Biomaterials
No. 10
528 pages 234 x 156mm (6 x 9) hardback 2008
ISBN: 978 1 84569 296 4 E-ISBN: 978 1 84569 424 1

Bone repair
biomaterials
Edited by Principal editor
J A Planell, Institute for
Bioengineering of Catalonia
(IBEC), Spain, Section editors
S M Best, University of
Cambridge, UK, D Lacroix,
Institute for Bioengineering
of Catalonia (IBEC), Spain and A Merolli, The
Catholic University in Rome, Italy
Woodhead Publishing Series in Biomaterials
No. 20
The book is beautifully referenced. Certain chapters
are recommended for all orthopaedic surgeons... For
a new researcher it is an invaluable introduction from
start to fnish.
Journal of Bone and Joint Surgery
CONTENTS
Part 1 Introduction: Challenges of bone repair; Bone
anatomy, physiology and adaptation to mechanical loading;
Bone repair and regeneration; Biomechanical aspects of bone
repair. Part 2 Biomaterials: Properties and characterisation
of bone repair materials; Metals as bone repair materials;
Ceramics as bone repair materials; Polymers for bone repair;
Composite biomaterials for bone repair; Cements as bone
repair materials; Bioactive polymer coatings to improve bone
repair; Long-term performance and failure of orthopaedic
devices. Part 3 Clinical applications: Using bone repair
materials in orthopaedic surgery; Bone tissue engineering;
Retrieval and analysis of orthopaedic implants; Ethical issues
in bone repair and bone tissue engineering.
496 pages 234 x 156mm (6 x 9) hardback 2009
ISBN: 978 1 84569 385 5 E-ISBN: 978 1 84569 661 0

Orthopaedic bone
cements
Edited by S Deb, Kings
College London, UK
Woodhead Publishing Series
in Biomaterials No. 14
CONTENTS
Part 1 Bone cements in medicine: Bone disease; Hip
replacements; Knee replacements; Vertebroplasty
and kyphoplasty; Antibiotic-impregnated polymethyl-
methacrylate (PMMA) spacers in hip surgery; Commercial
aspects and delivery systems of bone cements; Wear
particles and osteolysis. Part 2 Materials: Acrylic bone
cement: Genesis and evolution; Poly(methylmethacrylate)
bone cement: Chemical composition and chemistry; Calcium
phosphate bone cements. Part 3 Properties of bone cements:
Mechanical properties of bone cements; Fracture toughness
and fatigue characteristics of bone cements; Dynamic creep
in bone cements. Part 4 Enhancing the properties of bone
cements; Antibiotic-loaded bone cements; Modifcations
of bone cements; Design of bioactive bone cement based
on organic-inorganic hybrids; Clinical aspects of calcium
phosphate bone cements.
424 pages 234 x 156mm (6 x 9) hardback 2008
ISBN: 978 1 84569 376 3 E-ISBN: 978 1 84569 517 0
Applications
28
Biomaterials and
tissue engineering in
urology
Edited by J Denstedt,
University of Western
Ontario, Canada and A Atala,
Wake Forest Institute for
Regenerative Medicine, USA
Woodhead Publishing Series in Biomaterials
No. 18
CONTENTS
Part 1 Fundamentals: Introduction to bioflms in urology: In
vivo models for ureteral stents; Models for the assessment
of bioflm and encrustation formation on urological
materials. Part 2 Materials and design of urological devices:
Ureteral stents: Design and materials; Metal stents in
the upper urinary tract; Coated ureteral stents; Proteus
mirabilis bioflm formation and catheter design; Self-
lubricating catheter materials; Temporary urethral stents;
Penile implants. Part 3 Urological tissue engineering:
Artifcial biomaterials for urological tissue engineering;
Natural biomaterials for urological tissue engineering;
Nanotechnology and urological tissue engineering; Assessing
the performance of tissue-engineered urological implants;
Regenerative pharmacology and bladder regeneration;
Autologous cell sources for urological applications;
Embryonic stem cells, nuclear transfer, and parthenogenesis-
derived stem cells for urological reconstruction; Amniotic
fuid and placental stem cells as a source for urological
regenerative medicine; The use of adipose progenitor cells
in urology; Regenerative medicine of the urinary sphincter
via an endoscopic approach; Regenerative medicine of the
urinary sphincter via direct injection; Regenerative medicine
for the urethra; Penile reconstruction; Tissue engineering
in reproductive medicine; Regenerative medicine of the
kidney; Stem cells and kidney regeneration; Techniques for
engineering bladder tissue.
592 pages 234 x 156mm (6 x 9) hardback 2009
ISBN: 978 1 84569 402 9 E-ISBN: 978 1 84569 637 5

Biomaterials for
treating skin loss
Edited by D P Orgill, Brigham
and Womens Hospital and
C Blanco, Joseph M. Still
Research Foundation, USA
Woodhead Publishing Series
in Biomaterials No. 17
CONTENTS
Part 1 Introduction: Development of skin substitutes;
Skin replacement products and markets; Biomechanics of
skin; The pathophysiologic basis for wound healing and
cutaneous regeneration; Skin grafts; Understanding the
cellular basis of skin growth; The regulatory approval process
for biomaterials for treating skin loss. Part 2 Epidermal
and dermal replacement technologies: Enhancing skin
epidermal stability; Human-derived acellular matrices for
dermal replacement; Lyophilized xenogenic products for
skin replacement. Part 3 Combined dermis and epidermal
replacement: Cultured skin substitutes; The use of
keratinocytes in combination with a dermal replacement to
treat skin loss; Principles of skin regeneration; Summary:
Biomaterials for treating skin loss.
256 pages 234 x 156mm (6 x 9) hardback 2009
ISBN: 978 1 84569 363 3 E-ISBN: 978 1 84569 554 5

CLINICAL TECHNIQUES
NEW
Perspectives in total hip
arthroplasty
Advances in biomaterials and their
tribological interactions
Edited by S Affatato, Rizzoli Orthopaedic
Institute, Italy
Due to an ageing population in the western
world, total hip arthroplasty (THA), is the
most commonly performed orthopaedic
procedure. Arthroplasty comes from two
Greek words, arthros or joint and plassein,
to form or shape. THA is performed to
replace or reconstruct a joint with an
artifcial joint (prosthesis). Hip prostheses
may be made of metal, ceramic, plastic,
or various combinations of these materials.
Chapters in the frst part of the book cover
techniques from innovative surgeons, designs
from multinational manufacturers as well as
information on improvements in technologies
and biomaterials. The second part of the
book discusses the tribology of all the major
materials used in total hip arthroplasty,
allowing readers to understand the wear of
these load bearing surfaces which is one of the
major causes in the failure of hip prostheses.
CONTENTS
Part 1 Advances in total hip arthroplasty (THA) techniques:
The history of total hip arthroplasly (THA); The history of
Biomaterials used in total hip arthroplasty (THA); Historical
techniques and designs in total hip arthroplasty (THA);
Contemporary designs in total hip arthroplasty (THA);
Fixation of total hip arthroplsaty (THA) components;
Recent developments and future trends in total hip
arthroplasty (THA). Part 2 Tribology of biomaterials for
total hip arthroplasty (THA): Tribology of the modern
Biomaterials used in total hip arthroplasty (THA); Tribology
of Polyethylene in total hip arthroplasty (THA); Tribology of
Metal in total hip arthroplasty (THA); Tribology of Ceramic
bearings in total hip arthroplasty (THA); Tribology of hybrid
hard bearings in total hip arthroplasty (THA).
390 pages 234 x 156mm (6 x 9) hardback Q2 2014
ISBN: 978 1 78242 031 6 E-ISBN: 978 1 78242 039 2

NEW
The hip resurfacing handbook
A practical guide to the use and
management of modern hip resurfacings
Edited by K De Smet, ANCA Clinic, Belgium, P
Campbell, UCLA, USA and C Van Der Straeten,
Consultant, Belgium
Woodhead Publishing Series in Biomaterials
No. 47
For the orthopaedic surgeon who wishes to consider
undertaking hip resurfacing as part of a clinical
workload, they would defnitely beneft from the wealth
of experience and the comparative data from the large
range of designs available described in this book.
R J Minns PhD, SCOPE, IPEM
Surface arthroplasty (surface replacement) of
the hip with metal-on-metal bearings is one
of the fastest growing areas within the feld
of joint surgery. Chapters in part one provide
readers with information on a wide range
of hip resurfacing designs. Part two focuses
on clinical follow-up to hip resurfacing.
Part three discusses a variety of operative
techniques, and the fnal section provides
readers with case studies and conclusions.
CONTENTS
Part 1 Hip resurfacing designs: The ACCIS hip resurfacing
prosthesis; The ADEPT

hip resurfacing prosthesis; The


DePuy Articular Surface Replacement (ASR) hip resurfacing
prosthesis; The Birmingham Hip Resurfacing (BHR)
prosthesis; The Conserve

Plus hip resurfacing prosthesis;


The Cormet
TM
hip resurfacing prosthesis; The Durom hip
resurfacing prosthesis; The ESKA hip resurfacing prosthesis;
The ICON hip resurfacing prosthesis; The MRS Modular
Hip Resurfacing prosthesis; The MIHR International

hip
resurfacing prosthesis; The MITCH hip resurfacing prosthesis;
The BIOMET RECAP hip resurfacing prosthesis; The ROMAX


hip resurfacing system; The Tornier DynaMoM hip resurfacing
prosthesis; Design issues and comparison of hip resurfacing
prostheses. Part 2 Clinical follow-up: Clinical follow-up
of the hip resurfacing patient; Acoustic phenomena in hip
resurfacing; Rehabilitation of patients after hip resurfacing;
The use of radiography to evaluate hip resurfacing; The
use of bone scintigraphy to evaluate hip resurfacing; The
use of ultrasound to evaluate hip resurfacing; The use of
Computerized Tomography (CT) to evaluate hip resurfacing;
The use of magnetic resonance imaging (MRI) to evaluate
hip resurfacing; The use of Positron Emission Tomography
(PET) to evaluate hip resurfacing; The use of dual energy
x-ray absorptiometry (DEXA) to evaluate hip resurfacing;
The use of metal ion level measurements to evaluate hip
resurfacing; The practical application of metal ion level
measurement in evaluating hip resurfacing. Part 3 Operative
techniques: Comparing surgical techniques in hip resurfacing;
Surgical technique in hip resurfacing: The modifed posterior
approach; Surgical technique in hip resurfacing: The anterior
approach; Tips and tricks for successful hip resurfacing;
Surgical instruments in hip resurfacing; Anaesthesia in hip
resurfacing; Revision surgery for failed hip resurfacing. Part
4 Failure modes in hip resurfacing; Retrieval studies showing
failure modes in hip resurfacing; Case studies of femoral
neck fractures in hip resurfacing; Case studies of femoral
loosening and femoral head collapse in hip resurfacing;
Case studies of acetabular loosening in hip resurfacing;
Case studies of acetabular malposition and high wear in hip
resurfacing; Case studies of suspected metal allergy in hip
resurfacing. Part 5 General issues: The patient experience
of hip resurfacing; Comparing hip resurfacing arthroplasty
(HRA) and total hip arthroplasty (THA); The current
regulatory status of hip resurfacing arthroplasty (HRA); Web
sites relating to hip resurfacing.
576 pages 279 x 216mm (8 x 11) hardback 2013
ISBN: 978 1 84569 948 2 E-ISBN: 978 0 85709 620 3

Clinical techniques
29
NEW
Decontamination in hospitals and
healthcare
Edited by J Walker, Public Health England, UK
Woodhead Publishing Series in Biomaterials
No. 62
Effective infection control and
decontamination in the healthcare sector
is vital to public health. This unique book
discusses decontamination practices and the
development of technologies for cleaning
and control of infection. Part one considers
the role of standards in decontamination
and infection control in Europe. Part two
focuses on decontamination practices in
healthcare, particularly the role of nurses,
issues of microbial bioflm in waterlines,
control of waterborne microorganisms and
gaseous decontamination technologies. It
explores decontamination of prions, no-touch
automated room disinfection systems and
controlling the presence of microorganisms
in hospitals. Part three discusses
decontamination and sterilisation of surgical
instruments and endoscopes. The choice
framework for protocols for decontamination
of surgical instruments and novel technologies
for cleaning and detection of contamination
are examined.
CONTENTS
Part 1 Fundamentals of decontamination in hospitals and
healthcare: The importance of decontamination in hospitals
and healthcare; The history of decontamination in hospitals;
The role of standards in decontamination; Infection control
in Europe; Future trends in decontamination in hospitals
and healthcare. Part 2 Decontamination practices in
hospitals and healthcare: Decontamination in primary care:
Dental and hospital perspectives; The role of the nursing
in decontamination; Minimising microbial contamination
in dental unit water systems and microbial control in
dental hospitals; Control of waterborne microorganisms
and reducing the threat from Legionella and Pseudomonas;
The role of continuous microbial debulking in the hospital
environment and its effect on reducing HCAIs; Provision
and control of water for healthcare purposes; Use of
gaseous decontamination technologies for wards and
isolation rooms in hospitals and healthcare settings;
Biocides and Decontamination agents including sporicides
for decontamination in hospitals; Decontamination of
prions; Cleaning and decontamination of the healthcare
environment; The role of protective clothing in healthcare
and its decontamination; A guide to no-touch automated
room disinfection systems; New technologies to control the
presence of microorganisms in hospitals; Testing strategies
and international standards for disinfectants. Part 3
Decontamination of surgical instruments and endoscopes: An
overview of current decontamination practices of surgical
instruments and medical devices; An overview of choice
framework for policies and protocols for decontamination
of surgical instruments; New technologies for the
decontamination of surgical instruments and subsequent
detection of protein (EFSCAN); Effcacy of current and
novel cleaning technologies (ID Box) for assessing protein
contamination on surgical instruments; Decontamination of
fexible endoscopes; Sterilisation of fexible endoscopes.
640 pages 234 x 156mm (6 x 9) hardback Q1 2014
ISBN: 978 0 85709 657 9 E-ISBN: 978 0 85709 669 2

