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Bringing more efficiency and performance to the hematology lab.

The HematoFlow Cellular Analysis Solution

BR-14342A-OUS

lab. The HematoFlow Cellular Analysis Solution BR-14342A-OUS Blood Banking Centrifugation Chemistry Flow Cytometry

Blood Banking

Centrifugation

Chemistry

Flow Cytometry

Hematology

Hemostasis

Immunoassay

Information Systems

Lab Automation

Molecular Diagnostics

Rapid Diagnostics

Combining our Flow Cytometry and Hematology Technology.

Hematology laboratories, the world over, are being pressured to improve productivity, decrease turnaround time (TAT) and reduce costs. You asked and we listened. By combining our hematology and flow cytometry technology to characterize abnormal WBC populations, the hematology laboratory is offered a unique automated solution. This combination of Beckman Coulter technologies is known as HematoFlow. Samples with abnormal WBC results are first identified using one of our hematology analyzers. Then using our FC 500 Flow Cytometer with CytoDiff, a ready-to-use cocktail, composed of six monoclonal antibodies, in five colors, those abnormal WBC samples are characterized into nine distinct populations.

Why is this beneficial to the hematology laboratory?

You get all of these advantages:

• Lab technologists can focus on other tasks

• Automated flow differential

• Accurate and standardized results

• Simple, paperless process

• Precise (>20k cells)

• 9 cell populations

• Auto-verification via decision rules

• Faster turnaround time

Surety vs Screening

Manual differentials are performed on an average of 100 to 200 cells. Using the CytoDiff reagent in conjunction with the Beckman Coulter FC 500 Flow Cytometer, over 20,000 cells can automatically be characterized.

• Accurate and precise results

• Increased reliability and decreased subjectivity of the data

• Provides a differential for even the most difficult cases (leukopenic samples)

Standardization

Performing a manual differential can often be time consuming and subjective. By automating this process with the CytoDiff reagent, standardization is now available for hematology labs everywhere.

Improved Efficiency

The exclusive Beckman Coulter algorithms automatically identify and enumerate multiple cell populations. This dramatically increases the reliability of your results, and reduces the need for manual gating and interpretation.

Unique Cellular Solutions

The CytoDiff reagent yields an automated 9-part cytometric differential. It provides the traditional 5-part differential with the addition of immature granulocytes and blasts. Lymphoblasts are subdivided into T and B cell blasts. Non-T blasts, non-B blasts and plasma cells are classified into their own category called “other abnormal cells”.

Antibody

Cell Population

CD36-FITC

Monocytes

CD2-PE

T

lymphocytes, NK cells

CD294-PE

Eosinophils, Basophils, T cells

CD19-ECD

B

lymphocytes

CD16-PC5

Mature and immature granulocytes, T cytotoxic lymphocytes

CD45-PC7

Leukocytes

HematoFlow Workflow Process

Samples are routinely analyzed on the UniCel DxH 800 or LH 700 Series Hematology Analyzer.

Normal CBC results are automatically transmitted to the Laboratory Information System (LIS) via the data manager.

Abnormal RBC results are investigated by microscope.

For abnormal WBC results, the data manager automatically requests a reflex CytoDiff test, which prompts sample preparation for CytoDiff analysis.

The CytoDiff-prepared sample is then analyzed on the Beckman Coulter FC 500 Flow Cytometer.

The result is then transmitted to the data manager and matched to the patient’s original hematology result(s).

Final results are transmitted to the laboratory’s LIS.

Hematology Analyzer

(UniCel DxH 800 Coulter Cellular Analysis System)

Microscopy
Microscopy
Laboratory Information System (LIS)
Laboratory
Information System
(LIS)

Clinical Information Systems

(Remisol Advance*/DM2)

(LIS) Clinical Information Systems (Remisol Advance*/DM2) Cell Preparation System (FP 1000 shown) Flow Cytometer (FC

Cell Preparation System

(FP 1000 shown)

Flow Cytometer

(FC 500 Flow Cytometer with Automated Algorithm)

Scan this QR code with your Smartphone to watch a video about our HematoFlow Cellular

Scan this QR code with your Smartphone to watch a video about our HematoFlow Cellular Analysis Solution. Free QR Code Scanner software can be downloaded at sites such as www.beetagg.com.

www.beckmancoulter.com/cytodiff

such as www.beetagg.com. www.beckmancoulter.com/cytodiff CytoDiff is not yet available in the US and Canada for in

CytoDiff is not yet available in the US and Canada for in vitro diagnostic use. Beckman Coulter, the stylized logo and UniCel are registered trademarks of Beckman Coulter, Inc. CytoDiff, HematoFlow and DxH are trademarks of Beckman Coulter, Inc. *REMISOL Advance is a trademark of Normand Info SAS.

For Beckman Coulter’s worldwide office locations and phone numbers, please visit “Contact Us” at www.beckmancoulter.com

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© 2011 Beckman Coulter, Inc.

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