Documente Academic
Documente Profesional
Documente Cultură
Ornish
Dean
Ornish
Mike
Milken
Mike
Milken
William
Nelson
William
Nelson
Deepak
Chopra
Deepak
Chopra
Alternative Medicine Joins the Mainstream
Alternative Medicine Joins the Mainstream
Consciousness Creates Reality
Consciousness Creates Reality
Co-create and
reflect each
other,
interdependently
co-arise, are a
tangled
hierarchy.
They are
synchronistically
arising emergent
properties that
co-emerge
depending on the
level of vibration
of individual and
collective
consciousness.
Co-create and
reflect each
other,
interdependently
co-arise, are a
tangled
hierarchy.
They are
synchronistically
arising emergent
properties that
co-emerge
depending on the
level of vibration
of individual and
collective
consciousness.
5 Breakthroughs for the Body
5 Breakthroughs for the Body
s only motivation
s only motivation
--Boden
WE et al. N Engl J Med 2007;356:1-14.
COURAGE TRIAL
Angioplasty did not reduce the
risk of death, heart attack, or
other major cardiovascular
events.
--Boden
WE et al. N Engl J Med 2007;356:1-14.
In 2006, 448,000 coronary bypass
operations were performed at a
cost of more than $44 billion.
In 2006, 448,000 coronary bypass
operations were performed at a
cost of more than $44 billion.
Coronary bypass surgery prolongs
life in only 2-3% of those who
receive it.
.
--Caracciolo
EA et al.Circulation. 1995;91(9):2325-34.
Coronary bypass surgery prolongs
life in only 2-3% of those who
receive it.
.
--Caracciolo
EA et al.Circulation. 1995;91(9):2325-34.
Dangerous, invasive, expensive,
and ineffective
Dangerous, invasive, expensive,
and ineffective
Coronary heart disease is not only
preventable, it is usually
reversible
by changing diet
and lifestyle.
Coronary heart disease is not only
preventable, it is usually
reversible
by changing diet
and lifestyle.
Optimal Lifestyle Program
Optimal Lifestyle Program
Nutrition
Stress management
Moderate exercise
Psychosocial support
The primary determinant of
improvement
was the degree of lifestyle change.
The primary determinant of
improvement
was the degree of lifestyle change.
Scaleability
& Cost Effectiveness
Scaleability
& Cost Effectiveness
Three demonstration projects
More than 3,000 patients
Greater changes in diet and lifestyle, larger
improvements in risk factors and quality of life,
and bigger cost reductions than have ever before
been reported in an ambulatory group of patients.
Three demonstration projects
More than 3,000 patients
Greater changes in diet and lifestyle, larger
improvements in risk factors and quality of life,
and bigger cost reductions than have ever before
been reported in an ambulatory group of patients.
1. The Multicenter Lifestyle
Demonstration Project
1. The Multicenter Lifestyle
Demonstration Project
Almost 80% of 333 patients who were
eligible for bypass surgery or angioplasty
were able to safely avoid it.
Ornish
D. Avoiding revascularization with lifestyle changes: The Multicenter Lifestyle Demonstration Project. American Journal of
Cardiology. 1998;82:72T-76T.
Koertge
J, Weidner G, Elliott-Eller M, et al. Improvement in medical risk factors and quality
of life in women and men with
coronary artery disease in the Multicenter Lifestyle Demonstration Project. American Journal of Cardiology. 2003;91:1316-1322.
Almost 80% of 333 patients who were
eligible for bypass surgery or angioplasty
were able to safely avoid it.
Ornish
D. Avoiding revascularization with lifestyle changes: The Multicenter Lifestyle Demonstration Project. American Journal of
Cardiology. 1998;82:72T-76T.
Koertge
J, Weidner G, Elliott-Eller M, et al. Improvement in medical risk factors and quality
of life in women and men with
coronary artery disease in the Multicenter Lifestyle Demonstration Project. American Journal of Cardiology. 2003;91:1316-1322.
Mutual of Omaha calculated saving
almost $30,000 per patient in the first
year.
Ornish
D. Avoiding revascularization with lifestyle changes: The Multicenter Lifestyle Demonstration Project. American Journal
of Cardiology. 1998;82:72T-76T.
Koertge
J, Weidner G, Elliott-Eller M, et al. Improvement in medical risk factors and quality
of life in women and men with
coronary artery disease in the Multicenter Lifestyle Demonstration Project. American Journal of Cardiology. 2003;91:1316-1322.
Mutual of Omaha calculated saving
almost $30,000 per patient in the first
year.
Ornish
D. Avoiding revascularization with lifestyle changes: The Multicenter Lifestyle Demonstration Project. American Journal
of Cardiology. 1998;82:72T-76T.
Koertge
J, Weidner G, Elliott-Eller M, et al. Improvement in medical risk factors and quality
of life in women and men with
coronary artery disease in the Multicenter Lifestyle Demonstration Project. American Journal of Cardiology. 2003;91:1316-1322.