NEW
A practical approach to spinal
trauma
Edited by H N Bajaj and S Katoch, Max
Healthcare Hospital, India
Woodhead Publishing Series in Biomaterials
No. 69
The book deals with fractures of the spine and
it details classifcation and the management of
spinal injuries. Authors share their experiences
and include useful tips and practical approach
to spinal trauma. There is also a discussion on
non-operative management. Ultimately the
treating surgeon needs to decide, with the
resources and facilities in mind, what is best
for the patient.
CONTENTS
Part 1 Terminology; Applied anatomy of the spinal cord;
Setting goals; Is walking possible in paraplegia? Psycological
support in spinal cord injury; Acute care in spinal cord
injury; Problems unique to tetraplegia; Operative or non
operative management? Select issues in chronic spinal cord
injury. Part 2 Fractures of the cervical spine; Fractures of
the cervico dorsal junction; Fractures of the thoracolumbar
spine; Fractures of the sacrum; Fractures of the spine in
ankylosing spondylitis; Osteoporotic fractures of the spine.
A Woodhead Publishing India title
150 pages 234 x 156mm (6 x 9) hardback Q4 2014
ISBN: 978 1 78242 066 8 E-ISBN: 978 1 78242 070 5

Preprosthetic and
maxillofacial surgery
Biomaterials, bone
grafting and tissue
engineering
Edited by J Ferri, Roger
Salengro Hospital, France
and E Hunziker, University of
Bern, Switzerland
Woodhead Publishing Series in Biomaterials
No. 32
CONTENTS
Bone tissue engineering. Part 1 Bone reconstruction in
implantology and reconstructive preprosthetic surgery:
Fundamentals of bone grafting in implantology; Cranial
bone grafting in maxillary preprosthetic surgery;
Maxillary sinus grafting for implant insertion; Symphyseal
and alveolar reconstruction in preprosthetic surgery;
Mandible corpus reconstruction for implant insertion: The
available techniques; Alveolar bi-directional distraction in
preprosthetic surgery; Alveolar widening using distraction
osteogenesis (DO) in maxillofacial surgery; Bone grafting
and Le fort 1 osteotomy in cases of major atrophy of the
maxilla. Part 2 Reconstruction in particular situations:
Applications of biomaterials in alveolar and maxillofacial
bone reconstruction; Implants in congenital missing teeth;
Maxillo-mandibular amputations and implants rehabilitation;
Alveolar reconstruction in cleft for implant rehabilitation;
Bone reconstruction in irradiated situations; Periodontal
surgery related to alveolar bone reconstruction for implant
insertion. Part 3 Tissue engineering: Mucosal and gingival
tissue engineering; Osteoinductivization of dental implants
and bone-defect-flling materials; Tissue engineering and
endodontics; Tooth regeneration: Current status.
400 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 84569 589 7 E-ISBN: 978 0 85709 242 7

MATERIALS
NEW
Bone substitute biomaterials
Edited by K Mallick, University of Warwick, UK
Woodhead Publishing Series in Biomaterials
No. 78
Bone substitute biomaterials are a
fundamental part of the biomaterials
and biomedical sector and this area has
beneftted from many recent technological
developments. Recent research has
particularly focussed on minimising failure
rates and the need for further surgery,
which can be achieved in particular through
osseointegration and regeneration. The frst
section of this book provides readers with
the principles of bone substitute biomaterials
whilst the fnal section reviews biomaterials
for bone regeneration.
CONTENTS
Bone mechanics. Part 1 Properties of bone substitutes
biomaterials in medicine: Composite materials for
bone repair; Zirconia toughened composites for hard
tissue replacements; Ceramic Foam; Titanium foam for
replacing bone; Bioresorbable bone graft substitutes. Part
2 Biomaterials and implants: Bone substitutes based on
biomineralization; Ceramics for skeletal bone regeneration;
Osteoinductivization of dental implants and bone-defect-
flling materials; Cartilage grafts for bone regeneration;
Marine organisms for bone repair; Chitosan for bone repair.
390 pages 234 x 156mm (6 x 9) hardback Q2 2014
ISBN: 978 0 85709 497 1 E-ISBN: 978 0 85709 903 7
NEW
Regulatory affairs for
biomaterials and medical devices
Edited by S Amato and B Ezzell, Northeastern
University, USA
Woodhead Publishing Series in Biomaterials
No. 79
All biomaterials and medical devices are
subject to a long list of regulatory practises
and policies which must be adhered to
in order to receive clearance. This book
provides readers with information on the
systems in place in the USA and the rest of
the world. Chapters focuses on a series of
procedures and policies including topics such
as commercialization, clinical development,
general good practise manufacturing and post
market surveillance.
CONTENTS
Historical overview and current situation; Technical aspects
of biomaterial commercialization;
Regulatory strategies for USA; Clinical development and
endpoint strategies; Supply Chain Risk Management; Approval
of devices and biomaterials; Good manufacturing practice;
Vigilance procedures/post market surveillance; Regulatory
Strategies in Asia; Continuing evolution of market access
paradigms from a health policy perspective.
300 pages 234 x 156mm (6 x 9) hardback Q2 2014
ISBN: 978 0 85709 542 8 E-ISBN: 978 0 85709 920 4
Materials
30
NEW
Semiconducting silicon
nanowires for biomedical
applications
Edited by J L Coffer, Texas Christian
University, USA
Woodhead Publishing Series in Biomaterials
No. 73
The unique fundamental physico-chemical
properties of semiconductor silicon nanowires
provide a diverse toolbox from which scientists
are tackling signifcant problems in human
health at the nanoscale. Biological systems at
both the in vitro and in vivo levels are being
investigated, as is the fabrication, surface
chemistry, and electronic properties of such
materials. This book seeks to address the
most critical range of issues emerging in this
important feld and its applications. Part
one provides readers with a comprehensive
overview of the feld and fundamental
technologies. Chapters in part two look
at tissue engineering and selected drug
delivery therapies. The fnal set of chapters
address biomolecular detection and sensing
applications of silicon nanowires.
CONTENTS
Part 1 Introduction to silicon nanowires for biomedical
applications: Overview of semiconducting silicon nanowires
for biomedical applications; Growth and characterization
of semiconducting silicon nanowires for biomedical
applications; Surface modifcation of semiconducting silicon
nanowires for biosensing applications; Biocompatibility of
semiconducting silicon nanowires. Part 2 Silicon nanowires
for tissue engineering and delivery applications: Functional
semiconducting silicon nanowires for cellular binding and
internalization; Functional semiconducting silicon nanowires
and their composites as orthopaedic tissue scaffolds;
Mediated differentiation of stem cells by engineered
semiconducting silicon nanowires; Silicon nanoneedles for
drug delivery. Part 3 Silicon nanowires for detection and
sensing: Semiconducting silicon nanowire array fabrication
for high throughput screening in the biosciences; Neural
cell pinning on surfaces by semiconducting silicon nanowire
arrays; Semiconducting silicon nanowires and nanowire
composites for biosensing and therapy; Probe-free
semiconducting silicon nanowire platforms for biosensing.
390 pages 234 x 156mm (6 x 9) hardback Q1 2014
ISBN: 978 0 85709 766 8 E-ISBN: 978 0 85709 771 2
NEW
Porous silicon for biomedical
applications
Edited by H A Santos, University of Helsinki,
Finland
Woodhead Publishing Series in Biomaterials
No. 68
Porous silicon is rapidly attracting increasing
interest in the biomaterials community. This
nanostructured and biodegradable material
has a range of properties, making it ideal
for drug delivery and tissue engineering.
In particular the pores of the material and
surface chemistry can be manipulated to tune
the rate of drug release from hours to months.
Porous silicon for biomedical applications
provides the reader with a comprehensive
review of this emerging material. Chapters
in part one focus on the fundamentals and
properties of the material. Part two discusses
applications in bio-imaging and sensing whilst
the fnal set of chapters look at drug delivery,
cancer therapy and tissue engineering
applications.
CONTENTS
Part 1 Fundamentals of porous silicon for biomedical
applications: Porous silicon for biomedical applications:
from conception to clinical use; Thermal stabilization
of porous silicon for biomedical applications; Thermal
properties of nanoporous silicon materials; Photochemical
and non-thermal chemical modifcation of porous silicon
for biomedical applications; Modifying porous silicon with
self-assembled monolayers for biomedical applications;
Protein-modifed porous silicon flms for biomedical
applications; Biocompatibility of porous silicon for
biomedical applications. Part 2 Porous silicon for bio-imaging
and bio-sensing applications: Optical Properties of porous
silicon materials for biomedical applications; In vivo imaging
assessment of porous silicon; Radiolabeled porous silicon for
bio-imaging applications; Desorption/ionization on porous
silicon (DIOS) for metabolite bio-imaging; Porous silicon
for bacteria detection; Nanoporous silicon biosensors for
DNA sensing. Part 3 Porous silicon for drug delivery, cancer
therapy and tissue engineering applications: Drug loading
and characterization of porous silicon materials; Nanoporous
silicon to enhance drug solubility; Multistage porous silicon
for cancer therapy; Porous silicon for tumour targeting
and imaging; Porous silicon - polymer composites for cell
culture and tissue engineering applications; Porous silicon
and related composites as functional tissue engineering
scaffolds; Porous silicon scaffolds for stem cells growth and
osteodifferentiation.
630 pages 234 x 156mm (6 x 9) hardback Q1 2014
ISBN: 978 0 85709 711 8 E-ISBN: 978 0 85709 715 6
NEW
Precious metals for biomedical
applications
Edited by N Baltzer and T Copponnex,
Cendres+Mtaux, Switzerland
Woodhead Publishing Series in Biomaterials
No. 77
Precious metals and semi-precious metals
have been used in medicine for many years.
The properties of these metals and their
alloys make them suitable for an increasing
number of medical applications. This book
provides readers with a useful review of this
group of materials unique properties and
applications. The frst part provides readers
with the fundamentals of precious metals for
biomedical applications before chapters in
part two look at a wide range of applications
of precious metals in medicine.
CONTENTS
Part 1 Fundamentals of precious metals for biomedical
applications: Common alloys, properties and processing or
precious metals for biomedical applications; Biocompatibility
of precious metals for biomedical applications; Corrosion
resistance of precious metals for biomedical applications;
Optimizing the interface between gold nanoparticles
(NPs) and the biological environment. Part 2 Biomedical
applications of precious metals: Precious metal alloys
for dental applications; Platinium group metals (PGMs)
for permanent implantable electronic medical devices;
Nanoporous gold for biomedical applications: Structure,
properties and applications; Gold nanoparticles for
bioimaging, drug delivery and therapeutics; Properties and
applications of silver anti-bacterial coatings; Antibacterial
silver doped bioactive glasses (BG) for tissue engineering
applications.
330 pages 234 x 156mm (6 x 9) hardback Q2 2014
ISBN: 978 0 85709 434 6 E-ISBN: 978 0 85709 905 1

Metals for
biomedical devices
Edited by M Niinomi, Tohoku
University, Japan
Woodhead Publishing Series
in Biomaterials No. 25
CONTENTS
Part 1 General introduction: Overview of metals and
biomedical applications; Metal selection for biomedical
devices. Part 2 Mechanical behaviour, degradation and
testing of metals for biomedical devices: Mechanical
properties of metallic biomaterials; Corrosion of metallic
biomaterials; Fatigue and failure of metallic biomaterials;
Mechanical testing of metallic biomaterials; Tribology and
tribo-corrosion testing and analysis of metallic biomaterials;
Biocompatibility and fabrication of in situ bioceramic
coating/titanium alloy biocomposites. Part 3 Processing
metals for biomedical applications: Forging metals and
alloys for biomedical applications; Surface treatment of
metallic biomaterials; Coatings for metallic biomaterials;
Biocompatible polymer assembly on metal surfaces;
Sterilisation and cleaning of metallic biomaterials. Part
4 Specifc applications of metals for biomedical devices:
Orthopaedic applications of metallic biomaterials; New
generation metallic biomaterials; Degradable metallic
biomaterials for cardiovascular applications.
432 pages 234 x 156mm (6 x 9) hardback 2010
ISBN: 978 1 84569 434 0 E-ISBN: 978 1 84569 924 6

