Drugs Causing Prolonged QT

By Class

Antiarrhythmics
Class 1: ajmaline*, cibenzoline*, dihydroquinidine*, disopyramide, encainide*, flecainide, mexiletine,
pirmenol*, procainamide, propafenone quinidine*
Class 3: almokalant*, amiodarone, azimilide*, bretylium, dofetilide*, dronedarone*, d-sotalol*,
ersentilide*, ibutilide*, nifekalant*, sematilide*, sotalol, terikalant*

Anti-anginals/vasodilators
bepridil*, lidoflazine*, prenylamine*, ranolazine, terodiline*, vardenafil

Anti-hypertensives
indapamide, isradipine, moexipril/hydrochlorthiazide, nicardipine

Antihistamines
astemizole*, azelastine, diphenhydramine, ebastine*, hydroxyzine, terfenadine*

Serotonin agonists and antagonists
cisapride*, dolasetron, granisetron, ketanserin*, ondansetron

Antimicrobials
Macrolide antibiotics:
azithromycin, clarithromycin, erythromycin, roxithromycin*, spiramycin, telithromycin
Quinolone antibiotics:
ciprofloxacin, gatifloxacin*, gemifloxacin*, grepafloxacin*, levofloxacin, moxifloxacin, ofloxacin,
sparfloxacin*
Other antibiotic:
trimethoprim sulfa (bactrim)
Antifungals:
ketoconazole, cotrimoxazole, fluconazole (caution with itraconazole), voriconazole
Antiviral:
foscarnet (HIV)
Antimalarials
amantidine, chloroquine, halofantrine*, quinine
Antiprotozoal:
pentamidine

Psychiatric drugs
Tricyclic antidepressants:
amitriptyline, amoxapine*, clomipramine, desipramine*, doxepin, imipramine, nortriptyline,
protriptyline*, trimipramine
Phenothiazines:
chlorpromazine, fluphenazine, prochlorperazine, thioridazine*, trifluoperazine
Others:
atomoxetine, citalopram, clozapine, droperidol*, fluoxetine, haloperidol, levomethadyl*, lithium,
maprotiline, mesoridazine, methadone, paroxetine, pericycline, pimozide, quetiapine,
risperidone, sertindole, sertraline, trazodone, venlafaxine, zimeldine*, ziprasidone

Anticonvulsant
felbamate*, fosphenytoin (prodrug of phenytoin)

Anti-migraine
naratriptan, sumatriptan, zolmitriptan

Anti-cancer
arsenic trioxide, geldanamycin*, sunitib, tacrolimus, tamoxifen

Stimulants, decongestants, and anti-asthmatics
adrenaline (epinephrine), amphetamine, cocaine, dexmethylphenidate, dobutamine, dopamine,
ephedrine, fenfluramine, isoprenaline (isoproterenol), levalbuterol, metaproterenol, methylphenidate,
midodrine, norepinephrine (noradrenaline), phentermine, phenylephrine, phenylpropanolamine,
pseudoephidrine, ritodrine, salbutamol (albuterol), salmeterol, sibutramine, terbutaline
Some cold remedies contain these drugs so it is important always to check the label.

Others
alfuzosin, chloral hydrate, clobutinol*, domperidone, galantamine, octreotide, organophosphates*,
perflutren lipid microspheres, probucol, solifenacin, tizanidine, tolterodine, vasopressin



Drugs Causing Prolonged QT
By Generic Name

Adrenaline (Epinephrine)
Ajmaline*
Alfuzosin
Almokalant*
Amantidine
Amiodarone)
Amitriptyline
Amoxapine*
Amphetamine
Arsenic trioxide
Astemizole*
Atomoxetine
Azelastine
Azimilide*
Azithromycin
Bepridil*
Bretylium
Chloral hydrate
Chloroquine
Chlorpromazine
Cibenzoline*
Ciprofloxacin
Cisapride*
Citalopram
Clarithromycin
Clobutinol*
Clomipramine
Clozapine
Cocaine
Cold remedies
Cotrimoxazole
d-sotalol*
Desipramine*
Dexmethylphenidate
Dihydroquinidine*
Diphenhydramine
Disopyramide
Dobutamine
Dofetilide*
Dolasetron
Domperidone
Dopamine
Doxepin
Dronedarone*
Droperidol*
Ebastine*
Encainide*
Ephedrine
Ersentilide*
Erythromycin
Felbamate*
Fenfluramine
Flecainide
Fluconazole
Fluoxetine
Fluphenazine
Foscarnet (HIV)
Fosphenytoin
Galantamine
Gatifloxacin*
Geldanamycin*
Gemifloxacin*
Granisetron
Grepafloxacin*
Halofantrine*
Haloperidol
Hydroxyzine
Ibutilide*
Imipramine
Indapamide
Isoprenaline
Isradipine
Itraconazole
Ketanserin*
Ketoconazole
Levalbuterol
Levofloxacin
Levomethadyl*
Lidoflazine*
Lithium
Maprotiline
Mesoridazine
Metaproterenol
Methadone
Methylphenidate
Mexiletine
Midodrine
Moexipril /HCTZ
Moxifloxacin
Naratriptan
Nicardipine
Nifekalant*
Norepinephrine
Nortriptyline
Octreotide(Sandostatin)
Ofloxacin
Ondansetron
Organophosphates*
Paroxetine
Pentamidine
Perflutren lipid microspheres
Pericycline
Phentermine
Phenylephrine
Phenylpropanolamine
Pimozide
Pirmenol*
Prenylamine*
Probucol
Procainamide
Prochlorperazine
Propafenone
Protriptyline*
Pseudoephidrine
Quetiapine
Quinidine*
Quinine
Ranolazine
Risperidone
Ritodrine
Roxithromycin*
Salbutamol
Salmeterol
Sematilide*
Sertindole
Sertraline
Sibutramine
Solifenacin
Sotalol
Sparfloxacin*
Spiramycin
Sumatriptan
Sunitib
Tacrolimus
Tamoxifen
Telithromycin
Terbutaline
Terfenadine*
Terikalant*
Terodiline*
Thioridazine*
Tizanidine
Tolterodine
Trazodone
Trifluoperazine
Trimethoprim sulfa
Trimipramine
Vardenafil
Vasopressin
Venlafaxine
Voriconazole
Zimeldine*
Ziprasidone
Zolmitriptan