1. The Multicenter Lifestyle
Demonstration Project
1. The Multicenter Lifestyle
Demonstration Project
2. The Highmark Blue Cross Blue
Shield Demonstration Project:
Cost Comparisons After 3 Years
2. The Highmark Blue Cross Blue
Shield Demonstration Project:
Cost Comparisons After 3 Years
Experimental Group (CAD) (N=75) Baseline vs. 3 year average
= 8.7% decrease in costs
Matched Cohort Members (CAD) (N=75) Baseline vs. 3 year average = 47.2% increase in costs
Experimental Group (CAD) vs. Matched Cohort (CAD) Members Year by Year
$-
$2,000.00
$4,000.00
$6,000.00
$8,000.00
$10,000.00
Ornish Members (CAD) Matched Cohort Members
Ornish Members (CAD) 5377.56 4627.88 5241.27 4865.17
Matched Cohort Members 5344.32 8586.89 8115.56 6897.78
baseline year 1 year 2 year 3
Medicare is now covering this program
for reversing heart disease
Medicare is now covering this program
for reversing heart disease
6.74
6.23
5.98
6.36
5.8
6.05
6.3
6.55
6.8
Baseline 12 months
Control
(n=41)
Experimental
(n=43)
Changes in PSA
P= 0.002
Ornish
D et al. Journal of Urology. 2005;174:1065
8%
1%
- 5%
- 5 %
- 1 %
3 %
7 %
L o w ( < 4 8 %) Me d iu m
( 4 8 - 8 8 %)
Hig h ( > 8 8 %)
D e g r e e o f L i fe s tyl e C h a n g e a n d
C h a n g e s i n P S A
P = 0 . 0 0 1
Ornish
D et al. Journal of Urology. 2005;174:1065
Change in Prostate Tumor Growth
(LNCaP)
-9%
-70%
-70%
-55%
-40%
-25%
-10%
%FBS
Control
Experimental
t = -6.9, P = .000
Ornish
D et al. Journal of Urology. 2005;174:1065
- 7. 9
- 38. 7
- 71. 9
- 8 0
- 6 0
- 4 0
- 2 0
0
L o w
( < 4 8 %)
Me d iu m
( 4 8 - 8 8 %)
Hig h
( > 8 8 %)
D e g r e e o f L i fe s tyl e C h a n g e a n d
I n h i b i ti o n o f L N C a P T u mo r G r o w th
B a s e lin e - 1 2 m c h a n g e in L NC A P c e ll g r o wt h
P = 0 .0 0 0 1
Ornish
D et al. Journal of Urology. 2005;174:1065
1 year later
PSA -
4.5 ng/ml
Baseline
PSA -
6.4 ng/ml
Changes in MRI spectroscopy
Change your lifestyle, Change your
genes
Gene expression in over 500
genes was beneficially
affected.
Gene expression in over 500
genes was beneficially
affected.
Ornish D et al, Proc Nat Acad
Sci
2008; 105: 8369.
Genes controlling tumor
formation, oxidative stress, and
inflammation were
downregulated.
We found a set of RAS family
oncogenes
(RAN, RAB14, RAB8A) to be
downregulated.
Downregulation
of Oncogenes
by Lifestyle Changes
Ornish
et al. Proc Nat Acad Sci USA 2008; 105: 8369.
p < 0.05 (two-tailed)
Increase in telomerase activity from baseline to 3 months
Ornish
D et al. Lancet Oncol. 2008; 9: 104857.
1820
1820
1900
1900
1950
1950
2004
2004
26
Years
31
Years
49
Years
66
Years
Source: United Nations Development Program
+5
+5
+18
+18
+17
+17
+35
+35
Worldwide Life Expectancy Growth
Worldwide Life Expectancy Growth
Lifestyle Affects Quality of Life
U.S. vs. Japan
Lifestyle Affects Quality of Life
U.S. vs. Japan
Life Expectancy
Life Expectancy
67.6
9.4
73.6 7.7
Healthy years
Healthy years
Disabled
years
Disabled
years
U.S. Economy
$13.84 trillion
U.S. Economy
$13.84 trillion
Lifestyle Makes a Difference
Lifestyle Makes a Difference
16% = health care spending
$2.2 trillion
16% = health care spending
$2.2 trillion
Date: September 22, 2008
U.S. Economy
$13.84 trillion
U.S. Economy
$13.84 trillion
70% of health-care spending
about $1.5 trillion
is spent
on lifestyle-related diseases.
70% of health-care spending
about $1.5 trillion
is spent
on lifestyle-related diseases.
Lifestyle Makes a Difference
Lifestyle Makes a Difference
Date: September 22, 2008
Only in America Only in America
Who told you to smoke?
Who told you to smoke?
Hall of Fame baseball players
Hall of Fame baseball players
Who told you to smoke?
Who told you to smoke?
Ann Sheridan
Ann Sheridan
Barbara Stanwyck
Barbara Stanwyck
Joan Crawford
Joan Crawford
Famous actresses
Famous actresses
Who told you to smoke?
Who told you to smoke?
Your dentist
Your dentist
Who told you to smoke?