Materials
31
NEW
New functional biomaterials for
medicine and healthcare
E P Ivanova, Swinburne University of
Technology, K Bazaka, James Cook University
and R J Crawford, Swinburne University of
Technology, Australia
Woodhead Publishing Series in Biomaterials
No. 67
There has been a huge amount of recent
research into developing and refning
biomaterials for use in implants and other
biomedical applications. This book provides
a concise summary of this research. It begins
with an overview of the different types of
biomaterials, as well as their use in the
design and assembly of medical implants.
The book then reviews the main types of
material used in biomaterials, including
natural and synthetic polymers, metals, inert
and bioactive ceramics. Individual chapters
review particular types of biomaterial,
their properties and applications. The book
provides an ideal one-volume summary in this
important feld.
CONTENTS
Introduction to biomaterials and implantable device design;
Natural polymer biomaterials: Advanced applications;
Advanced synthetic polymer biomaterials derived from
organic sources; Advanced synthetic and hybrid polymer
biomaterials derived from inorganic and mixed organic-
inorganic sources; Metallic biomaterials: Types and advanced
applications; Cytotoxicity and biocompatibility of metallic
biomaterials; Bioinert ceramic biomaterials: Advanced
applications; Advanced bioactive and biodegradable ceramic
biomaterials.
304 pages 234 x 156mm (6 x 9) hardback Q1 2014
ISBN: 978 1 78242 265 5 E-ISBN: 978 1 78242 266 2

Bioactive materials
in medicine
Design and applications
Edited by X Zhao, China
Research Academy of
Bioactive Molecules and
Materials (RABMM) and
University of Strathclyde,
UK, J M Courtney, University
of Strathclyde, UK and H Qian, Queen Mary
University London, UK
Woodhead Publishing Series in Biomaterials
No. 33
CONTENTS
Introduction to bioactive materials in medicine. Part 1
Designing bioactive materials for use in medicine: Molecular
design of bioactive materials with controlled bioactivity;
Bioactive materials and nanotechnology; Bioactive materials
and tissue engineering. Part 2 Applications of bioactive
materials in medicine: Antibacterial bioactive materials;
Bioactive materials in orthopaedics; Bioactive materials
in the circulatory system; Bioactive materials in gene
therapy; Bioactive materials in plastic surgery and body
reconstruction; Bioactive materials in drug delivery systems.
288 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 84569 624 5 E-ISBN: 978 0 85709 293 9

NEW
Biomaterials and
medical tribology
Research and
development
Edited by J Paulo Davim,
University of Aveiro, Portugal
Woodhead Publishing Series
in Biomaterials No. 65
Medical tribology can be defned as the
science of tribological phenomena in the
human body, both those that naturally occur
in the tissues or organs and those that arise
after implantation of an artifcial device,
while biomaterials are inert substances
designed to be incorporated into living
systems. Biomaterials and medical tribology
brings together a collection of high quality
articles and case studies focussing on new
research and developments in these two
important felds. The book provides details of
the different types of biomaterial available,
including metals, polymers and composites,
while chapters in the latter half offer an
analysis of friction, wear, lubrication and
other related issues in specifc applications.
CONTENTS
Nanoparticles for biomedical applications: Current status,
trends and future challenges; Synergism effects during
friction and fretting corrosion experiments focusing on
biomaterials used as orthopedic implants; Application of
biomedical-grade titanium alloys in trabecular bone and
artifcial joints; Fatigue strengthening of an orthopedic
Ti6Al4V alloy: What is the potential of a fnal shot peening
process? Wear determination on retrieved metal-on-metal hip
arthroplasty: An example of extreme wear; Natural articular
joints: Model of lamellar-rollerbearing lubrication and the
nature of the cartilage surface; Importance of bearing
porosity in engineering and natural lubrication; Tribological
characterization of human tooth enamel; Liposome-based
carrier systems and devices used for pulmonary drug delivery.
490 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 0 85709 017 1 E-ISBN: 978 0 85709 220 5

Biomedical composites
Edited by L Ambrosio, National Research
Council, Italy
Woodhead Publishing Series in Biomaterials
No. 21
648 pages 234 x 156mm (6 x 9) hardback 2009
ISBN: 978 1 84569 436 4 E-ISBN: 978 1 84569 737 2

Natural-based polymers for
biomedical applications
Principal editor: R L Reis, Section editors: N M
Neves, J F Mano, M E Gomes, A P Marques and
H S Azevedo, University of Minho, Portugal
Woodhead Publishing Series in Biomaterials
No. 12
832 pages 234 x 156mm (6 x 9) hardback 2008
ISBN: 978 1 84569 264 3 E-ISBN: 978 1 84569 481 4

NEW
Biomimetic biomaterials
Structure and applications
Edited by A J Ruys, University of Sydney,
Australia
Woodhead Publishing Series in Biomaterials
No. 57
The only workable strategy in developing new
biomaterials is to follow the best scientifc practices
in design and evaluation. Yet the vastness of the
biomaterials literature and the general trend towards
publishing only positive results makes it diffcult to
determine those best practicesThis book is an antidote
to many of these shortcomings by focusing on the state
of the art in biomimetic biomaterials and their design.
From the Foreword by Professor Luke
Hanley, University of Illinois at Chicago, USA
A signifcant proportion of modern medical
technology has been developed through
biomimetics, which is biologically inspired
by studying pre-existing functioning systems
in nature. Typical biomimetically inspired
biomaterials include nano-biomaterials,
smart biomaterials, hybrid biomaterials,
nano-biocomposites, hierarchically porous
biomaterials and tissue scaffolds. This
important book summarises key research in
this important feld. The frst part of the book
is devoted to the biomimetics of biomaterials
themselves, while part two provides overviews
and case studies of tissue engineering
applications from a biomimetics perspective.
CONTENTS
Part 1 Biomimetic biomaterials, structure and surfaces:
Biomimetic materials in regenerative medicine; Biomimetic
potential of chitin-based composite biomaterials of poriferan
origin; Hierarchical structure, mechanical properties and
fabrication of biomimetic biomaterials; Biomimetic coatings
for biomaterial surfaces; Functional gradients in natural and
biomimetic spinal disk structures. Part 2 Tissue engineering
applications of biomimetic biomaterials: Biomimetic
scaffolds for skin tissue and wound repair; Biomimetic
scaffolds for stem cell based tissue engineering; Biomimetic
bone regeneration; Biomimetic hydrogels as scaffolds for
tissue engineering applications; Injectable biomimetic
hydrogels for soft tissue repair.
344 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 0 85709 416 2 E-ISBN: 978 0 85709 888 7

Biomedical polymers
Edited by M Jenkins, University of Birmingham,
UK
Woodhead Publishing Series in Biomaterials
No. 7
...this publication offers an unsurpassable opportunity
to facilitate immersion in a rapidly expanding
interdisciplinary area.
...a source of reference for scientists and, in general,
all professionals involved in the development and use of
this important group of biomaterials.
Revista de Plsticos Modernos
236 pages 234 x 156mm (6 x 9) hardback 2007
ISBN: 978 1 84569 070 0 E-ISBN: 978 1 84569 364 0

Materials
32
NEW
Diamond-based
materials for
biomedical
applications
Edited by R Narayan,
University of North Carolina,
USA
Woodhead Publishing Series in Biomaterials
No. 55
Carbon is light weight, strong, conductive and
able to mimic natural materials within the
body, making it ideal for many uses within
biomedicine. Consequently a great deal of
research and funding is being put into this
interesting material with a view to increasing
the variety of medical applications for which
it is suitable. Diamond-based materials for
biomedical applications presents readers
with the fundamental principles and novel
applications of this versatile material.
CONTENTS
Part 1 Introduction to diamond based materials for medical
applications: Introduction to medical applications of
diamond particles and surfaces; Functionalisation of diamond
surfaces for medical applications; Biotribology and biological
behaviour of nanocrystalline diamond (NCD) coatings for
medical applications; Blood compatibility of diamond-like
carbon (DLC) coatings. Part 2 Biomedical applications
of diamond based materials: Nanostructured diamond
coatings for orthopaedic applications; Ultrananocrystalline
diamond (UNCD) flms for ophthalmological applications;
Ultrananocrystalline diamond (UNCD) for neural applications;
Nanodiamonds for drug delivery systems; Diamond nucleation
and seeding techniques for tissue regeneration; Diamond
materials for microfuidic devices.
296 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 0 85709 340 0 E-ISBN: 978 0 85709 351 6

Shape memory
alloys for biomedical
applications
Edited by T Yoneyama, Nihon
University and S Miyazaki,
University of Tsukuba, Japan
Woodhead Publishing Series
in Biomaterials No. 15
CONTENTS
Part 1 Materials: The shape memory effect and
superelasticity in Ti-Ni alloys; Mechanical properties of
shape memory alloys; Thermodynamics of the shape memory
effect in Ti-Ni alloys; Alternative shape memory alloys;
Fabrication of shape memory alloy parts; Response of Ti-Ni
alloys for dental biomaterials to conditions in the mouth;
Understanding, predicting and preventing failure of Ti-Ni
shape memory alloys used in medical implants; Surface
modifcation of Ti-Ni alloys for biomedical applications;
Biocompatibility of Nitinol for biomedical applications. Part 2
Medical and dental devices: Self-expanding Nitinol stents for
the treatment of vascular disease; Orthodontic devices using
Ti-Ni shape memory alloys; Endodontic instruments for root
canal treatment using Ti-Ni shape memory alloys; Regulation
orthopaedic, dental, endovascular and other applications of
Ti-Ni shape memory alloys.
352 pages 234 x 156mm (6 x 9) hardback 2008
ISBN: 978 1 84569 344 2 E-ISBN: 978 1 84569 524 8
Characterization of
biomaterials
Edited by M Jaffe,
New Jersey Institute of
Technology, W Hammond, P
Tolias, University of Medicine
and Dentistry New Jersey
and T Arinzeh, New Jersey
Institute of Technology, USA
Woodhead Publishing Series in Biomaterials
No. 64
A brief, yet very well-written and useful overview,
suitable for specialists as well as researchers new to
the feld.
Dr. Aleksandr Ovsianikov, The Biomaterials
Network.
Biomaterials and medical devices must be
rigorously tested in the laboratory before
they may be implanted into test subjects. By
ensuring that these test methods are both
quick and effcient, an increased number
of materials can be tested and working
implants can be produced more rapidly.
The development of such tests is therefore
essential to biomedical advancement, and
Characterization of biomaterials reviews the
latest methods for defning properties and
characterizing materials. Beginning with an
introduction to microscopy techniques for
analyzing the phase nature and morphology of
biomaterials, Characterization of biomaterials
goes on to discuss a wide array of techniques
and various unique approaches to the
problems faced in characterizing biomaterials,
whilst also providing information on standards
and methods for assessing the safety and
biocompatibility of biomaterials.
CONTENTS
Microscopy techniques for analyzing the phase nature and
morphology of biomaterials; Scattering techniques for
structural analysis of biomaterials; Quantitative assays
for measuring cell adhesion and motility in biomaterials;
Assays for determining cell differentiation in biomaterials;
Bioreactors for evaluating cell infltration and tissue
formation in biomaterials; Studying molecular-scale protein-
surface interactions in biomaterials; Assessing the mutagenic
effects of biomaterials: Analyzing the cellular genome
and abnormalities; Using microarrays to measure cellular
changes induced by biomaterials; Standards and methods for
assessing the safety and biocompatibility of biomaterials.
338 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 84569 810 2 E-ISBN: 978 0 85709 368 4
Wear of orthopaedic
implants and
artifcial joints
Edited by S Affatato,
Istituto Ortopedico Rizzoli di
Bologna, Italy
Woodhead Publishing Series
in Biomaterials No. 41
This important book reviews the causes and
prevention of implant wear. Part one discusses
fundamental issues such as tissue response to
wear, the anatomy and biomechanics of hips
and knees as well as the materials and design
issues they raise for hip, knee and other types
of orthopaedic implant. Part two considers
wear phenomena in a range of materials,
including ultra-high molecular weight
(UHMWPE), metal and ceramic joints. It also
covers surgical and other factors infuencing
wear as well as ways of detecting, analysing
and predicting implant wear and failure.
CONTENTS
Part 1 Fundamentals of implant wear: Introduction to wear
phenomenon of orthopaedic implants; Biology of implant
wear; Biomechanics of the hip and knee: Implant wear;
Anatomy of the hip and suitable prostheses; Anatomy of the
knee and suitable prostheses; Orthopaedic implant materials
and design; Materials used for hip and knee implants. Part
2 Wear phenomenon: The wear phenomenon of Ultra-High
Molecular Weight Polyethylene (UHMWPE) joints; The wear
phenomenon of metal joints; Wear phenomenon of ceramic
joints; The infuence of surgical techniques on implant wear;
Factors contributing to orthopaedic implant wear; Diagnosis
and surveillance of orthopaedic implants; Failure analysis
of orthopaedic implants; Wear prediction of orthopaedic
implants.
448 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 0 85709 128 4 E-ISBN: 978 0 85709 612 8

