FC Path(SA) Anat Part II

THE COLLEGES OF MEDICINE OF SOUTH AFRICA

Incorporated Association not for gain
Reg No 1955/000003/08

Final examination for the Fellowship of the
College of Pathologists of South Africa - Anatomical

22 August 2013

Paper 1 (3 hours)

All questions to be answered. Each question to be answered in a separate book (or books if more than one is required
for the answer)

1 Discuss
a) The concept of epigenetic gene silencing and its role in carcinogenesis. (10)
b) The ultrastructural stability of the hemi-desmosomal complex of the skin, indicating
potential areas of defect that may give rise to bullous skin disorders. (15)
[25]

2 Discuss
a) Double-hit B-cell non-Hodgkin lymphomas. (8)
b) The molecular heterogeneity of salivary gland mucoepidermoid carcinoma. (7)
c) The role of virtual microscopy in anatomical pathology. (10)
[25]

3 Discuss
a) The role of immunohistochemistry in the diagnosis of muscular dystrophies. (12)
b) The role of fluorescent in-situ hybridisation in the diagnosis of oligodendroglial neoplasms.
(6)
c) The significance of Hrthle cells in fine needle aspiration cytology of thyroid nodular
disease. (7)
[25]

4 Discuss current concepts in the molecular classification of breast carcinoma correlating these
to the interpretation of morphology and supportive (adjunct) investigations used in the day-to-
day reporting of patients with this disease. [25]














FC Path(SA) Anat Part II

THE COLLEGES OF MEDICINE OF SOUTH AFRICA

Incorporated Association not for gain
Reg No 1955/000003/08

Final Examination for the Fellowship of the
College of Pathologists of South Africa - Anatomical

23 August 2013
Paper 2 (3 hours)

All questions to be answered. Each question to be answered in a separate book (or books if more than one is
required for the answer)

1 Discuss
a) The diagnostic work-up of organoid amyloid-like glomerular deposits. (13)
b) Intraductal papillary mucinous neoplasm of the pancreas. (12)
[25]

2 Discuss
a) The range and significance of crypt architectural alterations in colonic biopsies. (12)
b) Superficial acral fibromyxoma. (8)
c) Histomorphological alterations associated with hepatolithiasis. (5)
[25]

3 Write notes on
a) The morphology of intimomedial mucoid degeneration. (8)
b) The histopathological spectrum of detritic synovitis. (7)
c) Pulmonary adenocarcinoma of fetal type. (5)
d) Microcystic variant of urothelial carcinoma. (5)
[25]

4 Discuss the pathology of trophoblastic tumours describing how you would differentiate
between them. [25]