Who told you to smoke?
and your doctors
and your doctors
Who told you to smoke?
Who told you to smoke?
Scientific researchers!
Scientific researchers!
Soldiers and sailors
Soldiers and sailors
Who told you to smoke?
Who told you to smoke?
Who has NOT
been used in cigarette
advertisements to get you to smoke?
Who has NOT
been used in cigarette
advertisements to get you to smoke?
a.
Babies
b.
Santa Claus
c.
Supreme court justices
d.
U.S. Presidents
a.
Babies
b.
Santa Claus
c.
Supreme court justices
d.
U.S. Presidents
Babies
Babies
U.S. Presidents
U.S. Presidents
Santa Claus!!
Santa Claus!!
Who has NOT
been used in cigarette
advertisements to get you to smoke?
Who has NOT
been used in cigarette
advertisements to get you to smoke?
a.
Babies
b.
Santa Claus
c.
Supreme court justices
d.
U.S. Presidents
a.
Babies
b.
Santa Claus
c.
Supreme court justices
d.
U.S. Presidents
There is a
staggering
cost for failing
to contain the
containable.
There is a
staggering
cost for failing
to contain the
containable.
Failure to address chronic diseases
adequately costs the
U.S. economy more than
$1 trillion annually.
Failure to address chronic diseases
adequately costs the
U.S. economy more than
$1 trillion annually.
Chronic Disease Study
Chronic Disease Study
Diabetes
Heart disease
Hypertension
Stroke
Diabetes
Heart disease
Hypertension
Stroke
Cancers
Pulmonary conditions
Mental disorders
Cancers
Pulmonary conditions
Mental disorders
Chronic Disease Study
Chronic Disease Study
Obesity Prevalence Among U.S. Adults
1991
Obesity Prevalence Among U.S. Adults
1991
> 15%
> 15%
< 15%
< 15%
Obesity Prevalence Among U.S. Adults
2001
Obesity Prevalence Among U.S. Adults
2001
> 15%
> 15%
< 15%
< 15%
Obesity Prevalence Among U.S. Adults
2002
Obesity Prevalence Among U.S. Adults
2002
> 15%
> 15%
< 15%
< 15%
Obesity Rates: U.S. vs. World
Obesity Rates: U.S. vs. World
2002
2005
Source: World Health Organization / Estimated obesity rates for
people aged 15 years and older / 2005
1.5%
1.5%
1.9%
1.9%
6.6%
6.6%
20.4%
20.4%
24.2%
24.2%
41.8%
41.8%
1.8%
1.8%
1.6%
1.6%
7.8%
20.9%
21.6%
36.5%
Japan
Japan
China
China
France
France
Germany
Germany
U.K.
U.K.
U.S.
U.S.
MEN
WOMEN
WOMEN
34.3%
34.3%
24.0%
Mexico
Mexico
39%of U.S. children
ages 9-13 take part in
organized exercise
each week.
39%of U.S. children
ages 9-13 take part in
organized exercise
each week.
29%of U.S. high
school students
participate in physical
education classes.
29%of U.S. high
school students
participate in physical
education classes.
Physical Inactivity
Physical Inactivity
Treatment Costs Are a Small Portion of the
Economic Costs
Treatment Costs Are a Small Portion of the
Economic Costs
Cancer
Cancer
$500
$500
$400
$400
$300
$300
$200
$200
$100
$100
Heart
Heart
Hypertension
Hypertension
Mental
Mental
Diabetes
Diabetes
Pulmonary
Pulmonary
Stroke
Stroke
Direct Costs
Indirect Costs
Source: Milken Institute 2007
QUIZ:
How much larger is the average soda
in the U.S. compared to France ?
QUIZ:
How much larger is the average soda
in the U.S. compared to France ?
1.
5%
2.
18%
3.
33%
4.
52%
5.
74%
1.
5%
2.
18%
3.
33%
4.
52%
5.
74%
U.S. soft drink portions are 52% larger than
in France.
U.S. soft drink portions are 52% larger than
in France.
Source: University of Miami School of Medicine/Sheah
Rarback, R.D.
Candy bars sold in Philadelphia are 41%
larger than those in Paris.
Candy bars sold in Philadelphia are 41%
larger than those in Paris.
Source: University of Miami School of Medicine/Sheah
Rarback, R.D.
A carton of yogurt in the U.S. is 82% larger
than in France.
A carton of yogurt in the U.S. is 82% larger
than in France.
Source: University of Miami School of Medicine/Sheah
Rarback, R.D.
Source: William Nelson, M.D., Johns Hopkins Hospital
Fewer carcinogens are detected if you flip your
burgers multiple times.
Fewer carcinogens are detected if you flip your
burgers multiple times.
15-20% decrease in the
progression of prostate
cancer by increasing
consumption of fish and
cooked-tomato products by
two servings per week
after diagnosis.
15-20% decrease in the
progression of prostate
cancer by increasing
consumption of fish and
cooked-tomato products by
two servings per week
after diagnosis.
What You Eat Matters
What You Eat Matters
Source: June Chan, ScD, UCSF