Bioceramics and their clinical
applications
Edited by T Kokubo, Chubu University, Japan
Woodhead Publishing Series in Biomaterials
No. 9
CONTENTS
Part 1 Fundamentals of bioceramics: The structure and
mechanical properties of bone; Fabrication processes
for bioceramics; The microstructure of bioceramics and
its analysis; The mechanical properties of bioceramics;
The design of ceramics for joint replacement; Cellular
response to bioactive ceramics; In vitro evaluation of
bone bioactivity; Osteoconduction and its evaluation;
Osteoinduction and its evaluation. Part 2 Types of
bioceramics: Alumina ceramics; Zirconia ceramics; Bioactive
glasses; Bioactive glass-ceramics; Calcium sulphate;
Tricalcium phosphate-based ceramics; Hydroxyapatite;
Tricalcium phosphate/hydroxyapatite biphasic ceramics;
Si-substituted hydroxyapatite; Calcium phosphate cement;
Calcium phosphate coatings; Titania-based materials;
Ceramic-polymer composites; Dental ceramics; Dental
glass-ceramics. Part 3 Clinical applications of bioceramics:
Clinical application of bioactive glasses; Clinical application
of bioactive glass-ceramics; Clinical application of
hydroxyapatite; Clinical applications of alumina ceramics
in joint replacement; Clinical applications of ceramics/
polyethylene in joint replacement; Tissue engineering using
bioceramics.
784 pages 234 x 156mm (6 x 9) hardback 2008
ISBN: 978 1 84569 204 9 E-ISBN: 978 1 84569 422 7

Materials
33
Coatings for
biomedical
applications
Edited by M Driver, Vertellus,
UK
Woodhead Publishing Series
in Biomaterials No. 37
The biomaterials sector is rapidly expanding
due to the increase in healthcare spending
worldwide. Coatings and surface modifcation
of biomaterials provides a means to improve
the wear of joints, change the biological
interaction between implant and host and
combine the properties of various materials to
improve device performance. The considerable
interest in coatings for biomedical applications
has resulted in a great deal of research in
industry and academia. This book provides a
comprehensive review of coatings and surface
modifcation for biomedical applications,
including background, theory, materials
and applications. The clear structure and
concise review of research provides a valuable
resource to researchers in the feld of
biomedical coatings.
CONTENTS
Part 1 Coating types and applications: Hydrophilic coatings
for biomedical applications in and ex vivo; Mineral
coatings for orthopaedic applications; Other commonly-
used biomedical coatings: Pyrolytic carbon coatings;
Electrochemical surface modifcations of titanium and
titanium alloys for biomedical applications; Surface
preparation techniques for biomedical applications;
Characterization of biomedical coatings. Part 2 Case studies:
Coatings for cardiovascular devices: Coronary stents;
Coatings for cardiovascular devices: Extracorporeal circuits;
Surface coatings for ventricular assist devices; Orthopaedic
coatings; Surface coatings in urology; Ophthalmic coatings.
376 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 84569 568 2 E-ISBN: 978 0 85709 367 7

Bioactive glasses
Materials, properties and
applications
Edited by H O Ylnen,
Tampere University of
Technology, Finland
Woodhead Publishing Series
in Biomaterials No. 36
CONTENTS
Part 1 Materials and mechanical properties of bioactive
glass: Melt-derived bioactive glasses; Surface modifcation
of bioactive glasses; Cell interaction with bioactive glasses
and ceramics; Regulatory aspects of bioactive glass. Part
2 Applications of bioactive glass: Bioactive glass and glass
ceramic scaffolds for bone tissue engineering; Nanoscaled
bioactive glass particles and nanofbres; Bioactive glasses
containing composites for bone and musculoskeletal tissue
engineering scaffolds; Use of bioactive glasses as bone
substitutes in orthopaedics and traumatology; Bioactive
glass S53P4 as a bone graft substitute in the treatment
of osteomyelitis; Bioactive glass for maxillofacial and
dental repair; Bioactive glass and biodegradable polymer
composites; Bioactive glasses for wound healing.
288 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 84569 768 6 E-ISBN: 978 0 85709 331 8

Biomedical hydrogels
Biochemistry, manufacture and medical
applications
Edited by S Rimmer, University of Sheffeld,
UK
Woodhead Publishing Series in Biomaterials
No. 31
CONTENTS
Part 1 Processing of hydrogels: Hydrogel swelling behaviour
and its biomedical applications; Superabsorbent cellulose-
based hydrogels for biomedical applications; Synthesis of
hydrogels control of structure and properties; Processing
and fabrication technologies for biomedical hydrogels;
Regulation of novel biomedical hydrogel products; Failure
of hydrogel implants mechanical properties. Part 2
Applications: Spinal disc implants using hydrogels; Hydrogels
for intraocular lenses and other ophthalmic prostheses;
Cartilage replacement implants using hydrogels; Imaging
implants in situ.
288 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 84569 590 3 E-ISBN: 978 0 85709 138 3

Injectable biomaterials
Science and applications
Edited by B Vernon, Arizona State University,
USA
Woodhead Publishing Series in Biomaterials
No. 30
CONTENTS
Part 1 Materials and properties: Designing clinically
useful substitutes for the extracellular matrix; Designing
ceramics for injectable bone graft substitutes; Rheological
properties of injectable biomaterials; Improving mechanical
properties of injectable polymers and composites. Part
2 Clinical applications: Drug delivery applications of
injectable biomaterials; Tissue engineering applications of
injectable biomaterials; Vascular applications of injectable
biomaterials; Orthopaedic applications of injectable
biomaterials; Dental applications of injectable biomaterials;
Injectable polymeric carriers for gene delivery systems.
Part 3 Technologies and developments: Environmentally
responsive injectable materials; Injectable nanotechnology;
Injectable biodegradable materials; Troubleshooting and
hurdles to development of biomaterials; Biocompatibility
of injectable materials; Future applications of injectable
biomaterials: The use of microgels as modular injectable
scaffolds.
432 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 84569 588 0 E-ISBN: 978 0 85709 137 6

Hyaluronan
Proceedings of an international meeting,
September 2000, North East Wales
Institute, UK
Edited by J F Kennedy, University of
Birmingham, G O Phillips, Phillips Hydrocolloid
Research Ltd, P A Williams, North East Wales
Institute of Higher Education, UK and Guest
editor V C Hascall, Lerner Research Institute,
USA
1152 pages 244 x 172mm (6 1/2 x 9 1/2) hardback 2002
ISBN: 978 1 85573 570 5 E-ISBN: 978 1 84569 312 1
MEDICAL TEXTILES
NEW
Biotextiles as medical implants
Edited by M W King, B S Gupta, North Carolina
State University, USA and R Guidoin, Laval
University Quebec, Canada
Woodhead Publishing Series in Textiles No. 113
Textiles play a vital role in the manufacture
of various medical implants including the
replacement of diseased or non-functioning
parts of the body. Biotextiles as medical
implants provides an invaluable single source
of information on the main types of textile
materials and products used for medical
implants. Chapters in the frst part of the
book are concerned with the manufacture,
properties and types of biotextiles used for
medical applications, while the second part of
the book provides a concise overview of the
various medical applications of biotextiles,
including stents, drug delivery systems and
medical sutures. The book is an invaluable
reference for manufacturers, designers,
producers of textile implant materials. It will
also be of interest to professionals within
the healthcare industry, including scientists,
nurses and students.
CONTENTS
Part 1 Technologies: Manufacture, types and properties of
biotextiles for medical applications; Nanofber structures
for medical biotextiles; Resorbable polymers for medical
applications; Shaped biotextiles for medical implants;
Surface modifcation of biotextiles for medical applications;
Sterilization techniques for biotextiles for medical
applications; Regulation of biotextiles for medical use;
Retrieval studies for medical biotextiles. Part 2 Applications:
Drug delivery systems (DDS) using biotextiles; Types and
properties of surgical sutures; Materials for absorbable and
non-absorbable surgical sutures; Surgical knot performance
in sutures; Barbed suture technology; Small diameter arterial
grafts using biotextiles; Vascular prostheses for open surgery;
Biotextiles as percutaneous heart valves; Biotextiles as
vena cava flters; Biotextiles for atrial septal defect repair;
Hemostatic wound dressings; Anterior cruciate ligament
prostheses using biotextiles; Endovascular prostheses for
aortic aneurysms: a new era for vascular surgery.
Published in association with The Textile Institute
704 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 84569 439 5 E-ISBN: 978 0 85709 560 2

Smart textiles for medicine and
healthcare
Materials, systems and applications
Edited by L Van Langenhove, University of
Ghent, Belgium
Woodhead Publishing Series in Textiles No. 63
Published in association with The Textile Institute
336 pages 234 x 156mm (6 x 9) hardback 2007
ISBN: 978 1 84569 027 4 E-ISBN: 978 1 84569 293 3

Medical textiles
34
NEW
Science of compression bandages
B Kumar, A Das and R Alagirusamy, IIT Delhi,
India
Compression treatment for chronic venous
diseases is associated with a wide range of
challenges and often produces uncertain
clinical outcomes. Investigating and exploiting
the performance of compression bandage
would further improve the knowledge of
compression management and would give
a holistic picture of this promising area.
This book discusses the fundamentals of
compression therapy i.e. compression or
pressure through multi-disciplinary approaches
involving various concepts of physics,
biological science, biomaterials, fabric
engineering, structural dynamics, material
science, technical textiles and instrumentation
to better deal with compression bandaging
from different perspectives.
CONTENTS
Introduction to compression therapy; Bandage; Sub-bandage
pressure; Compression performance under static state; Effect
of material and structure on compression; Compression
performance under dynamic state; Assessment of dynamic
stiffness index; Time dependent study of compression
management under dynamic conditions; Modelling of sub-
bandage pressure profle generated over time.
A Woodhead Publishing India title
250 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 78242 268 6 E-ISBN: 978 1 78242 272 3

Handbook of medical
textiles
Edited by V Bartels, Bartels
Scientifc Consulting GmbH,
Germany
Woodhead Publishing Series
in Textiles No. 100
CONTENTS
Part 1 Types and properties of medical textiles: Modern
textiles and biomaterials for healthcare; Hi-tech textiles
for interactive wound therapies; Reusable medical
textiles; Nonwoven materials and technologies for medical
applications; Textiles for implants and regenerative
medicine; Textiles with cosmetic effects; Drug-releasing
textiles; Medical textiles and thermal comfort. Part 2
Textiles and the skin: Contact sensations of medical textiles
on the skin; Mechanical skin irritations due to textiles;
Allergies caused by textiles; Biofunctional textiles based on
cellulose and their approaches for therapy and prevention
of atopic eczema. Part 3 Textiles for hygiene: Infection
prevention and control and the role of medical textiles;
Absorbent products for personal health care and hygiene;
Bio-functional textiles; Hospital laundries and their role in
medical textiles; Odour control of medical textiles. Part
4 Medical textile case studies and applications: Textiles
for medical flters; Textiles for patient heat preservation
during operations; Evaluation of occupational clothing for
surgeons: Achieving comfort and avoiding physiological stress
through suitable gowns; Superabsorbents and their medical
applications; Nanofbrous textiles in medical applications.
Published in association with The Textile Institute
608 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 84569 691 7 E-ISBN: 978 0 85709 369 1
Textiles for hygiene and
infection control
Edited by B J McCarthy, TechniTex Faraday
Limited, UK
Woodhead Publishing Series in Textiles No. 108
CONTENTS
Part 1 Design and production techniques for hygiene textiles:
The design of novel hygiene textile products; Nanotechnology
and its applications in medical hygiene textiles; Use of
knitted spacer fabrics for hygiene applications; Innovative
and sustainable packaging strategies for hygiene products;
Biodegradable hygiene products. Part 2 Design and
production techniques for infection-control textiles: Micro-
organisms, infection and the role of textiles; Creating barrier
textiles through plasma processing; Disposable and reusable
medical textiles; Ensuring fabrics survive sterilisation. Part
3 Product types: Washable textile-based absorbent products
for incontinence; Biological containment suits used in
microbiological high containment facilities and by emergency
responders; Coated textiles for skin infections; Antimicrobial
treatments of textiles for hygiene and infection control
applications: An industrial perspective.
Published in association with The Textile Institute
240 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 84569 636 8 E-ISBN: 978 0 85709 370 7

Medical and healthcare textiles
Edited by S C Anand, University of Bolton, J F
Kennedy, Chembiotech Ltd, M Miraftab and S
Rajendran, University of Bolton, UK
Woodhead Publishing Series in Textiles No. 75
Published in association with The Textile Institute
560 pages 234 x 156mm (6 x 9) hardback 2010
ISBN: 978 1 84569 224 7 E-ISBN: 978 0 85709 034 8

Medical textiles and biomaterials
for healthcare
Edited by S C Anand, University of Bolton, J
F Kennedy, Chembiotech Ltd, UK, M Miraftab
and S Rajendran, University of Bolton
Woodhead Publishing Series in Textiles No. 48
520 pages 234 x 156mm (6 x 9) hardback 2005
ISBN: 978 1 85573 683 2 E-ISBN: 978 1 84569 410 4

Advanced textiles for wound
care
Edited by S Rajendran, University of Bolton,
UK
Woodhead Publishing Series in Textiles No. 85
a detailed and thorough look into this exciting
application of textiles.
International Textile and Apparel Association
Published in association with The Textile Institute
360 pages 234 x 156mm (6 x 9) hardback 2009
ISBN: 978 1 84569 271 1 E-ISBN: 978 1 84569 630 6

