Republic of the Philippines

CAVITE STATE UNIVERSITY

(CvSU)
Don Severino Delas Alas Campus
Indang, Cavite
(046) 4150-010 / 4150-011 (046) 4150-012

DRUG STUDY

NAME OF PATIENT: PBB DATE OF ADMISSION: JULY 24, 2014
AGE: 84 YEARS OLD DIAGNOSIS: PGO SECONDARY TO NEW COLONIC GROWTH
SEX: FEMALE
Drug Features
Mechanism of
Action
Indication

Contraindication

Effects Nursing Responsibilities
Generic Name:
CEFOXITIN
Brand Name:
ALFOXTIN
Classification:
ANTI-INFECTIVES
Sub Classification:
SECOND-
GENERATION
CEPHALOSPORINS
Dosage:
1 g
Route:
IV
Frequency:
Q 8
Form:
LIQUID IN AMPULE
Color:
CLEAR
Binds to bacterial
cell wall
membrane,
causing cell death.
Therapeutic
Effects:
Bactericidal action
against
susceptible
bacteria.
Treatment of the
following infections
caused by
susceptible
organisms: : Lower
respiratory tract
infections, Skin and
skin structure
infections, Bone and
joint infections,
Urinary tract
infections,
Gynecological
infections, Intra-
abdominal infections,
Septicemia.
Perioperative
prophylaxis.
Contraindicated in:
Hypersensitivity to
cephalosporins;
Serious
hypersensitivity to
penicillins.
Side Effects
Swelling, redness, pain, or
soreness at the injection
site, loss of appetite,
nausea, vomiting,
diarrhea, or headache
Adverse Effects
CNS: SEIZURES (HIGH
DOSES). GI:
PSEUDOMEMBRANOUS
COLITIS, diarrhea, nausea,
vomiting. Derm: rashes,
urticaria. Hemat: bleeding,
eosinophilia, hemolytic
anemia, leukopenia,
thrombocytopenia. Local:
pain at IM site, phlebitis at
IV site. Misc: ALLERGIC
REACTIONS INCLUDING
ANAPHYLAXIS,
superinfection.
Check for Doctors order
Observe 10Rs of the patient in
medicine administration
Assess for infection (vital signs;
appearance of wound, sputum,
urine, and stool; WBC) at
beginning of and throughout
therapy.
Before initiating therapy, obtain a
history to determine previous
use of and reactions to penicillins
or cephalosporins. Persons with a
negative history of penicillin
sensitivity may still have an
allergic response.
Obtain specimens for culture and
sensitivity before initiating
therapy. First dose may be given
before receiving results.
Observe patient for signs and
symptoms of anaphylaxis (rash,
pruritus, laryngeal edema,
wheezing). Discontinue the drug


and notify health care
professional immediately if these
symptoms occur. Keep
epinephrine, an antihistamine,
and resuscitation equipment
close by in the event of an
anaphylactic reaction.
Monitor bowel function. Diarrhea,
abdominal cramping, fever, and
bloody stools should be reported
to health care professional
promptly as a sign of
pseudomembranous colitis. May
begin up to several weeks
following cessation of therapy.
Lab Test Considerations: May cause
positive results for Coombs' test,
especially in patients with
azotemia.
May cause serum AST, ALT,
alkaline phosphatase, bilirubin,
LDH, BUN, and creatinine.
May cause falsely elevated test
results for serum and urine
creatinine; do not obtain serum
samples within 2 hr of
administration.
May rarely cause leukopenia,
neutropenia, agranulocytosis,
thrombocytopenia, and
eosinophilia. Patient & Family
Education
Advise patient to report signs of
superinfection (furry overgrowth
on the tongue, vaginal itching or
discharge, loose or foul-smelling
stools) and allergy.


Instruct patient to notify health care
professional if fever and diarrhea
develop, especially if stool
contains blood, pus, or mucus.
Advise patient not to treat
diarrhea without consulting
health care professional.
SUBMITTED BY: ANGELICA CASSANDRA P. VILLENA CLINICAL INSTRUCTOR:
YEAR & SEC. GRP: BSN 3 1 GRP 1
DATE: AUGUST 4, 2014