TECHNOLOGIES AND
PERFORMANCE
NEW
Biophotonics for medical
applications
Edited by I Meglinski, University of Otago, New
Zealand
Woodhead Publishing Series in Biomaterials
No. 82
The feld of biophotonics is concerned with
the interface between laser optics and cell
biology/medicine. In particular, biophotonic
technologies allow scientists to create
new tools for analysing and manipulating
nano and macro scale objects. This book
discusses the development and application of
photonic techniques which aid the diagnosis
and therapeutics of biological tissues in
both healthy and diseased states. Chapters
discuss the fundamental technologies used in
biophotinics and a wide range of therapeutic
and diagnostic applications.
CONTENTS
Multimodal biomedical imaging; Optical fbres and sensors;
Biomedicine with SERS; Optical biopsy in prostate cancer
detection; Biophonitcs for cancer treatment; Therapeutic
photonics in pulmonary medicine; Laser processing of
medical devices; Tissue oxygenation analysis; Biophotonics in
dental health; Assessing skin fap survival.
330 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 0 85709 662 3 E-ISBN: 978 0 85709 674 6

Degradation rate
of bioresorbable
materials
Prediction and evaluation
Edited by F J Buchanan,
Queens University Belfast,
UK
Woodhead Publishing Series
in Biomaterials No. 13
CONTENTS
Part 1 Introduction. Part 2 Degradation mechanisms:
Synthetic bioresorbable polymers. Part 3 Bioresorption test
methods. Part 4 Factors infuencing bioresorption. Part 5
Clinical application.
424 pages 234 x 156mm (6 x 9) hardback 2008
ISBN: 978 1 84569 329 9 E-ISBN: 978 1 84569 503 3
Technologies and performance
35
NEW
Computational modelling of
biomechanics and biotribology in
the musculoskeletal system
Biomaterials and tissues regeneration
Edited by Z Jin, University of Leeds, UK
Woodhead Publishing Series in Biomaterials
No. 81
Modelling is an important aspect of the
design process for biomaterials and medical
devices. By effectively modelling biomaterials
and implants before their implantation, it
is now possible to predict certain implant-
tissue reactions, degradation and wear.
Consequently, computational modelling is
becoming increasingly important in the design
and manufacture of biomedical materials,
allowing scientists to more accurately tailor
their materials properties for the in vivo
environment. Computational modelling
of biomechanics and biotribology in the
musculoskeletal system begins with an
introduction to the feld and the software
and technologies. Part two covers generic
modelling of cells and tissues whilst chapters
in part three discuss modelling of biomaterials
and interfaces. Part four reviews biomechanics
and biotribology with chapters in part fve
discussing applications of modelling for joint
replacements and tissue engineering.
CONTENTS
Part 1 Introduction: Fundamentals of computational
modelling; Software. Part 2 Generic modelling of cells
and tissues: Computational modelling of cell mechanics;
Computational modelling of soft tissues and ligaments;
Computational modelling of cartilage; Computational
modelling of bone and bone remodelling; Modelling
fracture processes in bones. Part 3 Generic modelling of
biomaterials and interfaces: Computational modelling
of polymeric biomaterials; Modelling fatigue of bone
cement; Modelling fracture processes in orthopaedic
implants; Modelling orthopaedic fxation. Part 4 Generic
modelling of biomechanics and biotribology: Finite element
modelling in the musculoskeletal system; Computational
modelling of Muscle biomechanics; Joint wear simulation.
Part 5 Applications of computational modelling for joint
replacements and tissue regeneration: Computational
modelling of hip implants; Computational modelling of
knee implants; Computational modelling of spinal implants;
Computer aided design of bone tissue scaffolds.
570 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 0 85709 661 6 E-ISBN: 978 0 85709 673 9
NEW
Modelling degradation of
bioresorbable polymeric medical
devices
Edited by J Pan, University of Leicester, UK
Woodhead Publishing Series in Biomaterials
No. 83
The use of bioresorbable polymers in stents,
fxation devices and tissue engineering is
revolutionising medicine. Both industry
and academic researchers are interested
in using computer modelling to replace
some experiments which are costly and
time consuming. This book provides readers
with a comprehensive review of modelling
polymers and polymeric medical devices as an
alternative to practical experiments. Chapters
in part one provide readers with an overview
of the fundamentals of biodegradation. Part
two looks at a wide range of degradation
theories for bioresorbable polymers and
devices. The fnal set of chapters looks
at advances in modelling biodegradation
of bioresorbable polymers. This book is
an essential guide to those concerned
with replacing tests and experiments with
modelling.
CONTENTS
Part 1 Fundamentals of biodegradation of bioresorbable
polymer devices: Introduction to bioresorbable medical
devices and the need for computer modelling; Degradation
pathway of bioresorbable polymer devices. Part 2
Degradation theories for bioresorbable polymers and devices:
Modelling biodegradation of amorphous bioresorbable
polymers; Modelling biodegradation of semicrystalline
bioresorbable polymer devices; Modelling biodegradation of
polymer/TCP composites devices; Degradation of mechanical
properties of bioresorbable polymers. Part 3 Advanced topics
in modelling biodegradation of bioresorbable polymers:
Effective diffusion coeffcient in degrading polymer devices;
Finite element analysis of polymer device biodegradation.
300 pages 234 x 156mm (6 x 9) hardback Q3 2014
ISBN: 978 1 78242 016 3 E-ISBN: 978 1 78242 025 5
NEW
Biomedical imaging
Applications and advances
Edited by P Morris, University of Nottingham,
UK
Woodhead Publishing Series in Biomaterials
No. 63
The development of imaging techniques is
of great importance for the monitoring of
medical implants, diagnosis of disease and
for strategies for personalised medicine.
Signifcant advances are being made in
this technology and this book discusses the
latest advances and developments in this
increasingly important feld. The book begins
with an introduction to the feld and its
various technologies. Following on from this,
chapters provide readers with a wide ranging
review of medical applications such as brain,
ophthalmic, musculoskeletal and whole body
imaging. This text will be invaluable to those
concerned with imaging and diagnosis.
CONTENTS
Part 1 Imaging technologies: Biomedical Positron Emission
Tomograpgy (PET) imaging; Atomic Force Microscopy
(AFM) in biomedical research; Next Generation techniques
for biomedical imaging. Part 2 Application specifc
biomedical imaging techniques: Brain imaging: Assessing
therapy responses; Neural brain activation imaging;
Ophthalmic imaging of ocular circulation for detecting
disease; Intravascular Magnetic resonance imaging (MRI);
Cardiovascular magnetic resonance imaging (MRI); Imaging
methods for detection of joint degeneration; Whole body
magnetic resonance imaging (MRI).
330 pages 234 x 156mm (6 x 9) hardback Q1 2014
ISBN: 978 0 85709 127 7 E-ISBN: 978 0 85709 747 7
Technologies and performance
36
NEW
Rapid prototyping of biomaterials
Principles and applications
Edited by R Narayan, University of North
Carolina, USA
Woodhead Publishing Series in Biomaterials
No. 70
Rapid prototyping techniques, like the Inkjet
Printer, are capable of building complex
structures. These techniques have been
used frequently in mechanical engineering
and this technology has now been proven
to successfully build biomaterials. The
technology is particularly useful as the layer
by layer fabrication approach also allows
the internal architecture to be controlled.
Chapters in this book frstly cover the
fundamentals of additive manufacturing and
its various related technologies. Further
chapters continue to discuss a wide range of
medical applications from tissue engineering
and biosensors to printed prosthetic limbs.
CONTENTS
Introduction to rapid prototyping of biomaterials; Freeform
fabrication of nano-biomaterials using 3D printing; Rapid
prototyping techniques for the fabrication of biosensors;
Rapid prototyping technologies for tissue regeneration; Rapid
prototyping of complex tissues with laser assisted bioprinting
(LAB); Scaffolding hydrogels for rapid prototyping based
tissue engineering; Bioprinting for constructing microvascular
systems for organs; Feasibility of 3D scaffolds for organs;
3-D Organ printing technologies for tissue engineering
applications; Rapid prototyping technology for bone
regeneration; Additive manufacturing of a prosthetic limb.
328 pages 234 x 156mm (6 x 9) hardback Q1 2014
ISBN: 978 0 85709 599 2 E-ISBN: 978 0 85709 721 7

Medical modelling
The application of
advanced design and
development techniques
in medicine
R Bibb, University of Wales,
UK
Woodhead Publishing Series
in Biomaterials No. 5
CONTENTS
Basic human anatomy; Computed tomography scanning;
Magnetic resonance scanning; Non contact surface scanning;
Export data format and media; Using medical scan data;
Physical reproduction; Case studies; Future developments,
Bibliography.
312 pages 234 x 156mm (6 x 9) hardback 2006
ISBN: 978 1 84569 138 7 E-ISBN: 978 1 84569 200 1
NEW
Microfuidic devices for
biomedical applications
Edited by X-J Li, University of Texas and Y
Zhou, Genus Plc, USA
Woodhead Publishing Series in Biomaterials
No. 61
Microfuidic devices are used to manipulate
fuid such as blood, cell suspensions and
therapies. This important technology is
suitable for numerous applications from drug
delivery to tissue engineering. The use of
microfuidics in medicine is still evolving and
microfuidic devices can be cheaply made
and are small, applications are continually
being researched and produced in the
medical feld. This important book discusses
the fundamentals of microfuidics and will
provide information on a wide range of
medical applications. The frst set of chapters
discuss the fundamentals of microfuidic
devices for medical applications. Subsequent
chapters look at drug delivery applications,
applications in cell biology, tissue engineering
and diagnostics. In the fnal set of chapters,
sensing applications are then reviewed.
CONTENTS
Part 1 Fundamentals of microfuidic technologies for
biomedical applications: Materials and methods for the
microfabrication of microfuidic biomedical devices;
Surface coatings for microfuidic-based biomedical devices;
Actuation mechanisms for microfuidic biomedical devices;
Digital microfuidics technologies for biomedical devices.
Part 2 Applications of microfuidic devices for drug delivery
and discovery: Controlled drug delivery using microfuidic
devices; Microneedles for drug delivery applications;
Microfuidic devices for drug discovery and analysis. Part 3
Applications of microfuidic devices for cellular analysis and
tissue engineering: Microfuidic devices for cell manipulation;
Microfuidic devices for automated micro-robotic cell
injection and trapping; Microfuidic devices for developing
tissue scaffolds; Microfuidic devices for stem cell analysis.
Part 4 Applications of microfuidic devices in diagnostic
sensing: Development of immunoassays for protein analysis
on nanobioarray chips; Integrated microfuidic systems for
genetic analysis; Low-cost assays in paper-based microfuidic
biomedical devices; Microfuidic devices for viral detection;
Microfuidics for monitoring and imaging pancreatic islets and
-cells; Microfuidic devices for radio chemical synthesis.
752 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 0 85709 697 5 E-ISBN: 978 0 85709 704 0
NEW
Bio-tribocorrosion
in biomaterials and
medical implants
Edited by Y Yan, University
of Science and Technology
Beijing, China
Woodhead Publishing Series
in Biomaterials No. 60
During their service life, most biomaterials and
medical implants are vulnerable to tribological
damage. In addition, the environments in
which they are placed are often corrosive. The
combination of triobology, corrosion and the
biological environment has been named bio-
tribocorrosion. Understanding this complex
phenomenon is critical to improving the design
and service life of medical implants. This
important book reviews key recent research
in this area. After an introduction to the
topography of bio-tribocorrosion, part one
discusses different types of tribocorrosion
as well as the prediction of wear in medical
devices. Part two looks at biological effects on
tribocorrosion processes. Part three reviews
the issue of bio-tribocrrosion in clinical
practice, including dental and orthopaedic
applications.
CONTENTS
Topography in bio-tribocorrosion. Part 1 Wear-corrosion
mechanisms in biomaterials: Synergistic mechanisms of
bio-tribocorrosion in medical implants; Fretting corrosion
processes and wear mechanisms in medical implants; Wear
and corrosion in the loosening of total joint replacements
(TJRs); Abrasion-corrosion mechanisms of implant
materials; Wear prediction in dental composites. Part 2
Bio-tribocorrosion and the biological environment: Growth
of passive tribo-flms in medical implants; Bioflms in
the oral environment; Infuence of protein adsorption on
corrosion of biomedical alloys. Part 3 Bio-tribocorrosion
in the clinical environment: Bio-tribocorrosion in dental
applications; Corrosion resistant coatings for dental
implants; Biotribocorrosion: surface interactions in total
joint replacement (TJR); Tribocorrosion in artifcial joints:
in vitro testing and clinical implications; Testing protocol for
the study of bio-tribocorrosion.
432 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 0 85709 540 4 E-ISBN: 978 0 85709 860 3

Molecular interfacial phenomena
of polymers and biopolymers
Edited by P Chen, University of Waterloo,
Canada
Woodhead Publishing Series in Biomaterials
No. 3
it will be valued by researchers and postgraduate
students with interest in polymers or biopolymers.
All the sections are unique and specialised to the
authors feld of expertise.
Materials World
712 pages 234 x 156mm (6 x 9) hardback 2005
ISBN: 978 1 85573 928 4 E-ISBN: 978 1 84569 083 0

Technologies and performance
37
NEW
Joining and assembly of medical
materials and devices
Edited by Y N Zhou, University of Waterloo,
Canada and M D Breyen, Medtronic Inc, USA
Woodhead Publishing Series in Biomaterials
No. 54
As medical devices become more intricate,
with an increasing number of components
made from a wide range of materials,
it is important that they meet stringent
requirements to ensure that they are safe
to be implanted and will not be rejected
by the human body. Joining and assembly
of medical materials and devices provides
a comprehensive overview of joining
techniques for a range of medical materials
and applications. Part one provides an
introduction to medical devices and joining
methods. Part two moves on to explore the
joining and assembly of medical metals. Part
three focuses on medical plastics. Finally,
part four discusses the joining and assembly of
biomaterial and tissue implants.
CONTENTS
Part 1 Fundamentals of joining and assembly in medical
materials and devices: Introduction to medical materials
and devices; Introduction to joining methods in medical
applications; Micro-welding methods in medical components
and devices; The effects of sterilization on medical materials
and welded devices. Part 2 Joining and assembly of medical
metals: Microwelding of shape memory alloys; Joining of
platinum (Pt) alloys and stainless steel wires for electronic
medical devices; Evaluating the corrosion performance
of metal medical device welds; Laser hermetic welding
of implantable medical devices; Validating hermeticity in
welded metallic implantable medical devices. Part 3 Joining
and assembly of medical plastics: Overview of welding
methods for medical plastics; Ultrasonic welding of medical
plastics; Radio frequency (RF)/dielectric welding of medical
plastics; Transmission laser welding strategies for medical
plastics; Bonding strategies and adhesives for joining
medical device components. Part 4 Joining and assembly of
biomaterial and tissue implants: Advanced metal-ceramic
joining techniques for orthopaedic applications; Tissue
adhesives and sealants for surgical applications; Antibacterial
adhesives for bone and tooth repair; Testing bond strength:
The case of dental biomaterials.
580 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 84569 577 4 E-ISBN: 978 0 85709 642 5

Surfaces and interfaces for
biomaterials
Edited by P Vadgama, Queen Mary University
of London, UK
Woodhead Publishing Series in Biomaterials
No. 2
824 pages 234 x 156mm (6 x 9) hardback 2005
ISBN: 978 1 85573 930 7 E-ISBN: 978 1 84569 080 9
NEW
Lasers for medical applications
Diagnostics, therapy and surgery
Edited by H Jelinkova, Czech Technical
University, Czech Republic
Woodhead Publishing Series in Electronic and
Optical Materials No. 37
Lasers have a wide and growing range of
applications in medicine. Lasers for medical
applications summarises the wealth of recent
research on the principles, technologies and
application of lasers in diagnostics, therapy
and surgery. Part one gives an overview of the
use of lasers in medicine, key principles of
lasers and radiation interactions with tissue.
The respective types of the laser (solid state,
gas, dye, and semiconductor) are reviewed
in part two. Part three describes diagnostic
laser methods, for example optical coherence
tomography, spectroscopy, optical biopsy,
and time-resolved fuorescence polarization
spectroscopy. Part four concentrates on the
therapeutic applications of laser radiation in
particular branches of medicine.
CONTENTS
Introduction: The history of lasers in medicine. Part 1 Laser-
tissue interaction: Laser characteristics; The response of
tissue to laser light; Optical fbers for medical applications.
Part 2 Types of laser used in medicine: Solid-state lasers for
medical applications; Gas lasers for medical applications;
Liquid and solid-state tunable organic dye lasers for
medical applications; Semiconductor lasers for medical
applications. Part 3 Lasers in diagnostics: Optical sources
for optical coherence tomography (OCT); Laser spectroscopy
in medical diagnostics; Optical biopsy for cancer detection;
Time-resolved fuorescence polarization spectroscopy
and optical imaging of smart receptor-targeted contrast
agents in tissues for cancer detection. Part 4 Laser therapy
and surgery: Laser therapy in ophthalmology; Lasers in
dermatology; Lasers in cardiology; Lasers in urology; Lasers
in gynecology; Lasers in otorhinolaryngology (ORL) and head
and neck surgery; Lasers in neurology; Lasers in dentistry;
Laser in orthopaedic surgery; Cancer laser therapy using
gold nanoparticles; Hybrid laser technology for biomaterials;
Laser safety: Regulations, standards, and guidelines for
practice; Photodynamic therapy for human malignancies with
superfcial and interstitial illumination.
800 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 0 85709 237 3 E-ISBN: 978 0 85709 754 5

Cellular response to biomaterials
Edited by L Di Silvio, Kings College London,
UK
Woodhead Publishing Series in Biomaterials
No. 16
648 pages 234 x 156mm (6 x 9) hardback 2008
ISBN: 978 1 84569 358 9 E-ISBN: 978 1 84569 547 7
Non-metallic
biomaterials for
tooth repair and
replacement
Edited by P Vallittu,
University of Turku, Finland
Woodhead Publishing Series
in Biomaterials No. 53
As the demand for healthy, beautiful teeth
increases, the methods and materials
employed in restorative dentistry have
become progressively advanced. Non-metallic
biomaterials for tooth repair and replacement
focuses on the use of biomaterials for a
range of applications in tooth repair and, in
particular, dental restoration.
CONTENTS
Part 1 Structure, modifcation and repair of dental
tissues: Structure and properties of enamel and dentin;
Biomineralization and biomimicry of tooth enamel; Enamel
and dentin bonding for adhesive dental restorations;
Enamel matrix proteins (EMP) for periodontal regeneration.
Part 2 Dental ceramics and glasses for tooth repair and
replacement: Processing and bonding of dental ceramics;
Wear properties of dental ceramics; Sol-gel derived bioactive
glass ceramics for dental applications. Part 3 Dental
composites for tooth repair and replacement: Composite
adhesive restorative materials for dental applications;
Antibacterial composite restorative materials for dental
applications; Effects of particulate fller systems on the
properties and performance of dental polymer composites;
Composite based oral implants; Fibre reinforced composites
(FRCs) as dental materials; Luting cements for dental
applications.
432 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 0 85709 244 1 E-ISBN: 978 0 85709 643 2
Medical robotics
Minimally invasive surgery
Edited by P Gomes, Cambridge Consultants,
UK
Woodhead Publishing Series in Biomaterials
No. 51
Advances in research have led to the use of
robotics in a range of surgical applications.
Medical robotics: Minimally invasive surgery
provides authoritative coverage of the core
principles, applications and future potential of
this enabling technology.
CONTENTS
Introduction to robot-assisted Minimally Invasive Surgery
(MIS); Localisation and tracking technologies for medical
robotics; Robotics for neurosurgery; Robotic systems for
cardiovascular interventions; Robotics in orthopaedic
surgery; Robotic-assisted knee replacement surgery; Robotics
in Ear, Nose and Throat (ENT) surgery; Robotic-assisted
vitreoretinal surgery; Robotics for minimally invasive surgery
(MIS) and natural orifce transluminal endoscopic surgery
(NOTES); Meso-Scale mobile robots for gastrointestinal
Minimally Invasive Surgery (MIS); Real-time software
platform using magnetic resonance imaging (MRI) for in vivo
navigation of magnetic microrobots; Robotic surgery and
ethical issues.
320 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 0 85709 130 7 E-ISBN: 978 0 85709 739 2
Technologies and performance
38
Biocompatibility
and performance of
medical devices
Edited by J-P Boutrand,
Biomatech, France
Woodhead Publishing Series
in Biomaterials No. 50
Implant and device manufacturers are
increasingly facing the challenge of proving
that their products are safe, biocompatible,
and perform as expected. Biocompatibility
and performance of medical devices provides
an essential guide to the performance analysis
of these vital devices. Part one introduces
key concepts and challenges faced in relation
to biocompatibility in medical devices. Part
two goes on to discuss the evaluation and
characterisation of biocompatibility in medical
devices, including material and chemical
characterization, allowable limits for toxic
leachables, in vivo and in vitro testing, and
blood compatibility assessment. Testing and
interpreting medical device performance
is the focus of part three, with preclinical
performance studies for bone, dental and
soft tissue implants, and mechanical testing
for soft and hard tissues implants discussed.
Part four provides information on the
international regulation of medical devices
in the European Union, Japan and China,
before concluding in part fve with a review of
histopathology principles for biocompatibility
and performance studies.
CONTENTS
Part 1 Introduction to biocompatibility in medical
devices: Concepts in biocompatibility: New biomaterials,
new paradigms and new testing regimes; Challenges in
biocompatibility and failure of biomaterials; Biological
safety evaluation planning of biomaterials; Biomechanical
and biochemical compatibility in innovative biomaterials.
Part 2 Evaluation and characterisation of biocompatibility in
medical devices: Material and chemical characterization for
the biological evaluation of medical device biocompatibility;
Allowable limits for toxic leachables: Practical Use of
ISOStandard; In vivo and in vitro testing for the biological
safety evaluation of biomaterials and medical devices;
Practical approach to blood compatibility assessments:
General considerations and standards; Medical device
biocompatibility evaluation: An industry perspective; Case
study: Overcoming negative tests results during manufacture;
Methods for the characterisation and evaluation of
drug-device combination products. Part 3 Testing and
interpreting the performance of medical devices: Methods
and interpretation of performance studies for bone implants;
Methods and interpretation of performance studies for dental
implants; Non-clinical functional evaluation of medical
devices: General recommendations and examples for soft
tissue implants; Mechanical testing for soft and hard tissues
implants. Part 4 International regulation of medical devices:
Biological evaluation and regulation of medical devices in
the European Union; Biological evaluation and regulation
of medical devices in Japan; Medical device regulations in
China. Part 5 Histopathology principles for biocompatibility
and performance studies: Microscopic and ultrastructural
pathology in medical devices.
540 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 0 85709 070 6 E-ISBN: 978 0 85709 645 6
Sterilisation of
biomaterials and
medical devices
Edited by S Lerouge, Ecole
de Technologie Suprieure,
Canada and A Simmons,
University of New South
Wales, Australia
Woodhead Publishing Series in Biomaterials
No. 46
The effective sterilisation of any material or
device to be implanted in or used in close
contact with the human body is essential
for the elimination of harmful agents such
as bacteria. Sterilisation of biomaterials
and medical devices reviews established and
commonly used technologies alongside new
and emerging processes. This book reviews
the sterilisation of biomaterials and medical
devices using steam and dry heat, ionising
radiation and ethylene oxide. A range of
non-traditional sterilisation techniques, such
as hydrogen peroxide gas plasma, ozone
and steam formaldehyde, is then discussed
together with research in sterilisation and
decontamination of surfaces by plasma
discharges. Sterilisation techniques for
polymers, drug-device products and tissue
allografts are then reviewed, together with
antimicrobial coatings for self-sterilisation
and the challenge presented by prions and
endotoxins in the sterilisation of reusable
medical devices.
CONTENTS
Introduction to sterilisation: Defnitions and challenges;
Steam and dry heat sterilisation of biomaterials and
medical devices; Sterilisation of healthcare products by
ionising radiation: Principles and standards; Ethylene Oxide
(ETO) sterilisation of healthcare products; Non-traditional
sterilisation techniques for biomaterials and medical
devices; Sterilisation and decontamination of surfaces by
plasma discharges; Sterilisation techniques for polymers;
Sterilisation of healthcare products by ionising radiation:
Sterilisation of drug-device products and tissue allografts;
Antimicrobial coatings for self-sterilisation; Prions and
endotoxins: Reprocessing strategies for reusable medical
devices; Future trends for the sterilisation of biomaterials
and medical devices.
352 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 84569 932 1 E-ISBN: 978 0 85709 626 5

Sterilisation of polymer
healthcare products
W Rogers
326 pages 255 x 190mm (7 1/2 x 10) paperback 2005
ISBN: 978 1 85957 490 4
Durability and
reliability of medical
polymers
Edited by M Jenkins and A
Stamboulis, University of
Birmingham, UK
Woodhead Publishing Series
in Biomaterials No. 44
Given the widespread use of polymers in
medical devices, the durability and reliability
of this material in use is an area of critical
importance. Durability and reliability of
medical polymers reviews the performance
of both bioresorbable and non-bioresorbable
medical polymers.
CONTENTS
Part 1 Types and properties of bioresorbable medical
polymers: Types of bioresorbable polymers for medical
applications; The effect of molecular structure on
the properties of biomedical polymers; Processing of
bioresorbable and other polymers for medical applications;
Understanding transport phenomena and degradation of
bioresorbable medical polymers; Synthetic bioresorbable
polymers; Using synthetic bioresorbable polymers for
orthopaedic tissue regeneration. Part 2 Aspects of durability
and reliability of non-bioresorbable medical polymers:
Wear processes in polymer implants; Ageing processes of
biomedical polymers in the body; The failure of synthetic
polymeric medical devices; Manufacturing defects in
polymeric medical devices.
296 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 84569 929 1 E-ISBN: 978 0 85709 651 7

Biointegration of
medical implant
materials
Science and design
Edited by C P Sharma, Sree
Chitra Tirunal Institute
for Medical Sciences and
Technology, India
Woodhead Publishing Series in Biomaterials
No. 26
CONTENTS
Biointegration: An introduction. Part 1 Soft tissue
biointegration: Biocompatibility of engineered soft tissue
created by stem cells; Replacement materials for facial
reconstruction at the soft tissue-bone interface; Corneal
tissue engineering; Tissue engineering for small-diameter
vascular graft; Stem cells for organ regeneration. Part 2
Drug delivery: Materials facilitating protein drug delivery
and vascularisation; Inorganic nanoparticles for targeted
drug delivery; Alginate-based drug delivery devices;
Functionalised nanoparticles for targeted drug delivery.
Part 3 Design considerations: Biocompatibility of Materials
and its relevance to drug delivery and tissue engineering;
Mechanisms of failure of medical implants during long-term
use; Rapid prototyping in biomedical Engineering: Structural
intricacies of biological materials.
424 pages 234 x 156mm (6 x 9) hardback 2010
ISBN: 978 1 84569 509 5 E-ISBN: 978 1 84569 980 2
Technologies and performance
39
Implantable sensor
systems for medical
applications
Edited by A Inmann, Andreas
Inmann Consulting, USA
and D Hodgins, European
Technology for Business
Limited, UK
Woodhead Publishing Series in Biomaterials
No. 52
Implantable sensor systems offer great
potential for enhanced medical care and
improved quality of life, consequently leading
to vast investment in this exciting feld.
Implantable sensor systems for medical
applications provides a wide-ranging overview
of the core technologies, key challenges and
main issues related to the development and
use of these devices in a diverse range of
medical applications.
CONTENTS
Part 1 Fundamentals of implantable systems: Materials
for implantable systems; Material-tissue interfaces in
implantable systems; Packaging and coating materials for
implantable systems; Microassembly and micropackaging of
implantable systems; Electrode array design and fabrication
for implantable systems; Biofuel cells as sustainable
power sources for implantable systems. Part 2 Challenges
of implantable systems: Biocompatibility of implantable
systems; Sterilisation considerations for implantable
sensor systems; Protection of data confdentiality and
patient privacy in medical sensor networks; Developing
active implantable medical devices in a regulated
environment. Part 3 Applications of implantable systems:
Microelectromechanical systems (MEMS) for in-vivo
applications; Tripolar interfaces for neural recording; Sensors
for motor neuroprostheses; Implantable wireless body area
networks; Retina implants.
544 pages 234 x 156mm (6 x 9) hardback 2013
ISBN: 978 1 84569 987 1 E-ISBN: 978 0 85709 628 9

Biosensors for medical
applications
Edited by S Higson, Cranfeld University, UK
Woodhead Publishing Series in Biomaterials
No. 45
Biosensors for medical applications provides a
comprehensive review of established, cutting
edge and future trends in biomedical sensors
and their applications.
CONTENTS
Part 1 Principles and transduction approaches:
Electrochemical biosensors for medical applications;
Piezoelectric biosensors for medical applications; Nano-sized
biosensors for medical applications; Impedence interrogated
affnity biosensors for medical applications: Novel targets
and mechanistic studies; Practical applications and protocols
for enzyme biosensors. Part 2 Applications of medical
biosensors: Biosensors for DNA and RNA detection and
characterization; Biosensors for disease biomarker detection;
Affbodies as an alternative to antibodies in biosensors for
cancer markers; Biosensors for drug testing and discovery;
Biosensors for non-invasive measurements; Wearable
biosensors for medical applications.
360 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 84569 935 2 E-ISBN: 978 0 85709 718 7
MEMS for biomedical
applications
Edited by S Bhansali
and A Vasudev, Florida
International University, USA
Woodhead Publishing Series
in Biomaterials No. 43
The application of Micro Electro Mechanical
Systems (MEMS) in the biomedical feld is
leading to a new generation of medical
devices. MEMS for biomedical applications
reviews the wealth of recent research on
fabrication technologies and applications of
this exciting technology. Part one introduces
the fundamentals of MEMS for biomedical
applications, exploring the microfabrication of
polymers and reviewing sensor and actuator
mechanisms. Part two goes on to consider
MEMS for biomedical sensing and diagnostic
applications. MEMS for tissue engineering
and clinical applications are the focus of part
three. Finally, part four reviews emerging
biomedical applications of MEMS, from
implantable neuroprobes and ocular implants
to cellular microinjection.
CONTENTS
Part 1 Fundamentals of MEMS for biomedical applications:
Microfabrication of polymers for bioMEMS; Review of
sensor and actuator mechanisms for bioMEMS. Part 2
MEMS for biomedical sensing and diagnostic applications:
MEMS for in vivo sensing; MEMS and electrical impedance
spectroscopy (EIS) for non-invasive measurement of cells;
MEMS ultrasonic transducers for biomedical applications;
Lab-on-chip (LOC) devices and microfuidics for biomedical
applications. Part 3 MEMS for tissue engineering and clinical
applications: Fabrication of cell culture microdevices
for tissue engineering applications; MEMS manufacturing
techniques for tissue scaffolding devices; BioMEMS for drug
delivery applications; Applications of MEMS technologies for
minimally invasive medical procedures; Smart Microgrippers
for bioMEMS applications; Microfuidic techniques for the
detection, manipulation and isolation of rare cells. Part
4 Emerging biomedical applications of MEMS: MEMS as
implantable neuroprobes; MEMS as ocular implants; Cellular
microinjection for therapeutics and research applications;
Hybrid MEMS: Integrating inorganic structures into live
organisms.
512 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 0 85709 129 1 E-ISBN: 978 0 85709 627 2
Developments in
tissue engineered
and regenerative
medicine products
A practical approach
J Basu and J W Ludlow,
Tengion Inc, USA
Woodhead Publishing Series
in Biomaterials No. 48
Developments in tissue engineered and
regenerative medicine products summarizes
recent developments in tissue engineering and
regenerative medicine with an emphasis on
commercialization and product development.
Features of current cell therapy and tissue
engineered products which have facilitated
successful commercialization are emphasized.
Roadblocks to successful product development
are also highlighted. Preclinical and clinical
testing of tissue engineered and regenerative
medicine products, regulatory, quality
control, manufacturing issues, as well as
generating and securing intellectual property
and freedom to operate considerations are
presented. This book represents a complete
how-to manual for the development of
tissue engineered and regenerative medicine
products from conceptualization to clinical
trial to manufacturing.
CONTENTS
Overview of tissue engineering/regenerative medicine;
Cells; Biomaterials for TE/RM products; Neo-Bladder:
A foundational technology platform for tubular organ
regeneration; Neo-Urinary Conduit; Tissue engineering
of non-bladder tubular organs; Tissue engineering of solid
organs; Regulatory and quality control; Pre-clinical and
clinical evaluation of TE/RM products; Manufacturing;
Intellectual property.
226 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 907568 76 3 E-ISBN: 978 1 908818 11 9

Electrospinning for
tissue regeneration
Edited by L Bosworth and
S Downes, University of
Manchester, UK
Woodhead Publishing Series
in Biomaterials No. 35
CONTENTS
Part 1 Fundamentals of electrospinning: Introduction to
electrospinning; Polymer chemistry; The electrospinning
process, conditions and control; Regulatory issues relating
to electrospinning. Part 2 Electrospinning for tissue
regeneration: Bone tissue regeneration; Cartilage tissue
regeneration; Muscle tissue regeneration; Tendon tissue
regeneration; Nerve tissue regeneration; Heart valve tissue
regeneration; Bladder tissue regeneration; Tracheal tissue
regeneration; Dental regeneration; Skin tissue regeneration;
Wound dressings. Part 3 Electrospinning for in vitro
applications applications: Cell culture systems for kidney
research; Cell culture systems for pancreatic research; Cell
culture systems for stem cell research.
424 pages 234 x 156mm (6 x 9) hardback 2011
ISBN: 978 1 84569 741 9 E-ISBN: 978 0 85709 291 5
Technologies and performance
40
Minimized
cardiopulmonary
bypass techniques
and technologies
Edited by T Gourlay,
University of Strathclyde,
UK and S Gunaydin, K. Kale
University, Turkey
Woodhead Publishing Series in Biomaterials
No. 40
Traditional cardiopulmonary bypass (CPB)
techniques have suffered from a number
of disadvantages including haemodilution,
infammation and post-operative bleeding.
Minimised cardiopulmonary bypass techniques
use developments in perfusion technology
to signifcantly reduce foreign surface-blood
interactions to make bypass simpler and safer.
This important book reviews key developments
and issues relating to this promising
technology.
CONTENTS
Part 1 Introduction to minimized cardiopulmonary bypass:
Historical development of minimized cardiopulmonary
bypass; Anticoagulation protocols for minimized
cardiopulmonary bypass; Minimized extracorporeal
circulation: Physiology and pathophysiology; Bloodsurface
interface in miniatururised extracorporeal circulation
systems; Hemodilution: Physiology and pathophysiology;
Infammatory response and minimized cardiopulmonary
bypass. Part 2 Minimized cardiopulmonary bypass equipment:
Design and principles of the minimized extracorporeal
circuit; Cardiopulmonary bypass perfusate; Myocardial
preservation techniques for mini-bypass. Part 3 Clinical
applications of minimized cardiopulmonary bypasses:
Minimized cardiopulmonary bypass: Objectives and
indications; Coronary artery bypass grafting (CABG); Valve
surgery using minimized perfusion circuits; Minimising
cardiopulmonary bypass in children; Comparison of
minimized circulation with off-pump coronary artery bypass
grafting (OPCAB) and conventional surgery; Minimally
invasive cardiac surgery, port-access and robotic surgery.
272 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 84569 800 3 E-ISBN: 978 0 85709 602 9

Sterilisation of tissues using
ionising radiations
Edited by J F Kennedy, University of
Birmingham, G O Phillips, Phillips Hydrocolloid
Research Ltd and P A Williams, The North East
Wales Institute, UK
Woodhead Publishing Series in Biomaterials
No. 1
352 pages 244 x 172mm (6 1/2 x 9 1/2) hardback 2005
ISBN: 978 1 85573 838 6 E-ISBN: 978 1 84569 077 9
Progenitor and stem
cell technologies
and therapies
Edited by A Atala,
Wake Forest Institute of
Regenerative Medicine, USA
Woodhead Publishing Series
in Biomaterials No. 38
Progenitor and stem cells have the ability to
renew themselves and change into a variety of
specialised types, making them ideal materials
for therapy and regenerative medicine.
Progenitor and stem cell technologies and
therapies reviews the range of available
progenitor and stem cells and their
therapeutic application.
CONTENTS
Part 1 Basic principles of stem cells: Basic principles for
stem cell culture; Basic principles of human embryonic stem
cells; Basic principles in generating induced pluirpotent
stem cells; Basic principles of amniotic and placental
stem cells; Basic principles of cord blood stem cells;
Basic principles of multipotent stem cells. Part 2 Enabling
cell therapy: Intellectual property claims to stem cell
technologies: Research, clinical testing and product sales;
Regulatory considerations of stem and progenitor cell-based
products: US Food and Drug Administration; Cell therapy
commercialisation; Stem cell tourism. Part 3 Tissue-specifc
progenitor cells: Adipose tissue-derived stem cell biology
and therapy; Umbilical cord blood (UCB) progenitor stem cell
biology and therapy; Auditory progenitor stem cell biology
and therapy; Olfactory mucosa: Neural stem and progenitor
cells for nervous system repair and cell models of brain
disease; Oral cavity progenitor and stem cell biology and
therapy; Bone marrow mesenchymal progenitor and stem
cell biology and therapy; Progenitor and stem cell therapies
for cartilage repair; Cardiac stem and progenitor cell biology
and therapy; Renal progenitor and stem cell biology and
therapy; Lung progenitor and stem cell biology and therapy;
Genitourinary progenitor and stem cell biology and therapy.
568 pages 234 x 156mm (6 x 9) hardback 2012
ISBN: 978 1 84569 984 0 E-ISBN: 978 0 85709 607 4

Biomaterials,
artifcial organs and
tissue engineering
Edited by L Hench and J
Jones, Imperial College of
Science, Technology and
Medicine, UK
Woodhead Publishing Series
in Biomaterials No. 4
highly useful for students of biomaterials, material
science and medicine.
International Journal of Biological
Macromolecules
304 pages 234 x 156mm (6 x 9)
paperback + CD-ROM 2005
ISBN: 978 1 85573 737 2 E-ISBN: 978 1 84569 086 1
Surface modifcation
of biomaterials
Methods analysis and
applications
Edited by R Williams,
University of Liverpool, UK
Woodhead Publishing Series
in Biomaterials No. 28
CONTENTS
Part 1 Surface modifcation techniques: Surface
modifcation of biomaterials by plasma polymerisation;
Surface modifcation of biomaterials by covalent binding
of poly(ethylene glycol) (PEG); Surface modifcation
of biomaterials by heparinisation to improve blood
compatibility; Surface modifcation of biomaterials by
peptide functionalisation; Metal surface oxidation and
surface interactions; Surface modifcation of biomaterials
by calcium phosphate deposition; Biomaterial surface
topography to control cellular response: Technologies, cell
behaviour and biomedical applications. Part 2 Analytical
techniques and applications: Techniques for analysing
biomaterial surface chemistry; Techniques for analysing
biomaterial surface structure, morphology and topography;
Modifying biomaterial surfaces to optimise interactions with
blood; Modifying biomaterials surfaces with bioactives to
control infection; Modifying biomaterial surfaces to optimise
interactions with soft tissues; Modifying biomaterial surfaces
for the repair and regeneration of nerve cells; Modifying
biomaterial surfaces to control stem cell growth and
differentiation; Modifying biomaterial surfaces to optimise
interactions with bone.
436 pages 234 x 156mm (6 x 9) hardback 2010
ISBN: 978 1 84569 640 5 E-ISBN: 978 0 85709 076 8

Tissue engineering
using ceramics and
polymers
Edited by A R Boccaccini,
Imperial College London
and J Gough, University of
Manchester, UK
Woodhead Publishing Series
in Biomaterials No. 8
624 pages 234 x 156mm (6 x 9) hardback 2007
ISBN: 978 1 84569 176 9 E-ISBN: 978 1 84569 381 7

Artifcial cells, cell
engineering and
therapy
Edited by S Prakash, McGill
University, Canada
Woodhead Publishing Series
in Biomaterials No. 6
544 pages 234 x 156mm (6 x 9)
hardback 2007
ISBN: 978 1 84569 036 6 E-ISBN: 978 1 84569 307 7
Technologies and performance
41
21st Century quality management and good
management practices, 12, 14
Advanced textiles for wound care, 34
Advanced wound repair therapies, 26
Advancement in carrier-based drug
delivery, 17
Allergens and respiratory pollutants, 16
An introduction to biotechnology, 2, 8
An introduction to pharmaceutical
sciences, 18
Annotating new genes, 4, 6
Application of statistical process control in the
pharmaceutical and biotechnology
industries, The, 11, 13
Artifcial cells, cell engineering and
therapy, 40
Bacterial cellular metabolic systems, 9
Bioactive glasses, 33
Bioactive materials in medicine, 30
Biobanks, 7
Bioceramics and their clinical applications, 32
Biocompatibility and performance of medical
devices, 38
Bioinformatics for biomedical science and
clinical applications, 3, 15
Biointegration of medical implant
materials, 38
Biomaterials and devices for the circulatory
system, 23
Biomaterials and medical tribology, 31
Biomaterials and regenerative medicine in
ophthalmology, 27
Biomaterials and tissue engineering in
urology, 28
Biomaterials for artifcial organs, 26
Biomaterials for cancer therapeutics, 24
Biomaterials for spinal surgery, 26
Biomaterials for treating skin loss, 28
Biomaterials in plastic surgery, 26
Biomaterials, artifcial organs and tissue
engineering, 40
Biomedical composites, 31
Biomedical foams for tissue engineering
applications, 23
Biomedical hydrogels, 33
Biomedical imaging, 35
Biomedical polymers, 31
Biomimetic biomaterials, 31
Biophotonics for medical applications, 34
Biosensors for medical applications, 39
Biotech managers handbook, A, 3, 12
Biotextiles as medical implants, 33
Bio-tribocorrosion in biomaterials and medical
implants, 36
Bone repair biomaterials, 27
Bone substitute biomaterials, 29
CAPA in the pharmaceutical and biotech
industries, 11, 13
Cardiac regeneration and repair, 23
Cellular response to biomaterials, 37
Characterization of biomaterials, 32
Clinical research in Asia, 13, 21
Clinical research in paediatric
psychopharmacology, 17
Clinical trial management, 17
Coatings for biomedical applications, 33
Commercializing the stem cell sciences, 12,
22
Computational modelling of biomechanics and
biotribology in the musculoskeletal system,
35
Computer-aided applications in
pharmaceutical technology, 3, 20
Computer-aided vaccine design, 4
Concepts and techniques in genomics and
proteomics, 6, 9
Contract research and manufacturing services
(CRAMS) in India, 7, 12
Controlled drug delivery, 17
Decontamination in hospitals and
healthcare, 29
Degradation rate of bioresorbable
materials, 34
Dental biomaterials, 27
Deterministic versus stochastic modelling in
biochemistry and systems biology, 3
Developments in tissue engineered and
regenerative medicine products, 22, 39
Diamond-based materials for biomedical
applications, 32
Drug-biomembrane interaction studies, 19
Drug-device combination products, 27
Durability and reliability of medical
polymers, 38
Electroporation-based therapies for
cancer, 2, 15
Electrospinning for tissue regeneration, 39
Fed-batch fermentation, 7
Formulation tools for pharmaceutical
development, 20
From plant genomics to plant
biotechnology, 2, 8
Funding of biopharmaceutical research and
development, The, 11
Gene expression analysis in the RNA
world, 5, 8
Gene therapy, 5
Handbook of cosmeceutical excipients, 18
Handbook of medical textiles, 34
Hip resurfacing handbook, The, 28
Human papillomavirus infections, 9, 16
Hyaluronan, 33
Impact of regulation on drug development,
The, 6, 10
Implantable sensor systems for medical
applications, 39
Imported infectious diseases, 15
Inhaler devices, 25
Injectable biomaterials, 33
Innovative brain tumor therapy, 14
Joining and assembly of medical materials
and devices, 37
Joint replacement technology, 22
Lasers for medical applications, 37
Lean biomanufacturing, 11, 14
Life-cycle of pharmaceuticals in the
environment, The, 17
Marine enzymes for biocatalysis, 8
Materials science for dentistry, 27
MATLAB

in bioscience and
biotechnology, 2, 5
Medical and healthcare textiles, 34
Medical education, training and care delivery
in a virtual world, 15
Medical modelling, 36
Medical robotics, 37
Medical textiles and biomaterials for
healthcare, 34
MEMS for biomedical applications, 39
Metals for biomedical devices, 30
Microfuidic devices for biomedical
applications, 36
Minimized cardiopulmonary bypass techniques
and technologies, 40
Modelling degradation of bioresorbable
polymeric medical devices, 35
Molecular interfacial phenomena of polymers
and biopolymers, 36
Nanomaterials in tissue engineering, 24
Nanomedicine, 25
Nanoparticle-based approaches to targeting
drugs for severe diseases, 16, 19
Nanoparticulate drug delivery, 16
Natural-based polymers for biomedical
applications, 31
New functional biomaterials for medicine and
healthcare, 31
NMR metabolomics in cancer research, 16
Non-metallic biomaterials for tooth repair and
replacement, 37
Novel biomaterials for bone regeneration, 24
Ocular transporters and receptors, 19
Open source software in life science
research, 4, 10
Oral delivery of insulin, 18
Orphan drugs, 11, 18
Orthopaedic bone cements, 27
Outsourcing biopharma R&D to India, 12
Patently innovative, 7, 13
Perspectives in total hip arthroplasty, 28
Porous silicon for biomedical applications, 30
Practical approach to spinal trauma, A, 29
Practical leadership for biopharmaceutical
executives, 12
Precious metals for biomedical
applications, 30
Preprosthetic and maxillofacial surgery, 29
Progenitor and stem cell technologies and
therapies, 40
Protein folding in silico, 4
Quality assurance, 6
Rapid prototyping of biomaterials, 36
Regenerative medicine and biomaterials for
the repair of connective tissues, 27
Regulatory affairs for biomaterials and
medical devices, 29
Science of compression bandages, 34
Title index
42
Semiconducting silicon nanowires for
biomedical applications, 30
Shape memory alloys for biomedical
applications, 32
Silk for biomaterials and tissue engineering
applications, 23
Smart textiles for medicine and
healthcare, 33
Standardisation in cell and tissue
engineering, 25
Stem cell bioprocessing, 14, 22
Sterilisation of biomaterials and medical
devices, 38
Sterilisation of polymer healthcare
products, 38
Sterilisation of tissues using ionising
radiations, 40
Sterility, sterilisation and sterility assurance
for pharmaceuticals, 20
Successful biopharmaceutical operations, 10
Surface modifcation of biomaterials, 40
Surfaces and interfaces for biomaterials, 37
Textiles for hygiene and infection control, 34
Therapeutic antibody engineering, 9, 21
Therapeutic protein drug products, 9, 21
Therapeutic risk management of
medicines, 10, 18
Tissue engineering using ceramics and
polymers, 40
Translational biology in medicine, 15
Transporters in drug discovery and
development, 19
Ultrafltration for bioprocessing, 8, 13
Wear of orthopaedic implants and artifcial
joints, 32
Title index
43
Affatato, S 28, 32
Aguilar, J E 20
Alagirusamy, R 34
Amato, S 29
Ambrosio, L 26, 31
Anand, S C 34
Antani, M 7, 12
Archer, C 27
Arias, J L 16, 19
Arinzeh, T 32
Assaad, E 17
Atala, A 28, 40
Auby, P 17
Azevedo, H S 31
Bajaj, H N 29
Baltzer, N 30
Banerjee, A K 10, 18
Bartels, V 34
Basu, J 22, 39
Bazaka, K 31
Best, S M 27
Bhansali, S 39
Bibb, R 36
Black, R 23
Blanco, C 28
Boccaccini, A R 40
Bosworth, L 39
Bouchard, R A 7, 13
Boutrand, J-P 38
Brandon, H 26
Braund, R 17
Breyen, M D 37
Buchanan, F J 34
Burbulis, N 2, 8
Burstein, L 2, 5
Cabral, J M S 14, 22
Caffo, M 14
Campbell, P 28
Caruso, G 14
Chen, P 36
Chin, J Y 12
Chirila, T V 27
Chowdhury, P R 12
Clement, J Q 5, 8
Cobo, F 9, 15, 16
Cochrane, T 11, 13
Coffer, J L 30
Copponnex, T 30
Courtney, J M 31
Crawford, R J 31
Cuperlovic-Culf, M 16
Curtis, R V 27
Dandekar, P 16
Darvell, B W 27
Das, A 34
De Robbio, A 7
De Smet, K 28
Deb, S 27
Denstedt, J 28
Di Silvio, L 37
Diogo, M M 14, 22
Djuris, J 3, 20
Downes, S 39
Driscoll, C 10
Driver, M 33
Dubruel, P 24
Ezzell, B 29
Farrar, D 26
Fernandes, T G 14, 22
Ferri, J 29
Fogher, C 2, 8
Forster, M 4, 10
Gaharwar, A K 24
Godbey, W T 2, 8
Gokhale, G 7, 12
Gomes, M E 31
Gomes, P 37
Gough, J 40
Gourlay, T 23, 40
Guidoin, R 33
Gunaydin, S 40
Gupta, B S 33
Hacking, S A 24
Hammond, W 32
Hancock, M J 24
Harland, L 4, 10
Harvey, O 12, 22
Hascall, V C 33
Hench, L 40
Hennings, G H 6, 10
Hernberg-Stahl, E 11, 18
Higson, S 39
Hodgins, D 39
Hopkins, M M 3, 12
Hunziker, E 29
Inmann, A 39
Ispas-Szabo, P 17
Ivanova, E P 31
Jaffe, M 32
Jain, A 17
Jain, R 16
Jain, S K 17
Jelinkova, H 37
Jenkins, M 31, 38
Jerina, K L 26
Jin, Z 35
Jones, J 40
Jordan, F 3
Kahol, K 15
Kang, L 18
Katoch, S 29
Kennedy, J F 33, 34, 40
King, M W 33
Kochhar, J S 18
Kokubo, T 32
Kumar, B 34
Kundu, S 23
Kwan, Y H 18
Lacroix, D 27
Lai, L 19
Laurenzi, I 3
Lecca, P 3
Lerouge, S 38
Lewis, A 27
Li, R-K 23
Li, X-J 36
Liang, K-H 3, 15
Ludlow, J W 22, 39
Lutz, H 8, 13
Lysaght, M 26
Mallick, K 29
Mano, J F 31
Marques, A P 31
Mateescu, M A 17
Mayall, S 10, 18
McCarthy, B J 34
Meglinski, I 34
Merlo, L 14
Merolli, A 27
Meyer, B K 9, 21
Miraftab, M 34
Mitra, A K 19
Miyazaki, S 32
Montano, M 15
Morris, P 35
Moulton, G G 7
Narayan, R 32, 36
Netti, P 23
Neves, N M 31
Niinomi, M 30
Nimesh, S 5
ONeill, M 3, 12
Orgill, D P 28
Pan, J 35
Park, K 24
Patravale, V 16
Peake, B M 17
Peters, W 26
Phillips, G O 33, 40
Pignatello, R 19
Planell, J A 27
Poh, A-L 18
Poltronieri, P 2, 8
Prakash, S 40
Prokopovich, P 25
Qian, H 31
Rajendran, S 34
Ralphs, J 27
Ramalingam, P 6, 9
Ranganathan, S 4
Reis, R L 31
Reljanovic, M 11, 18
Revell, P A 22
Rimmer, S 33
Rodriguez, J 11, 13
Rogers, W 38
Roterman-Konieczna, I 4
Roy, J 18
Ruys, A J 31
Sahoo, U 13, 17, 21
Salih, V 25
Sandle, T 20
Sant, S 24
Santos, H A 30
Saraswathy, N 6, 9
Sawant, D 17
Sharma, C P 18, 38
Shimizu, K 9
Simmons, A 38
Smart, N J 11, 14
Sonia, T A 18
Stamboulis, A 38
Strohl, L M 9, 21
Strohl, W R 9, 21
Sundararajan, R 2, 15
Tanner, E 26
Tolias, P 32
Tong, J C 4
Trincone, A 8
Tung, Y K 18
Uchida, S 4, 6
Vadgama, P 37
Vallittu, P 37
Van Der Straeten, C 28
Van Langenhove, L 33
Vasudev, A 39
Vernon, B 33
Vlierberghe, S V 24
Walker, J 29
Watson, T F 27
Webster, T J 25, 26
Weisel, R D 23
Welty, G 6
Williams, D R 11
Williams, M A 16
Williams, P A 33, 40
Williams, R 40
Williams, S 12, 14
Wolf, C 26
Yan, Y 36
Ylnen, H O 33
Yoneyama, T 32
Young, V L 26
Zhao, X 31
Zhou, Y 36
Zhou, Y N 37
Author index
44
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